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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Practical insights for paediatric otolaryngology surgical cases and performing microlaryngobronchoscopy during the COVID-19 pandemic</title><author><name sortKey="Frauenfelder, Claire" sort="Frauenfelder, Claire" uniqKey="Frauenfelder C" first="Claire" last="Frauenfelder">Claire Frauenfelder</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">University of Adelaide, South Australia, Australia</nlm:aff></affiliation></author><author><name sortKey="Butler, Colin" sort="Butler, Colin" uniqKey="Butler C" first="Colin" last="Butler">Colin Butler</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">UCL Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hartley, Ben" sort="Hartley, Ben" uniqKey="Hartley B" first="Ben" last="Hartley">Ben Hartley</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Cochrane, Lesley" sort="Cochrane, Lesley" uniqKey="Cochrane L" first="Lesley" last="Cochrane">Lesley Cochrane</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Jephson, Chris" sort="Jephson, Chris" uniqKey="Jephson C" first="Chris" last="Jephson">Chris Jephson</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Nash, Robert" sort="Nash, Robert" uniqKey="Nash R" first="Robert" last="Nash">Robert Nash</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Hewitt, Richard" sort="Hewitt, Richard" uniqKey="Hewitt R" first="Richard" last="Hewitt">Richard Hewitt</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Albert, David" sort="Albert, David" uniqKey="Albert D" first="David" last="Albert">David Albert</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Wyatt, Michelle" sort="Wyatt, Michelle" uniqKey="Wyatt M" first="Michelle" last="Wyatt">Michelle Wyatt</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Hall, Andrew" sort="Hall, Andrew" uniqKey="Hall A" first="Andrew" last="Hall">Andrew Hall</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32278168</idno><idno type="pmc">7142686</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142686</idno><idno type="RBID">PMC:7142686</idno><idno type="doi">10.1016/j.ijporl.2020.110030</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000692</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000692</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Practical insights for paediatric otolaryngology surgical cases and performing microlaryngobronchoscopy during the COVID-19 pandemic</title><author><name sortKey="Frauenfelder, Claire" sort="Frauenfelder, Claire" uniqKey="Frauenfelder C" first="Claire" last="Frauenfelder">Claire Frauenfelder</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">University of Adelaide, South Australia, Australia</nlm:aff></affiliation></author><author><name sortKey="Butler, Colin" sort="Butler, Colin" uniqKey="Butler C" first="Colin" last="Butler">Colin Butler</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">UCL Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hartley, Ben" sort="Hartley, Ben" uniqKey="Hartley B" first="Ben" last="Hartley">Ben Hartley</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Cochrane, Lesley" sort="Cochrane, Lesley" uniqKey="Cochrane L" first="Lesley" last="Cochrane">Lesley Cochrane</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Jephson, Chris" sort="Jephson, Chris" uniqKey="Jephson C" first="Chris" last="Jephson">Chris Jephson</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Nash, Robert" sort="Nash, Robert" uniqKey="Nash R" first="Robert" last="Nash">Robert Nash</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Hewitt, Richard" sort="Hewitt, Richard" uniqKey="Hewitt R" first="Richard" last="Hewitt">Richard Hewitt</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Albert, David" sort="Albert, David" uniqKey="Albert D" first="David" last="Albert">David Albert</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Wyatt, Michelle" sort="Wyatt, Michelle" uniqKey="Wyatt M" first="Michelle" last="Wyatt">Michelle Wyatt</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author><author><name sortKey="Hall, Andrew" sort="Hall, Andrew" uniqKey="Hall A" first="Andrew" last="Hall">Andrew Hall</name><affiliation><nlm:aff id="aff1">Great Ormond Street Hospital for Children, UK</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Pediatric Otorhinolaryngology</title><idno type="ISSN">0165-5876</idno><idno type="eISSN">1872-8464</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Paediatric otolaryngology practice involves examining and operating in anatomical locations with high levels of aerosol generation and transmission of COVID-19 to treating clinicians, especially from the asymptomatic patient populations including children. During the COVID-19 pandemic all emergent otolaryngological conditions affecting the airway, oral, and nasal cavities should be managed medically where possible and any operating deferred. We present guidelines for operating on paediatric otolaryngological patients when necessary during the COVID-19 pandemic, and incorporate experience gathered during microlaryngobronchoscopy on a COVID-19 positive infant at our institution.