Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings
Identifieur interne : 000002 ( PascalFrancis/Corpus ); précédent : 000001; suivant : 000003Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings
Auteurs : Agustín Ibá Ez ; Juan F. Cardona ; Yamil Vidal Dos Santos ; Alejandro Blenkmann ; Pía Aravena ; María Roca ; Esteban Hurtado ; Mirna Nerguizian ; Lucía Amouso ; Gonzalo G Mez-Arévalo ; Anabel Chade ; Alberto Dubrovsky ; Oscar Gershanik ; Silvia Kochen ; Arthur Glenberg ; Facundo Manes ; Tristán BekinschteinSource :
- Cortex : (Testo stampato) [ 0010-9452 ] ; 2013.
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Abstract
Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.
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Format Inist (serveur)
| NO : | PASCAL 13-0230428 INIST |
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| ET : | Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings |
| AU : | IBÁÑEZ (Agustín); CARDONA (Juan F.); DOS SANTOS (Yamil Vidal); BLENKMANN (Alejandro); ARAVENA (Pía); ROCA (María); HURTADO (Esteban); NERGUIZIAN (Mirna); AMOUSO (Lucía); GÓMEZ-ARÉVALO (Gonzalo); CHADE (Anabel); DUBROVSKY (Alberto); GERSHANIK (Oscar); KOCHEN (Silvia); GLENBERG (Arthur); MANES (Facundo); BEKINSCHTEIN (Tristán) |
| AF : | Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University/Buenos Aires/Argentine (1 aut., 2 aut., 3 aut., 6 aut., 8 aut., 9 aut., 10 aut., 11 aut., 12 aut., 13 aut., 16 aut., 17 aut.); National Scientific and Technical Research Council (CONICET)/Buenos Aires/Argentine (1 aut., 2 aut., 4 aut., 9 aut., 13 aut.); Faculty of Psychology, Universidad de Buenos Aires (UBA)/Argentine (2 aut.); Laboratory of Cognitive and Social Neuroscience, Universidad Diego Portales/Santiago/Chili (1 aut.); Epilepsy Laboratory, IBCN, "Prof. E. De Robertis", School of Medicine, University of Buenos Aires/Argentine (4 aut., 14 aut.); Epilepsy Section, Division Neurology, Ramos Mejía Hospital/Buenos Aires/Argentine (4 aut., 14 aut.); School of Engineering, Exact and Natural Sciences, Favaloro University/Buenos Aires/Argentine (4 aut., 8 aut.); L2C2-Institut des Sciences Cognitives/Bron/France (5 aut.); School of Psychology, Pontificia Universidad Católica de Chile/Santiago/Chili (7 aut.); Department of Psychology, Arizona State University/Tempe, AZ/Etats-Unis (15 aut.); Department of Psychology, University of Wisconsin-Madison/Madison, WI/Etats-Unis (15 aut.); Laboratory of Integrative Neuroscience, Faculty of Physics, Universidad de Buenos Aires/Argentine (3 aut.); LEICI, School of Engineering, National University of La Plata/La Plata/Argentine (4 aut.); Cognition and Brain Sciences Unit, Medical Research Council/Cambridge/Royaume-Uni (17 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Cortex : (Testo stampato); ISSN 0010-9452; Coden CRTXAZ; Italie; Da. 2013; Vol. 49; No. 4; Pp. 968-984; Bibl. 4 p.3/4 |
| LA : | Anglais |
| EA : | Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling. |
| CC : | 002B18C13; 002B17G; 002B17A01; 002A26D03 |
| FD : | Mouvement corporel; Temps réaction; Maladie de Parkinson; Electrocorticographie; Potentiel évoqué cognitif; Etude expérimentale; Compréhension verbale; Phrase; Homme |
| FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux; Electrophysiologie; Cognition; Encéphale; Système nerveux central; Langage; Motricité |
| ED : | Body movement; Reaction time; Parkinson disease; Electrocorticography; Event evoked potential; Experimental study; Verbal comprehension; Sentence; Human |
| EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Electrophysiology; Cognition; Encephalon; Central nervous system; Language; Motricity |
| SD : | Movimiento corporal; Tiempo reacción; Parkinson enfermedad; Electrocorticografía; Potencial evocado cognitivo; Estudio experimental; Comprensión verbal; Frase; Hombre |
| LO : | INIST-4814.354000503610550070 |
| ID : | 13-0230428 |
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Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hurtado, Esteban" sort="Hurtado, Esteban" uniqKey="Hurtado E" first="Esteban" last="Hurtado">Esteban Hurtado</name><affiliation><inist:fA14 i1="09"><s1>School of Psychology, Pontificia Universidad Católica de Chile</s1><s2>Santiago</s2><s3>CHL</s3><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Nerguizian, Mirna" sort="Nerguizian, Mirna" uniqKey="Nerguizian M" first="Mirna" last="Nerguizian">Mirna Nerguizian</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>School of Engineering, Exact and Natural Sciences, Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Amouso, Lucia" sort="Amouso, Lucia" uniqKey="Amouso L" first="Lucía" last="Amouso">Lucía