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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak</title><author><name sortKey="Chew, Nicholas W S" sort="Chew, Nicholas W S" uniqKey="Chew N" first="Nicholas W. S." last="Chew">Nicholas W. S. Chew</name><affiliation><nlm:aff id="af005">Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lee, Grace K H" sort="Lee, Grace K H" uniqKey="Lee G" first="Grace K. H." last="Lee">Grace K. H. Lee</name><affiliation><nlm:aff id="af010">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Tan, Benjamin Y Q" sort="Tan, Benjamin Y Q" uniqKey="Tan B" first="Benjamin Y. Q." last="Tan">Benjamin Y. Q. Tan</name><affiliation><nlm:aff id="af010">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Jing, Mingxue" sort="Jing, Mingxue" uniqKey="Jing M" first="Mingxue" last="Jing">Mingxue Jing</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Goh, Yihui" sort="Goh, Yihui" uniqKey="Goh Y" first="Yihui" last="Goh">Yihui Goh</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ngiam, Nicholas J H" sort="Ngiam, Nicholas J H" uniqKey="Ngiam N" first="Nicholas J. H." last="Ngiam">Nicholas J. H. Ngiam</name><affiliation><nlm:aff id="af005">Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Yeo, Leonard L L" sort="Yeo, Leonard L L" uniqKey="Yeo L" first="Leonard L. L." last="Yeo">Leonard L. L. Yeo</name><affiliation><nlm:aff id="af010">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ahmad, Aftab" sort="Ahmad, Aftab" uniqKey="Ahmad A" first="Aftab" last="Ahmad">Aftab Ahmad</name><affiliation><nlm:aff id="af020">Department of Neurology, Ng Teng Fong General Hospital, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ahmed Khan, Faheem" sort="Ahmed Khan, Faheem" uniqKey="Ahmed Khan F" first="Faheem" last="Ahmed Khan">Faheem Ahmed Khan</name><affiliation><nlm:aff id="af025">Department of Intensive Care Medicine, Ng Teng Fong General Hospital, Singapore</nlm:aff></affiliation></author><author><name sortKey="Napolean Shanmugam, Ganesh" sort="Napolean Shanmugam, Ganesh" uniqKey="Napolean Shanmugam G" first="Ganesh" last="Napolean Shanmugam">Ganesh Napolean Shanmugam</name><affiliation><nlm:aff id="af020">Department of Neurology, Ng Teng Fong General Hospital, Singapore</nlm:aff></affiliation></author><author><name sortKey="Sharma, Arvind K" sort="Sharma, Arvind K" uniqKey="Sharma A" first="Arvind K." last="Sharma">Arvind K. Sharma</name><affiliation><nlm:aff id="af030">Department of Neurology, Zydus Hospital and BJ Hospital, Ahmedabad, India</nlm:aff></affiliation></author><author><name sortKey="Komalkumar, R N" sort="Komalkumar, R N" uniqKey="Komalkumar R" first="R. N." last="Komalkumar">R. N. Komalkumar</name><affiliation><nlm:aff id="af035">Department of Neurology, Yashoda Hospital, Secunderabad, India</nlm:aff></affiliation></author><author><name sortKey="Meenakshi, P V" sort="Meenakshi, P V" uniqKey="Meenakshi P" first="P. V." last="Meenakshi">P. V. Meenakshi</name><affiliation><nlm:aff id="af040">Department of Neurology, SMS Hospital, Erode, India</nlm:aff></affiliation></author><author><name sortKey="Shah, Kenam" sort="Shah, Kenam" uniqKey="Shah K" first="Kenam" last="Shah">Kenam Shah</name><affiliation><nlm:aff id="af030">Department of Neurology, Zydus Hospital and BJ Hospital, Ahmedabad, India</nlm:aff></affiliation></author><author><name sortKey="Patel, Bhargesh" sort="Patel, Bhargesh" uniqKey="Patel B" first="Bhargesh" last="Patel">Bhargesh Patel</name><affiliation><nlm:aff id="af030">Department of Neurology, Zydus Hospital and BJ Hospital, Ahmedabad, India</nlm:aff></affiliation></author><author><name sortKey="Chan, Bernard P L" sort="Chan, Bernard P L" uniqKey="Chan B" first="Bernard P. L." last="Chan">Bernard P. L. Chan</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Sunny, Sibi" sort="Sunny, Sibi" uniqKey="Sunny S" first="Sibi" last="Sunny">Sibi Sunny</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chandra, Bharatendu" sort="Chandra, Bharatendu" uniqKey="Chandra B" first="Bharatendu" last="Chandra">Bharatendu Chandra</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ong, Jonathan J Y" sort="Ong, Jonathan J Y" uniqKey="Ong J" first="Jonathan J. Y." last="Ong">Jonathan J. Y. Ong</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Paliwal, Prakash R" sort="Paliwal, Prakash R" uniqKey="Paliwal P" first="Prakash R." last="Paliwal">Prakash R. Paliwal</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Wong, Lily Y H" sort="Wong, Lily Y H" uniqKey="Wong L" first="Lily Y. H." last="Wong">Lily Y. H. Wong</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Sagayanathan, Renarebecca" sort="Sagayanathan, Renarebecca" uniqKey="Sagayanathan R" first="Renarebecca" last="Sagayanathan">Renarebecca Sagayanathan</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chen, Jin Tao" sort="Chen, Jin Tao" uniqKey="Chen J" first="Jin Tao" last="Chen">Jin Tao Chen</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ying Ng, Alison Ying" sort="Ying Ng, Alison Ying" uniqKey="Ying Ng A" first="Alison Ying" last="Ying Ng">Alison Ying Ying Ng</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Teoh, Hock Luen" sort="Teoh, Hock Luen" uniqKey="Teoh H" first="Hock Luen" last="Teoh">Hock Luen Teoh</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Tsivgoulis, Georgios" sort="Tsivgoulis, Georgios" uniqKey="Tsivgoulis G" first="Georgios" last="Tsivgoulis">Georgios Tsivgoulis</name><affiliation><nlm:aff id="af045">Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital, Athens, Greece and The University of Tennessee Health Science Center, Memphis, TN, United States</nlm:aff></affiliation></author><author><name sortKey="Ho, Cyrus S" sort="Ho, Cyrus S" uniqKey="Ho C" first="Cyrus S." last="Ho">Cyrus S. Ho</name><affiliation><nlm:aff id="af050">Department of Psychological Medicine, National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ho, Roger C" sort="Ho, Roger C" uniqKey="Ho R" first="Roger C." last="Ho">Roger C. Ho</name><affiliation><nlm:aff id="af050">Department of Psychological Medicine, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="af055">Institute of Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Sharma, Vijay K" sort="Sharma, Vijay K" uniqKey="Sharma V" first="Vijay K." last="Sharma">Vijay K. Sharma</name><affiliation><nlm:aff id="af010">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32330593</idno><idno type="pmc">7172854</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172854</idno><idno type="RBID">PMC:7172854</idno><idno type="doi">10.1016/j.bbi.2020.04.049</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000622</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000622</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak</title><author><name sortKey="Chew, Nicholas W S" sort="Chew, Nicholas W S" uniqKey="Chew N" first="Nicholas W. S." last="Chew">Nicholas W. S. Chew</name><affiliation><nlm:aff id="af005">Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lee, Grace K H" sort="Lee, Grace K H" uniqKey="Lee G" first="Grace K. H." last="Lee">Grace K. H. Lee</name><affiliation><nlm:aff id="af010">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Tan, Benjamin Y Q" sort="Tan, Benjamin Y Q" uniqKey="Tan B" first="Benjamin Y. Q." last="Tan">Benjamin Y. Q. Tan</name><affiliation><nlm:aff id="af010">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Jing, Mingxue" sort="Jing, Mingxue" uniqKey="Jing M" first="Mingxue" last="Jing">Mingxue Jing</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Goh, Yihui" sort="Goh, Yihui" uniqKey="Goh Y" first="Yihui" last="Goh">Yihui Goh</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ngiam, Nicholas J H" sort="Ngiam, Nicholas J H" uniqKey="Ngiam N" first="Nicholas J. H." last="Ngiam">Nicholas J. H. Ngiam</name><affiliation><nlm:aff id="af005">Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Yeo, Leonard L L" sort="Yeo, Leonard L L" uniqKey="Yeo L" first="Leonard L. L." last="Yeo">Leonard L. L. Yeo</name><affiliation><nlm:aff id="af010">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ahmad, Aftab" sort="Ahmad, Aftab" uniqKey="Ahmad A" first="Aftab" last="Ahmad">Aftab Ahmad</name><affiliation><nlm:aff id="af020">Department of Neurology, Ng Teng Fong General Hospital, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ahmed Khan, Faheem" sort="Ahmed Khan, Faheem" uniqKey="Ahmed