[A case of parkinsonism induced by an oral contraceptive].
Identifieur interne : 000049 ( PubMed/Curation ); précédent : 000048; suivant : 000050[A case of parkinsonism induced by an oral contraceptive].
Auteurs : M. Yasui [Japon] ; T. Kihira ; K. Ota ; K. Funahashi ; N. KomaiSource :
- Nō to shinkei = Brain and nerve [ 0006-8969 ] ; 1992.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Contraceptifs oraux combinés (effets indésirables), Femelle (MeSH), Humains (MeSH), Imagerie par résonance magnétique (MeSH), Norgestrel (effets indésirables), Syndrome parkinsonien secondaire (diagnostic), Syndrome parkinsonien secondaire (induit chimiquement), Éthinyloestradiol (effets indésirables).
- MESH :
- diagnostic : Syndrome parkinsonien secondaire.
- effets indésirables : Contraceptifs oraux combinés, Norgestrel, Éthinyloestradiol.
- induit chimiquement : Syndrome parkinsonien secondaire.
- Adulte, Femelle, Humains, Imagerie par résonance magnétique.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Contraceptives, Oral, Combined, Ethinyl Estradiol, Norgestrel.
- chemically induced : Parkinson Disease, Secondary.
- diagnosis : Parkinson Disease, Secondary.
- Adult, Female, Humans, Magnetic Resonance Imaging.
Abstract
We report a case of parkinsonism induced by long term administration of an oral contraceptive. A 38-year-old woman complained of easily stumbling, démarche à petit pas and fatiguability in her lower extremities since January, 1991. When examined on April 5, 1991, she explained taking an oral contraceptive for 7 years on her doctor's recommendation after two times artificial abortions. Her facial expression was mask-like and body was bent forward with knee joints flexed and arms flexed at elbow joints. She had frozen gait with inactive pendulousness of the arms. We could find her muscle rigidity in both upper and lower extremities, especially in her right side extremities. A brain MRI finding was lacunar infarction which proton density weighted and T2-weighted MR images showed small patches of high-signal intensities in white matter of the bilateral frontal lobes and in left periventricular white matter. Her symptoms improved after stopping administration of the oral contraceptive and starting combination therapy with nicergoline and bromocriptine. She had some leg fatiguability at the onset of her next menstruation in May, but it was much less than her previous condition. When her menstruation terminated, those symptoms disappeared and it was possible to stop the administration of bromocriptine and nicergoline, and her symptoms have improved.
PubMed: 1567736
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[A case of parkinsonism induced by an oral contraceptive].</title><author><name sortKey="Yasui, M" sort="Yasui, M" uniqKey="Yasui M" first="M" last="Yasui">M. Yasui</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurological Diseases, Wakayama Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Neurological Diseases, Wakayama Medical College</wicri:regionArea></affiliation></author><author><name sortKey="Kihira, T" sort="Kihira, T" uniqKey="Kihira T" first="T" last="Kihira">T. Kihira</name></author><author><name sortKey="Ota, K" sort="Ota, K" uniqKey="Ota K" first="K" last="Ota">K. Ota</name></author><author><name sortKey="Funahashi, K" sort="Funahashi, K" uniqKey="Funahashi K" first="K" last="Funahashi">K. Funahashi</name></author><author><name sortKey="Komai, N" sort="Komai, N" uniqKey="Komai N" first="N" last="Komai">N. Komai</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1567736</idno><idno type="pmid">1567736</idno><idno type="wicri:Area/PubMed/Corpus">000049</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000049</idno><idno type="wicri:Area/PubMed/Curation">000049</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000049</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[A case of parkinsonism induced by an oral contraceptive].</title><author><name sortKey="Yasui, M" sort="Yasui, M" uniqKey="Yasui M" first="M" last="Yasui">M. Yasui</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurological Diseases, Wakayama Medical College, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Neurological Diseases, Wakayama Medical College</wicri:regionArea></affiliation></author><author><name sortKey="Kihira, T" sort="Kihira, T" uniqKey="Kihira T" first="T" last="Kihira">T. Kihira</name></author><author><name sortKey="Ota, K" sort="Ota, K" uniqKey="Ota K" first="K" last="Ota">K. Ota</name></author><author><name sortKey="Funahashi, K" sort="Funahashi, K" uniqKey="Funahashi K" first="K" last="Funahashi">K. Funahashi</name></author><author><name sortKey="Komai, N" sort="Komai, N" uniqKey="Komai N" first="N" last="Komai">N. Komai</name></author></analytic><series><title