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Du, H" uniqKey="Du H">H. Du</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Li, Y Y" uniqKey="Li Y">Y.Y. Li</name></author><author><name sortKey="Qu, J" uniqKey="Qu J">J. Qu</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Pediatr Otorhinolaryngol</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Pediatr. Otorhinolaryngol</journal-id><journal-title-group><journal-title>International Journal of Pediatric Otorhinolaryngology</journal-title></journal-title-group><issn pub-type="ppub">0165-5876</issn><issn pub-type="epub">1872-8464</issn><publisher><publisher-name>Published by Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32278168</article-id><article-id pub-id-type="pmc">7142686</article-id><article-id pub-id-type="publisher-id">S0165-5876(20)30173-7</article-id><article-id pub-id-type="doi">10.1016/j.ijporl.2020.110030</article-id><article-id pub-id-type="publisher-id">110030</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Practical insights for paediatric otolaryngology surgical cases and performing microlaryngobronchoscopy during the COVID-19 pandemic</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Frauenfelder</surname><given-names>Claire</given-names></name><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Butler</surname><given-names>Colin</given-names></name><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au3"><name><surname>Hartley</surname><given-names>Ben</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au4"><name><surname>Cochrane</surname><given-names>Lesley</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au5"><name><surname>Jephson</surname><given-names>Chris</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au6"><name><surname>Nash</surname><given-names>Robert</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au7"><name><surname>Hewitt</surname><given-names>Richard</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au8"><name><surname>Albert</surname><given-names>David</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au9"><name><surname>Wyatt</surname><given-names>Michelle</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au10"><name><surname>Hall</surname><given-names>Andrew</given-names></name><email>andrew.hall@gosh.nhs.uk</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Great Ormond Street Hospital for Children, UK</aff><aff id="aff2"><label>b</label>UCL Institute of Child Health, London, UK</aff><aff id="aff3"><label>c</label>University of Adelaide, South Australia, Australia</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author. Great Ormond Street Hospital, Great Ormond Street, Holborn, London, WC1N 3JH, UK. <email>andrew.hall@gosh.nhs.uk</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>30</day><month>3</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>7</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>30</day><month>3</month><year>2020</year></pub-date><volume>134</volume><fpage>110030</fpage><lpage>110030</lpage><permissions><copyright-statement>© 2020 Published by Elsevier B.V.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0033"><p>Paediatric otolaryngology practice involves examining and operating in anatomical locations with high levels of aerosol generation and transmission of COVID-19 to treating clinicians, especially from the asymptomatic patient populations including children. During the COVID-19 pandemic all emergent otolaryngological conditions affecting the airway, oral, and nasal cavities should be managed medically where possible and any operating deferred. We present guidelines for operating on paediatric otolaryngological patients when necessary during the COVID-19 pandemic, and incorporate experience gathered during microlaryngobronchoscopy on a COVID-19 positive infant at our institution.