Dopamine and the Biology of Creativity: Lessons from Parkinson’s Disease
Identifieur interne : 000167 ( Ncbi/Merge ); précédent : 000166; suivant : 000168Dopamine and the Biology of Creativity: Lessons from Parkinson’s Disease
Auteurs : Eugénie Lhommée [France] ; Alina Batir [France] ; Jean-Louis Quesada [France] ; Claire Ardouin [France] ; Valérie Fraix [France] ; Eric Seigneuret [France] ; Stéphan Chabardès [France] ; Alim-Louis Benabid [France] ; Pierre Pollak [France] ; Paul Krack [France]Source :
- Frontiers in Neurology [ 1664-2295 ] ; 2014.
Abstract
Url:
DOI: 10.3389/fneur.2014.00055
PubMed: 24795692
PubMed Central: 4001035
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PMC:4001035Le document en format XML
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<author><name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name>
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<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
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<author><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name>
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<author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
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,<addr-line>Grenoble</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
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<series><title level="j">Frontiers in Neurology</title>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
Parkinson’s disease (PD) is characterized by reduced flexibility, conceptualization, and visuo-spatial abilities. Although these are essential to creativity, case studies show emergence of creativity during PD. Knowledge about the role of dopamine in creativity so far only stems from a few case reports. We aim at demonstrating that creativity can be induced by dopaminergic treatments in PD, and tends to disappear after withdrawal of dopamine agonists.</p>
<p><bold>Methods:</bold>
Eleven consecutive creative PD patients were selected from candidates for subthalamic nucleus deep brain stimulation (STN DBS) surgery, and compared to 22 non-creative control PD patients. Motor disability (UPDRS III), cognition (Frontal score, Mattis scale), and behavior (Ardouin scale) were assessed before surgery and 1 year after.</p>
<p><bold>Results:</bold>
Before surgery, whereas cognitive and motor assessments were similar between groups, dopamine agonist (but not levodopa) dosages were higher in creative patients (<italic>p</italic>
= 0.01). The Ardouin scale revealed also a specific psycho-behavioral profile of creative patients which had higher scores for mania (<italic>p</italic>
< 0.001), hobbyism (<italic>p</italic>
= 0.001), nocturnal hyperactivity (<italic>p</italic>
= 0.041), appetitive functioning (<italic>p</italic>
= 0.003), and ON euphoria (<italic>p</italic>
= 0.007) and lower scores for apathy and OFF dysphoria (<italic>p</italic>
= 0.04 for each). Post-operative motor, cognitive, and behavioral scores as dopaminergic treatment dosages were equivalent between groups. Motor improvement allowed for a 68.6% decrease in dopaminergic treatment. Only 1 of the 11 patients remained creative after surgery. Reduction of dopamine agonist was significantly correlated to the decrease in creativity in the whole population of study (Spearman correlation coefficient ρ = 0.47 with confidence index of 95% = 0.16; 0.70, <italic>p</italic>
= 0.0053).</p>
<p><bold>Conclusion:</bold>
Creativity in PD is linked to dopamine agonist therapy, and tends to disappear after STN DBS in parallel to reduction of dopamine agonists, which are relatively selective for the mesolimbic D3 dopamine receptors.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Neurol</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Neurol</journal-id>
<journal-id journal-id-type="publisher-id">Front. Neurol.</journal-id>
<journal-title-group><journal-title>Frontiers in Neurology</journal-title>
</journal-title-group>
<issn pub-type="epub">1664-2295</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24795692</article-id>
<article-id pub-id-type="pmc">4001035</article-id>
<article-id pub-id-type="doi">10.3389/fneur.2014.00055</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject>
<subj-group><subject>Original Research</subject>
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<title-group><article-title>Dopamine and the Biology of Creativity: Lessons from Parkinson’s Disease</article-title>
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<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Quesada</surname>
<given-names>Jean-Louis</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ardouin</surname>
<given-names>Claire</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fraix</surname>
<given-names>Valérie</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://frontiersin.org/people/u/153616"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Seigneuret</surname>
<given-names>Eric</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chabardès</surname>
<given-names>Stéphan</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://frontiersin.org/people/u/17619"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Benabid</surname>
<given-names>Alim-Louis</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<xref ref-type="author-notes" rid="fn001"><sup>†</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://frontiersin.org/people/u/132858"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Pollak</surname>
<given-names>Pierre</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn001"><sup>†</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://frontiersin.org/people/u/43603"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Krack</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://frontiersin.org/people/u/102457"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>U836, INSERM</institution>
,<addr-line>Grenoble</addr-line>
,<country>France</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>University of Grenoble Alpes, GIN</institution>
,<addr-line>Grenoble</addr-line>
,<country>France</country>
</aff>
<aff id="aff3"><sup>3</sup>
<institution>Movement Disorder Unit, CHU de Grenoble</institution>
,<addr-line>Grenoble</addr-line>
,<country>France</country>
</aff>
<aff id="aff4"><sup>4</sup>
