Infectomics Screening for Novel Antiviral Drug Targets
Identifieur interne : 001408 ( Main/Exploration ); précédent : 001407; suivant : 001409Infectomics Screening for Novel Antiviral Drug Targets
Auteurs : Yuan Liu [République populaire de Chine] ; Qi Yin [République populaire de Chine] ; Yao Yuan [République populaire de Chine] ; Wenyong Yang [République populaire de Chine] ; Chuangui Jiang [République populaire de Chine] ; Canhua Huang [République populaire de Chine]Source :
- Drug Development Research [ 0272-4391 ] ; 2012-11.
English descriptors
- Teeft :
- Activitybased protein, Anal chem, Antimicrobial drug discovery, Antisense inhibitors, Antiviral, Antiviral drug discovery, Antiviral therapy, Apoptosis, Assay, Autophagy, Biol, Biotechnol, Brain tumor cells, Caenorhabditis elegans, Canhua huang, Cell host microbe, Cellular, Cellular functions, Cellular mirnas, Cellular processes, Chem, Chemical genomics, Chemical infectomics, Chemical probes, Clin, Clin microbiol, Collisional activation, Complex proteomes, Critical role, Cultured cells, Curr, Curr drug targets, Cysteine proteases, Dengue, Dengue virus, Denv, Drug discovery, Drug resistance, Drug targets, Escherichia coli bacteriophage, Essential roles, Expert opin, Expression monitoring, Functional genomic analysis, Functional genomic screen, Functional transcription factor, Gene acquisition, Gene expression, Genet, Genome, Genomic, Genomics, Glucose metabolism, Hepatitis, Hepatocellular carcinoma, Hepatoma cells, Hepg2 cells, Herpes simplex virus, Host cell invasion, Host cells, Host factors, Host interactions, Host perspective, Host proteins, Host response, Huang, Human cytomegalovirus, Human genome project, Human host factors, Human proteins, Human virus, Ight mass spectrometry, Important role, Important roles, Infection, Infectious diseases, Infectomics, Infectomics approaches, Infectomics screening, Infectomics view, Inhibitor, Kinase, Large number, Liver hepatitis, Mass proteomics, Membrane receptors, Microarray, Microarray analysis, Microarrays, Microbial, Microbial infections, Microbial pathogens, Microbiol, Microrna, Micrornas, Mirna, Mirnas, Mrna, Mutation, Nonstructural protein, Ns4b protein, Nuclear factor kappa, Nuclear receptors, Omics approaches, Online issue, Opin, Other viruses, Pathogen, Pathway, Physical interaction, Plo, Point mutation, Precore region, Previous studies, Prey proteins, Proc natl acad, Protease, Protease inhibitors, Protein, Protein kinase, Protein microarray analysis, Protein microarrays, Proteome, Proteomic, Proteomic analysis, Proteomic approach, Proteomic approaches, Proteomics, Quantitative analysis, Receptor, Replication, Reporter gene, Rnai, Rnai screen, Rnai screening, Sample consumption, Schematic view, Screening, Sichuan university, Sirna screening, Solid substrate, Spectrometry, Syncytial virus, Systems biology, Transcription, Transcription factors, Tumor suppression, Vaccine, Viral, Viral encoding proteins, Viral infection, Viral infections, Viral perspective, Viral proteins, Viral replication, Viral strategies, Viral transcription, Virol, Virology, Virus, Virus core protein, Virus infection, Virus nonstructural protein, Virus replication, Wang, West china, West china hospital, Wiley periodicals, Yeast, Yeast assay, Yeast host cell, Yeast system, Zhang, Zhou.
Abstract
Preclinical Research Infectomics, a novel way to globally and comprehensively understand the interactions between microbial pathogens and their hosts, has significantly expanded understanding of the microbial infections. The infectomics view of viral–host interactions on the viral perspective principally focuses on gene acquisition, deletion, and point mutation, while traditional antiviral drug discovery concentrates on viral encoding proteins. Recently, high‐throughput technologies, such as mass spectrometry‐based proteomics, activity‐based protein profiling, microarray analysis, yeast two‐hybrid assay, small interfering RNA screening, and micro RNA profiling, have been gradually employed in the research of virus–host interactions. Besides, signaling pathways and cellular processes involved in viral–host interactions provide new insights of infectomics in antiviral drug discovery. In this review, we summarize related infectomics approaches in the studies of virus–host interactions, which shed light on the development of novel antiviral drug targets screening.