</p></abstract><kwd-group id="kwrds0010"><title>Keywords</title><kwd>COVID-19</kwd><kwd>SARS CoV2</kwd><kwd>Coronavirus</kwd><kwd>Paediatric airway</kwd><kwd>Microlaryngobronchoscopy</kwd></kwd-group></article-meta></front><body><sec id="sec1"><label>1</label><title>Introduction</title><p id="p0010">The current COVID-19 pandemic requires paediatric otolaryngologists to carefully select operative procedures undertaken during this time. However, the nature of many conditions treated by this group means that urgent operative evaluation and intervention in the airway, oral, and nasal cavities is still required. This paper produced by the Otolaryngology team at Great Ormond Street Hospital, London, UK aims to provide guidance for operative modifications to these necessary paediatric procedures at the time of the COVID-19 pandemic. Additionally, we share our experience performing microlaryngobronchoscopy in COVID-19 positive patients. It is recommended this paper be read in conjunction with supporting guidance from local otolaryngological societies and further literature as it becomes available.</p><sec id="sec1.1"><label>1.1</label><title>Patient assessment for risk of COVID-19</title><p id="p0015">Children have been infected from the early stages of the current pandemic, and those that are symptomatic have had a less-severe clinical illness than most adults admitted for treatment. Current data suggests that 15% paediatric COVID positive cases are asymptomatic and 25% present with features of an upper respiratory tract infection [<xref rid="bib1" ref-type="bibr">1</xref>]. There are also concerns regarding the high viral load of asymptomatic paediatric patients [<xref rid="bib2" ref-type="bibr">2</xref>]. A disproportionately high number of health care workers (otolaryngologists in particular) have been infected during the course of their recent clinical work [<xref rid="bib3" ref-type="bibr">[3]</xref>, <xref rid="bib4" ref-type="bibr">[4]</xref>, <xref rid="bib5" ref-type="bibr">[5]</xref>]. The current risk of transmission from asymptomatic patients with COVID-19 to clinicians is difficult to gage based on clinical patient assessment.</p><p id="p0020">Patient COVID-19 status is being formally confirmed via testing, however not all patients requiring urgent surgical treatment of the oral cavity and respiratory tract will have been tested.</p><p id="p0025">A key difficulty in paediatric otolaryngology practice is examining and operating in anatomical locations with high possibility of aerosol generation within a potentially asymptomatic population affected by COVID-19 [<xref rid="bib2" ref-type="bibr">2</xref>]. Asymptomatic patients are at risk of viral shedding during examination and procedural work involving these areas should also recognise the risk of transmission across adjacent surfaces [<xref rid="bib6" ref-type="bibr">6</xref>]. Our current recommendation is all paediatric patients undergoing urgent otolaryngology procedures should be treated as suspected COVID-19 cases until proven otherwise due to the higher proportion of asymptomatic children carrying COVID-19. This is in keeping with guidance emerging from surgical societies and professional organisations [<xref rid="bib7" ref-type="bibr">7</xref>]. While universal screening of patients prior to surgery would be ideal, few institutions around the world are currently equipped to do so due to restricted availability of testing resources. False negative test results remain an area of concern. As such, specific recommendations about which patients to test is currently evolving day by day and is beyond the scope of our discussion.</p></sec><sec id="sec1.2"><label>1.2</label><title>Personal Protective Equipment (PPE)</title><p id="p0030">Appropriate PPE must be utilized to protect staff and local guidelines should reflect the increased risk of aerosol generating procedures (AGP), as described by the World Health Organization [<xref rid="bib8" ref-type="bibr">8</xref>]. The following are the ENT-UK guidelines current at the time of publishing.