Neural networks engaged in milliseconds and seconds time processing: evidence from transcranial magnetic stimulation and patients with cortical or subcortical dysfunction
Identifieur interne : 000312 ( Pmc/Corpus ); précédent : 000311; suivant : 000313Neural networks engaged in milliseconds and seconds time processing: evidence from transcranial magnetic stimulation and patients with cortical or subcortical dysfunction
Auteurs : Giacomo Koch ; Massimiliano Oliveri ; Carlo CaltagironeSource :
- Philosophical Transactions of the Royal Society B: Biological Sciences [ 0962-8436 ] ; 2009.
Abstract
Here, we review recent transcranial magnetic stimulation studies and investigations in patients with neurological disease such as Parkinson's disease and stroke, showing that the neural processing of time requires the activity of wide range-distributed brain networks. The neural activity of the cerebellum seems most crucial when subjects are required to quickly estimate the passage of brief intervals, and when time is computed in relation to precise salient events. Conversely, the circuits involving the striatum and the substantia nigra projecting to the prefrontal cortex (PFC) are mostly implicated in supra-second time intervals and when time is processed in conjunction with other cognitive functions. A conscious representation of temporal intervals relies on the integrity of the prefrontal and parietal cortices. The role of the PFC becomes predominant when time intervals have to be kept in memory, especially for longer supra-second time intervals, or when the task requires a high cognitive level. We conclude that the contribution of these strongly interconnected anatomical structures in time processing is not fixed, depending not only on the duration of the time interval to be assessed by the brain, but also on the cognitive set, the chosen task and the stimulus modality.
Url:
DOI: 10.1098/rstb.2009.0018
PubMed: 19487193
PubMed Central: 2685818
Links to Exploration step
PMC:2685818Le document en format XML
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Oliveri</name><affiliation><nlm:aff id="aff1"><institution>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS</institution><addr-line>Via Ardeatina, 306, 00179 Rome, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Dipartimento di Psicologia, Università di Palermo</institution><addr-line>90128 Palermo, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Caltagirone, Carlo" sort="Caltagirone, Carlo" uniqKey="Caltagirone C" first="Carlo" last="Caltagirone">Carlo Caltagirone</name><affiliation><nlm:aff id="aff1"><institution>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS</institution><addr-line>Via Ardeatina, 306, 00179 Rome, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata</institution><addr-line>Via Montpellier 1, 00133 Rome, 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Comportamentale, Fondazione Santa Lucia IRCCS</institution><addr-line>Via Ardeatina, 306, 00179 Rome, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata</institution><addr-line>Via Montpellier 1, 00133 Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Oliveri, Massimiliano" sort="Oliveri, Massimiliano" uniqKey="Oliveri M" first="Massimiliano" last="Oliveri">Massimiliano Oliveri</name><affiliation><nlm:aff id="aff1"><institution>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS</institution><addr-line>Via Ardeatina, 306, 00179 Rome, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Dipartimento di Psicologia, Università di Palermo</institution><addr-line>90128 Palermo, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Caltagirone, Carlo" sort="Caltagirone, Carlo" uniqKey="Caltagirone C" first="Carlo" last="Caltagirone">Carlo Caltagirone</name><affiliation><nlm:aff id="aff1"><institution>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS</institution><addr-line>Via Ardeatina, 306, 00179 Rome, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata</institution><addr-line>Via Montpellier 1, 00133 Rome, Italy</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Philosophical Transactions of the Royal Society B: Biological Sciences</title><idno type="ISSN">0962-8436</idno><idno type="eISSN">1471-2970</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Here, we review recent transcranial magnetic stimulation studies and investigations in patients with neurological disease such as Parkinson's disease and stroke, showing that the neural processing of time requires the activity of wide range-distributed brain networks. The neural activity of the cerebellum seems most crucial when subjects are required to quickly estimate the passage of brief intervals, and when time is computed in relation to precise salient events. Conversely, the circuits involving the striatum and the substantia nigra projecting to the prefrontal cortex (PFC) are mostly implicated in supra-second time intervals and when time is processed in conjunction with other cognitive functions. A conscious representation of temporal intervals relies on the integrity of the prefrontal and parietal cortices. The role of the PFC becomes predominant when time intervals have to be kept in memory, especially for longer supra-second time intervals, or when the task requires a high cognitive level. We conclude that the contribution of these strongly interconnected anatomical structures in time processing is not fixed, depending not only on the duration of the time interval to be assessed by the brain, but also on the cognitive set, the chosen task and the stimulus modality.