level="j">Nō to shinkei = Brain and nerve</title><idno type="ISSN">0006-8969</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Contraceptives, Oral, Combined (adverse effects)</term><term>Ethinyl Estradiol (adverse effects)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Magnetic Resonance Imaging (MeSH)</term><term>Norgestrel (adverse effects)</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (diagnosis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Contraceptifs oraux combinés (effets indésirables)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Imagerie par résonance magnétique (MeSH)</term><term>Norgestrel (effets indésirables)</term><term>Syndrome parkinsonien secondaire (diagnostic)</term><term>Syndrome parkinsonien secondaire (induit chimiquement)</term><term>Éthinyloestradiol (effets indésirables)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Contraceptives, Oral, Combined</term><term>Ethinyl Estradiol</term><term>Norgestrel</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome parkinsonien secondaire</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Contraceptifs oraux combinés</term><term>Norgestrel</term><term>Éthinyloestradiol</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Syndrome parkinsonien secondaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report a case of parkinsonism induced by long term administration of an oral contraceptive. A 38-year-old woman complained of easily stumbling, démarche à petit pas and fatiguability in her lower extremities since January, 1991. When examined on April 5, 1991, she explained taking an oral contraceptive for 7 years on her doctor's recommendation after two times artificial abortions. Her facial expression was mask-like and body was bent forward with knee joints flexed and arms flexed at elbow joints. She had frozen gait with inactive pendulousness of the arms. We could find her muscle rigidity in both upper and lower extremities, especially in her right side extremities. A brain MRI finding was lacunar infarction which proton density weighted and T2-weighted MR images showed small patches of high-signal intensities in white matter of the bilateral frontal lobes and in left periventricular white matter. Her symptoms improved after stopping administration of the oral contraceptive and starting combination therapy with nicergoline and bromocriptine. She had some leg fatiguability at the onset of her next menstruation in May, but it was much less than her previous condition. When her menstruation terminated, those symptoms disappeared and it was possible to stop the administration of bromocriptine and nicergoline, and her symptoms have improved.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">1567736</PMID><DateCreated><Year>1992</Year><Month>05</Month><Day>26</Day></DateCreated><DateCompleted><Year>1992</Year><Month>05</Month><Day>26</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0006-8969</ISSN><JournalIssue CitedMedium="Print"><Volume>44</Volume><Issue>2</Issue><PubDate><Year>1992</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Nō to shinkei = Brain and nerve</Title><ISOAbbreviation>No To Shinkei</ISOAbbreviation></Journal><ArticleTitle>[A case of parkinsonism induced by an oral contraceptive].</ArticleTitle><Pagination><MedlinePgn>163-6</MedlinePgn></Pagination><Abstract><AbstractText>We report a case of parkinsonism induced by long term administration of an oral contraceptive. A 38-year-old woman complained of easily stumbling, démarche à petit pas and fatiguability in her lower extremities since January, 1991. When examined on April 5, 1991, she explained taking an oral contraceptive for 7 years on her doctor's recommendation after two times artificial abortions. Her facial expression was mask-like and body was bent forward with knee joints flexed and arms flexed at elbow joints. She had frozen gait with inactive pendulousness of the arms. We could find her muscle rigidity in both upper and lower extremities, especially in her right side extremities. A brain MRI finding was lacunar infarction which proton density weighted and T2-weighted MR images showed small patches of high-signal intensities in white matter of the bilateral frontal lobes and in left periventricular white matter. Her symptoms improved after stopping administration of the oral contraceptive and starting combination therapy with nicergoline and bromocriptine. She had some leg fatiguability at the onset of her next menstruation in May, but it was much less than her previous condition. When her menstruation terminated, those symptoms disappeared and it was possible to stop the administration of bromocriptine and nicergoline, and her symptoms have improved.