</p></sec><sec id="sec1.3"><label>1.3</label><title><bold><italic>Minimum PPE for urgent ENT procedures</italic></bold> [<xref rid="bib9" ref-type="bibr">9</xref>]</title><p id="p0035"><list list-type="simple" id="ulist0010"><list-item id="u0010"><label>-</label><p id="p0040">FFP3 or Powered Air Purifying Respirator (PAPR) if fit test not achievable</p></list-item><list-item id="u0015"><label>-</label><p id="p0045">Long sleeved gowns</p></list-item><list-item id="u0020"><label>-</label><p id="p0050">Gloves</p></list-item><list-item id="u0025"><label>-</label><p id="p0055">Disposable eye protection</p></list-item></list></p></sec><sec id="sec1.4"><label>1.4</label><title>General principles of paediatric patient treatment during COVID-19 pandemic</title><p id="p0060"><list list-type="simple" id="ulist0015"><list-item id="u0030"><label>-</label><p id="p0065">Protection of staff, patient and future patients</p></list-item><list-item id="u0035"><label>-</label><p id="p0070">Only most urgent procedures should be performed</p></list-item><list-item id="u0040"><label>-</label><p id="p0075">Appropriate use of Personal Protective Equipment (PPE) at all times</p></list-item><list-item id="u0045"><label>-</label><p id="p0080">Where no appropriate PPE available, no oral cavity and invasive respiratory tract examination or procedure should be undertaken</p></list-item></list></p></sec><sec id="sec1.5"><label>1.5</label><title>Specific airway & procedural principles</title><p id="p0085">Intubation of the airway is widely recognized as a high-risk intervention for respiratory virus transmission to healthcare workers [<xref rid="bib10" ref-type="bibr">10</xref>]. Procedural work undertaken in oral cavity and respiratory tract is also recognized to generate high volume of viral-laden aerosols [<xref rid="bib11" ref-type="bibr">11</xref>].</p><p id="p0090">Only the most urgent procedures should be performed. Management of the airway during urgent paediatric otolaryngology procedures should aim to keep aerosol generation and gas escape from the airway to a minimum. Airway circuits should be closed for as long as possible and minimal airway or mucosal instrumentation and suctioning should be performed [<xref rid="bib12" ref-type="bibr">12</xref>].</p><p id="p0095">Procedures should be restricted to urgent components only and any suitable modifications or abbreviations to usual procedure should be employed, with the goal of limiting staff exposure to operating time and aerosol generation. No powered instrumentation should be used for soft tissue (e.g. microdebrider or laser). Minimal power should be used where drills or burrs are required for bone, however this work should be deferred wherever possible.</p><p id="p0100">Allow significantly more time for the procedure than it would usually take, especially while teams are adjusting to the operating conditions.</p></sec></sec><sec id="sec2"><label>2</label><title>COVID-19 positive microlaryngobronchoscopy: practical insights</title><p id="p0105">Within our institution we have performed urgent microlaryngobronchoscopies in a COVID-19 positive paediatric patient in order to secure and evaluate a known difficult airway. We share our experience to assist other providers prepare to operate in this situation. Many of the general considerations for care of patients with COVID-19 have been explored in early literature, however there are a number of specific operative insights that may be useful.</p><p id="p0110">MLB and rigid bronchoscopy should be considered very high-risk in terms of exposure to staff for the entirety of the procedure due to a combination of aerosol-generation and prolonged gas flow. The requirement for an open circuit delivery of gas/oxygen via the nasopharynx or oropharynx combined with the manipulation of mucosa distributes a very high aerosol volume. Every effort should be made to shorten the procedure time before, during and after the case to minimize the exposure to viral aerosol by staff [<xref rid="bib11" ref-type="bibr">11</xref>,<xref rid="bib13" ref-type="bibr">13</xref>].</p><p id="p0115">As these procedures routinely involve oxygenating the patient via a nasopharyngeal or oropharyngeal airway, without any containment of aerosols, the follow advice applies:<list list-type="simple" id="olist0010"><list-item id="o0010"><label>-</label><p id="p0120">Only urgent cases should be performed</p></list-item><list-item id="o0015"><label>-</label><p id="p0125">All patients should be treated as infective</p></list-item><list-item id="o0020"><label>-</label><p id="p0130">Procedural time should be kept to a bare minimum with an expert provider performing the case</p></list-item><list-item id="o0025"><label>-</label><p id="p0135">Consider minimal 2 person operators given additional challenges of operating in additional PPE</p></list-item></list></p><sec id="sec2.1"><label>2.1</label><title>Pre-operative considerations</title><sec id="sec2.1.1"><label>2.1.1</label><title>Time</title><p id="p0140">All cases performed under these conditions are taking significantly longer time and patience with all team members during preparation is important. Especially with the addition of staff upskilling with donning and doffing of PPE, allow for a significant increase in the usual time required for a case from brief to transfer of the patient back to intensive care or their ward environment. This should be taken into account in discussion with relatives and ward staff.