Khan F" first="Faheem" last="Ahmed Khan">Faheem Ahmed Khan</name><affiliation><nlm:aff id="af025">Department of Intensive Care Medicine, Ng Teng Fong General Hospital, Singapore</nlm:aff></affiliation></author><author><name sortKey="Napolean Shanmugam, Ganesh" sort="Napolean Shanmugam, Ganesh" uniqKey="Napolean Shanmugam G" first="Ganesh" last="Napolean Shanmugam">Ganesh Napolean Shanmugam</name><affiliation><nlm:aff id="af020">Department of Neurology, Ng Teng Fong General Hospital, Singapore</nlm:aff></affiliation></author><author><name sortKey="Sharma, Arvind K" sort="Sharma, Arvind K" uniqKey="Sharma A" first="Arvind K." last="Sharma">Arvind K. Sharma</name><affiliation><nlm:aff id="af030">Department of Neurology, Zydus Hospital and BJ Hospital, Ahmedabad, India</nlm:aff></affiliation></author><author><name sortKey="Komalkumar, R N" sort="Komalkumar, R N" uniqKey="Komalkumar R" first="R. N." last="Komalkumar">R. N. Komalkumar</name><affiliation><nlm:aff id="af035">Department of Neurology, Yashoda Hospital, Secunderabad, India</nlm:aff></affiliation></author><author><name sortKey="Meenakshi, P V" sort="Meenakshi, P V" uniqKey="Meenakshi P" first="P. V." last="Meenakshi">P. V. Meenakshi</name><affiliation><nlm:aff id="af040">Department of Neurology, SMS Hospital, Erode, India</nlm:aff></affiliation></author><author><name sortKey="Shah, Kenam" sort="Shah, Kenam" uniqKey="Shah K" first="Kenam" last="Shah">Kenam Shah</name><affiliation><nlm:aff id="af030">Department of Neurology, Zydus Hospital and BJ Hospital, Ahmedabad, India</nlm:aff></affiliation></author><author><name sortKey="Patel, Bhargesh" sort="Patel, Bhargesh" uniqKey="Patel B" first="Bhargesh" last="Patel">Bhargesh Patel</name><affiliation><nlm:aff id="af030">Department of Neurology, Zydus Hospital and BJ Hospital, Ahmedabad, India</nlm:aff></affiliation></author><author><name sortKey="Chan, Bernard P L" sort="Chan, Bernard P L" uniqKey="Chan B" first="Bernard P. L." last="Chan">Bernard P. L. Chan</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Sunny, Sibi" sort="Sunny, Sibi" uniqKey="Sunny S" first="Sibi" last="Sunny">Sibi Sunny</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chandra, Bharatendu" sort="Chandra, Bharatendu" uniqKey="Chandra B" first="Bharatendu" last="Chandra">Bharatendu Chandra</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ong, Jonathan J Y" sort="Ong, Jonathan J Y" uniqKey="Ong J" first="Jonathan J. Y." last="Ong">Jonathan J. Y. Ong</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Paliwal, Prakash R" sort="Paliwal, Prakash R" uniqKey="Paliwal P" first="Prakash R." last="Paliwal">Prakash R. Paliwal</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Wong, Lily Y H" sort="Wong, Lily Y H" uniqKey="Wong L" first="Lily Y. H." last="Wong">Lily Y. H. Wong</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Sagayanathan, Renarebecca" sort="Sagayanathan, Renarebecca" uniqKey="Sagayanathan R" first="Renarebecca" last="Sagayanathan">Renarebecca Sagayanathan</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Chen, Jin Tao" sort="Chen, Jin Tao" uniqKey="Chen J" first="Jin Tao" last="Chen">Jin Tao Chen</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ying Ng, Alison Ying" sort="Ying Ng, Alison Ying" uniqKey="Ying Ng A" first="Alison Ying" last="Ying Ng">Alison Ying Ying Ng</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Teoh, Hock Luen" sort="Teoh, Hock Luen" uniqKey="Teoh H" first="Hock Luen" last="Teoh">Hock Luen Teoh</name><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Tsivgoulis, Georgios" sort="Tsivgoulis, Georgios" uniqKey="Tsivgoulis G" first="Georgios" last="Tsivgoulis">Georgios Tsivgoulis</name><affiliation><nlm:aff id="af045">Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital, Athens, Greece and The University of Tennessee Health Science Center, Memphis, TN, United States</nlm:aff></affiliation></author><author><name sortKey="Ho, Cyrus S" sort="Ho, Cyrus S" uniqKey="Ho C" first="Cyrus S." last="Ho">Cyrus S. Ho</name><affiliation><nlm:aff id="af050">Department of Psychological Medicine, National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Ho, Roger C" sort="Ho, Roger C" uniqKey="Ho R" first="Roger C." last="Ho">Roger C. Ho</name><affiliation><nlm:aff id="af050">Department of Psychological Medicine, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="af055">Institute of Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Sharma, Vijay K" sort="Sharma, Vijay K" uniqKey="Sharma V" first="Vijay K." last="Sharma">Vijay K. Sharma</name><affiliation><nlm:aff id="af010">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="af015">Division of Neurology, Department of Medicine, National University Health System, Singapore</nlm:aff></affiliation></author></analytic><series><title level="j">Brain, Behavior, and Immunity</title><idno type="ISSN">0889-1591</idno><idno type="eISSN">1090-2139</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">Commonly reported symptoms are headache, throat pain and lethargy.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">A large number of healthcare workers report more than four symptoms.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">Those with physical symptoms had higher rates of depression, anxiety, stress, PTSD.</p></list-item><list-item id="o0020"><label>•</label><p id="p0020">Those with physical symptoms had higher mean scores in the IES-R, DASS subscales.</p></list-item><list-item id="o0025"><label>•</label><p id="p0025">Association between physical symptoms and psychological outcomes may be bidirectional.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Basant, K" uniqKey="Basant K">K. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Brain Behav Immun</journal-id><journal-id journal-id-type="iso-abbrev">Brain Behav. Immun</journal-id><journal-title-group><journal-title>Brain, Behavior, and Immunity</journal-title></journal-title-group><issn pub-type="ppub">0889-1591</issn><issn pub-type="epub">1090-2139</issn><publisher><publisher-name>Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32330593</article-id><article-id pub-id-type="pmc">7172854</article-id><article-id pub-id-type="publisher-id">S0889-1591(20)30523-7</article-id><article-id pub-id-type="doi">10.1016/j.bbi.2020.04.049</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak</article-title></title-group><contrib-group><contrib contrib-type="author" id="au005"><name><surname>Chew</surname><given-names>Nicholas W.S.</given-names></name><xref rid="af005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au010"><name><surname>Lee</surname><given-names>Grace K.H.</given-names></name><xref rid="af010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au015"><name><surname>Tan</surname><given-names>Benjamin Y.Q.</given-names></name><xref rid="af010" ref-type="aff">b</xref><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au020"><name><surname>Jing</surname><given-names>Mingxue</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au025"><name><surname>Goh</surname><given-names>Yihui</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au030"><name><surname>Ngiam</surname><given-names>Nicholas J.H.</given-names></name><xref rid="af005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au035"><name><surname>Yeo</surname><given-names>Leonard L.L.</given-names></name><xref rid="af010" ref-type="aff">b</xref><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au040"><name><surname>Ahmad</surname><given-names>Aftab</given-names></name><xref rid="af020" ref-type="aff">d</xref></contrib><contrib contrib-type="author" id="au045"><name><surname>Ahmed Khan</surname><given-names>Faheem</given-names></name><xref rid="af025" ref-type="aff">e</xref></contrib><contrib contrib-type="author" id="au050"><name><surname>Napolean Shanmugam</surname><given-names>Ganesh</given-names></name><xref rid="af020" ref-type="aff">d</xref></contrib><contrib contrib-type="author" id="au055"><name><surname>Sharma</surname><given-names>Arvind K.</given-names></name><xref rid="af030" ref-type="aff">f</xref></contrib><contrib contrib-type="author" id="au060"><name><surname>Komalkumar</surname><given-names>R.N.</given-names></name><xref rid="af035" ref-type="aff">g</xref></contrib><contrib contrib-type="author" id="au065"><name><surname>Meenakshi</surname><given-names>P.V.