Amouso</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>National Scientific and Technical Research Council (CONICET)</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="G Mez Arevalo, Gonzalo" sort="G Mez Arevalo, Gonzalo" uniqKey="G Mez Arevalo G" first="Gonzalo" last="G Mez-Arévalo">Gonzalo G Mez-Arévalo</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Chade, Anabel" sort="Chade, Anabel" uniqKey="Chade A" first="Anabel" last="Chade">Anabel Chade</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Dubrovsky, Alberto" sort="Dubrovsky, Alberto" uniqKey="Dubrovsky A" first="Alberto" last="Dubrovsky">Alberto Dubrovsky</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gershanik, Oscar" sort="Gershanik, Oscar" uniqKey="Gershanik O" first="Oscar" last="Gershanik">Oscar Gershanik</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>National Scientific and Technical Research Council (CONICET)</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kochen, Silvia" sort="Kochen, Silvia" uniqKey="Kochen S" first="Silvia" last="Kochen">Silvia Kochen</name><affiliation><inist:fA14 i1="05"><s1>Epilepsy Laboratory, IBCN, "Prof. E. De Robertis", School of Medicine, University of Buenos Aires</s1><s3>ARG</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Epilepsy Section, Division Neurology, Ramos Mejía Hospital</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Glenberg, Arthur" sort="Glenberg, Arthur" uniqKey="Glenberg A" first="Arthur" last="Glenberg">Arthur Glenberg</name><affiliation><inist:fA14 i1="10"><s1>Department of Psychology, Arizona State University</s1><s2>Tempe, AZ</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="11"><s1>Department of Psychology, University of Wisconsin-Madison</s1><s2>Madison, WI</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Manes, Facundo" sort="Manes, Facundo" uniqKey="Manes F" first="Facundo" last="Manes">Facundo Manes</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bekinschtein, Tristan" sort="Bekinschtein, Tristan" uniqKey="Bekinschtein T" first="Tristán" last="Bekinschtein">Tristán Bekinschtein</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="14"><s1>Cognition and Brain Sciences Unit, Medical Research Council</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0230428</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0230428 INIST</idno><idno type="RBID">Pascal:13-0230428</idno><idno type="wicri:Area/PascalFrancis/Corpus">000002</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings</title><author><name sortKey="Iba Ez, Agustin" sort="Iba Ez, Agustin" uniqKey="Iba Ez A" first="Agustín" last="Ibá Ez">Agustín Ibá Ez</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>National Scientific and Technical Research Council (CONICET)</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>Laboratory of Cognitive and Social Neuroscience, Universidad Diego Portales</s1><s2>Santiago</s2><s3>CHL</s3><sZ>1 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cardona, Juan F" sort="Cardona, Juan F" uniqKey="Cardona J" first="Juan F." last="Cardona">Juan F. Cardona</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>National Scientific and Technical Research Council (CONICET)</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Faculty of Psychology, Universidad de Buenos Aires (UBA)</s1><s3>ARG</s3><sZ>2 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Dos Santos, Yamil Vidal" sort="Dos Santos, Yamil Vidal" uniqKey="Dos Santos Y" first="Yamil Vidal" last="Dos Santos">Yamil Vidal Dos Santos</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="12"><s1>Laboratory of Integrative Neuroscience, Faculty of Physics, Universidad de Buenos Aires</s1><s3>ARG</s3><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Blenkmann, Alejandro" sort="Blenkmann, Alejandro" uniqKey="Blenkmann A" first="Alejandro" last="Blenkmann">Alejandro Blenkmann</name><affiliation><inist:fA14 i1="02"><s1>National Scientific and Technical Research Council (CONICET)</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>Epilepsy Laboratory, IBCN, "Prof. E. De Robertis", School of Medicine, University of Buenos Aires</s1><s3>ARG</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Epilepsy Section, Division Neurology, Ramos Mejía Hospital</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>School of Engineering, Exact and Natural Sciences, Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="13"><s1>LEICI, School of Engineering, National University of La Plata</s1><s2>La Plata</s2><s3>ARG</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Aravena, Pia" sort="Aravena, Pia" uniqKey="Aravena P" first="Pía" last="Aravena">Pía