</p></sec><sec id="sec2.1.2"><label>2.1.2</label><title>Team preparation</title><p id="p0145">Pre-operative briefing prior to patient arriving in theatre allows for targeted planning and optimized equipment preparation. A modified WHO checklist was utilized to adequately prepare all staff as to their roles and responsibilities. Where time permits and while teams are learning about how to operate under these conditions, we found that short rehearsal of the procedure with the team beneficial. Our overnight theatre teams have begun their shift with a quick simulation to familiarize themselves with who will be performing what role and checking PPE stocking in the relevant theatres to ensure things are ready for an emergent case involving a COVID patient.</p><p id="p0150">The role of simulation and its principles in preparation for scenarios such as this has also been recommended by the Royal College of Anesthetists in the UK with supporting documents available to assist with local planning prior to an emergency event. This include activities such as rehearsal of donning and doffing in PPE or use of physical action cards to talk/walk through likely scenarios and how this may be planned for [<xref rid="bib14" ref-type="bibr">14</xref>]. Any opportunities to practice ‘in situ’ as a team were felt to be invaluable at our subsequent debriefs.</p></sec><sec id="sec2.1.3"><label>2.1.3</label><title>Team members</title><p id="p0155">While the principle of keeping the number of team members within the theatre is important, overall the team may need to be larger and we have increased allocation of nursing staff, operating department practitioners for a COVID case, and changed our on-call theatre staff arrangements and numbers. We have also included the security team in briefing for the patient as they are key for safe transfer of the patient to and from the operating theatre, keeping contamination of doors, lifts etc. to a minimum as they walk with the clinical team while moving a COVID positive patient around the hospital.</p><p id="p0160">During the case an additional nurse remained clean but with PPE donned in the preparation area with supply of anticipated extra equipment and disposables after different possible outcomes of the procedure was discussed. This minimized delays while waiting for equipment. Also, a second operating department practitioner (ODP) was in the anesthetic room performing the same role: remaining clean but able to liaise with a runner allocated outside of the theatre for communication and to facilitate access to additional medication or equipment without contaminating other parts of the operating suite.</p></sec><sec id="sec2.1.4"><label>2.1.4</label><title>Communication within the team is challenging</title><p id="p0165">PPE required by involved staff can affect intra-operative communication owing to loss of visual cues and sound attenuation. As such particular attention should be given to minimize background noise and precise closed loop communication. Communication between team members in the theatre is more challenging and requires patience at a time of already-increased stress. Good briefing prior to the case helps with this as team members have an idea of what should be happening at each step. Speaker phones or walkie-talkies can be challenging due to PPE, however additional staff members and satellite members of the team with appropriate PPE donned were very helpful.</p></sec><sec id="sec2.1.5"><label>2.1.5</label><title>Theatre environment</title><p id="p0170">Within our institution no negative pressure theatre environment is available and as such a normal pressure room with closed doors was used yet if present would be preferable [<xref rid="bib12" ref-type="bibr">12</xref>]. Currently a group of nominated theatres for COVID cases have been allocated and stock/equipment within them has been modified.</p></sec><sec id="sec2.1.6"><label>2.1.6</label><title>Transfer to theatre</title><p id="p0175">The patient should be sent for once the team is ready with all equipment. PPE needs to be donned and checked prior to receiving the patient and time should be allocated even in emergent cases.