</given-names></name><xref rid="af040" ref-type="aff">h</xref></contrib><contrib contrib-type="author" id="au070"><name><surname>Shah</surname><given-names>Kenam</given-names></name><xref rid="af030" ref-type="aff">f</xref></contrib><contrib contrib-type="author" id="au075"><name><surname>Patel</surname><given-names>Bhargesh</given-names></name><xref rid="af030" ref-type="aff">f</xref></contrib><contrib contrib-type="author" id="au080"><name><surname>Chan</surname><given-names>Bernard P.L.</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au085"><name><surname>Sunny</surname><given-names>Sibi</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au090"><name><surname>Chandra</surname><given-names>Bharatendu</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au095"><name><surname>Ong</surname><given-names>Jonathan J.Y.</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au100"><name><surname>Paliwal</surname><given-names>Prakash R.</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au105"><name><surname>Wong</surname><given-names>Lily Y.H.</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au110"><name><surname>Sagayanathan</surname><given-names>Renarebecca</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au115"><name><surname>Chen</surname><given-names>Jin Tao</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au120"><name><surname>Ying Ng</surname><given-names>Alison Ying</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au125"><name><surname>Teoh</surname><given-names>Hock Luen</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au130"><name><surname>Tsivgoulis</surname><given-names>Georgios</given-names></name><xref rid="af045" ref-type="aff">i</xref></contrib><contrib contrib-type="author" id="au135"><name><surname>Ho</surname><given-names>Cyrus S.</given-names></name><xref rid="af050" ref-type="aff">j</xref></contrib><contrib contrib-type="author" id="au140"><name><surname>Ho</surname><given-names>Roger C.</given-names></name><xref rid="af050" ref-type="aff">j</xref><xref rid="af055" ref-type="aff">k</xref></contrib><contrib contrib-type="author" id="au145"><name><surname>Sharma</surname><given-names>Vijay K.</given-names></name><email>Vijay_Kumar_SHARMA@nuhs.edu.sg</email><xref rid="af010" ref-type="aff">b</xref><xref rid="af015" ref-type="aff">c</xref><xref rid="cor1" ref-type="corresp">⁎</xref></contrib><aff id="af005"><label>a</label>Department of Medicine, National University Health System, Singapore</aff><aff id="af010"><label>b</label>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</aff><aff id="af015"><label>c</label>Division of Neurology, Department of Medicine, National University Health System, Singapore</aff><aff id="af020"><label>d</label>Department of Neurology, Ng Teng Fong General Hospital, Singapore</aff><aff id="af025"><label>e</label>Department of Intensive Care Medicine, Ng Teng Fong General Hospital, Singapore</aff><aff id="af030"><label>f</label>Department of Neurology, Zydus Hospital and BJ Hospital, Ahmedabad, India</aff><aff id="af035"><label>g</label>Department of Neurology, Yashoda Hospital, Secunderabad, India</aff><aff id="af040"><label>h</label>Department of Neurology, SMS Hospital, Erode, India</aff><aff id="af045"><label>i</label>Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, “Attikon” University Hospital, Athens, Greece and The University of Tennessee Health Science Center, Memphis, TN, United States</aff><aff id="af050"><label>j</label>Department of Psychological Medicine, National University of Singapore, Singapore</aff><aff id="af055"><label>k</label>Institute of Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore</aff></contrib-group><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. <email>Vijay_Kumar_SHARMA@nuhs.edu.sg</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>21</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>21</day><month>4</month><year>2020</year></pub-date><history><date date-type="received"><day>10</day><month>4</month><year>2020</year></date><date date-type="rev-recd"><day>18</day><month>4</month><year>2020</year></date><date date-type="accepted"><day>18</day><month>4</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Elsevier Inc.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="ab005"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">Commonly reported symptoms are headache, throat pain and lethargy.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">A large number of healthcare workers report more than four symptoms.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">Those with physical symptoms had higher rates of depression, anxiety, stress, PTSD.</p></list-item><list-item id="o0020"><label>•</label><p id="p0020">Those with physical symptoms had higher mean scores in the IES-R, DASS subscales.</p></list-item><list-item id="o0025"><label>•</label><p id="p0025">Association between physical symptoms and psychological outcomes may be bidirectional.</p></list-item></list></p></abstract><abstract id="ab010"><sec><title>Objective</title><p>Since the declaration of the coronavirus 2019 (COVID-19) outbreak as pandemic, there are reports on the increased prevalence of physical symptoms observed in the general population. We investigated the association between psychological outcomes and physical symptoms among healthcare workers.</p></sec><sec><title>Methods</title><p>Healthcare workers from 5 major hospitals, involved in the care for COVID-19 patients, in Singapore and India were invited to participate in a study by performing a self-administered questionnaire within the period of February 19 to April 17, 2020. Healthcare workers included doctors, nurses, allied healthcare workers, administrators, clerical staff and maintenance workers. This questionnaire collected information on demographics, medical history, symptom prevalence in the past month, Depression Anxiety Stress Scales (DASS-21) and the Impact of Events Scale-Revised (IES-R) instrument. The prevalence of physical symptoms displayed by healthcare workers and the associations between physical symptoms and psychological outcomes of depression, anxiety, stress, and post-traumatic stress disorder (PTSD) were evaluated.</p></sec><sec><title>Results</title><p>Out of the 906 healthcare workers who participated in the survey, 48 (5.3%) screened positive for moderate to very-severe depression, 79 (8.7%) for moderate to extremely-severe anxiety, 20 (2.2%) for moderate to extremely-severe stress, and 34 (3.8%) for moderate to severe levels of psychological distress. The commonest reported symptom was headache (32.3%), with a large number of participants (33.4%) reporting more than four symptoms. Participants who had experienced symptoms in the preceding month were more likely to be older, have pre-existing comorbidities and a positive screen for depression, anxiety, stress, and PTSD. After adjusting for age, gender and comorbidities, it was found that depression (OR 2.79, 95% CI 1.54–5.07, p = 0.001), anxiety (OR 2.18, 95% CI 1.36–3.48, p = 0.001), stress (OR 3.06, 95% CI 1.27–7.41, p = 0.13), and PTSD (OR 2.20, 95% CI 1.12–4.35, p = 0.023) remained significantly associated with the presence of physical symptoms experienced in the preceding month. Linear regression revealed that the presence of physical symptoms was associated with higher mean scores in the IES-R, DASS Anxiety, Stress and Depression subscales.</p></sec><sec><title>Conclusions</title><p>Our study demonstrates a significant association between the prevalence of physical symptoms and psychological outcomes among healthcare workers during the COVID-19 outbreak. We postulate that this association may be bi-directional, and that timely psychological interventions for healthcare workers with physical symptoms should be considered once an infection has been excluded.