</p></div></front></TEI><pmc article-type="review-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Philos Trans R Soc Lond B Biol Sci</journal-id><journal-id journal-id-type="publisher-id">RSTB</journal-id><journal-title>Philosophical Transactions of the Royal Society B: Biological Sciences</journal-title><issn pub-type="ppub">0962-8436</issn><issn pub-type="epub">1471-2970</issn><publisher><publisher-name>The Royal Society</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19487193</article-id><article-id pub-id-type="pmc">2685818</article-id><article-id pub-id-type="publisher-id">rstb20090018</article-id><article-id pub-id-type="doi">10.1098/rstb.2009.0018</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Neural networks engaged in milliseconds and seconds time processing: evidence from transcranial magnetic stimulation and patients with cortical or subcortical dysfunction</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Koch</surname><given-names>Giacomo</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Oliveri</surname><given-names>Massimiliano</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Caltagirone</surname><given-names>Carlo</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS</institution><addr-line>Via Ardeatina, 306, 00179 Rome, Italy</addr-line></aff><aff id="aff2"><label>2</label><institution>Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata</institution><addr-line>Via Montpellier 1, 00133 Rome, Italy</addr-line></aff><aff id="aff3"><label>3</label><institution>Dipartimento di Psicologia, Università di Palermo</institution><addr-line>90128 Palermo, Italy</addr-line></aff><author-notes><corresp id="cor1"><label>*</label>Author and address for correspondence: Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS, Via Ardeatina, 306, 00179 Rome, Italy (<email>g.koch@hsantalucia.it</email>)</corresp></author-notes><pub-date pub-type="ppub"><day>12</day><month>7</month><year>2009</year></pub-date><volume>364</volume><issue>1525</issue><issue-title>Theme Issue ‘The experience of time: neural mechanisms and the interplay of emotion, cognition and embodiment’ compiled by Marc Wittmann and Virginie van Wassenhove</issue-title><fpage>1907</fpage><lpage>1918</lpage><permissions><copyright-statement>© 2009 The Royal Society</copyright-statement><copyright-year>2009</copyright-year></permissions><abstract><p>Here, we review recent transcranial magnetic stimulation studies and investigations in patients with neurological disease such as Parkinson's disease and stroke, showing that the neural processing of time requires the activity of wide range-distributed brain networks. The neural activity of the cerebellum seems most crucial when subjects are required to quickly estimate the passage of brief intervals, and when time is computed in relation to precise salient events. Conversely, the circuits involving the striatum and the substantia nigra projecting to the prefrontal cortex (PFC) are mostly implicated in supra-second time intervals and when time is processed in conjunction with other cognitive functions. A conscious representation of temporal intervals relies on the integrity of the prefrontal and parietal cortices. The role of the PFC becomes predominant when time intervals have to be kept in memory, especially for longer supra-second time intervals, or when the task requires a high cognitive level. We conclude that the contribution of these strongly interconnected anatomical structures in time processing is not fixed, depending not only on the duration of the time interval to be assessed by the brain, but also on the cognitive set, the chosen task and the stimulus modality.</p></abstract><kwd-group><kwd>time perception</kwd><kwd>timing</kwd><kwd>stroke</kwd><kwd>transcranial magnetic stimulation</kwd><kwd>repetitive transcranial magnetic stimulation</kwd><kwd>Parkinson's disease</kwd></kwd-group></article-meta></front><floats-wrap><fig id="fig1" position="float"><label>Figure 1</label><caption><p>(<italic>a</italic>) For cerebellar rTMS investigations, precise anatomical information about the brain area stimulated was obtained by performing a T1-weighted image magnetic resonance imaging on a sample subject after marking the cerebellar scalp sites with capsules containing soya oil. In the milliseconds range, significant differences were selectively found for (<italic>b</italic>) the left cerebellar but not for (<italic>d</italic>) the right dorsolateral prefrontal cortex (DLPFC) stimulation. In the supra-second intervals, right DLPFC stimulation altered (<italic>e</italic>) time perception, whereas no effect was found for (<italic>c</italic>) the left cerebellar stimulation. The <italic>x</italic>- and <italic>y</italic>-axis values are expressed in milliseconds. Pre-rTMS, grey bars; Post-rTMS, black bars. Error bars indicate 1 s.e.m. <sup>*</sup><italic>p</italic><0.05. Adapted from <xref ref-type="bibr" rid="bib47">Koch <italic>et al</italic>. (2007<italic>a</italic>)</xref>.</p></caption><graphic xlink:href="rstb20090018f01"></graphic></fig><fig id="fig2" position="float"><label>Figure 2</label><caption><p>Schematic of the connections between the subcortical and cortical structures involved in time processing of time intervals with different durations and cognitive loads. The arrow in the left indicates length of time intervals and the arrow in the right indicates the difficulty of the task being performed. PPC, posterior parietal cortex; PFC, prefrontal cortex; VLa, anterior ventrolateral nucleus; VLp, posterior ventrolateral nucleus; VIm, intermediate ventral nucleus.</p></caption><graphic xlink:href="rstb20090018f02"></graphic></fig></floats-wrap></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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