</p></sec><sec id="sec2.1.7"><label>2.1.7</label><title>Anesthesia and airway management during MLB</title><p id="p0180">Anesthetic rooms should not be used and induction of anesthesia should be in the operating theatre itself. Where the patient is being transferred from intensive care, minimal manipulation of airway adjuncts or suctioning should be minimized until all staff and equipment for the procedure is ready to begin immediately.</p><p id="p0185">Insertion of an LMA at induction of anesthesia and prior to commencement of MLB/rigid bronchoscopy should also be considered. This decreases distribution of aerosols compared to open airway [<xref rid="bib10" ref-type="bibr">10</xref>,<xref rid="bib11" ref-type="bibr">11</xref>]. It allows a short but additional time period for preparation of equipment, clinician positioning, WHO surgical safety checklist etc while minimising time with an open airway. Caution should employed though as the LMA does not provide protection from spread of viral spread so should be used for the shortest possible period of time. There are many other guidelines being published by our anesthetic colleagues and these are beyond the scope of this discussion.</p></sec></sec><sec id="sec2.2"><label>2.2</label><title>Intra-operative</title><sec id="sec2.2.1"><label>2.2.1</label><title>Equipment</title><p id="p0190">Familiarity with the procedure and equipment is important and team members should be selected accordingly. Reassurance of anxious team members that in fact these procedures are well executed by your team on a regular basis is helpful. A brief but detailed discussion of how the procedure is expected to ‘play-out’ is important and allows nursing staff to prepare a stockpile of equipment for all eventualities in close proximity to the theatre without contaminating other areas or risking staff by rushed doffing of PPE to leave the room. As mentioned, a PPE-protected clean member of nursing staff allocated to this equipment stockpile streamlined the time taken for the case. All equipment including light-leads, cameras, suction should all be set up and checked prior to arrival of patient in the room.</p></sec><sec id="sec2.2.2"><label>2.2.2</label><title>Anticipate and verbalize potential difficulties</title><p id="p0195">Attention should be paid to possible anatomical abnormalities or patient factors that will affect equipment selection (e.g. cleft palates with sumps of thick secretions, ex-premature infants with small airways that have been previously intubated with possible stenoses). Suction attachments and laryngoscope blades set up should reflect these to streamline time and aerosol generation while manipulating the airway.</p></sec></sec><sec id="sec2.3"><label>2.3</label><title>Post-operative</title><sec id="sec2.3.1"><label>2.3.1</label><title>Pause at the end of the case for safety</title><p id="p0200">Doffing of PPE is high risk for transmission of aerosolized material and poor technique has been associated with increased COVID infection rates in healthcare workers [<xref rid="bib10" ref-type="bibr">10</xref>,<xref rid="bib11" ref-type="bibr">11</xref>]. Where the temptation is to remove PPE quickly at the end of the case, additional time should be allocated for this. As team members doff, team members need to supervise each other as they doff (especially while staff are new to PPE) to prompt the steps of doffing with proper hand hygiene to be performed between steps. Laminated guides on the wall in these areas are also helpful. This is especially important given the high level of contamination of the theatre and onto staff's PPE during MLB. Aerosol settling time of 20 min is allocated at our institution between the patient leaving at the end of the case prior to any cleaning by nursing staff.</p></sec><sec id="sec2.3.2"><label>2.3.2</label><title>Debrief</title><p id="p0205">A short team debrief at the end of the case, especially during early experience of COVID cases being performed in the operating suite, allows for identification of steps to streamline, any system or equipment issues that should be addressed and to allow peripheral team members to learn from those involved in the case.</p></sec></sec></sec><sec id="sec3"><label>3</label><title>Other procedures</title><sec id="sec3.1"><label>3.1</label><title>Flexible bronchoscopy via airway-adjunct or ETT</title><p id="p0210">Flexible bronchoscopy should continue to be performed via an LMA or ETT with minimal opening or disconnection of the ventilatory circuit to prevent spread of aerosol.