Aravena</name><affiliation><inist:fA14 i1="08"><s1>L2C2-Institut des Sciences Cognitives</s1><s2>Bron</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Roca, Maria" sort="Roca, Maria" uniqKey="Roca M" first="María" last="Roca">María Roca</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hurtado, Esteban" sort="Hurtado, Esteban" uniqKey="Hurtado E" first="Esteban" last="Hurtado">Esteban Hurtado</name><affiliation><inist:fA14 i1="09"><s1>School of Psychology, Pontificia Universidad Católica de Chile</s1><s2>Santiago</s2><s3>CHL</s3><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Nerguizian, Mirna" sort="Nerguizian, Mirna" uniqKey="Nerguizian M" first="Mirna" last="Nerguizian">Mirna Nerguizian</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>School of Engineering, Exact and Natural Sciences, Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Amouso, Lucia" sort="Amouso, Lucia" uniqKey="Amouso L" first="Lucía" last="Amouso">Lucía Amouso</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>National Scientific and Technical Research Council (CONICET)</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="G Mez Arevalo, Gonzalo" sort="G Mez Arevalo, Gonzalo" uniqKey="G Mez Arevalo G" first="Gonzalo" last="G Mez-Arévalo">Gonzalo G Mez-Arévalo</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Chade, Anabel" sort="Chade, Anabel" uniqKey="Chade A" first="Anabel" last="Chade">Anabel Chade</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Dubrovsky, Alberto" sort="Dubrovsky, Alberto" uniqKey="Dubrovsky A" first="Alberto" last="Dubrovsky">Alberto Dubrovsky</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gershanik, Oscar" sort="Gershanik, Oscar" uniqKey="Gershanik O" first="Oscar" last="Gershanik">Oscar Gershanik</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>National Scientific and Technical Research Council (CONICET)</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kochen, Silvia" sort="Kochen, Silvia" uniqKey="Kochen S" first="Silvia" last="Kochen">Silvia Kochen</name><affiliation><inist:fA14 i1="05"><s1>Epilepsy Laboratory, IBCN, "Prof. E. De Robertis", School of Medicine, University of Buenos Aires</s1><s3>ARG</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Epilepsy Section, Division Neurology, Ramos Mejía Hospital</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Glenberg, Arthur" sort="Glenberg, Arthur" uniqKey="Glenberg A" first="Arthur" last="Glenberg">Arthur Glenberg</name><affiliation><inist:fA14 i1="10"><s1>Department of Psychology, Arizona State University</s1><s2>Tempe, AZ</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="11"><s1>Department of Psychology, University of Wisconsin-Madison</s1><s2>Madison, WI</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Manes, Facundo" sort="Manes, Facundo" uniqKey="Manes F" first="Facundo" last="Manes">Facundo Manes</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bekinschtein, Tristan" sort="Bekinschtein, Tristan" uniqKey="Bekinschtein T" first="Tristán" last="Bekinschtein">Tristán Bekinschtein</name><affiliation><inist:fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="14"><s1>Cognition and Brain Sciences Unit, Medical Research Council</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Cortex : (Testo stampato)</title><title level="j" type="abbreviated">Cortex : (Testo stamp.)</title><idno type="ISSN">0010-9452</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Cortex : (Testo stampato)</title><title level="j" type="abbreviated">Cortex : (Testo stamp.)</title><idno type="ISSN">0010-9452</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Body movement</term><term>Electrocorticography</term><term>Event evoked potential</term><term>Experimental study</term><term>Human</term><term>Parkinson disease</term><term>Reaction time</term><term>Sentence</term><term>Verbal comprehension</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Mouvement corporel</term><term>Temps réaction</term><term>Maladie de Parkinson</term><term>Electrocorticographie</term><term>Potentiel évoqué cognitif</term><term>Etude expérimentale</term><term>Compréhension verbale</term><term>Phrase</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0010-9452</s0></fA01><fA02 i1="01"><s0>CRTXAZ</s0></fA02><fA03 i2="1"><s0>Cortex : (Testo stamp.)</s0></fA03><fA05><s2>49</s2></fA05><fA06><s2>4</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings</s1></fA08><fA11 i1="01" i2="1"><s1>IBÁÑEZ (Agustín)</s1></fA11><fA11 i1="02" i2="1"><s1>CARDONA (Juan F.)