Url:
- https://api.istex.fr/ark:/67375/WNG-K4XR5H06-S/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163650
DOI: 10.1002/ddr.21027
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000431
- to stream Istex, to step Curation: 000431
- to stream Istex, to step Checkpoint: 000469
- to stream Pmc, to step Corpus: 000899
- to stream Pmc, to step Curation: 000899
- to stream Pmc, to step Checkpoint: 000856
- to stream Ncbi, to step Merge: 001350
- to stream Ncbi, to step Curation: 001350
- to stream Ncbi, to step Checkpoint: 001350
- to stream Main, to step Merge: 001410
- to stream Main, to step Curation: 001408
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Infectomics Screening for Novel Antiviral Drug Targets</title>
<author><name sortKey="Liu, Yuan" sort="Liu, Yuan" uniqKey="Liu Y" first="Yuan" last="Liu">Yuan Liu</name>
</author>
<author><name sortKey="Yin, Qi" sort="Yin, Qi" uniqKey="Yin Q" first="Qi" last="Yin">Qi Yin</name>
</author>
<author><name sortKey="Yuan, Yao" sort="Yuan, Yao" uniqKey="Yuan Y" first="Yao" last="Yuan">Yao Yuan</name>
</author>
<author><name sortKey="Yang, Wenyong" sort="Yang, Wenyong" uniqKey="Yang W" first="Wenyong" last="Yang">Wenyong Yang</name>
</author>
<author><name sortKey="Jiang, Chuangui" sort="Jiang, Chuangui" uniqKey="Jiang C" first="Chuangui" last="Jiang">Chuangui Jiang</name>
</author>
<author><name sortKey="Huang, Canhua" sort="Huang, Canhua" uniqKey="Huang C" first="Canhua" last="Huang">Canhua Huang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:B90474B7CD36BA2935C01CEF5A7D4AEFAC7E4E1D</idno>
<date when="2012" year="2012">2012</date>
<idno type="doi">10.1002/ddr.21027</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-K4XR5H06-S/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000431</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000431</idno>
<idno type="wicri:Area/Istex/Curation">000431</idno>
<idno type="wicri:Area/Istex/Checkpoint">000469</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000469</idno>
<idno type="wicri:doubleKey">0272-4391:2012:Liu Y:infectomics:screening:for</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163650</idno>
<idno type="RBID">PMC:7163650</idno>
<idno type="wicri:Area/Pmc/Corpus">000899</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000899</idno>
<idno type="wicri:Area/Pmc/Curation">000899</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000899</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000856</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000856</idno>
<idno type="wicri:Area/Ncbi/Merge">001350</idno>
<idno type="wicri:Area/Ncbi/Curation">001350</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001350</idno>
<idno type="wicri:doubleKey">0272-4391:2012:Liu Y:infectomics:screening:for</idno>
<idno type="wicri:Area/Main/Merge">001410</idno>
<idno type="wicri:Area/Main/Curation">001408</idno>
<idno type="wicri:Area/Main/Exploration">001408</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Infectomics Screening for Novel Antiviral Drug Targets</title>
<author><name sortKey="Liu, Yuan" sort="Liu, Yuan" uniqKey="Liu Y" first="Yuan" last="Liu">Yuan Liu</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The State Key Laboratory of Biotherapy, West China Hospital, West China, Sichuan University, 610041, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yin, Qi" sort="Yin, Qi" uniqKey="Yin Q" first="Qi" last="Yin">Qi Yin</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The State Key Laboratory of Biotherapy, West China Hospital, West China, Sichuan University, 610041, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yuan, Yao" sort="Yuan, Yao" uniqKey="Yuan Y" first="Yao" last="Yuan">Yao Yuan</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The State Key Laboratory of Biotherapy, West China Hospital, West China, Sichuan University, 610041, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Wenyong" sort="Yang, Wenyong" uniqKey="Yang W" first="Wenyong" last="Yang">Wenyong Yang</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The State Key Laboratory of Biotherapy, West China Hospital, West China, Sichuan University, 610041, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Chuangui" sort="Jiang, Chuangui" uniqKey="Jiang C" first="Chuangui" last="Jiang">Chuangui Jiang</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The State Key Laboratory of Biotherapy, West China Hospital, West China, Sichuan University, 610041, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Canhua" sort="Huang, Canhua" uniqKey="Huang C" first="Canhua" last="Huang">Canhua Huang</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The State Key Laboratory of Biotherapy, West China Hospital, West China, Sichuan University, 610041, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