</p></sec></abstract><kwd-group id="kg005"><title>Keywords</title><kwd>COVID-19</kwd><kwd>Healthcare workers</kwd><kwd>Psychological impact</kwd><kwd>Anxiety</kwd><kwd>Depression</kwd><kwd>Stress</kwd><kwd>Pandemic</kwd><kwd>Physical symptoms</kwd></kwd-group></article-meta></front><body><sec id="s0005"><label>1</label><title>Introduction</title><p id="p0030">On December 31, 2019, the China office of World Health Organization (WHO) was notified regarding some cases of pneumonia of unknown etiology in Wuhan City of Hubei province. It was subsequently termed coronavirus disease 2019 (COVID-19) by the WHO. The rapid global spread of the disease led to the declaration of COVID-19 as a pandemic on March 11, 2020 (<xref rid="b0135" ref-type="bibr">Organization, 2020</xref>). Being a global hub with high international traffic, Singapore observed an increasing spread of COVID-19. Accordingly, the Disease Outbreak Response System Condition (DORSCON) alert level was escalated to orange on February 7, 2020, which indicates that the outbreak is deemed to have moderate to high public health impact, necessitating additional measures like quarantine and temperature screening to minimize risk of further virus transmission in the community (<xref rid="b0140" ref-type="bibr">S K. Singapore raises cornavirus outbreak alert to orange: What does it mean, 2020</xref>, <xref rid="b0145" ref-type="bibr">SK CA-L, 2020</xref>). Similarly, being a densely populated country, the Indian authorities imposed a lockdown on March 24, 2020, which involved barring of all public transport and prohibiting opening of public spaces (<xref rid="b0170" ref-type="bibr">The Times of India, 2020</xref>). Between February 19 to April 17, 2020, Singapore reported slightly over 5000 confirmed COVID-19 cases with 11 deaths, while India has reported >13,000 confirmed cases with >400 deaths (<xref rid="b0165" ref-type="bibr">The Times of India, 2020</xref>, <xref rid="b0120" ref-type="bibr">Ministry of Health Singapore, 2019</xref>). Much uncertainty revolved around the nature of spread of COVID-19, its severity, associated mortality and the availability of essential resources like facial masks, hand sanitizers and digital thermometers. Widespread fear of imposed quarantine and lockdown measures led to the unusual displays of panic in the form of frenzied buying of goods by the general public observed in many countries (<xref rid="b0020" ref-type="bibr">Coronavirus: Hong Kong shoppers snap up rice and noodles as fears over outbreak mount, 2020</xref>, <xref rid="b0050" ref-type="bibr">'It's pandemonium': virus panic-buying hits Los Angeles, 2020</xref>, <xref rid="b0150" ref-type="bibr">T A. Coronavirus: Politicians, supermarkets urge calm amid panic-buying of groceries, 2020</xref>).</p><p id="p0035">Infectious disease outbreaks are known to have psychological impact on healthcare workers as well as the general population. A notable example would be the psychological sequelae observed during the Severe Acute Respiratory Syndrome (SARS) outbreak in 2003 (<xref rid="b0105" ref-type="bibr">McAlonan et al., 2007</xref>, <xref rid="b0115" ref-type="bibr">Ministry of Health S, 2004</xref>). Studies on the SARS outbreak revealed that healthcare workers experienced acute stress reactions (<xref rid="b0155" ref-type="bibr">Tam et al., 2004</xref>, <xref rid="b0035" ref-type="bibr">Grace et al., 2005</xref>).</p><p id="p0040">In addition to the specific physical manifestations of various diseases, some symptoms may arise due to the psychological sequelae of these infection outbreaks. Such psychosomatic symptoms have been reported with increased prevalence during and after the outbreaks, such as the SARS and Ebola virus (<xref rid="b0065" ref-type="bibr">Lam et al., 2009</xref>, <xref rid="b0070" ref-type="bibr">Lee et al., 2005</xref>, <xref rid="b0090" ref-type="bibr">Marco et al., 2015</xref>, <xref rid="b0100" ref-type="bibr">Matua and Wal, 2015</xref>, <xref rid="b0180" ref-type="bibr">Tucker, xxxx</xref>, <xref rid="b0205" ref-type="bibr">Xiang et al., 2020</xref>). The commonly reported symptoms range from more specific symptoms like pain(<xref rid="b0065" ref-type="bibr">Lam et al., 2009</xref>) to non-specific ones like fatigue, weakness and lethargy (<xref rid="b0075" ref-type="bibr">Leow et al., 2005</xref>). In some cases, symptoms not perceived to be directly related to a particular infectious disease may be reported. For instance, some survivors of SARS outbreak developed chronic extra-pulmonary symptoms during outpatient clinical follow-up (<xref rid="b0075" ref-type="bibr">Leow et al., 2005</xref>). It is important to understand the prevalence and patterns of such somatic manifestations since they can lead to undesirable overcrowding of hospital emergency departments (<xref rid="b0030" ref-type="bibr">Farr, 2020</xref>, <xref rid="b0005" ref-type="bibr">Abelson, 2020</xref>), causing additional workload to the already constrained healthcare systems. We investigate the association between various physical symptoms and psychological distress amongst healthcare workers in Singapore and India during the current COVID-19 outbreak.</p></sec><sec id="s0010"><label>2</label><title>Methods</title><sec id="s0015"><label>2.1</label><title>Study setting and population</title><p id="p0045">From February 19 to April 17, 2020, we recruited healthcare workers from major tertiary healthcare institutions in Singapore and India. During the study period, the healthcare institutions were actively involved in the care of COVID-19 patients. Study participants included doctors, nurses, allied healthcare workers (pharmacists, physiotherapists, occupational therapists), technicians, administrators, clerical staff and maintenance workers. Written informed consent was obtained from all participants and the study was approved by the institutional review board, in accordance to the principles in the Declaration of Helsinki.</p></sec><sec id="s0020"><label>2.2</label><title>Screening questionnaire</title><p id="p0050">The study questionnaire, written in English, comprised five main components- demographic characteristics, medical history, symptom prevalence in the previous month, Depression Anxiety Stress Scales (DASS-21) and the Impact of Events Scale-Revised (IES-R) instruments.</p><p id="p0055">Baseline demographic characteristics such as gender, age, ethnicity, marital status, occupation and past medical history were recorded. Participants had to indicate if they experienced any of the 16 listed physical symptoms, general or respiratory-related symptoms, during the previous month and rated the severity of the reported symptoms (<xref rid="s0090" ref-type="sec">Supplementary Material 1</xref>). The study questionnaire was adopted from our previous study related to the psychological impact on healthcare workers in Singapore during the COVID-19 outbreak (<xref rid="b0160" ref-type="bibr">Tay et al., 2020</xref>).</p><p id="p0060">Depression, anxiety and stress were assessed using DASS-21 (<xref rid="b0085" ref-type="bibr">LP, LS, 1995</xref>), which is a validated screening instrument for use among patients and general populations. It is a self-reported 21-item system developed by the University of New South Wales, Australia, which provides independent measures of depression, stress and anxiety with recommended severity thresholds for the depression, stress and anxiety subscales. The scores for each of the three components were calculated by summing up the scores for the relevant items, and multiplying by two to calculate the final score. Cut-off scores of > 9, >7 and > 14 represent a positive screen of depression, anxiety and stress, respectively. On the DASS-21 depression subscales, scores of 10–13 were deemed as “mild”, 14–20 as “moderate”, 21–27 as “severe”, and 28–42 as “extremely severe” depression. The DASS-21 anxiety subscale score was assessed as “mild” (8–9), “moderate” (10–14), “severe” (15–19), and extremely severe” (20–42). The DASS-21 stress subscale score was divided into “mild” (15–18), “moderate” (19–25), “severe” (26–33), and “extremely severe” stress (34–42) (<xref rid="b0160" ref-type="bibr">Tay et al., 2020</xref>).</p><p id="p0065">The psychological distress of the outbreak was assessed using the IES-R25, (<xref rid="b0200" ref-type="bibr">Weiss, 2007</xref>), which is a validated 22-item self-report that measures the subjective distress caused by traumatic events. It has 3 subscales (Intrusion, Avoidance and Hyperarousal), which are closely affiliated with post-traumatic stress disorder (PTSD) symptoms. Participants were asked to rate the level of distress for each component during the previous seven days of their interview. The total IES-R score was graded for severity from normal (0–23), mild (24–32), moderate (33–36), and severe psychological impact (>37). A cut-off score of 24 was used to define PTSD of a clinical concern (<xref rid="b0025" ref-type="bibr">Creamer et al., 2003</xref>, <xref rid="b0200" ref-type="bibr">Weiss, 2007</xref>). Both DASS-21 and IES-R have been validated for use in a recent Chinese study investigating the psychological impact of COVID-19 on the general population (<xref rid="b0195" ref-type="bibr">Wang et al., 2020a</xref>, <xref rid="b0045" ref-type="bibr">Ho et al., 2014</xref>).