The Efficacy of Traditional Chinese Medical Exercise for Parkinson’s Disease: A Systematic Review and Meta-analysis
Identifieur interne : 000013 ( Pmc/Corpus ); précédent : 000012; suivant : 000014The Efficacy of Traditional Chinese Medical Exercise for Parkinson’s Disease: A Systematic Review and Meta-analysis
Auteurs : Yan Yang ; Wei Qing Qiu ; Yan Lei Hao ; Zhan Yun Lv ; Shu Ji Jiao ; Jun Feng TengSource :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Several studies assessed the efficacy of traditional Chinese medical exercise in the management of Parkinson’s disease (PD), but its role remained controversial. Therefore, the purpose of this systematic review is to evaluate the evidence on the effect of traditional Chinese medical exercise for PD.
Seven English and Chinese electronic databases, up to October 2014, were searched to identify relevant studies. The PEDro scale was employed to assess the methodological quality of eligible studies. Meta-analysis was performed by RevMan 5.1 software.
Fifteen trials were included in the review. Tai Chi and Qigong were used as assisting pharmacological treatments of PD in the previous studies. Tai Chi plus medication showed greater improvements in motor function (standardized mean difference, SMD, -0.57; 95% confidence intervals, CI, -1.11 to -0.04), Berg balance scale (BBS, SMD, -1.22; 95% CI -1.65 to -0.80), and time up and go test (SMD, -1.06; 95% CI -1.44 to -0.68). Compared with other therapy plus medication, Tai Chi plus medication also showed greater gains in motor function (SMD, -0.78; 95% CI -1.46 to -0.10), BBS (SMD, -0.99; 95% CI -1.44 to -0.54), and functional reach test (SMD, -0.77; 95% CI -1.51 to -0.03). However, Tai Chi plus medication did not showed better improvements in gait or quality of life. There was not sufficient evidence to support or refute the effect of Qigong plus medication for PD.
In the previous studies, Tai Chi and Qigong were used as assisting pharmacological treatments of PD. The current systematic review showed positive evidence of Tai Chi plus medication for PD of mild-to-moderate severity. So Tai Chi plus medication should be recommended for PD management, especially in improving motor function and balance. Qigong plus medication also showed potential gains in the management of PD. However, more high quality studies with long follow-up are warrant to confirm the current findings.
Url:
DOI: 10.1371/journal.pone.0122469
PubMed: 25830664
PubMed Central: 4382160
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PMC:4382160Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Efficacy of Traditional Chinese Medical Exercise for Parkinson’s Disease: A Systematic Review and Meta-analysis</title><author><name sortKey="Yang, Yan" sort="Yang, Yan" uniqKey="Yang Y" first="Yan" last="Yang">Yan Yang</name><affiliation><nlm:aff id="aff001"><addr-line>Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Qiu, Wei Qing" sort="Qiu, Wei Qing" uniqKey="Qiu W" first="Wei Qing" last="Qiu">Wei Qing Qiu</name><affiliation><nlm:aff id="aff002"><addr-line>Department of Neurology, Laizhou People’s Hospital of Shangdong, Laizhou, Shandong, China</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff003"><addr-line>Binzhou Medical University Hospital, Binzhou, Shandong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hao, Yan Lei" sort="Hao, Yan Lei" uniqKey="Hao Y" first="Yan Lei" last="Hao">Yan Lei Hao</name><affiliation><nlm:aff id="aff001"><addr-line>Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lv, Zhan Yun" sort="Lv, Zhan Yun" uniqKey="Lv Z" first="Zhan Yun" last="Lv">Zhan Yun Lv</name><affiliation><nlm:aff id="aff001"><addr-line>Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jiao, Shu Ji" sort="Jiao, Shu Ji" uniqKey="Jiao S" first="Shu Ji" last="Jiao">Shu Ji Jiao</name><affiliation><nlm:aff id="aff004"><addr-line>Department of Neurology, The First People’s Hospital of Hebi, Hebi, Henan, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Teng, Jun Feng" sort="Teng, Jun Feng" uniqKey="Teng J" first="Jun Feng" last="Teng">Jun Feng Teng</name><affiliation><nlm:aff id="aff004"><addr-line>Department of Neurology, The First People’s Hospital of Hebi, Hebi, Henan, China</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25830664</idno><idno type="pmc">4382160</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382160</idno><idno type="RBID">PMC:4382160</idno><idno type="doi">10.1371/journal.pone.0122469</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000013</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000013</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Efficacy of Traditional Chinese Medical Exercise for Parkinson’s Disease: A Systematic Review and Meta-analysis</title><author><name sortKey="Yang, Yan" sort="Yang, Yan" uniqKey="Yang Y" first="Yan" last="Yang">Yan Yang</name><affiliation><nlm:aff id="aff001"><addr-line>Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Qiu, Wei Qing" sort="Qiu, Wei Qing" uniqKey="Qiu W" first="Wei Qing" last="Qiu">Wei Qing Qiu</name><affiliation><nlm:aff id="aff002"><addr-line>Department of Neurology, Laizhou People’s Hospital of Shangdong, Laizhou, Shandong, China</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff003"><addr-line>Binzhou Medical University Hospital, Binzhou, Shandong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hao, Yan Lei" sort="Hao, Yan Lei" uniqKey="Hao Y" first="Yan Lei" last="Hao">Yan Lei Hao</name><affiliation><nlm:aff id="aff001"><addr-line>Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lv, Zhan Yun" sort="Lv, Zhan Yun" uniqKey="Lv Z" first="Zhan Yun" last="Lv">Zhan Yun Lv</name><affiliation><nlm:aff id="aff001"><addr-line>Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jiao, Shu Ji" sort="Jiao, Shu Ji" uniqKey="Jiao S" first="Shu Ji" last="Jiao">Shu Ji Jiao</name><affiliation><nlm:aff id="aff004"><addr-line>Department of Neurology, The First People’s Hospital of Hebi, Hebi, Henan, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Teng, Jun Feng" sort="Teng, Jun Feng" uniqKey="Teng J" first="Jun Feng" last="Teng">Jun Feng Teng</name><affiliation><nlm:aff id="aff004"><addr-line>Department of Neurology, The First People’s Hospital of Hebi, Hebi, Henan, China</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background and Objective</title><p>Several studies assessed the efficacy of traditional Chinese medical exercise in the management of Parkinson’s disease (PD), but its role remained controversial. Therefore, the purpose of this systematic review is to evaluate the evidence on the effect of traditional Chinese medical exercise for PD.</p></sec><sec id="sec002"><title>Methods</title><p>Seven English and Chinese electronic databases, up to October 2014, were searched to identify relevant studies. The PEDro scale was employed to assess the methodological quality of eligible studies. Meta-analysis was performed by RevMan 5.1 software.</p></sec><sec id="sec003"><title>Results</title><p>Fifteen trials were included in the review. Tai Chi and Qigong were used as assisting pharmacological treatments of PD in the previous studies. Tai Chi plus medication showed greater improvements in motor function (standardized mean difference, SMD, -0.57; 95% confidence intervals, CI, -1.11 to -0.04), Berg balance scale (BBS, SMD, -1.22; 95% CI -1.65 to -0.80), and time up and go test (SMD, -1.06; 95% CI -1.44 to -0.68). Compared with other therapy plus medication, Tai Chi plus medication also showed greater gains in motor function (SMD, -0.78; 95% CI -1.46 to -0.10), BBS (SMD, -0.99; 95% CI -1.44 to -0.54), and functional reach test (SMD, -0.77; 95% CI -1.51 to -0.03). However, Tai Chi plus medication did not showed better improvements in gait or quality of life. There was not sufficient evidence to support or refute the effect of Qigong plus medication for PD.