Falls and mobility in Parkinson's disease: protocol for a randomised controlled clinical trial
Identifieur interne : 000160 ( Pmc/Curation ); précédent : 000159; suivant : 000161Falls and mobility in Parkinson's disease: protocol for a randomised controlled clinical trial
Auteurs : Meg E. Morris [Australie] ; Hylton B. Menz [Australie] ; Jennifer L. Mcginley [Australie] ; Frances E. Huxham [Australie] ; Anna T. Murphy [Australie] ; Robert Iansek [Australie] ; Mary Danoudis [Australie] ; Sze-Ee Soh [Australie] ; David Kelly [Australie] ; Jennifer J. Watts [Australie]Source :
- BMC Neurology [ 1471-2377 ] ; 2011.
Abstract
Although physical therapy and falls prevention education are argued to reduce falls and disability in people with idiopathic Parkinson's disease, this has not yet been confirmed with a large scale randomised controlled clinical trial. The study will investigate the effects on falls, mobility and quality of life of (i) movement strategy training combined with falls prevention education, (ii) progressive resistance strength training combined with falls prevention education, (iii) a generic life-skills social program (control group).
People with idiopathic Parkinson's disease who live at home will be recruited and randomly allocated to one of three groups. Each person shall receive therapy in an out-patient setting in groups of 3-4. Each group shall be scheduled to meet once per week for 2 hours for 8 consecutive weeks. All participants will also have a structured 2 hour home practice program for each week during the 8 week intervention phase. Assessments will occur before therapy, after the 8 week therapy program, and at 3 and 12 months after the intervention. A falls calendar will be kept by each participant for 12 months after outpatient therapy.
Consistent with the recommendations of the Prevention of Falls Network Europe group, three falls variables will be used as the primary outcome measures: the number of fallers, the number of multiple fallers and the falls rate. In addition to quantifying falls, we shall measure mobility, activity limitations and quality of life as secondary outcomes.
This study has the potential to determine whether outpatient movement strategy training combined with falls prevention education or progressive resistance strength training combined with falls prevention education are effective for reducing falls and improving mobility and life quality in people with Parkinson's disease who live at home.
Australia and New Zealand Clinical Trials Register (ANZCTR):
Url:
DOI: 10.1186/1471-2377-11-93
PubMed: 21801451
PubMed Central: 3160881
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Although physical therapy and falls prevention education are argued to reduce falls and disability in people with idiopathic Parkinson's disease, this has not yet been confirmed with a large scale randomised controlled clinical trial. The study will investigate the effects on falls, mobility and quality of life of (i) movement strategy training combined with falls prevention education, (ii) progressive resistance strength training combined with falls prevention education, (iii) a generic life-skills social program (control group).</p>
</sec>
<sec><title>Methods/Design</title>
<p>People with idiopathic Parkinson's disease who live at home will be recruited and randomly allocated to one of three groups. Each person shall receive therapy in an out-patient setting in groups of 3-4. Each group shall be scheduled to meet once per week for 2 hours for 8 consecutive weeks. All participants will also have a structured 2 hour home practice program for each week during the 8 week intervention phase. Assessments will occur before therapy, after the 8 week therapy program, and at 3 and 12 months after the intervention. A falls calendar will be kept by each participant for 12 months after outpatient therapy.</p>
<p>Consistent with the recommendations of the Prevention of Falls Network Europe group, three falls variables will be used as the primary outcome measures: the number of fallers, the number of multiple fallers and the falls rate. In addition to quantifying falls, we shall measure mobility, activity limitations and quality of life as secondary outcomes.</p>
</sec>
<sec><title>Discussion</title>
<p>This study has the potential to determine whether outpatient movement strategy training combined with falls prevention education or progressive resistance strength training combined with falls prevention education are effective for reducing falls and improving mobility and life quality in people with Parkinson's disease who live at home.</p>
</sec>
<sec><title>Trial registration</title>
<p>Australia and New Zealand Clinical Trials Register (ANZCTR): <ext-link ext-link-type="uri" xlink:href="http://www.anzctr.org.au/ACTRN12606000344594.aspx">ACTRN12606000344594</ext-link>
</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Neurol</journal-id>
<journal-title-group><journal-title>BMC Neurology</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2377</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21801451</article-id>
<article-id pub-id-type="pmc">3160881</article-id>
<article-id pub-id-type="publisher-id">1471-2377-11-93</article-id>
<article-id pub-id-type="doi">10.1186/1471-2377-11-93</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Study Protocol</subject>
</subj-group>
</article-categories>
<title-group><article-title>Falls and mobility in Parkinson's disease: protocol for a randomised controlled clinical trial</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Morris</surname>