</p></sec><sec id="s0025"><label>2.3</label><title>Study outcomes</title><p id="p0070">We evaluated the prevalence of physical symptoms reported by the healthcare workers during previous one month before the survey administration period. Additionally, we investigated the association between the presence of various physical symptoms and psychological outcomes, namely the DASS-21 score and IES-R score.</p></sec><sec id="s0030"><label>2.4</label><title>Statistical analyses</title><p id="p0075">Categorical variables are expressed as absolute values (percentage) and continuous variables were expressed as mean value ± (standard deviation). Student’s <italic>t</italic>-test was used to examine the association between continuous variables and Pearson’s chi-square test (or Fisher’s Exact Test, where appropriate) was used to evaluate categorical variables. Multivariable logistic regression was used to adjust for the effect of confounders when appropriate to determine independent associations of binary outcomes. Linear regression was employed to evaluate for associations between baseline characteristics, risk status, physical symptoms and the mean scores for DASS-21 and IES-R components. A p-value of<0.05 was deemed significant for this study. All statistical analyses were performed using IBM SPSS Statistics for Windows, Version 25.0. Armonk, NY.</p></sec></sec><sec id="s0035"><label>3</label><title>Results</title><sec id="s0040"><label>3.1</label><title>Participants</title><p id="p0080">Of the 1000 invited healthcare workers from the major hospitals in Singapore and India, 906 (90.6%) agreed to participate in this study. Of which, 480 respondents were from Singapore and 426 from India. Majority (583, 64.3%) were female and the median age was 29 (interquartile range: 25–35) years (<xref rid="t0005" ref-type="table">Table 1</xref>). Most (55.1%) of the participants were Indian, followed by Chinese (33.7%) and Malay (4.8%) ethnicity. Being a relatively younger study population, 50.2% of the participants were unmarried. Two hundred and five (22.6%) participants had pre-existing comorbidities, migraine (9.6%) being the most prevalent followed by eczema (4.1%) and asthma (4.0%). Nurses comprised 39.2% of the study population, followed by physicians (29.6%) and allied healthcare professionals (10.6%) (<xref rid="t0005" ref-type="table">Table 1</xref>).<table-wrap position="float" id="t0005"><label>Table 1</label><caption><p>Baseline characteristics of study participants (N = 906).</p></caption><table frame="hsides" rules="groups"><thead><tr><th><bold>Characteristic</bold></th><th><bold>N (%)</bold></th></tr></thead><tbody><tr><td colspan="2"><bold>Sex, n (%)</bold></td></tr><tr><td>Female</td><td>583 (64.3)</td></tr><tr><td>Male</td><td>323 (35.7)</td></tr><tr><td colspan="2"></td></tr><tr><td>Median Age (IQR), <italic>y</italic></td><td>29 (25 – 35)</td></tr><tr><td colspan="2"><bold>Ethnicity,</bold> n (%)</td></tr><tr><td>Chinese</td><td>305 (33.7)</td></tr><tr><td>Indian</td><td>499 (55.1)</td></tr><tr><td>Malay</td><td>44 (4.8)</td></tr><tr><td>Others</td><td>58 (6.4)</td></tr><tr><td colspan="2"><bold>Marital Status, n (%)</bold></td></tr><tr><td>Single</td><td>455 (50.2)</td></tr><tr><td>Married</td><td>434 (47.9)</td></tr><tr><td>Divorced, separated or widowed</td><td>17 (1.9)</td></tr><tr><td colspan="2"><bold>Occupation, n (%)</bold></td></tr><tr><td>Physician</td><td>268 (29.6)</td></tr><tr><td>Nurse</td><td>355 (39.2)</td></tr><tr><td>Allied health care professional</td><td>96 (10.6)</td></tr><tr><td>Technician</td><td>40 (4.4)</td></tr><tr><td>Clerical Staff</td><td>56 (6.2)</td></tr><tr><td>Administrator</td><td>39 (4.3)</td></tr><tr><td>Maintenance worker</td><td>52 (5.7)</td></tr><tr><td colspan="2"><bold>Medical History, n (%)</bold></td></tr><tr><td>Hypertension</td><td>34 (3.8)</td></tr><tr><td>Hyperlipidemia</td><td>29 (3.2)</td></tr><tr><td>Diabetes Mellitus</td><td>14 (1.4)</td></tr><tr><td>Asthma</td><td>36 (4.0)</td></tr><tr><td>Eczema</td><td>37 (4.1)</td></tr><tr><td>Migraine</td><td>87 (9.6)</td></tr><tr><td>Cigarette Smoking</td><td>29 (3.2)</td></tr><tr><td>Ischemic Heart Disease</td><td>4 (0.4)</td></tr><tr><td>Stroke</td><td>1 (0.1)</td></tr><tr><td>Other comorbid conditions</td><td>30 (3.3)</td></tr></tbody></table></table-wrap></p></sec><sec id="s0045"><label>3.2</label><title>Prevalence of physical symptoms</title><p id="p0085">The commonest reported symptoms were headache (289, 31.9%), throat pain (304, 33.6%), anxiety (242, 26.7%), lethargy (241, 26.6%), and insomnia (190, 21.0%) (<xref rid="f0005" ref-type="fig">Fig. 1</xref>). While 302 (33.3%) respondents did not report any symptom within the preceding 1-month of the survey administration date, 115 (12.7%) reported one symptom, 113 (12.5%) reported two, 73 (8.1%) reported three, and 303 (33.4%) reported more than four symptoms. Importantly, the symptoms were generally mild in severity.<fig id="f0005"><label>Fig. 1</label><caption><p>Five most common symptoms experienced during the past one month of the COVID-19 outbreak (N = 906).</p></caption><graphic xlink:href="gr1_lrg"></graphic></fig></p></sec><sec id="s0050"><label>3.3</label><title>Psychological outcomes</title><p id="p0090">Using our predefined cut-offs for the DASS-21 scoring system to screen for depression, anxiety and stress, we found anxiety in 142 (15.7%), depression in 96 (10.6%) and stress in 47 (5.2%) study participants. There was no difference in psychological outcomes between study participants from the two countries (<xref rid="t0010" ref-type="table">Table 2</xref>). The overall mean DASS-21 depression subscale score was 3.08 (SD 4.86). Of the 96 healthcare workers who screened positive for depression, 50% of them (48) were scored as moderate to very severe depression. The overall mean DASS-21 anxiety subscale score was 3.21 (SD 4.29). Of the 142 patients who screened positive for anxiety, 55.6% of them (79) showed moderate to very severe anxiety. In terms of the DASS-21 stress subscale, the overall mean score was 4.62 (SD 5.54). Stress was moderate-to-severe in 20 of the 47 participants (42.6%) who screened positive for it (<xref rid="f0010" ref-type="fig">Fig. 2</xref>).<table-wrap position="float" id="t0010"><label>Table 2</label><caption><p>Comparison of the prevalence of depression, anxiety, stress and post-traumatic stress disorder between the healthcare workers in Singapore and India (N = 906).</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th><bold>Overall (N = 906)</bold></th><th><bold>Singapore (N = 480)</bold></th><th><bold>India (N = 426)</bold></th><th><bold>p-value</bold></th></tr></thead><tbody><tr><td>Depression</td><td>96 (10.6%)</td><td>43 (9%)</td><td>53 (12.4%)</td><td>0.089</td></tr><tr><td>Anxiety</td><td>142 (15.7%)</td><td>69 (14.4%)</td><td>73 (17.1%)</td><td>0.254</td></tr><tr><td>Stress</td><td>47 (5.2%)</td><td>31 (6.5%)</td><td>16 (3.8%)</td><td>0.067</td></tr><tr><td>Post-traumatic stress disorder</td><td>67 (7.4%)</td><td>36 (7.5%)</td><td>31 (7.3%)</td><td>0.898</td></tr></tbody></table><table-wrap-foot><fn><p>Categorical variables displayed as n (%).</p></fn></table-wrap-foot></table-wrap><fig id="f0010"><label>Fig. 2</label><caption><p>Number of participants experiencing adverse psychological impact, stratified by severity using DASS-21 (depression, anxiety and stress) and IES-R (post-traumatic stress disorder) (N = 906).</p></caption><graphic xlink:href="gr2_lrg"></graphic></fig></p><p id="p0095">Healthcare workers rated their levels of psychological distress according to the IES-R during the preceding 7 days. The mean total IES-R score was 8.29 (SD 9.79) while the means (SD) for IES-R subsets for Intrusion, Avoidance and Hyperarousal were 0.39 (0.49), 0.38 (0.50) 0.36 (0.46), respectively. Of note, 67 (7.4%) of the study cohort screened positive for clinical concern of PTSD, of which 34 demonstrated moderate to severe levels of psychological distress.