Aerobic Exercise for Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Identifieur interne : 000062 ( Pmc/Checkpoint ); précédent : 000061; suivant : 000063Aerobic Exercise for Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Auteurs : Hai-Feng Shu ; Tao Yang ; Si-Xun Yu ; Hai-Dong Huang ; Ling-Li Jiang ; Jian-Wen Gu ; Yong-Qin KuangSource :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Although some trials assessed the effectiveness of aerobic exercise for Parkinson's disease (PD), the role of aerobic exercise in the management of PD remained controversial.
The purpose of this systematic review is to evaluate the evidence about whether aerobic exercise is effective for PD.
Seven electronic databases, up to December 2013, were searched to identify relevant studies. Two reviewers independently extracted data and assessed methodological quality based on PEDro scale. Standardised mean difference (SMD) and 95% confidence intervals (CI) of random-effects model were calculated. And heterogeneity was assessed based on the
18 randomized controlled trials (RCTs) with 901 patients were eligible. The aggregated results suggested that aerobic exercise should show superior effects in improving motor actions (SMD, −0.57; 95% CI −0.94 to −0.19; p = 0.003), balance (SMD, 2.02; 95% CI 0.45 to 3.59; p = 0.01), and gait (SMD, 0.33; 95% CI 0.17 to 0.49; p<0.0001) in patients with PD, but not in quality of life (SMD, 0.11; 95% CI −0.23 to 0.46; p = 0.52). And there was no valid evidence on follow-up effects of aerobic exercise for PD.
Aerobic exercise showed immediate beneficial effects in improving motor action, balance, and gait in patients with PD. However, given no evidence on follow-up effects, large-scale RCTs with long follow-up are warrant to confirm the current findings.
Url:
DOI: 10.1371/journal.pone.0100503
PubMed: 24983753
PubMed Central: 4077570
Affiliations:
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PMC:4077570Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Aerobic Exercise for Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</title>
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<author><name sortKey="Huang, Hai Dong" sort="Huang, Hai Dong" uniqKey="Huang H" first="Hai-Dong" last="Huang">Hai-Dong Huang</name>
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<author><name sortKey="Jiang, Ling Li" sort="Jiang, Ling Li" uniqKey="Jiang L" first="Ling-Li" last="Jiang">Ling-Li Jiang</name>
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<author><name sortKey="Gu, Jian Wen" sort="Gu, Jian Wen" uniqKey="Gu J" first="Jian-Wen" last="Gu">Jian-Wen Gu</name>
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<author><name sortKey="Kuang, Yong Qin" sort="Kuang, Yong Qin" uniqKey="Kuang Y" first="Yong-Qin" last="Kuang">Yong-Qin Kuang</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Although some trials assessed the effectiveness of aerobic exercise for Parkinson's disease (PD), the role of aerobic exercise in the management of PD remained controversial.</p>
</sec>
<sec><title>Objective</title>
<p>The purpose of this systematic review is to evaluate the evidence about whether aerobic exercise is effective for PD.</p>
</sec>
<sec><title>Methods</title>
<p>Seven electronic databases, up to December 2013, were searched to identify relevant studies. Two reviewers independently extracted data and assessed methodological quality based on PEDro scale. Standardised mean difference (SMD) and 95% confidence intervals (CI) of random-effects model were calculated. And heterogeneity was assessed based on the <italic>I<sup>2</sup>
</italic>
statistic.</p>
</sec>
<sec><title>Results</title>
<p>18 randomized controlled trials (RCTs) with 901 patients were eligible. The aggregated results suggested that aerobic exercise should show superior effects in improving motor actions (SMD, −0.57; 95% CI −0.94 to −0.19; p = 0.003), balance (SMD, 2.02; 95% CI 0.45 to 3.59; p = 0.01), and gait (SMD, 0.33; 95% CI 0.17 to 0.49; p<0.0001) in patients with PD, but not in quality of life (SMD, 0.11; 95% CI −0.23 to 0.46; p = 0.52). And there was no valid evidence on follow-up effects of aerobic exercise for PD.</p>
</sec>
<sec><title>Conclusion</title>
<p>Aerobic exercise showed immediate beneficial effects in improving motor action, balance, and gait in patients with PD. However, given no evidence on follow-up effects, large-scale RCTs with long follow-up are warrant to confirm the current findings.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24983753</article-id>
<article-id pub-id-type="pmc">4077570</article-id>
<article-id pub-id-type="publisher-id">PONE-D-14-02253</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0100503</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Health Care</subject>
<subj-group><subject>Physiotherapy</subject>
</subj-group>
</subj-group>
<subj-group><subject>Complementary and Alternative Medicine</subject>
</subj-group>
<subj-group><subject>Neurology</subject>
<subj-group><subject>Neurodegenerative Diseases</subject>
<subj-group><subject>Movement Disorders</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group><subject>Sports and Exercise Medicine</subject>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Physical Sciences</subject>
<subj-group><subject>Mathematics</subject>
<subj-group><subject>Statistics (Mathematics)</subject>
<subj-group><subject>Statistical Methods</subject>
