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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Physical activities and future risk of Parkinson disease</title><author><name sortKey="Xu, Q" sort="Xu, Q" uniqKey="Xu Q" first="Q." last="Xu">Q. Xu</name></author><author><name sortKey="Park, Y" sort="Park, Y" uniqKey="Park Y" first="Y." last="Park">Y. Park</name></author><author><name sortKey="Huang, X" sort="Huang, X" uniqKey="Huang X" first="X." last="Huang">X. Huang</name></author><author><name sortKey="Hollenbeck, A" sort="Hollenbeck, A" uniqKey="Hollenbeck A" first="A." last="Hollenbeck">A. Hollenbeck</name></author><author><name sortKey="Blair, A" sort="Blair, A" uniqKey="Blair A" first="A." last="Blair">A. Blair</name></author><author><name sortKey="Schatzkin, A" sort="Schatzkin, A" uniqKey="Schatzkin A" first="A." last="Schatzkin">A. Schatzkin</name></author><author><name sortKey="Chen, H" sort="Chen, H" uniqKey="Chen H" first="H." last="Chen">H. Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20660864</idno><idno type="pmc">2918886</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918886</idno><idno type="RBID">PMC:2918886</idno><idno type="doi">10.1212/WNL.0b013e3181ea1597</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000173</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000173</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Physical activities and future risk of Parkinson disease</title><author><name sortKey="Xu, Q" sort="Xu, Q" uniqKey="Xu Q" first="Q." last="Xu">Q. Xu</name></author><author><name sortKey="Park, Y" sort="Park, Y" uniqKey="Park Y" first="Y." last="Park">Y. Park</name></author><author><name sortKey="Huang, X" sort="Huang, X" uniqKey="Huang X" first="X." last="Huang">X. Huang</name></author><author><name sortKey="Hollenbeck, A" sort="Hollenbeck, A" uniqKey="Hollenbeck A" first="A." last="Hollenbeck">A. Hollenbeck</name></author><author><name sortKey="Blair, A" sort="Blair, A" uniqKey="Blair A" first="A." last="Blair">A. Blair</name></author><author><name sortKey="Schatzkin, A" sort="Schatzkin, A" uniqKey="Schatzkin A" first="A." last="Schatzkin">A. Schatzkin</name></author><author><name sortKey="Chen, H" sort="Chen, H" uniqKey="Chen H" first="H." last="Chen">H. Chen</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To prospectively investigate the relationship between physical activity and Parkinson disease (PD).</p></sec><sec><title>Methods:</title><p>We evaluated physical activity in relation to PD among 213,701 participants of the NIH-AARP Diet and Health Study cohort. Physical activities over 4 periods (ages 15-18, 19-29, and 35-39, and in the past 10 years) were noted in 1996-1997, and physician-diagnosed PD was reported on the 2004-2006 follow-up questionnaire. Only cases diagnosed after 2000 (n = 767) were included in the analyses.</p></sec><sec><title>Results:</title><p>Higher levels of moderate to vigorous activities at ages 35-39 or in the past 10 years as reported in 1996-1997 were associated with lower PD occurrence after 2000 with significant dose-response relationships. The multivariate odds ratios (OR) between the highest vs the lowest levels were 0.62 (95% CI confidence interval [CI] 0.48-0.81, <italic>p</italic> for trend 0.005) for ages 35-39 and 0.65 (95% CI 0.51-0.83, <italic>p</italic> for trend 0.0001) for in the past 10 years. Further analyses showed that individuals with consistent and frequent participation in moderate to vigorous activities in both periods had approximately a 40% lower risk than those who were inactive in both periods. Moderate to vigorous activities at earlier ages or light activities were not associated with PD. Finally, the association between higher moderate to vigorous physical activities and lower PD risk was demonstrated in a metaanalysis of prospective studies.</p></sec><sec><title>Conclusions:</title><p>Although we cannot exclude the possibility that less participation in physical activity is an early marker of PD, epidemiologic evidence suggests that moderate to vigorous exercise may protect against PD.</p></sec><sec><title>GLOSSARY</title><def-list list-type="abr"><def-item><term><bold>CI</bold></term><def><p> = confidence interval; </p></def></def-item><def-item><term><bold>CPS-II</bold></term><def><p> = Cancer Prevention Study II Nutrition Cohort; </p></def></def-item><def-item><term><bold>HAHS</bold></term><def><p> = Harvard Alumni Health Study; </p></def></def-item><def-item><term><bold>HPFS</bold></term><def><p> = Health Professionals Follow-up Study; </p></def></def-item><def-item><term><bold>NHS</bold></term><def><p> = Nurses Health Study; </p></def></def-item><def-item><term><bold>OR</bold></term><def><p> = odds ratio; </p></def></def-item><def-item><term><bold>PD</bold></term><def><p> = Parkinson disease.