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Engaging Neuroscience to Advance Translational Research in Brain Barrier Biology

Identifieur interne : 000247 ( Pmc/Corpus ); précédent : 000246; suivant : 000248

Engaging Neuroscience to Advance Translational Research in Brain Barrier Biology

Auteurs : Edward A. Neuwelt ; Björn Bauer ; Christoph Fahlke ; Gert Fricker ; Constantino Iadecola ; Damir Janigro ; Luc Leybaert ; Zoltan Molnar ; Martha O Onnell ; John Povlishock ; Norman Saunders ; Frank Sharp ; Danica Stanimirovic ; Ryan Watts ; Lester Drewes

Source :

RBID : PMC:3335275

Abstract

Preface

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, the most well known of which are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, control of cerebral blood flow, and, when barrier integrity is impaired, a contribution to the pathology of many common CNS disorders such as Alzheimer’s disease, Parkinson’s disease and stroke. Thus, many key areas of neuroscientific investigation are shared with the ‘brain barriers sciences’. However, despite this overlap there has been little crosstalk. This lack of crosstalk is of more than academic interest as our emerging understanding of the neurovascular unit (NVU), composed of local neuronal circuits, glia, pericytes and the endothelium, illustrates how the brain dynamically modulates its blood flow, metabolism, and electrophysiological regulation. A key insight is that the barriers are an essential part of the NVU and as such are influenced by all cellular elements of this unit.


Url:
DOI: 10.1038/nrn2995
PubMed: 21331083
PubMed Central: 3335275

Links to Exploration step

PMC:3335275

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<p id="P1">The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, the most well known of which are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, control of cerebral blood flow, and, when barrier integrity is impaired, a contribution to the pathology of many common CNS disorders such as Alzheimer’s disease, Parkinson’s disease and stroke. Thus, many key areas of neuroscientific investigation are shared with the ‘brain barriers sciences’. However, despite this overlap there has been little crosstalk. This lack of crosstalk is of more than academic interest as our emerging understanding of the neurovascular unit (NVU), composed of local neuronal circuits, glia, pericytes and the endothelium, illustrates how the brain dynamically modulates its blood flow, metabolism, and electrophysiological regulation. A key insight is that the barriers are an essential part of the NVU and as such are influenced by all cellular elements of this unit.</p>
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<name>
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<contrib contrib-type="author">
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Oregon Health & Science University, Portland, Oregon</aff>
<aff id="A2">
<label>2</label>
Portland Veterans Affairs Medical Center, Portland, Oregon</aff>
<aff id="A3">
<label>3</label>
University of Minnesota, Duluth, Minnesota</aff>
<aff id="A4">
<label>4</label>
Medizinische Hochschule Hannover, Hanover, Germany</aff>
<aff id="A5">
<label>5</label>
University of Heidelberg, Heidelberg, Germany</aff>
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Weill Cornell Medical College, New York, New York</aff>
<aff id="A7">
<label>7</label>
Cleveland Clinic Foundation, Cleveland, Ohio</aff>
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<label>8</label>
Ghent University, Ghent, Belgium</aff>
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<label>9</label>
University of Oxford, Oxford, United Kingdom</aff>
<aff id="A10">
<label>10</label>
University of California at Davis, Davis, California</aff>
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Virginia Commonwealth University, Richmond, Virginia</aff>
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University of Melbourne, Parkville, Victoria, Australia</aff>
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National Research Council, Ottawa, Ontario, Canada</aff>
<aff id="A14">
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Genentech, Inc., South San Francisco, California</aff>
<author-notes>
<corresp id="cor1">
<bold>Corresponding Author:</bold>
Edward A. Neuwelt, MD, Oregon Health & Science University, Blood-Brain Barrier Program, 3181 SW Sam Jackson Park Road, Mailcode L603, Portland, OR 97239,
<email>neuwelte@ohsu.edu</email>
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<abstract>
<title>Preface</title>
<p id="P1">The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, the most well known of which are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, control of cerebral blood flow, and, when barrier integrity is impaired, a contribution to the pathology of many common CNS disorders such as Alzheimer’s disease, Parkinson’s disease and stroke. Thus, many key areas of neuroscientific investigation are shared with the ‘brain barriers sciences’. However, despite this overlap there has been little crosstalk. This lack of crosstalk is of more than academic interest as our emerging understanding of the neurovascular unit (NVU), composed of local neuronal circuits, glia, pericytes and the endothelium, illustrates how the brain dynamically modulates its blood flow, metabolism, and electrophysiological regulation. A key insight is that the barriers are an essential part of the NVU and as such are influenced by all cellular elements of this unit.</p>
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</front>
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