</s1></fA11><fA11 i1="03" i2="1"><s1>DOS SANTOS (Yamil Vidal)</s1></fA11><fA11 i1="04" i2="1"><s1>BLENKMANN (Alejandro)</s1></fA11><fA11 i1="05" i2="1"><s1>ARAVENA (Pía)</s1></fA11><fA11 i1="06" i2="1"><s1>ROCA (María)</s1></fA11><fA11 i1="07" i2="1"><s1>HURTADO (Esteban)</s1></fA11><fA11 i1="08" i2="1"><s1>NERGUIZIAN (Mirna)</s1></fA11><fA11 i1="09" i2="1"><s1>AMOUSO (Lucía)</s1></fA11><fA11 i1="10" i2="1"><s1>GÓMEZ-ARÉVALO (Gonzalo)</s1></fA11><fA11 i1="11" i2="1"><s1>CHADE (Anabel)</s1></fA11><fA11 i1="12" i2="1"><s1>DUBROVSKY (Alberto)</s1></fA11><fA11 i1="13" i2="1"><s1>GERSHANIK (Oscar)</s1></fA11><fA11 i1="14" i2="1"><s1>KOCHEN (Silvia)</s1></fA11><fA11 i1="15" i2="1"><s1>GLENBERG (Arthur)</s1></fA11><fA11 i1="16" i2="1"><s1>MANES (Facundo)</s1></fA11><fA11 i1="17" i2="1"><s1>BEKINSCHTEIN (Tristán)</s1></fA11><fA14 i1="01"><s1>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="02"><s1>National Scientific and Technical Research Council (CONICET)</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="03"><s1>Faculty of Psychology, Universidad de Buenos Aires (UBA)</s1><s3>ARG</s3><sZ>2 aut.</sZ></fA14><fA14 i1="04"><s1>Laboratory of Cognitive and Social Neuroscience, Universidad Diego Portales</s1><s2>Santiago</s2><s3>CHL</s3><sZ>1 aut.</sZ></fA14><fA14 i1="05"><s1>Epilepsy Laboratory, IBCN, "Prof. E. De Robertis", School of Medicine, University of Buenos Aires</s1><s3>ARG</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="06"><s1>Epilepsy Section, Division Neurology, Ramos Mejía Hospital</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="07"><s1>School of Engineering, Exact and Natural Sciences, Favaloro University</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="08"><s1>L2C2-Institut des Sciences Cognitives</s1><s2>Bron</s2><s3>FRA</s3><sZ>5 aut.</sZ></fA14><fA14 i1="09"><s1>School of Psychology, Pontificia Universidad Católica de Chile</s1><s2>Santiago</s2><s3>CHL</s3><sZ>7 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Psychology, Arizona State University</s1><s2>Tempe, AZ</s2><s3>USA</s3><sZ>15 aut.</sZ></fA14><fA14 i1="11"><s1>Department of Psychology, University of Wisconsin-Madison</s1><s2>Madison, WI</s2><s3>USA</s3><sZ>15 aut.</sZ></fA14><fA14 i1="12"><s1>Laboratory of Integrative Neuroscience, Faculty of Physics, Universidad de Buenos Aires</s1><s3>ARG</s3><sZ>3 aut.</sZ></fA14><fA14 i1="13"><s1>LEICI, School of Engineering, National University of La Plata</s1><s2>La Plata</s2><s3>ARG</s3><sZ>4 aut.</sZ></fA14><fA14 i1="14"><s1>Cognition and Brain Sciences Unit, Medical Research Council</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>17 aut.</sZ></fA14><fA20><s1>968-984</s1></fA20><fA21><s1>2013</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>4814</s2><s5>354000503610550070</s5></fA43><fA44><s0>0000</s0><s1>© 2013 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>4 p.3/4</s0></fA45><fA47 i1="01" i2="1"><s0>13-0230428</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Cortex : (Testo stampato)</s0></fA64><fA66 i1="01"><s0>ITA</s0></fA66><fC01 i1="01" l="ENG"><s0>Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.</s0></fC01><fC02 i1="01" i2="X"><s0>002B18C13</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17A01</s0></fC02><fC02 i1="04" i2="X"><s0>002A26D03</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Mouvement corporel</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Body movement</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Movimiento corporal</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Temps réaction</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Reaction time</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Tiempo reacción</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Electrocorticographie</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Electrocorticography</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Electrocorticografía</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Potentiel évoqué cognitif</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Event evoked potential</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Potencial evocado cognitivo</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Etude expérimentale</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Experimental study</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Estudio experimental</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Compréhension verbale</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Verbal comprehension</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Comprensión