<subj-group><subject>Meta-Analysis</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Research and Analysis Methods</subject>
<subj-group><subject>Research Assessment</subject>
<subj-group><subject>Systematic Reviews</subject>
</subj-group>
</subj-group>
<subj-group><subject>Research Design</subject>
<subj-group><subject>Clinical Research Design</subject>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Aerobic Exercise for Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</article-title>
<alt-title alt-title-type="running-head">Review the Effects of Aerobic Exercise for Parkinson's Disease</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Shu</surname>
<given-names>Hai-Feng</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Tao</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yu</surname>
<given-names>Si-Xun</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huang</surname>
<given-names>Hai-Dong</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jiang</surname>
<given-names>Ling-Li</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gu</surname>
<given-names>Jian-Wen</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kuang</surname>
<given-names>Yong-Qin</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><addr-line>Department of Neurosurgery, General Hospital of the People's Liberation Army Chengdu Military Region, Chengdu, Sichuan, China</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Fasano</surname>
<given-names>Alfonso</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>University of Toronto, Italy</addr-line>
</aff>
<author-notes><corresp id="cor1">* E-mail: <email>yongqinkuangdr@163.com</email>
</corresp>
<fn fn-type="conflict"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con"><p>Conceived and designed the experiments: HFS JWG YQK. Performed the experiments: HFS TY SXY HDH. Analyzed the data: HFS SXY LLJ. Contributed reagents/materials/analysis tools: HFS TY SXY HDH. Wrote the paper: HFS YQK.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>1</day>
<month>7</month>
<year>2014</year>
</pub-date>
<volume>9</volume>
<issue>7</issue>
<elocation-id>e100503</elocation-id>
<history><date date-type="received"><day>27</day>
<month>1</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>23</day>
<month>5</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-year>2014</copyright-year>
<copyright-holder>Shu et al</copyright-holder>
<license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<abstract><sec><title>Background</title>
<p>Although some trials assessed the effectiveness of aerobic exercise for Parkinson's disease (PD), the role of aerobic exercise in the management of PD remained controversial.</p>
</sec>
<sec><title>Objective</title>
<p>The purpose of this systematic review is to evaluate the evidence about whether aerobic exercise is effective for PD.</p>
</sec>
<sec><title>Methods</title>
<p>Seven electronic databases, up to December 2013, were searched to identify relevant studies. Two reviewers independently extracted data and assessed methodological quality based on PEDro scale. Standardised mean difference (SMD) and 95% confidence intervals (CI) of random-effects model were calculated. And heterogeneity was assessed based on the <italic>I<sup>2</sup>
</italic>
statistic.</p>
</sec>
<sec><title>Results</title>
<p>18 randomized controlled trials (RCTs) with 901 patients were eligible. The aggregated results suggested that aerobic exercise should show superior effects in improving motor actions (SMD, −0.57; 95% CI −0.94 to −0.19; p = 0.003), balance (SMD, 2.02; 95% CI 0.45 to 3.59; p = 0.01), and gait (SMD, 0.33; 95% CI 0.17 to 0.49; p<0.0001) in patients with PD, but not in quality of life (SMD, 0.11; 95% CI −0.23 to 0.46; p = 0.52). And there was no valid evidence on follow-up effects of aerobic exercise for PD.</p>
</sec>
<sec><title>Conclusion</title>
<p>Aerobic exercise showed immediate beneficial effects in improving motor action, balance, and gait in patients with PD. However, given no evidence on follow-up effects, large-scale RCTs with long follow-up are warrant to confirm the current findings.</p>
</sec>
</abstract>
<funding-group><funding-statement>This work was supported by National Natural Science Foundation of China (No. 81100975, 81371430), China Postdoctoral Science Foundation (No. 2012T50850), Research Foundation of General Hospital of Chengdu Military Region (No. 424121H3), and Science Foundation of Health Office of Sichuan Province (No. 42412D16). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><page-count count="10"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Gu, Jian Wen" sort="Gu, Jian Wen" uniqKey="Gu J" first="Jian-Wen" last="Gu">Jian-Wen Gu</name>
<name sortKey="Huang, Hai Dong" sort="Huang, Hai Dong" uniqKey="Huang H" first="Hai-Dong" last="Huang">Hai-Dong Huang</name>
<name sortKey="Jiang, Ling Li" sort="Jiang, Ling Li" uniqKey="Jiang L" first="Ling-Li" last="Jiang">Ling-Li Jiang</name>
<name sortKey="Kuang, Yong Qin" sort="Kuang, Yong Qin" uniqKey="Kuang Y" first="Yong-Qin" last="Kuang">Yong-Qin Kuang</name>
<name sortKey="Shu, Hai Feng" sort="Shu, Hai Feng" uniqKey="Shu H" first="Hai-Feng" last="Shu">Hai-Feng Shu</name>
<name sortKey="Yang, Tao" sort="Yang, Tao" uniqKey="Yang T" first="Tao" last="Yang">Tao Yang</name>
<name sortKey="Yu, Si Xun" sort="Yu, Si Xun" uniqKey="Yu S" first="Si-Xun" last="Yu">Si-Xun Yu</name>
</noCountry>
</tree>
</affiliations>
</record>
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