<affiliation></affiliation>
<affiliation></affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Drug Development Research</title>
<title level="j" type="sub">Impact of Omics on Drug Discovery and Development. Part I</title>
<title level="j" type="alt">DRUG DEVELOPMENT RESEARCH</title>
<idno type="ISSN">0272-4391</idno>
<idno type="eISSN">1098-2299</idno>
<imprint><biblScope unit="vol">73</biblScope>
<biblScope unit="issue">7</biblScope>
<biblScope unit="page" from="365">365</biblScope>
<biblScope unit="page" to="380">380</biblScope>
<biblScope unit="page-count">16</biblScope>
<date type="published" when="2012-11">2012-11</date>
</imprint>
<idno type="ISSN">0272-4391</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0272-4391</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Activitybased protein</term>
<term>Anal chem</term>
<term>Antimicrobial drug discovery</term>
<term>Antisense inhibitors</term>
<term>Antiviral</term>
<term>Antiviral drug discovery</term>
<term>Antiviral therapy</term>
<term>Apoptosis</term>
<term>Assay</term>
<term>Autophagy</term>
<term>Biol</term>
<term>Biotechnol</term>
<term>Brain tumor cells</term>
<term>Caenorhabditis elegans</term>
<term>Canhua huang</term>
<term>Cell host microbe</term>
<term>Cellular</term>
<term>Cellular functions</term>
<term>Cellular mirnas</term>
<term>Cellular processes</term>
<term>Chem</term>
<term>Chemical genomics</term>
<term>Chemical infectomics</term>
<term>Chemical probes</term>
<term>Clin</term>
<term>Clin microbiol</term>
<term>Collisional activation</term>
<term>Complex proteomes</term>
<term>Critical role</term>
<term>Cultured cells</term>
<term>Curr</term>
<term>Curr drug targets</term>
<term>Cysteine proteases</term>
<term>Dengue</term>
<term>Dengue virus</term>
<term>Denv</term>
<term>Drug discovery</term>
<term>Drug resistance</term>
<term>Drug targets</term>
<term>Escherichia coli bacteriophage</term>
<term>Essential roles</term>
<term>Expert opin</term>
<term>Expression monitoring</term>
<term>Functional genomic analysis</term>
<term>Functional genomic screen</term>
<term>Functional transcription factor</term>
<term>Gene acquisition</term>
<term>Gene expression</term>
<term>Genet</term>
<term>Genome</term>
<term>Genomic</term>
<term>Genomics</term>
<term>Glucose metabolism</term>
<term>Hepatitis</term>
<term>Hepatocellular carcinoma</term>
<term>Hepatoma cells</term>
<term>Hepg2 cells</term>
<term>Herpes simplex virus</term>
<term>Host cell invasion</term>
<term>Host cells</term>
<term>Host factors</term>
<term>Host interactions</term>
<term>Host perspective</term>
<term>Host proteins</term>
<term>Host response</term>
<term>Huang</term>
<term>Human cytomegalovirus</term>
<term>Human genome project</term>
<term>Human host factors</term>
<term>Human proteins</term>
<term>Human virus</term>
<term>Ight mass spectrometry</term>
<term>Important role</term>
<term>Important roles</term>
<term>Infection</term>
<term>Infectious diseases</term>
<term>Infectomics</term>
<term>Infectomics approaches</term>
<term>Infectomics screening</term>
<term>Infectomics view</term>
<term>Inhibitor</term>
<term>Kinase</term>
<term>Large number</term>
<term>Liver hepatitis</term>
<term>Mass proteomics</term>
<term>Membrane receptors</term>
<term>Microarray</term>
<term>Microarray analysis</term>
<term>Microarrays</term>
<term>Microbial</term>
<term>Microbial infections</term>
<term>Microbial pathogens</term>
<term>Microbiol</term>
<term>Microrna</term>
<term>Micrornas</term>
<term>Mirna</term>
<term>Mirnas</term>
<term>Mrna</term>
<term>Mutation</term>
<term>Nonstructural protein</term>
<term>Ns4b protein</term>