</p></sec><sec id="sec004"><title>Conclusions</title><p>In the previous studies, Tai Chi and Qigong were used as assisting pharmacological treatments of PD. The current systematic review showed positive evidence of Tai Chi plus medication for PD of mild-to-moderate severity. So Tai Chi plus medication should be recommended for PD management, especially in improving motor function and balance. Qigong plus medication also showed potential gains in the management of PD. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25830664</article-id><article-id pub-id-type="pmc">4382160</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0122469</article-id><article-id pub-id-type="publisher-id">PONE-D-14-35352</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>The Efficacy of Traditional Chinese Medical Exercise for Parkinson’s Disease: A Systematic Review and Meta-analysis</article-title><alt-title alt-title-type="running-head">The Effect of Traditional Chinese Medical Exercise on PD</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Yang</surname><given-names>Yan</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref rid="cor001" ref-type="corresp">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Qiu</surname><given-names>Wei Qing</given-names></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref rid="cor001" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Hao</surname><given-names>Yan Lei</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lv</surname><given-names>Zhan Yun</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jiao</surname><given-names>Shu Ji</given-names></name><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Teng</surname><given-names>Jun Feng</given-names></name><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China</addr-line></aff><aff id="aff002"><label>2</label><addr-line>Department of Neurology, Laizhou People’s Hospital of Shangdong, Laizhou, Shandong, China</addr-line></aff><aff id="aff003"><label>3</label><addr-line>Binzhou Medical University Hospital, Binzhou, Shandong, China</addr-line></aff><aff id="aff004"><label>4</label><addr-line>Department of Neurology, The First People’s Hospital of Hebi, Hebi, Henan, China</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Lebedev</surname><given-names>Mikhail A.</given-names></name><role>Academic Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Duke University, UNITED STATES</addr-line></aff><author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: YY WQQ. Performed the experiments: YY WQQ YLH ZYL SJ JT. Analyzed the data: YY WQQ SJ JT. Contributed reagents/materials/analysis tools: YY SJ. Wrote the paper: YY WQQ SJ JT.</p></fn><corresp id="cor001">* E-mail: <email>yanyangdr@126.com</email> (YY); <email>qingweiqiudr@163.com</email> (WQQ)</corresp></author-notes><pub-date pub-type="epub"><day>1</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>10</volume><issue>4</issue><elocation-id>e0122469</elocation-id><history><date date-type="received"><day>6</day><month>8</month><year>2014</year></date><date date-type="accepted"><day>12</day><month>2</month><year>2015</year></date></history><permissions><copyright-year>2015</copyright-year><copyright-holder>Yang et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0122469.pdf"></self-uri><abstract><sec id="sec001"><title>Background and Objective</title><p>Several studies assessed the efficacy of traditional Chinese medical exercise in the management of Parkinson’s disease (PD), but its role remained controversial. Therefore, the purpose of this systematic review is to evaluate the evidence on the effect of traditional Chinese medical exercise for PD.</p></sec><sec id="sec002"><title>Methods</title><p>Seven English and Chinese electronic databases, up to October 2014, were searched to identify relevant studies. The PEDro scale was employed to assess the methodological quality of eligible studies. Meta-analysis was performed by RevMan 5.1 software.</p></sec><sec id="sec003"><title>Results</title><p>Fifteen trials were included in the review. Tai Chi and Qigong were used as assisting pharmacological treatments of PD in the previous studies. Tai Chi plus medication showed greater improvements in motor function (standardized mean difference, SMD, -0.57; 95% confidence intervals, CI, -1.11 to -0.04), Berg balance scale (BBS, SMD, -1.22; 95% CI -1.65 to -0.80), and time up and go test (SMD, -1.06; 95% CI -1.44 to -0.68). Compared with other therapy plus medication, Tai Chi plus medication also showed greater gains in motor function (SMD, -0.78; 95% CI -1.46 to -0.10), BBS (SMD, -0.99; 95% CI -1.44 to -0.54), and functional reach test (SMD, -0.77; 95% CI -1.51 to -0.03). However, Tai Chi plus medication did not showed better improvements in gait or quality of life. There was not sufficient evidence to support or refute the effect of Qigong plus medication for PD.</p></sec><sec id="sec004"><title>Conclusions</title><p>In the previous studies, Tai Chi and Qigong were used as assisting pharmacological treatments of PD. The current systematic review showed positive evidence of Tai Chi plus medication for PD of mild-to-moderate severity. So Tai Chi plus medication should be recommended for PD management, especially in improving motor function and balance. Qigong plus medication also showed potential gains in the management of PD. However, more high quality studies with long follow-up are warrant to confirm the current findings.</p></sec></abstract><funding-group><funding-statement>This study is supported by the National Natural Science Fund Projects of China (81271398). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><fig-count count="9"></fig-count><table-count count="2"></table-count><page-count count="17"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper and its Supporting Information files.</p></notes></front><body><sec sec-type="intro" id="sec005"><title>Introduction</title><p>Parkinson’s disease (PD) is a common neurodegenerative disorder with insidious onset. There is an estimation of at least 4 million people diagnosed as PD worldwide [<xref rid="pone.0122469.ref001" ref-type="bibr">1</xref>]. In China, PD is 1.70% in prevalence rate among people aged more than 65 years old [<xref rid="pone.0122469.ref002" ref-type="bibr">2</xref>]. Although the specific causes of PD are under investigation, incidence increases with age, especially after 50 years old [<xref rid="pone.0122469.ref003" ref-type="bibr">3</xref>]. The landmark symptoms of PD are resting tremor, bradykinesis, rigidity and decreased postural reflexes. These impairments lead to a decline in functional status as gait disturbance and balance decrements so that people with PD cannot cope with their daily tasks well [<xref rid="pone.0122469.ref004" ref-type="bibr">4</xref>–<xref rid="pone.0122469.ref005" ref-type="bibr">5</xref>]. It is reported that this decrease in functional status worsens as the disease progresses and often results in loss of independence and a decline in quality of life [<xref rid="pone.0122469.ref006" ref-type="bibr">6</xref>].</p><p>Although the precise reasons of the decrease in balance, gait and quality of life are still unknown, exercise is a preventive strategy that has demonstrated efficacy in PD [<xref rid="pone.0122469.ref007" ref-type="bibr">7</xref>,<xref rid="pone.0122469.ref008" ref-type="bibr">8</xref>]. Traditional Chinese medical exercise, including Qigong, Tai Chi, Wuqinxi, etc., combines body movements with mental focus. Tai Chi and Qigong, as representative traditional Chinese medical exercises, incorporate body movement, breath and mind training to maintain health and remove disease symptoms. Tai Chi, with slow body positions and dance-like movements that flow from one to the next continuously, promotes posture, flexibility, relaxation, well-being and mental concentration [<xref rid="pone.0122469.ref009" ref-type="bibr">9</xref>]. The difference between Qigong and Tai Chi is that Tai Chi is a martial art with movements practiced quickly which can provide self-defense and are externally focused. Meanwhile, Qigong cannot and it is internally focused [<xref rid="pone.0122469.ref010" ref-type="bibr">10</xref>].