<given-names>Meg E</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>m.morris@unimelb.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Menz</surname>
<given-names>Hylton B</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>h.menz@latrobe.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A3"><name><surname>McGinley</surname>
<given-names>Jennifer L</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I3">3</xref>
<email>mcginley@unimelb.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A4"><name><surname>Huxham</surname>
<given-names>Frances E</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>fhuxham@optusnet.com.au</email>
</contrib>
<contrib contrib-type="author" id="A5"><name><surname>Murphy</surname>
<given-names>Anna T</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I3">3</xref>
<email>annat.murphy@southernhealth.org.au</email>
</contrib>
<contrib contrib-type="author" id="A6"><name><surname>Iansek</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>robert.iansek@monash.edu</email>
</contrib>
<contrib contrib-type="author" id="A7"><name><surname>Danoudis</surname>
<given-names>Mary</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I3">3</xref>
<email>m.danoudis@unimelb.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A8"><name><surname>Soh</surname>
<given-names>Sze-Ee</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>s.soh@alfred.org.au</email>
</contrib>
<contrib contrib-type="author" id="A9"><name><surname>Kelly</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>d.kelly@unimelb.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A10"><name><surname>Watts</surname>
<given-names>Jennifer J</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I4">4</xref>
<email>Jenny.Watts@buseco.monash.edu.au</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Melbourne School of Health Sciences, The University of Melbourne, 3010, Melbourne, Australia</aff>
<aff id="I2"><label>2</label>
Musculoskeletal Research Centre, Faculty of Health Sciences, La Trobe University, 3086, Australia</aff>
<aff id="I3"><label>3</label>
National Parkinson Foundation Center for Excellence, Clinical Research Centre for Movement Disorders and Gait and Victorian Comprehensive Parkinson's Program, Kingston Centre, Warrigal Rd, Cheltenham, 3092, Australia</aff>
<aff id="I4"><label>4</label>
Centre for Health Economics, Monash University, Building 75, Clayton, 3168, Melbourne, Australia</aff>
<pub-date pub-type="collection"><year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>31</day>
<month>7</month>
<year>2011</year>
</pub-date>
<volume>11</volume>
<fpage>93</fpage>
<lpage>93</lpage>
<history><date date-type="received"><day>15</day>
<month>6</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>31</day>
<month>7</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>Copyright ©2011 Morris et al; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2011</copyright-year>
<copyright-holder>Morris et al; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.biomedcentral.com/1471-2377/11/93"></self-uri>
<abstract><sec><title>Background</title>
<p>Although physical therapy and falls prevention education are argued to reduce falls and disability in people with idiopathic Parkinson's disease, this has not yet been confirmed with a large scale randomised controlled clinical trial. The study will investigate the effects on falls, mobility and quality of life of (i) movement strategy training combined with falls prevention education, (ii) progressive resistance strength training combined with falls prevention education, (iii) a generic life-skills social program (control group).</p>
</sec>
<sec><title>Methods/Design</title>
<p>People with idiopathic Parkinson's disease who live at home will be recruited and randomly allocated to one of three groups. Each person shall receive therapy in an out-patient setting in groups of 3-4. Each group shall be scheduled to meet once per week for 2 hours for 8 consecutive weeks. All participants will also have a structured 2 hour home practice program for each week during the 8 week intervention phase. Assessments will occur before therapy, after the 8 week therapy program, and at 3 and 12 months after the intervention. A falls calendar will be kept by each participant for 12 months after outpatient therapy.</p>
<p>Consistent with the recommendations of the Prevention of Falls Network Europe group, three falls variables will be used as the primary outcome measures: the number of fallers, the number of multiple fallers and the falls rate. In addition to quantifying falls, we shall measure mobility, activity limitations and quality of life as secondary outcomes.</p>
</sec>
<sec><title>Discussion</title>
<p>This study has the potential to determine whether outpatient movement strategy training combined with falls prevention education or progressive resistance strength training combined with falls prevention education are effective for reducing falls and improving mobility and life quality in people with Parkinson's disease who live at home.</p>
</sec>
<sec><title>Trial registration</title>
<p>Australia and New Zealand Clinical Trials Register (ANZCTR): <ext-link ext-link-type="uri" xlink:href="http://www.anzctr.org.au/ACTRN12606000344594.aspx">ACTRN12606000344594</ext-link>
</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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