</p></def></def-item></def-list></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurology</journal-id><journal-title>Neurology</journal-title><issn pub-type="ppub">0028-3878</issn><issn pub-type="epub">1526-632X</issn><publisher><publisher-name>American Academy of Neurology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20660864</article-id><article-id pub-id-type="pmc">2918886</article-id><article-id pub-id-type="publisher-id">znl02810000341</article-id><article-id pub-id-type="doi">10.1212/WNL.0b013e3181ea1597</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Physical activities and future risk of Parkinson disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Q.</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Y.</given-names></name><degrees>ScD</degrees></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>X.</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Hollenbeck</surname><given-names>A.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Blair</surname><given-names>A.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Schatzkin</surname><given-names>A.</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>H.</given-names></name><degrees>MD, PhD</degrees></contrib></contrib-group><aff id="N0x3335e70N0x35dc998">From the Epidemiology Branch (Q.X., H.C.), National Institute of Environmental Health Sciences, Research Triangle Park, NC; Nutritional Epidemiology Branch (Y.P., A.S.) and Occupational and Environmental Epidemiology Branch (A.B.), National Cancer Institute, Rockville, MD; Departments of Neurology, Radiology, Neurosurgery, Pharmacology, Kinesiology & Bioengineering (X.H.), Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA; and AARP (A.H.), Washington, DC.<break></break></aff><pub-date pub-type="ppub"><day>27</day><month>7</month><year>2010</year></pub-date><volume>75</volume><issue>4</issue><fpage>341</fpage><lpage>348</lpage><copyright-statement>Copyright © 2010 by AAN Enterprises, Inc.</copyright-statement><abstract><sec><title>Objective:</title><p>To prospectively investigate the relationship between physical activity and Parkinson disease (PD).</p></sec><sec><title>Methods:</title><p>We evaluated physical activity in relation to PD among 213,701 participants of the NIH-AARP Diet and Health Study cohort. Physical activities over 4 periods (ages 15-18, 19-29, and 35-39, and in the past 10 years) were noted in 1996-1997, and physician-diagnosed PD was reported on the 2004-2006 follow-up questionnaire. Only cases diagnosed after 2000 (n = 767) were included in the analyses.</p></sec><sec><title>Results:</title><p>Higher levels of moderate to vigorous activities at ages 35-39 or in the past 10 years as reported in 1996-1997 were associated with lower PD occurrence after 2000 with significant dose-response relationships. The multivariate odds ratios (OR) between the highest vs the lowest levels were 0.62 (95% CI confidence interval [CI] 0.48-0.81, <italic>p</italic> for trend 0.005) for ages 35-39 and 0.65 (95% CI 0.51-0.83, <italic>p</italic> for trend 0.0001) for in the past 10 years. Further analyses showed that individuals with consistent and frequent participation in moderate to vigorous activities in both periods had approximately a 40% lower risk than those who were inactive in both periods. Moderate to vigorous activities at earlier ages or light activities were not associated with PD. Finally, the association between higher moderate to vigorous physical activities and lower PD risk was demonstrated in a metaanalysis of prospective studies.</p></sec><sec><title>Conclusions:</title><p>Although we cannot exclude the possibility that less participation in physical activity is an early marker of PD, epidemiologic evidence suggests that moderate to vigorous exercise may protect against PD.</p></sec><sec><title>GLOSSARY</title><def-list list-type="abr"><def-item><term><bold>CI</bold></term><def><p> = confidence interval; </p></def></def-item><def-item><term><bold>CPS-II</bold></term><def><p> = Cancer Prevention Study II Nutrition Cohort; </p></def></def-item><def-item><term><bold>HAHS</bold></term><def><p> = Harvard Alumni Health Study; </p></def></def-item><def-item><term><bold>HPFS</bold></term><def><p> = Health Professionals Follow-up Study; </p></def></def-item><def-item><term><bold>NHS</bold></term><def><p> = Nurses Health Study; </p></def></def-item><def-item><term><bold>OR</bold></term><def><p> = odds ratio; </p></def></def-item><def-item><term><bold>PD</bold></term><def><p> = Parkinson disease.</p></def></def-item></def-list></sec></abstract></article-meta><notes><p>Address correspondence and reprint requests to Dr. Honglei Chen, Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., PO Box 12233, Mail Drop A3-05, Research Triangle Park, NC 27709 <email>chenh2@niehs.nih.gov</email></p><p><italic>Study funding:</italic> Supported by the intramural research program of the NIH, the National Institute of Environmental Health Sciences (Z01-ES-101986), and the National Cancer Institute (Z01 CP010196-02).</p><p><italic>Disclosure:</italic> Author disclosures are provided at the end of the article.</p><p>Received November 18, 2009. Accepted in final form March 31, 2010.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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