</p><p>In the last decade, Tai Chi and Qigong have been studied in the management of PD [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>–<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>], but there were conflicting results. Li et al. reported significant improvements in balance, functional capacity and falls after Tai Chi exercise [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>]. In contrast, Amano et al. concluded that Tai Chi was not effective in improving parkinsonian disability [<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>]. And previous reviews did not show consistent and strong evidence of Tai Chi for PD [<xref rid="pone.0122469.ref016" ref-type="bibr">16</xref>–<xref rid="pone.0122469.ref019" ref-type="bibr">19</xref>]. What’s more, there was no comprehensive systematic review of traditional Chinese medical exercise for PD.</p><p>Therefore, the aim of this systematic review is to summarize and evaluate the evidence on the efficacy of traditional Chinese medical exercise for PD. To our knowledge, this is the first comprehensive systematic review summarizing the effect of traditional Chinese medical exercise for PD patients, focusing on motor function, gait and quality of life. Based on our findings, recommendations for future research are offered.</p></sec><sec sec-type="materials|methods" id="sec006"><title>Methods</title><sec id="sec007"><title>Search Strategy</title><p>The relevant studies were retrieved from the following online databases up to October 2014: PubMed, EMBASE, OVID-MEDLINE, Cochrane Library, China Knowledge Resource Integrated Database, Weipu Database for Chinese Technical Periodicals and Wan Fang Data. The following keywords were used: Parkinson, Parkinson’s disease, Parkinsonism, traditional Chinese medical exercise, Tai Chi, Qigong, Wuqinxi, Baduanjin and Yijinjing. WHO International Clinical Trials Registry Platform, ProQuest Dissertations and Chinese Dissertation Full-text Database were also searched to identify unpublished studies. And we contacted experts in relevant field. The literature search was performed independently by two authors (S Jiao and ZY Lv), and disagreements were resolved by discussion.</p></sec><sec id="sec008"><title>Study Selection</title><p>Two authors (Y Yang and WQ Qiu) independently identified and selected the studies based on standardized manner. The studies that met the following criteria were included: (1) study design: randomized controlled trials (RCTs) and non-randomized controlled trials (non-RCTs); (2) the target population was diagnosed as PD in any stage; (3) traditional Chinese medical exercise was practiced alone or combined with stable medication, such as Madopar, compared to placebo, no intervention and any other therapies with or without stable medication; (4) the primary outcomes were motor function assessed by Unified Parkinson’s Disease Rating Scale III (UPDRS III), health related quality of life assessed by Parkinson’s Disease Questionnaire-39 (PDQ-39) or Activities of Daily Living (ADL), balance assessed by Berg Balance Scale (BBS), Functional Reach Test (FRT) or Time Up and Go Test (TUG) and gait assessed by gait velocity, stride/step length, or 6-Minute Walking Test (6-MWT); (5) the studies contain available data for the meta-analysis; (6) the paper was available in either English or Chinese. Any disagreement was settled by discussion or by consulting a third author (J Teng).</p></sec><sec id="sec009"><title>Data Extraction</title><p>Two authors (Y Yang and WQ Qiu) independently performed data extraction from the eligible studies. The following information was extracted: (1) study source and study design; (2) patients characteristics: sample size, age, gender and disease stage; (3) details of the interventions: type, duration, dose and frequency; (4) main outcomes and (5) length of follow-up. For the crossover study, the first phase of the study was adopted for the sake of prohibiting carryover effects. The primary author was contacted by e-mails when the relevant data was not reported. Any disagreement was settled by discussion or by consulting a third author (YL Hao).</p></sec><sec id="sec010"><title>Quality Assessment</title><p>Two authors (Y Yang and S Jiao) independently assessed the methodological quality of eligible studies using PEDro scale. The PEDro score has a fair-to-good reliability for the physiotherapy studies in systematic reviews [<xref rid="pone.0122469.ref020" ref-type="bibr">20</xref>,<xref rid="pone.0122469.ref021" ref-type="bibr">21</xref>]. And higher scores represent a better quality. The necessary information in eligible studies was supplemented by contacting the corresponding authors. There was no disagreement between the authors regarding PEDro scores.</p></sec><sec id="sec011"><title>Data Synthesis and Analysis</title><p>Meta-analysis was conducted with Cochrane Collaboration software (Review Manager Version 5.1). D-value of the pre and post treatment was used as the change of curative effect. As for three or four-armed studies, the similar control groups have be merged with computational formula provided by the Cochrane handbook to create a single pair-wise comparison. For continuous data, standardized mean difference (SMD) and 95% confidence intervals (CI) of random-effects model were calculated for all eligible trials. The <italic>I</italic><sup><italic>2</italic></sup> statistic, a quantitative measure of inconsistency across studies, was employed in assessing heterogeneity. Heterogeneity was regarded high if the <italic>I</italic><sup><italic>2</italic></sup> is greater than 75%. Detailed subgroup analyses were performed to compare Tai Chi/Qigong plus medication with medication alone or other therapy plus medication. Publication bias was assessed using funnel plot if the group included more than 10 studies.</p></sec></sec><sec sec-type="results" id="sec012"><title>Results</title><sec id="sec013"><title>Study Selection</title><p>A total of 118 records were identified after removing duplicates. During the preliminary screening of the titles and abstracts, 62 studies were eliminated. After full-texts screening, 13 RCTs [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>,<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>–<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref021" ref-type="bibr">21</xref>–<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>–<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>] and 2 non-RCTs [<xref rid="pone.0122469.ref012" ref-type="bibr">12</xref>,<xref rid="pone.0122469.ref026" ref-type="bibr">26</xref>] were included in our review. 9 studies were published in English [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>–<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>–<xref rid="pone.0122469.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>] and 6 in Chinese [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>,<xref rid="pone.0122469.ref012" ref-type="bibr">12</xref>,<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0122469.ref026" ref-type="bibr">26</xref>,<xref rid="pone.0122469.ref029" ref-type="bibr">29</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>]. The studies were excluded due to without interested outcomes (n = 6), suspected repeat publication (n = 2) and repeated report of main outcomes (n = 1). The detailed process of search and identification was shown in <xref rid="pone.0122469.g001" ref-type="fig">Fig 1</xref>.</p><fig id="pone.0122469.g001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.g001</object-id><label>Fig 1</label><caption><title>Flow diagram of study selection.</title><p>RCT: randomized controlled trial.