DanceTherParkinsonV1, Pmc, Corpus, bibRecord, 000229

Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies

Identifieur interne : 000229 ( Pmc/Corpus ); précédent : 000228; suivant : 000230

Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies

Auteurs : G. Giovannoni ; J. O'Sullivan ; K. Turner ; A. Manson ; A. Lees

Source :

Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 2000.

RBID : PMC:1736875

Abstract

Hedonistic homeostatic dysregulation is a neuropsychological behavioural disorder associated with substance misuse and addiction. The disorder has been recognised as a consequence of dopamine replacement therapy (DRT) in 15 patients with Parkinson's disease. The syndrome typically develops in male patients with early onset Parkinson's disease, and can occur with orally and subcutaneously administered DRT. These patients take increasing quantities of their DRT, despite increasingly severe drug induced dyskinesias, and may develop a cyclical mood disorder with hypomania or manic psychosis. There is impairment of social and occupational functioning. Tolerance develops to mood elevating effects of DRT and a negative affective withdrawal state occurs if the drugs are withdrawn or doses decreased. The clinical features and guidelines for managing this syndrome are discussed. A set of diagnostic criteria for further investigating this condition is proposed.  

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1736875

DOI: 10.1136/jnnp.68.4.423
PubMed: 10727476
PubMed Central: 1736875

Links to Exploration step

PMC:1736875

Le document en format XML

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Parkinson's disease on dopamine replacement therapies</title>
<author><name sortKey="Giovannoni, G" sort="Giovannoni, G" uniqKey="Giovannoni G" first="G" last="Giovannoni">G. Giovannoni</name>
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<author><name sortKey="O Sullivan, J" sort="O Sullivan, J" uniqKey="O Sullivan J" first="J" last="O'Sullivan">J. O'Sullivan</name>
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<author><name sortKey="Turner, K" sort="Turner, K" uniqKey="Turner K" first="K" last="Turner">K. Turner</name>
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<author><name sortKey="Manson, A" sort="Manson, A" uniqKey="Manson A" first="A" last="Manson">A. Manson</name>
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<author><name sortKey="Lees, A" sort="Lees, A" uniqKey="Lees A" first="A" last="Lees">A. Lees</name>
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<author><name sortKey="O Sullivan, J" sort="O Sullivan, J" uniqKey="O Sullivan J" first="J" last="O'Sullivan">J. O'Sullivan</name>
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<author><name sortKey="Turner, K" sort="Turner, K" uniqKey="Turner K" first="K" last="Turner">K. Turner</name>
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<author><name sortKey="Manson, A" sort="Manson, A" uniqKey="Manson A" first="A" last="Manson">A. Manson</name>
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<author><name sortKey="Lees, A" sort="Lees, A" uniqKey="Lees A" first="A" last="Lees">A. Lees</name>
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<series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title>
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<front><div type="abstract" xml:lang="en"><p>Hedonistic homeostatic dysregulation is a
neuropsychological behavioural disorder associated with substance
misuse and addiction. The disorder has been recognised as a consequence
of dopamine replacement therapy (DRT) in 15 patients with Parkinson's
disease. The syndrome typically develops in male patients with early
onset Parkinson's disease, and can occur with orally and
subcutaneously administered DRT. These patients take increasing
quantities of their DRT, despite increasingly severe drug induced
dyskinesias, and may develop a cyclical mood disorder with hypomania or
manic psychosis. There is impairment of social and occupational
functioning. Tolerance develops to mood elevating effects of DRT and a
negative affective withdrawal state occurs if the drugs are withdrawn
or doses decreased. The clinical features and guidelines for managing this syndrome are discussed. A set of diagnostic criteria for further
investigating this condition is proposed.  </p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id>
<journal-title>Journal of Neurology, Neurosurgery, and Psychiatry</journal-title>
<issn pub-type="ppub">0022-3050</issn>
<issn pub-type="epub">1468-330X</issn>
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<article-id pub-id-type="doi">10.1136/jnnp.68.4.423</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Papers</subject>
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<title-group><article-title>Hedonistic homeostatic dysregulation in patients with
Parkinson's disease on dopamine replacement therapies</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Giovannoni</surname>
<given-names>G</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>O'Sullivan</surname>
<given-names>J</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Turner</surname>
<given-names>K</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Manson</surname>
<given-names>A</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lees</surname>
<given-names>A</given-names>
</name>
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<aff>Institute of Neurology, Queen Square, London WC1N 3BG, UK.<email>G.Giovannoni@ion.ucl.ac.uk</email>
</aff>
<pub-date pub-type="ppub"><month>4</month>
<year>2000</year>
</pub-date>
<volume>68</volume>
<issue>4</issue>
<fpage>423</fpage>
<lpage>428</lpage>
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<self-uri xlink:role="fulltext" xlink:type="simple" xlink:href="http://jnnp.bmj.com/cgi/content/full/68/4/423"></self-uri>
<abstract><p>Hedonistic homeostatic dysregulation is a
neuropsychological behavioural disorder associated with substance
misuse and addiction. The disorder has been recognised as a consequence
of dopamine replacement therapy (DRT) in 15 patients with Parkinson's
disease. The syndrome typically develops in male patients with early
onset Parkinson's disease, and can occur with orally and
subcutaneously administered DRT. These patients take increasing
quantities of their DRT, despite increasingly severe drug induced
dyskinesias, and may develop a cyclical mood disorder with hypomania or
manic psychosis. There is impairment of social and occupational
functioning. Tolerance develops to mood elevating effects of DRT and a
negative affective withdrawal state occurs if the drugs are withdrawn
or doses decreased. The clinical features and guidelines for managing this syndrome are discussed. A set of diagnostic criteria for further
investigating this condition is proposed.  </p>
</abstract>
</article-meta>
</front>
</pmc>
</record>

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Danse-thérapie et Parkinson

Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies

Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki