Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions
Identifieur interne : 000002 ( Pmc/Corpus ); précédent : 000001; suivant : 000003Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions
Auteurs : Roshan Cools ; Kae Nakamura ; Nathaniel D. DawSource :
- Neuropsychopharmacology [ 0893-133X ] ; 2010.
Abstract
Serotonin, like dopamine (DA), has long been implicated in adaptive behavior, including decision making and reinforcement learning. However, although the two neuromodulators are tightly related and have a similar degree of functional importance, compared with DA, we have a much less specific understanding about the mechanisms by which serotonin affects behavior. Here, we draw on recent work on computational models of dopaminergic function to suggest a framework by which many of the seemingly diverse functions associated with both DA and serotonin—comprising both affective and activational ones, as well as a number of other functions not overtly related to either—can be seen as consequences of a single root mechanism.
Url:
DOI: 10.1038/npp.2010.121
PubMed: 20736991
PubMed Central: 3055512
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PMC:3055512Le document en format XML
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Neuropsychopharmacology</journal-id><journal-title-group><journal-title>Neuropsychopharmacology</journal-title></journal-title-group><issn pub-type="ppub">0893-133X</issn><issn pub-type="epub">1740-634X</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20736991</article-id><article-id pub-id-type="pmc">3055512</article-id><article-id pub-id-type="pii">npp2010121</article-id><article-id pub-id-type="doi">10.1038/npp.2010.121</article-id><article-categories><subj-group subj-group-type="heading"><subject>Neuropsychopharmacology Reviews</subject></subj-group></article-categories><title-group><article-title>Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions</article-title><alt-title alt-title-type="running">Multiple functions of serotonin and dopamine</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cools</surname><given-names>Roshan</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="caf1">*</xref></contrib><contrib contrib-type="author"><name><surname>Nakamura</surname><given-names>Kae</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Daw</surname><given-names>Nathaniel D</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><aff id="aff1"><label>1</label><institution>Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Centre for Cognitive Neuroimaging</institution>, Nijmegen,<country>The Netherlands</country></aff><aff id="aff2"><label>2</label><institution>Department of Physiology, School of Medicine, Kansai Medical University</institution>, Moriguchi City,<country>Japan</country></aff><aff id="aff3"><label>3</label><institution>PRESTO</institution>, Honcho Kawaguchi, Saitama,<country>Japan</country></aff><aff id="aff4"><label>4</label><institution>Center for Neural Science & Department of Psychology, New York University</institution>, New York, NY,<country>USA</country></aff></contrib-group><author-notes><corresp id="caf1"><label>*</label><institution>Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen</institution>, Kapittelweg 29, Nijmegen 6500HB, <country>The Netherlands</country>, Tel: +31 243 610 656, Fax: +31 243 610 989, E-mail: <email>roshan.cools@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>01</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>25</day><month>08</month><year>2010</year></pub-date><volume>36</volume><issue>1</issue><fpage>98</fpage><lpage>113</lpage><history><date date-type="received"><day>12</day><month>04</month><year>2010</year></date><date date-type="rev-recd"><day>16</day><month>07</month><year>2010</year></date><date date-type="accepted"><day>16</day><month>07</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © 2011 American College of Neuropsychopharmacology</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>American College of Neuropsychopharmacology</copyright-holder></permissions><abstract><p>Serotonin, like dopamine (DA), has long been implicated in adaptive behavior, including decision making and reinforcement learning. However, although the two neuromodulators are tightly related and have a similar degree of functional importance, compared with DA, we have a much less specific understanding about the mechanisms by which serotonin affects behavior. Here, we draw on recent work on computational models of dopaminergic function to suggest a framework by which many of the seemingly diverse functions associated with both DA and serotonin—comprising both affective and activational ones, as well as a number of other functions not overtly related to either—can be seen as consequences of a single root mechanism.</p></abstract><kwd-group><kwd>aversion</kwd><kwd>reward</kwd><kwd>inhibition</kwd><kwd>impulsivity</kwd><kwd>activation</kwd><kwd>punishment</kwd></kwd-group><kwd-group kwd-group-type="author-keywords"><kwd>dopamine</kwd><kwd>serotonin</kwd><kwd>psychopharmacology</kwd><kwd>cognition</kwd><kwd>reward</kwd><kwd>punishment</kwd><kwd>impulsivity</kwd><kwd>inhibition</kwd><kwd>computational modeling</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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