</p></caption><graphic xlink:href="pone.0122469.g001"></graphic></fig></sec><sec id="sec014"><title>Study Characteristics</title><p>A total of 799 participants with the mean age of 64.57 ± 4.88 years were included. The patients in most studies were diagnosed as PD of mild-to-moderate severity. The patients in 10 studies [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>–<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>] were diagnosed as Hoehn and Yahr stage I to III and patients in 2 studies [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>] were Hoehn and Yahr stage I to IV. The other studies [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>,<xref rid="pone.0122469.ref012" ref-type="bibr">12</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>] did not report the Hoehn and Yahr stage of eligible patients, but the patients can finish Qigong or Tai Chi exercise independently. Qigong [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>–<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>,<xref rid="pone.0122469.ref029" ref-type="bibr">29</xref>] or Tai Chi [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>–<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>–<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>] was employed as assisting pharmacological therapies in the included studies. The control interventions included medication [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>,<xref rid="pone.0122469.ref012" ref-type="bibr">12</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0122469.ref023" ref-type="bibr">23</xref>,<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>], stretching/resistance training plus medication [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>], dancing plus medication [<xref rid="pone.0122469.ref023" ref-type="bibr">23</xref>], walking plus medication [<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0122469.ref026" ref-type="bibr">26</xref>] and other exercises plus medication [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>,<xref rid="pone.0122469.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>,<xref rid="pone.0122469.ref029" ref-type="bibr">29</xref>]. The intervention time ranged from 4 weeks to 50 weeks. The details of study characteristics were summarized in <xref rid="pone.0122469.t001" ref-type="table">Table 1</xref>.</p><table-wrap id="pone.0122469.t001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.t001</object-id><label>Table 1</label><caption><title>Characteristics of the included studies.</title></caption><alternatives><graphic id="pone.0122469.t001g" xlink:href="pone.0122469.t001"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col></colgroup><thead><tr><th align="left" rowspan="1" colspan="1">Study source</th><th align="left" rowspan="1" colspan="1">Design</th><th align="left" rowspan="1" colspan="1">Sample size</th><th align="left" rowspan="1" colspan="1">Mean age (years)</th><th align="left" rowspan="1" colspan="1">Gender (M/F)</th><th align="left" rowspan="1" colspan="1">Disease stage (Hoehn and Yahr stage)</th><th align="left" rowspan="1" colspan="1">Follow-up (weeks)</th><th align="left" rowspan="1" colspan="1">Duration (weeks)</th><th align="left" rowspan="1" colspan="1">Main outcome</th><th align="left" rowspan="1" colspan="1">Experimental group intervention</th><th align="left" rowspan="1" colspan="1">Control group intervention</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Yu 1998, China [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">83</td><td align="left" rowspan="1" colspan="1">58±11;71±10</td><td align="left" rowspan="1" colspan="1">38/14;29/2</td><td align="left" rowspan="1" colspan="1">NR</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">50</td><td align="left" rowspan="1" colspan="1">Webster scale</td><td align="left" rowspan="1" colspan="1">Qigong plus medication (30min/700sessions)</td><td align="left" rowspan="1" colspan="1">Medication</td></tr><tr><td align="left" rowspan="1" colspan="1">Gu 2002, China [<xref rid="pone.0122469.ref012" ref-type="bibr">12</xref>]</td><td align="left" rowspan="1" colspan="1">Non RCT</td><td align="left" rowspan="1" colspan="1">51</td><td align="left" rowspan="1" colspan="1">57±9;51±12</td><td align="left" rowspan="1" colspan="1">23/10;17/7</td><td align="left" rowspan="1" colspan="1">NR</td><td align="left" rowspan="1" colspan="1">36</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">Webster scale</td><td align="left" rowspan="1" colspan="1">Qigong plus medication (30min/168sessions)</td><td align="left" rowspan="1" colspan="1">Medication</td></tr><tr><td align="left" rowspan="1" colspan="1">Burini 2006, Italy [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">26</td><td align="left" rowspan="1" colspan="1">65.7±7;62.7±4</td><td align="left" rowspan="1" colspan="1">5/8;4/9</td><td align="left" rowspan="1" colspan="1">2–3</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1">UPDRS, 6-MWT, PDQ-39</td><td align="left" rowspan="1" colspan="1">Qigong plus medication(45min/20sessions)</td><td align="left" rowspan="1" colspan="1">Aerobic exercise plus medication(45min/20sessions)</td></tr><tr><td align="left" rowspan="1" colspan="1">Hackney 2008, US [<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">26</td><td align="left" rowspan="1" colspan="1">64.9±8.3;61.7±10.1</td><td align="left" rowspan="1" colspan="1">12/2; 9/3</td><td align="left" rowspan="1" colspan="1">2±0.46;2±0.3</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">13</td><td align="left" rowspan="1" colspan="1">UPDRS III, BBS, Gait, TUG, 6-MWT</td><td align="left" rowspan="1" colspan="1">Yang-style Tai Chi plus medication(60min/20sessions)</td><td align="left" rowspan="1" colspan="1">Medication</td></tr><tr><td align="left" rowspan="1" colspan="1">Hackney 2009, US [<xref rid="pone.0122469.ref023" ref-type="bibr">23</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">61</td><td align="left" rowspan="1" colspan="1">66.8±2.4;68.2±1.4;64.9±2.3;66.5±2.8</td><td align="left" rowspan="1" colspan="1">11/6;11/3;11/2;12/5</td><td align="left" rowspan="1" colspan="1">2.0±0.2;2.1±0.1;2.0±0.1;2.2±0.2</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">13</td><td align="left" rowspan="1" colspan="1">PDQ-39</td><td align="left" rowspan="1" colspan="1">Yang-style Tai Chi plus medication(60min/20sessions)</td><td align="left" rowspan="1" colspan="1">1) Tango plus medication;2) Waltz/Foxtrot plus medication(60min/20sessions);3) Medication</td></tr><tr><td align="left" rowspan="1" colspan="1">Gladfelter 2011, US [<xref rid="pone.0122469.ref024" ref-type="bibr">24</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">17</td><td align="left" rowspan="1" colspan="1">72±8.52</td><td align="left" rowspan="1" colspan="1">12/5</td><td align="left" rowspan="1" colspan="1">2.4±0.87</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">BBS, FRT, TUG, PDQ-39</td><td align="left" rowspan="1" colspan="1">Yang-style Tai Chi plus medication(60min/12sessions)</td><td align="left" rowspan="1" colspan="1">Physical exercise plus medication</td></tr><tr><td align="left" rowspan="1" colspan="1">Li 2011, China [<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">47</td><td align="left" rowspan="1" colspan="1">68.28±6.62; 67.13±6.73</td><td align="left" rowspan="1" colspan="1">11/13;11/12</td><td align="left" rowspan="1" colspan="1">2.5–3</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">UPDRS III, BBS, PDQ-39</td><td align="left" rowspan="1" colspan="1">Tai Chi plus medication(30-45min/80sessions)</td><td align="left" rowspan="1" colspan="1">Walking plus medication(40min/80sessions)</td></tr><tr><td align="left" rowspan="1" colspan="1">Zhu 2011, China [<xref rid="pone.0122469.ref026" ref-type="bibr">26</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">38</td><td align="left" rowspan="1" colspan="1">63.35±8.72; 64.83±9.29</td><td align="left" rowspan="1" colspan="1">11/9;12/8</td><td align="left" rowspan="1" colspan="1">1–2</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">UPDRS III, BBS</td><td align="left" rowspan="1" colspan="1">Tai Chi plus medication(30-45min/40sessions)</td><td align="left" rowspan="1" colspan="1">Walking plus medication(40min/40sessions)</td></tr><tr><td align="left" rowspan="1" colspan="1">Li 2012, US [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">195</td><td align="left" rowspan="1" colspan="1">68±9; 69±8; 69±9</td><td align="left" rowspan="1" colspan="1">45/20; 38/27;39/26</td><td align="left" rowspan="1" colspan="1">1–4</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">24</td><td align="left" rowspan="1" colspan="1">UPDRS III, Gait, FRT, TUG</td><td align="left" rowspan="1" colspan="1">Tai Chi plus medication(60min/48sessions)</td><td align="left" rowspan="1" colspan="1">1) Stretching plus medication;2) Resistance training plus medication(60min/48sessions)</td></tr><tr><td align="left" rowspan="1" colspan="1">Amano 2013, US [<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">45</td><td align="left" rowspan="1" colspan="1">64±13; (66±11);68±7; 66±7</td><td align="left" rowspan="1" colspan="1">7/5(7/8);7/2;7/2</td><td align="left" rowspan="1" colspan="1">2.3±0.4(2.4±0.6);2.2±0.4;2.4±0.4</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">UPDRS III, Gait</td><td align="left" rowspan="1" colspan="1">1) Yang-style Tai Chi plus medication(60min/32-48sessions);2) Qigong plus medication(60min/32sessions)</td><td align="left" rowspan="1" colspan="1">Medication</td></tr><tr><td align="left" rowspan="1" colspan="1">Cheon 2013, Korea [<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>]</td><td align="left" rowspan="1" colspan="1">Non-RCT</td><td align="left" rowspan="1" colspan="1">23</td><td align="left" rowspan="1" colspan="1">62.3±6.5;65.6±7.9;64.9±7.2</td><td align="left" rowspan="1" colspan="1">0/23</td><td align="left" rowspan="1" colspan="1">2–3</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">UPDRS, ADL</td><td align="left" rowspan="1" colspan="1">Sun-style Tai Chi plus medication(50-65min/24sessions)</td><td align="left" rowspan="1" colspan="1">1) Medication2) Exercise plus medication(60min/24sessions)</td></tr><tr><td align="left" rowspan="1" colspan="1">Choi 2013, Korea [<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">20</td><td align="left" rowspan="1" colspan="1">60.81±7.6;65.54±6.8</td><td align="left" rowspan="1" colspan="1">NR</td><td align="left" rowspan="1" colspan="1">1.6±0.6;1.8±0.3</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">UPDRS, TUG,6-MWT, OLS, ADL</td><td align="left" rowspan="1" colspan="1">Tai Chi plus medication(60min/36sessions)</td><td align="left" rowspan="1" colspan="1">Medication</td></tr><tr><td align="left" rowspan="1" colspan="1">Cheng 2014, China [<xref rid="pone.0122469.ref029" ref-type="bibr">29</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">66</td><td align="left" rowspan="1" colspan="1">57±9;51±12</td><td align="left" rowspan="1" colspan="1">23/10;17/16</td><td align="left" rowspan="1" colspan="1">NR</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">UPDRS, 6-MWT</td><td align="left" rowspan="1" colspan="1">Qigong plus medication (60min/24sessions)</td><td align="left" rowspan="1" colspan="1">Routine exercise plus medication (60min/24sessions)</td></tr><tr><td align="left" rowspan="1" colspan="1">Gao 2014, China [<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">80</td><td align="left" rowspan="1" colspan="1">69.54±7.32;68.28±8.53</td><td align="left" rowspan="1" colspan="1">23/14;27/12</td><td align="left" rowspan="1" colspan="1">1–4</td><td align="left" rowspan="1" colspan="1">24</td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1">UPDRS III, BBS, TUG</td><td align="left" rowspan="1" colspan="1">Yang-style Tai Chi plus medication(60min/36sessions)</td><td align="left" rowspan="1" colspan="1">Medication</td></tr><tr><td align="left" rowspan="1" colspan="1">Nocera 2014, US [<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>]</td><td align="left" rowspan="1" colspan="1">RCT</td><td align="left" rowspan="1" colspan="1">21</td><td align="left" rowspan="1" colspan="1">66±11;65±7</td><td align="left" rowspan="1" colspan="1">7/8;4/2</td><td align="left" rowspan="1" colspan="1">2–3</td><td align="left" rowspan="1" colspan="1">—</td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">PDQ-39</td><td align="left" rowspan="1" colspan="1">Yang-style Tai Chi plus medication(60min/48sessions)</td><td align="left" rowspan="1" colspan="1">Medication</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="t001fn001"><p>RCT = randomized controlled trial; NR = no reported; Non-RCT = non-randomized controlled trial; 6-MWT = 6-minute walking test; UPDRS = unified Parkinson’s disease rating scale; BBS = berg balance scale; TUG = timed up and go; PDQ-39 = Parkinson’s disease questionnaire-39; FRT = functional reach test; ADL = activities of daily living; OLS = one-leg standing time.</p></fn></table-wrap-foot></table-wrap></sec><sec id="sec015"><title>Methodological Quality</title><p>The methodological quality of the included studies was presented in <xref rid="pone.0122469.t002" ref-type="table">Table 2</xref>. The total scores on the PEDro scale ranged from 3 to 8 points. Randomized allocation was employed in most studies (87%) [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>,<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>–<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>–<xref rid="pone.0122469.ref026" ref-type="bibr">26</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>–<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>], but only 4 trials were considered as allocation concealment due to lack of detailed descriptions [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>]. None of the studies blinded the therapists or subjects, but independent assessors, who were unaware of the allocation, were employed in most studies (80%) [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>–<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>–<xref rid="pone.0122469.ref026" ref-type="bibr">26</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>–<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>]. 6 studies definitely showed a high expulsion rate over 15% [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>–<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>]. And 4 studies used the intention-to-treat analysis [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>,<xref rid="pone.0122469.ref012" ref-type="bibr">12</xref>,<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>]. The eligible studies showed good methodological quality in the remaining items of PEDro scale. Funnel plot analysis was not performed because none of the groups included more than 10 trials.</p><table-wrap id="pone.0122469.t002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.t002</object-id><label>Table 2</label><caption><title>PEDro scale of quality for included trials.</title></caption><alternatives><graphic id="pone.0122469.t002g" xlink:href="pone.0122469.t002"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col></colgroup><thead><tr><th align="left" rowspan="1" colspan="1">Study</th><th align="left" rowspan="1" colspan="1">Eligibility criteria</th><th align="left" rowspan="1" colspan="1">Random allocation</th><th align="left" rowspan="1" colspan="1">Concealed allocation</th><th align="left" rowspan="1" colspan="1">Similar atbaseline</th><th align="left" rowspan="1" colspan="1">Subjects blinded</th><th align="left" rowspan="1" colspan="1">Therapists blinded</th><th align="left" rowspan="1" colspan="1">Assessors blinded</th><th align="left" rowspan="1" colspan="1"><15%dropouts</th><th align="left" rowspan="1" colspan="1">Intention-to-treat analysis</th><th align="left" rowspan="1" colspan="1">Between-group comparisons</th><th align="left" rowspan="1" colspan="1">Point measures and variability data</th><th align="left" rowspan="1" colspan="1">Total</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Yu 1998 [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">6</td></tr><tr><td align="left" rowspan="1" colspan="1">Gu 2002 [<xref rid="pone.0122469.ref012" ref-type="bibr">12</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">5</td></tr><tr><td align="left" rowspan="1" colspan="1">Burini 2006 [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">6</td></tr><tr><td align="left" rowspan="1" colspan="1">Hackney 2008 [<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">5</td></tr><tr><td align="left" rowspan="1" colspan="1">Hackney 2009 [<xref rid="pone.0122469.ref023" ref-type="bibr">23</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">5</td></tr><tr><td align="left" rowspan="1" colspan="1">Gladfelter 2011 [<xref rid="pone.0122469.ref024" ref-type="bibr">24</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">5</td></tr><tr><td align="left" rowspan="1" colspan="1">Li 2011 [<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">6</td></tr><tr><td align="left" rowspan="1" colspan="1">Zhu 2011 [<xref rid="pone.0122469.ref026" ref-type="bibr">26</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">6</td></tr><tr><td align="left" rowspan="1" colspan="1">Li 2012 [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">7</td></tr><tr><td align="left" rowspan="1" colspan="1">Amano 2013 [<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">8</td></tr><tr><td align="left" rowspan="1" colspan="1">Cheon 2013 [<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">3</td></tr><tr><td align="left" rowspan="1" colspan="1">Choi 2013 [<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">6</td></tr><tr><td align="left" rowspan="1" colspan="1">Cheng 2014 [<xref rid="pone.0122469.ref029" ref-type="bibr">29</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">6</td></tr><tr><td align="left" rowspan="1" colspan="1">Gao 2014 [<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">7</td></tr><tr><td align="left" rowspan="1" colspan="1">Nocera 2014 [<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>]</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">6</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="t002fn001"><p>Criteria (2–11) were used to calculate the total PEDro score. Each criterion was scored as either 1 or 0 according to whether the criteria was met or not, respectively.</p></fn></table-wrap-foot></table-wrap></sec><sec id="sec016"><title>The Effect of Tai Chi for PD</title><sec id="sec017"><title>Motor function</title><p>UPDRS III was reported in 8 studies [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>–<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>], and subgroup analysis was performed. Most of them reported that Tai Chi plus medication showed beneficial effect in UPDRS III. The aggregated result also indicated that Tai Chi plus medication showed greater improvements in UPDRS III than medication alone (SMD, -0.57; 95% CI -1.11 to -0.04; p = 0.03, <xref rid="pone.0122469.g002" ref-type="fig">Fig 2</xref>) [<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>] and other therapy plus medication (SMD, -0.78; 95% CI -1.46 to -0.10; p = 0.02, <xref rid="pone.0122469.g002" ref-type="fig">Fig 2</xref>) [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>–<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>].</p><fig id="pone.0122469.g002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.g002</object-id><label>Fig 2</label><caption><title>The effect of Tai Chi plus medication in motor function.</title></caption><graphic xlink:href="pone.0122469.g002"></graphic></fig></sec><sec id="sec018"><title>Balance</title><p>7 studies assessed the effect of Tai Chi plus medication in improving balance in patients with PD [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0122469.ref024" ref-type="bibr">24</xref>–<xref rid="pone.0122469.ref026" ref-type="bibr">26</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>]. The aggregated result indicated that Tai Chi plus medication showed greater improvements on BBS (SMD, -1.22; 95% CI -1.65 to -0.80; p<0.00001, <xref rid="pone.0122469.g003" ref-type="fig">Fig 3</xref>) [<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>] and TUG (SMD, -1.06; 95% CI -1.44 to -0.68; p<0.00001, <xref rid="pone.0122469.g003" ref-type="fig">Fig 3</xref>) [<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>] than medication alone. Compared with other therapy plus medication, Tai Chi plus medication also showed greater improvements on BBS (SMD, -0.99; 95% CI -1.44 to -0.54; p<0.0001, <xref rid="pone.0122469.g004" ref-type="fig">Fig 4</xref>) [<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0122469.ref026" ref-type="bibr">26</xref>] and FRT (SMD, -0.77; 95% CI -1.51 to -0.03; p = 0.04, <xref rid="pone.0122469.g004" ref-type="fig">Fig 4</xref>) [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref024" ref-type="bibr">24</xref>], but not on TUG (SMD, -0.17; 95% CI -0.46 to 0.11; p = 0.24, <xref rid="pone.0122469.g004" ref-type="fig">Fig 4</xref>) [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref024" ref-type="bibr">24</xref>]</p><fig id="pone.0122469.g003" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.g003</object-id><label>Fig 3</label><caption><title>The effect of Tai Chi plus medication in balance compared with medication alone.</title><p>BBS = berg balance scale; FRT = functional reach test;TUG = timed up and go.</p></caption><graphic xlink:href="pone.0122469.g003"></graphic></fig><fig id="pone.0122469.g004" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.g004</object-id><label>Fig 4</label><caption><title>The effect of Tai Chi plus medication in balance compared with other therapy plus medication.</title><p>BBS = berg balance scale; FRT = functional reach test; TUG = timed up and go.</p></caption><graphic xlink:href="pone.0122469.g004"></graphic></fig></sec><sec id="sec019"><title>Gait</title><p>In 5 studies, gait function was assessed by gait velocity and step length [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>] and gait endurance was assessed by 6-MWT [<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>]. The subgroup analysis suggested that there was no significant difference between Tai Chi plus medication and medication alone in gait velocity (SMD, -0.02 95% CI -0.58 to 0.54; p = 0.94, <xref rid="pone.0122469.g005" ref-type="fig">Fig 5</xref>) [<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>], step length (SMD, -0.00 95% CI -0.57 to 0.56; p = 0.99, <xref rid="pone.0122469.g005" ref-type="fig">Fig 5</xref>) [<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>] or 6-MWT (SMD, 0.53 95% CI -0.07 to 1.12; p = 0.08, <xref rid="pone.0122469.g005" ref-type="fig">Fig 5</xref>) [<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>]. However, one study reported that Tai Chi plus medication group performed better in gait velocity and step length than stretching plus medication group, and outperformed the resistance-training plus medication group in step length [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>].</p><fig id="pone.0122469.g005" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.g005</object-id><label>Fig 5</label><caption><title>The effect of Tai Chi plus medication in gait velocity, step length and 6-minute walking test (6-MWT) compared with medication alone.</title></caption><graphic xlink:href="pone.0122469.g005"></graphic></fig></sec><sec id="sec020"><title>Quality of life</title><p>The quality of life was assessed in 6 trials [<xref rid="pone.0122469.ref023" ref-type="bibr">23</xref>–<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>], and the subgroup analysis was performed. Tai Chi plus medication showed greater improvements than medication alone on ADL (SMD, -0.81 95% CI -1.50 to -0.12; p = 0.02, <xref rid="pone.0122469.g006" ref-type="fig">Fig 6</xref>) [<xref rid="pone.0122469.ref027" ref-type="bibr">27</xref>,<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>]. On PDQ-39, however, the aggregated result indicated that there was no significant difference between Tai Chi plus medication and medication alone (SMD, 0.06 95% CI -1.92 to 2.04; p = 0.95, <xref rid="pone.0122469.g006" ref-type="fig">Fig 6</xref>) [<xref rid="pone.0122469.ref023" ref-type="bibr">23</xref>,<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>] or other therapy plus medication (SMD, 0.08 95% CI -1.81 to 1.97; p = 0.93, <xref rid="pone.0122469.g007" ref-type="fig">Fig 7</xref>) [<xref rid="pone.0122469.ref023" ref-type="bibr">23</xref>–<xref rid="pone.0122469.ref025" ref-type="bibr">25</xref>].