<term>Nuclear factor kappa</term>
<term>Nuclear receptors</term>
<term>Omics approaches</term>
<term>Online issue</term>
<term>Opin</term>
<term>Other viruses</term>
<term>Pathogen</term>
<term>Pathway</term>
<term>Physical interaction</term>
<term>Plo</term>
<term>Point mutation</term>
<term>Precore region</term>
<term>Previous studies</term>
<term>Prey proteins</term>
<term>Proc natl acad</term>
<term>Protease</term>
<term>Protease inhibitors</term>
<term>Protein</term>
<term>Protein kinase</term>
<term>Protein microarray analysis</term>
<term>Protein microarrays</term>
<term>Proteome</term>
<term>Proteomic</term>
<term>Proteomic analysis</term>
<term>Proteomic approach</term>
<term>Proteomic approaches</term>
<term>Proteomics</term>
<term>Quantitative analysis</term>
<term>Receptor</term>
<term>Replication</term>
<term>Reporter gene</term>
<term>Rnai</term>
<term>Rnai screen</term>
<term>Rnai screening</term>
<term>Sample consumption</term>
<term>Schematic view</term>
<term>Screening</term>
<term>Sichuan university</term>
<term>Sirna screening</term>
<term>Solid substrate</term>
<term>Spectrometry</term>
<term>Syncytial virus</term>
<term>Systems biology</term>
<term>Transcription</term>
<term>Transcription factors</term>
<term>Tumor suppression</term>
<term>Vaccine</term>
<term>Viral</term>
<term>Viral encoding proteins</term>
<term>Viral infection</term>
<term>Viral infections</term>
<term>Viral perspective</term>
<term>Viral proteins</term>
<term>Viral replication</term>
<term>Viral strategies</term>
<term>Viral transcription</term>
<term>Virol</term>
<term>Virology</term>
<term>Virus</term>
<term>Virus core protein</term>
<term>Virus infection</term>
<term>Virus nonstructural protein</term>
<term>Virus replication</term>
<term>Wang</term>
<term>West china</term>
<term>West china hospital</term>
<term>Wiley periodicals</term>
<term>Yeast</term>
<term>Yeast assay</term>
<term>Yeast host cell</term>
<term>Yeast system</term>
<term>Zhang</term>
<term>Zhou</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Preclinical Research Infectomics, a novel way to globally and comprehensively understand the interactions between microbial pathogens and their hosts, has significantly expanded understanding of the microbial infections. The infectomics view of viral–host interactions on the viral perspective principally focuses on gene acquisition, deletion, and point mutation, while traditional antiviral drug discovery concentrates on viral encoding proteins. Recently, high‐throughput technologies, such as mass spectrometry‐based proteomics, activity‐based protein profiling, microarray analysis, yeast two‐hybrid assay, small interfering RNA screening, and micro RNA profiling, have been gradually employed in the research of virus–host interactions. Besides, signaling pathways and cellular processes involved in viral–host interactions provide new insights of infectomics in antiviral drug discovery. In this review, we summarize related infectomics approaches in the studies of virus–host interactions, which shed light on the development of novel antiviral drug targets screening.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Yuan" sort="Liu, Yuan" uniqKey="Liu Y" first="Yuan" last="Liu">Yuan Liu</name>
</noRegion>
<name sortKey="Huang, Canhua" sort="Huang, Canhua" uniqKey="Huang C" first="Canhua" last="Huang">Canhua Huang</name>
<name sortKey="Jiang, Chuangui" sort="Jiang, Chuangui" uniqKey="Jiang C" first="Chuangui" last="Jiang">Chuangui Jiang</name>
<name sortKey="Yang, Wenyong" sort="Yang, Wenyong" uniqKey="Yang W" first="Wenyong" last="Yang">Wenyong Yang</name>
<name sortKey="Yin, Qi" sort="Yin, Qi" uniqKey="Yin Q" first="Qi" last="Yin">Qi Yin</name>
<name sortKey="Yuan, Yao" sort="Yuan, Yao" uniqKey="Yuan Y" first="Yao" last="Yuan">Yao Yuan</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001408 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001408 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= StressCovidV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:B90474B7CD36BA2935C01CEF5A7D4AEFAC7E4E1D |texte= Infectomics Screening for Novel Antiviral Drug Targets }}
This area was generated with Dilib version V0.6.33. |