</p></sec><sec id="s0055"><label>3.4</label><title>Comparing healthcare workers with and without physical symptoms</title><p id="p0100">The group which displayed presence of symptoms in the preceding month had less female participants compared to the group without symptoms (odds ratio (OR) 0.68, 95% confidence interval (CI) 0.50–0.91, P = 0.010). On the other hand, participants with physical symptoms were more likely to have pre-existing comorbidities (OR 2.87, 95% CI 1.94–4.24, p < 0.001) and older in age (mean difference 2.22, 95% CI 0.88–3.55, p = 0.001). In terms of study outcomes, those with physical symptoms were more likely to have a positive screening for depression (OR 3.23, 95% CI 1.80–5.80, p < 0.001), anxiety (OR 2.66, 95% CI 1.69–4.20, p < 0.001), stress (OR 3.59, 95% CI 1.51–8.56, p = 0.002), and PTSD (OR 2.70, 95% CI 1.40–5.24, p = 0.002) (<xref rid="t0010" ref-type="table">Table 2</xref>).</p></sec><sec id="s0060"><label>3.5</label><title>Physical symptoms and psychological outcomes</title><p id="p0105">In the multivariable logistic regression model, after adjustment for age, gender and presence of comorbidities, the psychological outcomes depression (OR 2.79, 95% CI 1.54–5.07, p = 0.001), anxiety (OR 2.18, 95% CI 1.36–3.48, p = 0.001), stress (OR 3.06, 95% CI 1.27–7.41, p = 0.13), and PTSD (OR 2.20, 95% CI 1.12–4.35, p = 0.023) remained significantly associated with the presence of physical symptoms experienced in the preceding month (<xref rid="t0015" ref-type="table">Table 3</xref>).<table-wrap position="float" id="t0015"><label>Table 3</label><caption><p>Univariate analysis of participants presenting with any symptoms and no symptoms experienced in the study population (N = 906).</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th><bold>Any symptoms experiences(n = 604)</bold></th><th><bold>No symptoms experiences(n = 302)</bold></th><th><bold>P-value</bold></th></tr></thead><tbody><tr><td><bold>Demographic</bold></td><td></td><td></td><td></td></tr><tr><td>Female Gender</td><td>371 (61.4%)</td><td>212 (70.2%)</td><td>0.009</td></tr><tr><td>Married</td><td>301 (49.8%)</td><td>133 (44.0%)</td><td>0.100</td></tr><tr><td>Presence of comorbidities</td><td>169 (28.0%)</td><td>36 (12.0%)</td><td><0.001</td></tr><tr><td>Age</td><td>31.40 (±9.4)</td><td>29.2 (±9.4)</td><td>0.001</td></tr><tr><td><bold>Outcomes</bold></td><td></td><td></td><td></td></tr><tr><td>Depression</td><td>82 (13.6%)</td><td>14 (4.6%)</td><td><0.001*</td></tr><tr><td>Anxiety</td><td>117 (19.4%)</td><td>25 (8.3%)</td><td><0.001*</td></tr><tr><td>Stress</td><td>41 (6.8%)</td><td>6 (2.0%)</td><td>0.002*</td></tr><tr><td>Post-traumatic stress disorder</td><td>56 (9.3%)</td><td>11 (3.6%)</td><td>0.002*</td></tr></tbody></table><table-wrap-foot><fn id="sp0065"><p>* Psychological outcome remains statistically significant after adjusting for age, gender and presence of comorbidities.</p></fn><fn id="sp0070"><p>Categorical variables displayed as n (%), continuous variables displayed as mean (±standard deviation)</p></fn></table-wrap-foot></table-wrap></p><p id="p0110">Linear regression revealed that the presence of physical symptoms was associated with higher mean scores in the IES-R, DASS-21 Anxiety, Stress and Depression subscales. This association was present across the three respiratory-related symptoms (sore throat, breathlessness and cough) as well as constitutional symptoms like lethargy, myalgia, poor appetite. However, there was no statistical significance between the association of coryza and psychological distress (<xref rid="t0020" ref-type="table">Table 4</xref>).<table-wrap position="float" id="t0020"><label>Table 4</label><caption><p>Linear regression of physical symptoms in the past one month associated with the psychological impact of the COVID-19 outbreak (N = 906).</p></caption><table frame="hsides" rules="groups"><thead><tr><th><bold>Variables</bold></th><th></th><th colspan="3"><bold>Impact of event scale</bold></th><th colspan="3"><bold>DASS-21 Stress</bold></th><th colspan="3"><bold>DASS-Anxiety</bold></th><th colspan="3"><bold>DASS-Depression</bold></th></tr><tr><th></th><th><bold>N (%)</bold></th><th><bold>R-Squared(R<sup>2</sup>)</bold></th><th><bold>Adjusted R-Squared (AR<sup>2</sup>)</bold></th><th><bold>β (95% CI)</bold></th><th><bold>R<sup>2</sup></bold></th><th><bold>AR<sup>2</sup></bold></th><th><bold>β (95% CI)</bold></th><th><bold>R<sup>2</sup></bold></th><th><bold>AR<sup>2</sup></bold></th><th><bold>β (95% CI)</bold></th><th><bold>R<sup>2</sup></bold></th><th><bold>AR<sup>2</sup></bold></th><th><bold>β (95% CI)</bold></th></tr></thead><tbody><tr><td>Throat pain</td><td>272 (30%)</td><td>0.026</td><td>0.025</td><td><bold>0.292* (0.176, 0.408)</bold></td><td>0.054</td><td>0.053</td><td><bold>0.418** (0.304, 0.533)</bold></td><td>0.080</td><td>0.079</td><td><bold>0.508** (0.396, 0.621)</bold></td><td>0.038</td><td>0.037</td><td><bold>0.351* (0.235, 0.466)</bold></td></tr><tr><td>Nausea/vomiting</td><td>96 (10.6%)</td><td>0.037</td><td>0.036</td><td><bold>0.548** (0.366, 0.729)</bold></td><td>0.017</td><td>0.016</td><td><bold>0.373** (0.190, 0.556)</bold></td><td>0.060</td><td>0.059</td><td><bold>0.696** (0.517, 875)</bold></td><td>0.017</td><td>0.016</td><td><bold>0.374** (0.190, 0.557)</bold></td></tr><tr><td>Anxiety</td><td>242 (26.7%)</td><td>0.137</td><td>0.136</td><td><bold>0.649** (0.543, 0.755)</bold></td><td>0.161</td><td>0.160</td><td><bold>0.704** (0.599, 0.809)</bold></td><td>0.133</td><td>0.133</td><td><bold>0.641** (0.534, 0.747)</bold></td><td>0.112</td><td>0.111</td><td><bold>0.587** (0.479, 0.695)</bold></td></tr><tr><td>Insomnia</td><td>190 (21.0%)</td><td>0.092</td><td>0.091</td><td><bold>0.535** (0.426, 0.645)</bold></td><td>0.082</td><td>0.081</td><td><bold>0.506** (0.396, 0.616)</bold></td><td>0.082</td><td>0.081</td><td><bold>0.505**(0.394, 0.615)</bold></td><td>0.080</td><td>0.079</td><td><bold>0.500** (0.389, 0.610)</bold></td></tr><tr><td>Poor appetite</td><td>128 (14.1%)</td><td>0.043</td><td>0.042</td><td><bold>0.450** (0.312, 0.589)</bold></td><td>0.025</td><td>0.024</td><td><bold>0.342** (0.202, 0.482)</bold></td><td>0.077</td><td>0.076</td><td><bold>0.602** (0.466, 0.738)</bold></td><td>0.047</td><td>0.046</td><td><bold>0.472** (0.334, 0.611)</bold></td></tr><tr><td>Headache</td><td>289 (31.9%)</td><td>0.044</td><td>0.043</td><td><bold>0.328** (0.229, 0.427)</bold></td><td>0.040</td><td>0.039</td><td><bold>0.310** (0.211, 0.410)</bold></td><td>0.066</td><td>0.065</td><td><bold>0.400** (0.302, 0.498)</bold></td><td>0.020</td><td>0.019</td><td><bold>0.219** (0.119, 0.320)</bold></td></tr><tr><td>Neck stiffness</td><td>149 (16.4%)</td><td>0.036</td><td>0.035</td><td><bold>0.370** (0.245, 0.494)</bold></td><td>0.046</td><td>0.045</td><td><bold>0.417** (0.293, 0.541)</bold></td><td>0.046</td><td>0.045</td><td><bold>0.415** (0.292, 0.539)</bold></td><td>0.030</td><td>0.029</td><td><bold>0.337** (0.212, 0.462)</bold></td></tr><tr><td>Cough</td><td>153 (16.9%)</td><td>0.012</td><td>0.011</td><td><bold>0.231* (0.095, 0.367)</bold></td><td>0.023</td><td>0.022</td><td><bold>0.314** (0.179, 0.449)</bold></td><td>0.032</td><td>0.031</td><td><bold>0.375** (0.241, 0.510)</bold></td><td>0.013</td><td>0.012</td><td><bold>0.238* (0.102, 0.373)</bold></td></tr><tr><td>Sputum</td><td>102 (11.3%)</td><td>0.031</td><td>0.030</td><td><bold>0.440** (0.279, 0.601)</bold></td><td>0.043</td><td>0.042</td><td><bold>0.519** (0.359, 0.679)</bold></td><td>0.052</td><td>0.051</td><td><bold>0.571** (0.411, 0.730)</bold></td><td>0.014</td><td>0.013</td><td><bold>0.292** (0.130, 0.455)</bold></td></tr><tr><td>Breathless-ness</td><td>56 (6.2%)</td><td>0.036</td><td>0.035</td><td><bold>0.699**(0.463,0.934)</bold></td><td>0.020</td><td>0.019</td><td><bold>0.525**(0.287, 0.762)</bold></td><td>0.077</td><td>0.076</td><td><bold>1.018** (0.787, 1.249)</bold></td><td>0.028</td><td>0.027</td><td><bold>0.616** (0.380, 0.853)</bold></td></tr><tr><td>Coryza</td><td>127 (14.0%)</td><td>0.003</td><td>0.002</td><td>0.126(-0.026, 0.278)</td><td>0.013</td><td>0.012</td><td><bold>0.262*(0.111, 0.413)</bold></td><td>0.016</td><td>0.014</td><td><bold>0.290** (0.139, 0.441)</bold></td><td>0.009</td><td>0.008</td><td><bold>0.218*(0.067, 