</p></sec><sec id="sec3.2"><label>3.2</label><title><italic>Paediatric</italic> tracheostomy</title><p id="p0215">Tracheostomy is a high-risk procedure because of aerosol-generation and any elective paediatric tracheostomy should be delayed until active COVID-19 disease has passed in keeping with current guidance [<xref rid="bib15" ref-type="bibr">15</xref>]. Any essential paediatric tracheostomy should proceed with PPE as for an AGP in suspected COVID-19 patients:<list list-type="simple" id="ulist0020"><list-item id="u0050"><label>-</label><p id="p0220">Non-fenestrated cuffed tracheostomy should be used to minimize aerosol</p></list-item><list-item id="u0055"><label>-</label><p id="p0225">Initial advancement of the endotracheal tube should be performed prior to tracheostomy being made</p></list-item><list-item id="u0060"><label>-</label><p id="p0230">Ventilation to cease prior to tracheostomy tube insertion where possible and ensure swift and accurate placement of tracheostomy tube with prompt inflation of the cuff</p></list-item><list-item id="u0065"><label>-</label><p id="p0235">Ensure there is no leak from the cuff and the tube is secured in position</p></list-item><list-item id="u0070"><label>-</label><p id="p0240">Post-operative tube changes should only be limited to the initial tube change. Tube exchange should be deferred until the patient has ceased being contagious where possible</p></list-item></list></p><p id="p0245">Humidification via tracheostomy tube following new paediatric tracheostomy should continue to be utilized to avoid crusting within the tube differing from adult guidance [<xref rid="bib16" ref-type="bibr">16</xref>]. Careful clinical judgment is required when selecting the appropriate method of humidification and a heat moisture exchanger (HME) represents an alternative to wet circuit and may decrease aerosol generation. Nebulisers should be avoided and spacers with a metered dose inhaler provide an alternative method of medication delivery to the airway. Caution should be used as unlike adult patients, paediatric tracheostomy tubes classically have no inner cannula for removal and without humidification, are more likely to occlude. An occluded tube would necessitate disruption of the circuit in as an emergency, increasing likelihood of aerosol spread.</p><sec id="sec3.2.1"><label>3.2.1</label><title>Paediatric tracheostomy tube changes</title><p id="p0250">Tracheostomy changes by staff should be minimized during the current COVID pandemic. Where possible the time to the next tracheostomy tube change should be extended or avoided until no active COVID disease present, or negative status is confirmed. If essential, any tracheostomy change should proceed with PPE as for an AGP.</p></sec></sec><sec id="sec3.3"><label>3.3</label><title>Paediatric nasal and sinus surgery & peri-orbital cellulitis</title><p id="p0255">Non-urgent nasal or sinus surgery should not be undertaken during the COVID-19 pandemic. In peri-orbital cellulitis, the British Association of Paediatric Otolaryngology have recommended only considering operating on patients whose infection threatens vision or has developed an intracranial complication [<xref rid="bib17" ref-type="bibr">17</xref>]. An external approach should be used where possible. Throat packs should be used with caution as insertion risks aerosol generation, however debris and secretions in the pharynx are likely to stimulate coughing on emergence from anesthesia.</p><p id="p0260">Paediatric nasal bone fracture reduction is not recommended at the present time unless there is a presence of a nasal septal haematoma [<xref rid="bib17" ref-type="bibr">17</xref>].</p></sec><sec id="sec3.4"><label>3.4</label><title>Other procedures</title><p id="p0265"><list list-type="simple" id="ulist0025"><list-item id="u0075"><label>-</label><p id="p0270">Other urgent paediatric ENT procedures should be performed with a cuffed or micro-cuff ETT where possible</p></list-item><list-item id="u0080"><label>-</label><p id="p0275">Tube-selection should be targeted to minimising a leak around the tube</p></list-item><list-item id="u0085"><label>-</label><p id="p0280">Operating time should be kept to a minimum</p></list-item></list></p></sec></sec><sec id="sec4"><label>4</label><title>Conclusion</title><p id="p0285">Optimal management in the era of COVID-19 necessitates careful consideration of staff safety while continuing to ensure best possible care of the paediatric otolaryngology patient. As further evidence develops as to COVID-19 the recommendations of this paper may be subject to change. 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