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yasui</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Neurological Diseases, Wakayama Medical College, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kihira</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Ota</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Funahashi</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Komai</LastName><ForeName>N</ForeName><Initials>N</Initials></Author></AuthorList><Language>jpn</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>JAPAN</Country><MedlineTA>No To Shinkei</MedlineTA><NlmUniqueID>0413550</NlmUniqueID><ISSNLinking>0006-8969</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003277">Contraceptives, Oral, Combined</NameOfSubstance></Chemical><Chemical><RegistryNumber>3J8Q1747Z2</RegistryNumber><NameOfSubstance UI="D009644">Norgestrel</NameOfSubstance></Chemical><Chemical><RegistryNumber>423D2T571U</RegistryNumber><NameOfSubstance UI="D004997">Ethinyl Estradiol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>J</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003277">Contraceptives, Oral, Combined</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004997">Ethinyl Estradiol</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009644">Norgestrel</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010302">Parkinson Disease, Secondary</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000139">chemically induced</QualifierName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="PIP">075647</OtherID><OtherID Source="POP">00217792</OtherID><OtherAbstract Type="PIP" Language="eng"><AbstractText>Symptoms of Parkinsonism, most likely induced by an oral contraceptive, were greatly reduced by combined therapy of nicergoline and bromocriptine. A 38-year-old housewife had taken an oral contraceptive, which contained .05 mg of ethinyl estradiol and .5mg of norgestrel per tablet, for 7 years, when she presented took the following symptoms: she stumbled easily, took short, quick dancing/skating steps without arm movement, and found it increasingly difficult to keep slippers on while walking. In the afternoons she experienced extreme fatigue and rigidity in her lower limbs. After a while, languor spread to other parts of her body as well, and she was examined on April 5, 1991. The patient's face was mask-like, and her body was bent forward with her forearms flexed. She showed frozen gait and lowered initiation in her movement. Muscle rigidity was found in both upper and lower extremities, and especially on the right side. A brain MRI showed lacunar infraction with small patches of high signal intensities in the white matter of the bilateral frontal lobes and high signal intensities in the left periventricular white matter. Urine was normal; blood cholesterol and iron were slightly raised. Hormonal examinations showed lowered LH, FSH, progesterone and 24-hr 17-KGS. CT was normal. She was ordered to stop taking pills and to take nicergoline and bromocriptine, which greatly reduced these symptoms except during the first menstruation following the treatment. When mask-like facial expressions, demarche a petit pas, and languor in her lower extremities did not recur during the next menstruation, bromocriptine treatment was discontinued. Four months later nicergoline therapy was also discontinued.</AbstractText></OtherAbstract><KeywordList Owner="PIP"><Keyword MajorTopicYN="N">Asia</Keyword><Keyword MajorTopicYN="N">Biology</Keyword><Keyword MajorTopicYN="Y">Case Studies</Keyword><Keyword MajorTopicYN="N">Contraception</Keyword><Keyword MajorTopicYN="Y">Contraception Termination</Keyword><Keyword MajorTopicYN="N">Contraceptive Methods--side effects</Keyword><Keyword MajorTopicYN="N">Developed Countries</Keyword><Keyword MajorTopicYN="N">Diseases</Keyword><Keyword MajorTopicYN="N">Eastern Asia</Keyword><Keyword MajorTopicYN="N">Family Planning</Keyword><Keyword MajorTopicYN="N">Japan</Keyword><Keyword MajorTopicYN="Y">Neurologic Effects</Keyword><Keyword MajorTopicYN="Y">Oral Contraceptives--side effects</Keyword><Keyword MajorTopicYN="N">Physiology</Keyword><Keyword MajorTopicYN="N">Research Methodology</Keyword><Keyword MajorTopicYN="Y">Signs And Symptoms</Keyword><Keyword MajorTopicYN="N">Studies</Keyword><Keyword MajorTopicYN="Y">Treatment</Keyword></KeywordList><GeneralNote Owner="PIP">TJ: NO TO SHINKEI.</GeneralNote></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year><Month>2</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1992</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1992</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1567736</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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