0.370)</bold></td></tr><tr><td>Joint/muscle pain</td><td>187 (20.6%)</td><td>0.101</td><td>0.099</td><td><bold>0.497** (0.362, 0.632)</bold></td><td>0.087</td><td>0.085</td><td><bold>0.463** (0.327, 0.600)</bold></td><td>0.062</td><td>0.060</td><td><bold>0.389** (0.251, 0.527)</bold></td><td>0.072</td><td>0.070</td><td><bold>0.420** (0.282, 0.557)</bold></td></tr><tr><td>Rashes</td><td>33 (3.6%)</td><td>0.087</td><td>0.086</td><td><bold>0.511** (0.403, 0.619)</bold></td><td>0.096</td><td>0.095</td><td><bold>0.536** (0.429, 0.643)</bold></td><td>0.073</td><td>0.072</td><td><bold>0.469** (0.361, 0.578)</bold></td><td>0.071</td><td>0.070</td><td><bold>0.462** (0.354, 0.571)</bold></td></tr><tr><td>Lethargy/tiredness</td><td>241 (26.6%)</td><td>0.066</td><td>0.065</td><td><bold>0.391** (0.295, 0.488)</bold></td><td>0.128</td><td>0.127</td><td><bold>0.547** (0.454, 0.640)</bold></td><td>0.099</td><td>0.098</td><td><bold>0.481** (0.387, 0.576)</bold></td><td>0.095</td><td>0.094</td><td><bold>0.470** (0.375, 0.565)</bold></td></tr><tr><td>Itching</td><td>53 (5.8%)</td><td>0.011</td><td>0.010</td><td><bold>0.351* (0.133, 0.568)</bold></td><td>0.012</td><td>0.011</td><td><bold>0.361* (0.143, 0.578)</bold></td><td>0.019</td><td>0.018</td><td><bold>0.468** (0.251, 0.684)</bold></td><td>0.019</td><td>0.018</td><td><bold>0.465** (0.247, 0.682)</bold></td></tr><tr><td>Watery eyes</td><td>50 (5.5%)</td><td>0.016</td><td>0.015</td><td><bold>0.463** (0.229, 0.697)</bold></td><td>0.015</td><td>0.014</td><td><bold>0.444** (0.210, 0.678)</bold></td><td>0.026</td><td>0.025</td><td><bold>0.588** (0.355, 0.820)</bold></td><td>0.015</td><td>0.014</td><td><bold>0.447** (0.213, 0.680)</bold></td></tr></tbody></table><table-wrap-foot><fn><p>* p-value < 0.05; ** p-value < 0.001.</p></fn></table-wrap-foot></table-wrap></p></sec></sec><sec id="s0065"><label>4</label><title>Discussion</title><p id="p0115">This multinational, multicenter study found significant association between adverse psychological outcomes and physical symptoms displayed by healthcare workers during the current COVID-19 pandemic. Our findings mirror the trend in recent studies on the psychological impact of the COVID-19 epidemic among the general population in China during its initial stages (<xref rid="b0195" ref-type="bibr">Wang et al., 2020a</xref>, <xref rid="b0080" ref-type="bibr">Li et al., 2020</xref>, <xref rid="b0060" ref-type="bibr">Kang et al., 2019</xref>). We have previously reported that the psychological impact (specifically anxiety) of COVID-19 was more common among non-medically trained healthcare workers when compared to the medically trained personnel (<xref rid="b0160" ref-type="bibr">Tay et al., 2020</xref>).</p><p id="p0120">Symptoms of COVID-19 infection are wide-ranging, and may be non-specific and similar to other viral infections (<xref rid="b0040" ref-type="bibr">Guan et al., 2019</xref>). Therefore, when healthcare workers develop any such symptoms, they often faced the dilemma of whether to apply for medical leave of absence, or to continue working alongside their over-worked colleagues during this critical period. Even though healthcare workers are entitled to take paid sick leave for a given number of days, little is known about the employment risks posed, especially to the low-paid non-medically trained healthcare contract workers in the event of a prolonged absence. Psychological distress levels may also be exacerbated by the fear of being a carrier of the virus, causing transmission amongst fellow healthcare workers and their own families if they choose to continue to work. The fear of transmission is especially high due to the reports of asymptomatic transmission of COVID-19, including high transmission rates amongst healthcare workers during in China where as many as 3000 healthcare workers contracted the infection and 22 of them succumbed (<xref rid="b0010" ref-type="bibr">Adams and Walls, 2020</xref>). Such prevailing and overwhelming thoughts in the current pandemic atmosphere often have adverse psychological sequelae and may lead to various somatic symptoms (<xref rid="b0055" ref-type="bibr">Joob and Wiwanitkit, 2020</xref>).</p><p id="p0125">Moderate to severe psychological symptoms were reported amongst the general population in a recent Chinese study during the COVID-19 outbreak (<xref rid="b0195" ref-type="bibr">Wang et al., 2020a</xref>, <xref rid="b0190" ref-type="bibr">Wang et al., 2020b</xref>). This is in sharp contrast to a low prevalence of moderate to severe psychological impact in our study (3.8% compared to 58% reported in the Chinese study). Furthermore, compared to the Chinese study population, our cohort had lower prevalence rates of moderate to severe depression (5.3% versus 16.5%), anxiety (8.7% versus 28.8%) and stress levels (2.2% versus 8.1%). However, despite our lower prevalence rates of emotional distress, our study population displayed higher prevalence rates of physical symptoms such as headache (32.3% versus 9.7%) and sore throat (33.6% versus 11.5%) when compared to the Chinese cohort. The true association of physical symptoms and psychological stress is indeed challenging to determine, especially in the current climate where the active infection needs to be urgently excluded in every suspected case before giving much importance to the ‘non-specific’ symptoms. Nevertheless, somatic symptoms may be more prevalent during periods of stress and these are hypothesized to represent a way of communicating emotions (<xref rid="b0015" ref-type="bibr">Basant et al., 2014</xref>). We hypothesize that the increased prevalence of self-reported physical symptoms is likely to have been contributed by the psychological impact of the outbreak. Another possible contributing factor could be the social stigma associated with mental health issues, which may have resulted in individuals having a higher tendency to express their psychological distress via physical symptoms instead (<xref rid="b0210" ref-type="bibr">Yl, 2007</xref>).</p><p id="p0130">Headache was the most commonly reported symptom in this study. A recent study on headache associated with personal protective equipment (PPE) among healthcare workers during the COVID-19 pandemic demonstrated that 81% of respondents reported PPE associated headaches, with a pre-existing primary headache diagnosis reported as an independent predictor for PPE associated headaches (<xref rid="b0130" ref-type="bibr">Ong et al., 2020</xref>). Similarly, migraine was the most commonly reported comorbidity in our study. Hence, the common presenting complaint of headache may be related to the increased adverse psychological impact or an exacerbation of their pre-existing condition. Notably in prior studies, fatigue was the most commonly reported symptom among SARS survivors in both healthcare workers and the general public.(<xref rid="b0065" ref-type="bibr">Lam et al., 2009</xref>) Interestingly, even in our study, lethargy was one of the most commonly reported symptom amongst healthcare workers. In a previous study from Hong Kong, Lam et al demonstrated that the prevalence of chronic fatigue was significantly higher among SARS survivors which persisted through the acute phase of infection till one month after the disease outbreak (<xref rid="b0065" ref-type="bibr">Lam et al., 2009</xref>). Interestingly, healthcare workers infected by SARS were more likely to give up their employment, and the occupational risks faced by the healthcare workers during an epidemic may potentially lead to psychiatric morbidity, physical symptoms such as fatigue, and eventually burnout. Although fatigue and headache may be vague and often unsubstantiated, it is crucial not to neglect such physical symptoms as they may be a reflection of underlying psychological distress (<xref rid="b0065" ref-type="bibr">Lam et al., 2009</xref>).