</p><fig id="pone.0122469.g006" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.g006</object-id><label>Fig 6</label><caption><title>The effect of Tai Chi plus medication in quality of life compared with medication alone.</title><p>PDQ-39 = Parkinson’s disease questionnaire-39; ADL = activities of daily living.</p></caption><graphic xlink:href="pone.0122469.g006"></graphic></fig><fig id="pone.0122469.g007" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.g007</object-id><label>Fig 7</label><caption><title>The effect of Tai Chi plus medication on Parkinson’s disease questionnaire-39 compared with other therapy plus medication.</title></caption><graphic xlink:href="pone.0122469.g007"></graphic></fig></sec></sec><sec id="sec021"><title>The Efficacy of Qigong for PD</title><sec id="sec022"><title>Webster scale</title><p>Webster scale is a comprehensive scale accessing clinical symptoms, quality of life and motor function in patients with PD. 2 studies reported that Qigong plus medication showed favorable improvements in Webster scale [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>,<xref rid="pone.0122469.ref012" ref-type="bibr">12</xref>]. The meta-analysis indicated that Qigong plus medication demonstrated a small, but not statistically significant effect in Webster scale compared with medication alone (SMD, -0.75; 95% CI -1.54 to 0.04; p = 0.06, <xref rid="pone.0122469.g008" ref-type="fig">Fig 8</xref>) [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>,<xref rid="pone.0122469.ref012" ref-type="bibr">12</xref>].</p><fig id="pone.0122469.g008" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.g008</object-id><label>Fig 8</label><caption><title>The effect of Qigong plus medication in Webster scale.</title></caption><graphic xlink:href="pone.0122469.g008"></graphic></fig></sec><sec id="sec023"><title>Motor function</title><p>UPDRS III was reported in 3 trials [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref029" ref-type="bibr">29</xref>]. One study reported that Qigong plus medication showed better effect than medication alone (UPDRS III mean changes: 3.4 versus 1.1) [<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>]. However, the meta-analysis showed that there was no significant difference between Qigong plus medication and other therapy plus medication (SMD, -0.01; 95% CI -0.42 to 0.40; p = 0.95, <xref rid="pone.0122469.g009" ref-type="fig">Fig 9</xref>) [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>,<xref rid="pone.0122469.ref029" ref-type="bibr">29</xref>].</p><fig id="pone.0122469.g009" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0122469.g009</object-id><label>Fig 9</label><caption><title>The effect of Qigong plus medication in Unified Parkinson’s Disease Rating Scale III (UPDRS III) and 6-minute walking test.</title></caption><graphic xlink:href="pone.0122469.g009"></graphic></fig></sec><sec id="sec024"><title>Gait</title><p>One study reported that Qigong plus medication did not show greater improvements than medication alone in gait velocity or step length [<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>]. Gait endurance was assessed by 6-MWT in 2 trials [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>,<xref rid="pone.0122469.ref029" ref-type="bibr">29</xref>] and the meta-analysis was performed. The aggregated result showed that there was no significant difference between Qigong plus medication and other therapy plus medication (SMD, -0.09; 95% CI -1.07 to 0.89; p = 0.85, <xref rid="pone.0122469.g009" ref-type="fig">Fig 9</xref>) [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>,<xref rid="pone.0122469.ref029" ref-type="bibr">29</xref>].</p></sec><sec id="sec025"><title>Quality of life</title><p>One study assessed the quality of life in patients with PD by PDQ-39, and reported that Qigong plus medication showed better effect than aerobic exercise plus medication (PDQ-39 mean changes: 2.8 versus -3.2) [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>].</p></sec></sec><sec id="sec026"><title>Adverse Events</title><p>No serious adverse events were reported during the Tai Chi/Qigong training in eligible studies. Only one study reported that there were few back pain and ankle sprain [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>].</p></sec></sec><sec sec-type="conclusions" id="sec027"><title>Discussion</title><p>This is the first comprehensive systematic review and meta-analysis to assess the effect of traditional Chinese medical exercise in the management of PD. Tai Chi and Qigong were used as assisting pharmacological treatments of PD in the previous studies. The positive finding was that Tai Chi plus medication showed greater gains than medication alone or other therapy plus medication in motor function and balance. However, there was not sufficient evidence on the efficacy of Tai Chi plus medication in improving gait or quality of life. Although some trials reported beneficial effect of Qigong plus medication for PD, the aggregated results did not support or refute it.</p><p>The positive finding of this systematic review should be available for patients with PD of mild-to-moderate severity due to most patients diagnosed as Hoehn and Yahr stage I to III [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>–<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>]. All eligible patients can finish Tai Chi or Qigong exercise independently. And traditional Chinese medical exercise is based on the ability to stand and move independently. Therefore, these assisting pharmacological exercises should be recommended for PD patients of mild-to-moderate severity, especially in improving motor function and balance.</p><p>The last systematic reviews of Tai Chi for PD concur with our positive findings [<xref rid="pone.0122469.ref017" ref-type="bibr">17</xref>,<xref rid="pone.0122469.ref018" ref-type="bibr">18</xref>]. One supported that Tai Chi plus medication resulted in promising gains in mobility and balance for PD patients at an early stage [<xref rid="pone.0122469.ref018" ref-type="bibr">18</xref>]. However, there were serious limitations in this review. Firstly, two control interventions were considered as no intervention [<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>] and routine physical exercise [<xref rid="pone.0122469.ref024" ref-type="bibr">24</xref>] respectively, but stable medications were not changed during the study according to the author’s reply. Secondly, some subgroup analyses only included one trial. It was not valid because the meta-analysis should be performed based at least on two studies. What’s more, the similar control groups should be combined to create a single pair-wise comparison according to Cochrane handbook, but it was not performed in this review. The other review concluded that Tai Chi was a valid complementary and alternative therapy for PD, especially on motor function and balance [<xref rid="pone.0122469.ref017" ref-type="bibr">17</xref>]. However, Tai Chi as an assisting pharmacological treatment was not compared with medication alone or other therapy plus medication. In our review, detailed subgroup analyses were performed to compare Tai Chi plus medication with medication alone or other therapy plus medication.</p><p>Our results were different from some previous reviews [<xref rid="pone.0122469.ref016" ref-type="bibr">16</xref>,<xref rid="pone.0122469.ref019" ref-type="bibr">19</xref>]. Lee’s review concluded that there was no sufficient evidence to support Tai Chi in the management of PD [<xref rid="pone.0122469.ref016" ref-type="bibr">16</xref>], but it was only a qualitative review including 3 RCTs [<xref rid="pone.0122469.ref032" ref-type="bibr">32</xref>–<xref rid="pone.0122469.ref034" ref-type="bibr">34</xref>], 1 non-RCT [<xref rid="pone.0122469.ref035" ref-type="bibr">35</xref>], and 3 uncontrolled clinical trials [<xref rid="pone.0122469.ref036" ref-type="bibr">36</xref>–<xref rid="pone.0122469.ref038" ref-type="bibr">38</xref>] published between 1997 and 2007. And most of them were published by conference abstracts without detailed information [<xref rid="pone.0122469.ref032" ref-type="bibr">32</xref>–<xref rid="pone.0122469.ref036" ref-type="bibr">36</xref>]. Although the meta-analysis was performed in Toh’s systematic review [<xref rid="pone.0122469.ref019" ref-type="bibr">19</xref>], it only included 4 RCTs [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0122469.ref023" ref-type="bibr">23</xref>]. The main suspected reason of the difference was that numerous studies of Tai Chi for PD were published from 2008 to 2014 [<xref rid="pone.0122469.