verbal</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Phrase</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Sentence</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Frase</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Homme</s0><s5>18</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Human</s0><s5>18</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Hombre</s0><s5>18</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Electrophysiologie</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Electrophysiology</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Electrofisiología</s0><s5>42</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Cognition</s0><s5>43</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Cognition</s0><s5>43</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Cognición</s0><s5>43</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Encéphale</s0><s5>44</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Encephalon</s0><s5>44</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Encéfalo</s0><s5>44</s5></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>45</s5></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Central nervous system</s0><s5>45</s5></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>45</s5></fC07><fC07 i1="10" i2="X" l="FRE"><s0>Langage</s0><s5>46</s5></fC07><fC07 i1="10" i2="X" l="ENG"><s0>Language</s0><s5>46</s5></fC07><fC07 i1="10" i2="X" l="SPA"><s0>Lenguaje</s0><s5>46</s5></fC07><fC07 i1="11" i2="X" l="FRE"><s0>Motricité</s0><s5>47</s5></fC07><fC07 i1="11" i2="X" l="ENG"><s0>Motricity</s0><s5>47</s5></fC07><fC07 i1="11" i2="X" l="SPA"><s0>Motricidad</s0><s5>47</s5></fC07><fN21><s1>217</s1></fN21></pA></standard><server><NO>PASCAL 13-0230428 INIST</NO><ET>Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings</ET><AU>IBÁÑEZ (Agustín); CARDONA (Juan F.); DOS SANTOS (Yamil Vidal); BLENKMANN (Alejandro); ARAVENA (Pía); ROCA (María); HURTADO (Esteban); NERGUIZIAN (Mirna); AMOUSO (Lucía); GÓMEZ-ARÉVALO (Gonzalo); CHADE (Anabel); DUBROVSKY (Alberto); GERSHANIK (Oscar); KOCHEN (Silvia); GLENBERG (Arthur); MANES (Facundo); BEKINSCHTEIN (Tristán)</AU><AF>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University/Buenos Aires/Argentine (1 aut., 2 aut., 3 aut., 6 aut., 8 aut., 9 aut., 10 aut., 11 aut., 12 aut., 13 aut., 16 aut., 17 aut.); National Scientific and Technical Research Council (CONICET)/Buenos Aires/Argentine (1 aut., 2 aut., 4 aut., 9 aut., 13 aut.); Faculty of Psychology, Universidad de Buenos Aires (UBA)/Argentine (2 aut.); Laboratory of Cognitive and Social Neuroscience, Universidad Diego Portales/Santiago/Chili (1 aut.); Epilepsy Laboratory, IBCN, "Prof. E. De Robertis", School of Medicine, University of Buenos Aires/Argentine (4 aut., 14 aut.); Epilepsy Section, Division Neurology, Ramos Mejía Hospital/Buenos Aires/Argentine (4 aut., 14 aut.); School of Engineering, Exact and Natural Sciences, Favaloro University/Buenos Aires/Argentine (4 aut., 8 aut.); L2C2-Institut des Sciences Cognitives/Bron/France (5 aut.); School of Psychology, Pontificia Universidad Católica de Chile/Santiago/Chili (7 aut.); Department of Psychology, Arizona State University/Tempe, AZ/Etats-Unis (15 aut.); Department of Psychology, University of Wisconsin-Madison/Madison, WI/Etats-Unis (15 aut.); Laboratory of Integrative Neuroscience, Faculty of Physics, Universidad de Buenos Aires/Argentine (3 aut.); LEICI, School of Engineering, National University of La Plata/La Plata/Argentine (4 aut.); Cognition and Brain Sciences Unit, Medical Research Council/Cambridge/Royaume-Uni (17 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Cortex : (Testo stampato); ISSN 0010-9452; Coden CRTXAZ; Italie; Da. 2013; Vol. 49; No. 4; Pp. 968-984; Bibl. 4 p.3/4</SO><LA>Anglais</LA><EA>Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.</EA><CC>002B18C13; 002B17G; 002B17A01; 002A26D03</CC><FD>Mouvement corporel; Temps réaction; Maladie de Parkinson; Electrocorticographie; Potentiel évoqué cognitif; Etude expérimentale; Compréhension verbale; Phrase; Homme</FD><FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux; Electrophysiologie; Cognition; Encéphale; Système nerveux central; Langage; Motricité</FG><ED>Body movement; Reaction time; Parkinson disease; Electrocorticography; Event evoked potential; Experimental study; Verbal comprehension; Sentence; Human</ED><EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Electrophysiology; Cognition; Encephalon; Central nervous system; Language; Motricity</EG><SD>Movimiento corporal; Tiempo reacción; Parkinson enfermedad; Electrocorticografía; Potencial evocado cognitivo; Estudio experimental; Comprensión verbal; Frase; Hombre</SD><LO>INIST-4814.354000503610550070</LO><ID>13-0230428</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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