</p><p id="p0135">The association of psychological distress and physical symptoms is poorly understood. In addition to the fear of transmitting the infection to colleagues and family members coupled with the dilemma of applying for sick leave in an already strained healthcare sector, many healthcare workers develop burnout and may experience a sense of intense fear, stigmatization and ostracism when displaying physical symptoms suggestive of the virus infection, which often leads to negative psychological pain (<xref rid="b0125" ref-type="bibr">Nezlek et al., 2012</xref>, <xref rid="b0175" ref-type="bibr">Troyer et al., 2020</xref>). This phenomenon has already been described in the studies during the current COVID-19 outbreak (<xref rid="b0195" ref-type="bibr">Wang et al., 2020a</xref>) as well as previous Ebola crisis (<xref rid="b0095" ref-type="bibr">Matua and Van Der, 2015</xref>). We postulate a bi-directional complex relationship between psychological distress and physical symptoms, where an inadvertent psychological distress exacerbates physical symptoms and vice versa (<xref rid="f0015" ref-type="fig">Fig. 3</xref>). Accordingly, the physical symptoms related to high levels of arousal in a stressful environment of a disease outbreak may lead to over-reporting of cardiovascular, respiratory, neurological or gastrointestinal symptoms (<xref rid="b0110" ref-type="bibr">McFarlane et al., 1994</xref>). Furthermore, a known stressor may precipitate or worsen specific physical symptoms. For example, a previous study has reported increased prevalence of respiratory symptoms seen in fire-fighters suffering from PTSD as a result of the psychological stress of smoke inhalation (<xref rid="b0110" ref-type="bibr">McFarlane et al., 1994</xref>). We believe that various symptoms of throat pain, cough and myalgia during the current COVID-19 outbreak may be over-represented as a result of the psychological stress, and further exacerbated by the presence of various comorbidities (<xref rid="b0110" ref-type="bibr">McFarlane et al., 1994</xref>). This observation is also commonly evident in patients with depression, with the somatization of back pain and headache (<xref rid="b0185" ref-type="bibr">von Knorring et al., 1983</xref>). This is in line with our finding of the significant association of the presence of comorbidities and physical symptoms amongst healthcare workers.<fig id="f0015"><label>Fig. 3</label><caption><p>Proposed bi-directional association between adverse psychological outcomes and physical symptoms amongst healthcare workers in the COVID-19 outbreak.</p></caption><graphic xlink:href="gr3_lrg"></graphic></fig></p><p id="p0140">Targeted multidisciplinary interventions are needed to support healthcare workers by addressing both the psychological manifestations and physical symptoms. All efforts should be made to offer psychological support and interventions once an acute infection has been excluded. Dedicated counselling may be arranged to allay their fear of transmitting the infection to their family members (<xref rid="b0195" ref-type="bibr">Wang et al., 2020a</xref>) as well as to boost the confidence and morale of our healthcare workers.</p></sec><sec id="s0070"><label>5</label><title>Limitations</title><p id="p0145">Given that this is a multinational, multicentre study, with similar prevalence of psychological outcomes in both countries, the observed psychological and physical symptoms findings are more likely generalizable. However, our study has its limitations. Firstly, the cross-sectional nature of the study does not allow interpretation for causality. Whilst we found a strong association between presence of physical symptoms and prevalence of psychological distress, we are unable to conclude that psychological distress had resulted in the manifestation of these physical symptoms. Secondly, we did not assess if study participants had taken medical leave of absence, or if they sought the testing for COVID-19 during the manifestation of physical symptoms. Thirdly, owing to the stringent hospital infection control protocols to minimize contact between healthcare workers, the questionnaire had to be self-administered and information provided on symptoms was not verified by a medical professional. Fourthly, we did not record socioeconomic status and education level, which could have influenced our results. We intend to re-evaluate our study participants if the current COVID-19 outbreak escalates further in the region, as well as after it subsides to obtain much reliable explanations about the association of psychological sequelae and various physical symptoms.</p></sec><sec id="s0075"><label>6</label><title>Conclusion</title><p id="p0150">This study describes an expansive range of physical symptoms experience by healthcare workers during the ongoing COVID-19 outbreak. There is a significant association between the prevalence of physical symptoms and psychological distress, which is probably bi-directional. We recommend the provision for timely psychological support and interventions for healthcare workers who present with physical symptoms once an infection has been excluded.</p></sec><sec id="s0080"><title>Author contribution</title><p id="ce.para_jnt_2rj_llb"><bold>Nicholas W.S. Chew:</bold> Data curation, Formal analysis, Methodology, Resources, Writing. <bold>Grace K.H. Lee:</bold> Data curation, Formal analysis, Methodology, Resources, Writing. <bold>Benjamin Y.Q. Tan:</bold> Data curation, Formal analysis, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing. <bold>Mingxue Jing:</bold> Data curation. <bold>Yihui Goh:</bold> Data curation. <bold>Leonard L.L. Yeo:</bold> Data curation. <bold>Aftab Ahmad:</bold> Data curation. <bold>Faheem Ahmed Khan:</bold> Data curation. <bold>Arvind K. Sharma:</bold> Data curation. <bold>R.N. Komalkumar:</bold> Data curation. <bold>P.V. Meenakshi:</bold> Data curation. <bold>Kenam Shah:</bold> Data curation. <bold>Bhargesh Patel:</bold> Data curation. <bold>Bernard P.L. Chan:</bold> Data curation. <bold>Sibi Sunny:</bold> Data curation. <bold>Bharatendu Chandra:</bold> Data curation. <bold>Jonathan J.Y. Ong:</bold> Data curation. <bold>Prakash R. Paliwal:</bold> Data curation. <bold>Lily Y.H. Wong:</bold> Project administration. <bold>Renarebecca Sagayanathan:</bold> Project administration. <bold>Jin Tao Chen:</bold> Project administration. <bold>Alison Ying Ying Ng:</bold> Project administration. <bold>Hock Luen Teoh:</bold> Project administration. <bold>Georgios Tsivgoulis:</bold> Writing. <bold>Cyrus S. Ho:</bold> Conceptualization, Supervision, Validation, Visualization, Writing. <bold>Roger C. Ho:</bold> Conceptualization, Supervision, Validation, Visualization, Writing. <bold>Vijay K. Sharma:</bold> Conceptualization, Formal analysis, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing.</p><p id="p0175"><bold>Declaration of Competing Interest</bold></p><p id="p0180">The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</p><p id="p0185"><bold>Disclosures</bold></p><p id="p0190">VKS is the current recipient of Senior Clinician Scientist Award from National Medical Research Council, Ministry of Health, Singapore. Other authors have no financial disclosures.</p></sec></body><back><ref-list id="bi005"><title>References</title><ref id="b0005"><mixed-citation publication-type="other" id="h0005">Abelson R. Doctors and Patients Turn to Telemedicine in the Coronavirus Outbreak. 2020. https://www.nytimes.com/2020/03/11/health/telemedicine-coronavirus.html. Published 11 March 2020. 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J.</source><volume>48</volume><issue>11</issue><year>2007</year><fpage>977</fpage><pub-id pub-id-type="pmid">17975685</pub-id></element-citation></ref></ref-list><sec id="s0090" sec-type="supplementary-material"><label>Appendix A</label><title>Supplementary data</title><p id="p0205">The following are the Supplementary data to this article:<supplementary-material content-type="local-data" id="m0010"><caption><title>Supplementary data 1</title></caption><media xlink:href="mmc1.doc"></media></supplementary-material></p><p id="p0210"><supplementary-material content-type="local-data" id="m0005"><caption><title>Supplementary data 2</title></caption><media xlink:href="mmc2.xml"></media></supplementary-material></p></sec><ack id="ak005"><title>Acknowledgement</title><p>No funding reported.</p></ack><fn-group><fn id="s0085" fn-type="supplementary-material"><label>Appendix A</label><p id="p0200">Supplementary data to this article can be found online at <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.bbi.2020.04.049" id="ir005">https://doi.org/10.1016/j.bbi.2020.04.049</ext-link>.</p></fn></fn-group></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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