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0122469.ref015" ref-type="bibr">15</xref>,<xref rid="pone.0122469.ref022" ref-type="bibr">22</xref>–<xref rid="pone.0122469.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0122469.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0122469.ref031" ref-type="bibr">31</xref>]. So current update provided stronger evidence of Tai Chi plus medication for PD.</p><p>Our result of Qigong for PD was supported by previous review [<xref rid="pone.0122469.ref039" ref-type="bibr">39</xref>]. The evidence was insufficient to support Qigong plus medication for PD due to limited number of studies. However, the beneficial finding of current review was that Qigong plus medication showed potential gains for PD. Two trials reported that Qigong plus medication showed better effect than medication alone in Webster scale [<xref rid="pone.0122469.ref011" ref-type="bibr">11</xref>,<xref rid="pone.0122469.ref012" ref-type="bibr">12</xref>], and one study reported that Qigong plus medication was superior to aerobic exercise plus medication in UPDRS III and PDQ-39 [<xref rid="pone.0122469.ref013" ref-type="bibr">13</xref>]. What’s more, it has been reported that Qigong has beneficial effects in improving physical performance, figure, quality of life, etc. [<xref rid="pone.0122469.ref040" ref-type="bibr">40</xref>–<xref rid="pone.0122469.ref042" ref-type="bibr">42</xref>]. Consequently, Qigong may be a valid assisting pharmacological treatment of PD. Further high quality RCTs are required to confirm current beneficial finding.</p><p>In previous studies, only Tai Chi and Qigong were focused, but other traditional Chinese medical exercises should also be investigated, such as Baduanjin and Wuqinxi. Li and his colleagues have reported beneficial effects of Baduanjin exercise in physical flexibility of healthy older [<xref rid="pone.0122469.ref043" ref-type="bibr">43</xref>]. Baduanjin has been recommended as a safe and feasible treatment option for patients with knee OA in disability, stiffness and quality of life [<xref rid="pone.0122469.ref044" ref-type="bibr">44</xref>]. Wuqinxi exercise may be a valid alternative treatment for low back pain in improving dysfunction [<xref rid="pone.0122469.ref045" ref-type="bibr">45</xref>], and for knee OA in balance function [<xref rid="pone.0122469.ref046" ref-type="bibr">46</xref>]. So Baduanjin and Wuqinxi exercise may be a valid assisting pharmacological treatment for PD.</p><p>Assuming that traditional Chinese medical exercise was beneficial for PD, some complex neurophysiological mechanisms may provide possible rationales [<xref rid="pone.0122469.ref047" ref-type="bibr">47</xref>–<xref rid="pone.0122469.ref050" ref-type="bibr">50</xref>]. Intensive exercise showed beneficial effects on neural plasticity, neuroprotection and preventing neural degeneration [<xref rid="pone.0122469.ref047" ref-type="bibr">47</xref>]. Especially, some animal studies have reported that intensive exercise may promote neurogenesis, dopamine synthesis and release in the striatum [<xref rid="pone.0122469.ref051" ref-type="bibr">51</xref>,<xref rid="pone.0122469.ref052" ref-type="bibr">52</xref>]. And such neural changes may affect behavioral recovery in individuals with PD [<xref rid="pone.0122469.ref053" ref-type="bibr">53</xref>,<xref rid="pone.0122469.ref054" ref-type="bibr">54</xref>]. In relevant studies, the intervention was generally considered as intensive exercise when involving 2–3 hours of exercise per week for 6–14 weeks (a total of 12–42 hours of treatment) [<xref rid="pone.0122469.ref047" ref-type="bibr">47</xref>]. In our systematic review, all eligible studies employed intensive traditional Chinese medical exercise (a total of 12–300 hours) for PD. And the intensive Tai Chi/Qigong also showed beneficial effects in improving motor function and balance. In addition, repetitive traditional Chinese medical exercise may also promote development of new motor programs which allow faster reactions responding to postural challenge [<xref rid="pone.0122469.ref055" ref-type="bibr">55</xref>]. And these new motor programs, which promoted behavioral recovery, may be due to making new synaptic connections.</p><p>There were some potential limitations in our systematic review: 1) there was the degree of uncertainty in locating relevant studies because of limited retrieving resources, language barrier, publication bias, etc. 2) there were few studies in some subgroup analyses because of strict eligibility criteria, which may bias the aggregated results. However, low eligibility criteria would conduct more doubtful results. 3) PEDro score was less than 6 in 5 studies. They were not considered as high quality, but they contributed valuable information to the evidence of Tai Chi/Qigong for PD. So they were included in our review. 4) synthetic results may be affected by different parameters (duration, frequency, dosage, etc.) of Tai Chi/Qigong exercise. 5) the follow-up effect of Tai Chi/Qigong for PD was not investigated in current studies. So further studies of Tai Chi/Qigong for PD should include long-term follow-up. 6) few adverse events were reported in included studies, but it was not concluded that Tai Chi/Qigong exercise was safe.</p></sec><sec sec-type="conclusions" id="sec028"><title>Conclusions</title><p>In the previous studies, Tai Chi and Qigong were used as assisting pharmacological treatments of PD. The current systematic review showed positive evidence of Tai Chi plus medication for PD of mild-to-moderate severity. So Tai Chi plus medication should be recommended for PD management, especially in improving motor function and balance. Qigong plus medication also showed potential gains in the management of PD. However, more high quality studies with long follow-up are warrant to confirm the current findings. And relevant mechanism research of traditional Chinese medical exercise for PD is also required.</p></sec><sec sec-type="supplementary-material" id="sec029"><title>Supporting Information</title><supplementary-material content-type="local-data" id="pone.0122469.s001"><label>S1 PRISMA Checklist</label><caption><title>PRISMA Checklist.</title><p>(DOC)</p></caption><media xlink:href="pone.0122469.s001.doc"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></sec></body><back><ref-list><title>References</title><ref id="pone.0122469.ref001"><label>1</label><mixed-citation publication-type="journal"><name><surname>Jankovic</surname><given-names>J</given-names></name>. <article-title>Parkinson’s disease: clinical features and diagnosis</article-title>. <source>J Neurol Neurosurg Psychiatry</source>. <year>2008</year>; <volume>79</volume>:<fpage>368</fpage>–<lpage>376</lpage>. <comment>doi: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1136/jnnp.2007.131045">10.1136/jnnp.2007.131045</ext-link></comment><pub-id pub-id-type="pmid">18344392</pub-id></mixed-citation></ref><ref id="pone.0122469.ref002"><label>2</label><mixed-citation publication-type="journal"><name><surname>Zhang</surname><given-names>ZX</given-names></name>, <name><surname>Roman</surname><given-names>GC</given-names></name>, <name><surname>Hong</surname><given-names>Z</given-names></name>, <name><surname>Wu</surname><given-names>CB</given-names></name>, <name><surname>Qu</surname><given-names>QM</given-names></name>. <article-title>Parkinson’s disease in China : prevalence in Beijing, Xian, and Shanghai</article-title>. <source>Lancet</source>. <year>2005</year>; 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