<institution>Centre d’Investigation Clinique, CHU de Grenoble, Université Joseph Fourier</institution>
,<addr-line>Grenoble</addr-line>
,<country>France</country>
</aff>
<aff id="aff5"><sup>5</sup>
<institution>Department of Neurosurgery, CHU de Grenoble</institution>
,<addr-line>Grenoble</addr-line>
,<country>France</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: Jaime Kulisevsky, Sant Pau Hospital, Spain</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: Francesca Morgante, University of Messina, Italy; Ubaldo Bonuccelli, University of Pisa, Italy</p>
</fn>
<corresp content-type="corresp" id="cor1">*Correspondence: Eugénie Lhommée, Movement Disorder Unit, Department of Psychiatry and Neurology, CHU de Grenoble, Pavillon de Neurologie, BP 217, Grenoble Cedex 38043, France e-mail: <email>elhommee@chu-grenoble.fr</email>
</corresp>
<fn fn-type="present-address" id="fn001"><p><sup>†</sup>
Present address: Alim-Louis Benabid, Clinatec, DRT/LETI, CEA-Grenoble, Grenoble, France; Pierre Pollak, Service de Neurologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland</p>
</fn>
<fn fn-type="other" id="fn002"><p>This article was submitted to Movement Disorders, a section of the journal Frontiers in Neurology.</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>22</day>
<month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<volume>5</volume>
<elocation-id>55</elocation-id>
<history><date date-type="received"><day>16</day>
<month>1</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>03</day>
<month>4</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014 Lhommée, Batir, Quesada, Ardouin, Fraix, Seigneuret, Chabardès, Benabid, Pollak and Krack.</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p><bold>Background:</bold>
Parkinson’s disease (PD) is characterized by reduced flexibility, conceptualization, and visuo-spatial abilities. Although these are essential to creativity, case studies show emergence of creativity during PD. Knowledge about the role of dopamine in creativity so far only stems from a few case reports. We aim at demonstrating that creativity can be induced by dopaminergic treatments in PD, and tends to disappear after withdrawal of dopamine agonists.</p>
<p><bold>Methods:</bold>
Eleven consecutive creative PD patients were selected from candidates for subthalamic nucleus deep brain stimulation (STN DBS) surgery, and compared to 22 non-creative control PD patients. Motor disability (UPDRS III), cognition (Frontal score, Mattis scale), and behavior (Ardouin scale) were assessed before surgery and 1 year after.</p>
<p><bold>Results:</bold>
Before surgery, whereas cognitive and motor assessments were similar between groups, dopamine agonist (but not levodopa) dosages were higher in creative patients (<italic>p</italic>
= 0.01). The Ardouin scale revealed also a specific psycho-behavioral profile of creative patients which had higher scores for mania (<italic>p</italic>
< 0.001), hobbyism (<italic>p</italic>
= 0.001), nocturnal hyperactivity (<italic>p</italic>
= 0.041), appetitive functioning (<italic>p</italic>
= 0.003), and ON euphoria (<italic>p</italic>
= 0.007) and lower scores for apathy and OFF dysphoria (<italic>p</italic>
= 0.04 for each). Post-operative motor, cognitive, and behavioral scores as dopaminergic treatment dosages were equivalent between groups. Motor improvement allowed for a 68.6% decrease in dopaminergic treatment. Only 1 of the 11 patients remained creative after surgery. Reduction of dopamine agonist was significantly correlated to the decrease in creativity in the whole population of study (Spearman correlation coefficient ρ = 0.47 with confidence index of 95% = 0.16; 0.70, <italic>p</italic>
= 0.0053).</p>
<p><bold>Conclusion:</bold>
Creativity in PD is linked to dopamine agonist therapy, and tends to disappear after STN DBS in parallel to reduction of dopamine agonists, which are relatively selective for the mesolimbic D3 dopamine receptors.</p>
</abstract>
<kwd-group><kwd>STN DBS</kwd>
<kwd>impulse control disorders</kwd>
<kwd>creativity</kwd>
<kwd>dopamine</kwd>
<kwd>Parkinson’s disease</kwd>
</kwd-group>
<counts><fig-count count="5"></fig-count>
<table-count count="3"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="52"></ref-count>
<page-count count="11"></page-count>
<word-count count="7850"></word-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Lhommee, Eugenie" sort="Lhommee, Eugenie" uniqKey="Lhommee E" first="Eugénie" last="Lhommée">Eugénie Lhommée</name>
</noRegion>
<name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name>
<name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name>
<name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name>
<name sortKey="Batir, Alina" sort="Batir, Alina" uniqKey="Batir A" first="Alina" last="Batir">Alina Batir</name>
<name sortKey="Batir, Alina" sort="Batir, Alina" uniqKey="Batir A" first="Alina" last="Batir">Alina Batir</name>
<name sortKey="Batir, Alina" sort="Batir, Alina" uniqKey="Batir A" first="Alina" last="Batir">Alina Batir</name>
<name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name>
<name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name>
<name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name>
<name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name>
<name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
<name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
<name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
<name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<name sortKey="Lhommee, Eugenie" sort="Lhommee, Eugenie" uniqKey="Lhommee E" first="Eugénie" last="Lhommée">Eugénie Lhommée</name>
<name sortKey="Lhommee, Eugenie" sort="Lhommee, Eugenie" uniqKey="Lhommee E" first="Eugénie" last="Lhommée">Eugénie Lhommée</name>
<name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
<name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
<name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
<name sortKey="Quesada, Jean Louis" sort="Quesada, Jean Louis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name>
<name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name>
<name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name>
<name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name>
</country>
</tree>
</affiliations>
</record>
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