Motor-language coupling: direct evidence from early Parkinson's disease and intracranial cortical recordings.
Identifieur interne : 000099 ( Ncbi/Merge ); précédent : 000098; suivant : 000100Motor-language coupling: direct evidence from early Parkinson's disease and intracranial cortical recordings.
Auteurs : Agustín Ibá Ez [Argentine] ; Juan F. Cardona ; Yamil Vidal Dos Santos ; Alejandro Blenkmann ; Pía Aravena ; María Roca ; Esteban Hurtado ; Mirna Nerguizian ; Lucía Amoruso ; Gonzalo G Mez-Arévalo ; Anabel Chade ; Alberto Dubrovsky ; Oscar Gershanik ; Silvia Kochen ; Arthur Glenberg ; Facundo Manes ; Tristán BekinschteinSource :
- Cortex; a journal devoted to the study of the nervous system and behavior [ 1973-8102 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Analyse de variance (MeSH), Antiparkinsoniens (usage thérapeutique), Compréhension (physiologie), Cortex cérébral (physiopathologie), Cortex moteur (physiopathologie), Femelle (MeSH), Humains (MeSH), Imagerie par résonance magnétique (MeSH), Interprétation statistique de données (MeSH), Langage (MeSH), Main (physiologie), Maladie de Parkinson (physiopathologie), Maladie de Parkinson (psychologie), Maladies du système nerveux (physiopathologie), Maladies du système nerveux (psychologie), Maladies neurodégénératives (physiopathologie), Maladies neurodégénératives (psychologie), Mouvement (physiologie), Mâle (MeSH), Niveau d'instruction (MeSH), Potentiels évoqués moteurs (physiologie), Stimulation magnétique transcrânienne (MeSH), Temps de réaction (physiologie), Traitement d'image par ordinateur (MeSH), Troubles de la cognition (psychologie), Troubles de la cognition (étiologie), Électroencéphalographie (MeSH).
- MESH :
- physiologie : Compréhension, Main, Mouvement, Potentiels évoqués moteurs, Temps de réaction.
- physiopathologie : Cortex cérébral, Cortex moteur, Maladie de Parkinson, Maladies du système nerveux, Maladies neurodégénératives.
- psychologie : Maladie de Parkinson, Maladies du système nerveux, Maladies neurodégénératives, Troubles de la cognition.
- usage thérapeutique : Antiparkinsoniens.
- étiologie : Troubles de la cognition.
- Adulte d'âge moyen, Analyse de variance, Femelle, Humains, Imagerie par résonance magnétique, Interprétation statistique de données, Langage, Mâle, Niveau d'instruction, Stimulation magnétique transcrânienne, Traitement d'image par ordinateur, Électroencéphalographie.
English descriptors
- KwdEn :
- Analysis of Variance (MeSH), Antiparkinson Agents (therapeutic use), Cerebral Cortex (physiopathology), Cognition Disorders (etiology), Cognition Disorders (psychology), Comprehension (physiology), Data Interpretation, Statistical (MeSH), Educational Status (MeSH), Electroencephalography (MeSH), Evoked Potentials, Motor (physiology), Female (MeSH), Hand (physiology), Humans (MeSH), Image Processing, Computer-Assisted (MeSH), Language (MeSH), Magnetic Resonance Imaging (MeSH), Male (MeSH), Middle Aged (MeSH), Motor Cortex (physiopathology), Movement (physiology), Nervous System Diseases (physiopathology), Nervous System Diseases (psychology), Neurodegenerative Diseases (physiopathology), Neurodegenerative Diseases (psychology), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Reaction Time (physiology), Transcranial Magnetic Stimulation (MeSH).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- etiology : Cognition Disorders.
- physiology : Comprehension, Evoked Potentials, Motor, Hand, Movement, Reaction Time.
- physiopathology : Cerebral Cortex, Motor Cortex, Nervous System Diseases, Neurodegenerative Diseases, Parkinson Disease.
- psychology : Cognition Disorders, Nervous System Diseases, Neurodegenerative Diseases, Parkinson Disease.
- Analysis of Variance, Data Interpretation, Statistical, Educational Status, Electroencephalography, Female, Humans, Image Processing, Computer-Assisted, Language, Magnetic Resonance Imaging, Male, Middle Aged, Transcranial Magnetic Stimulation.
Abstract
Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease - EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.
DOI: 10.1016/j.cortex.2012.02.014
PubMed: 22482695
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000024
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Links to Exploration step
pubmed:22482695Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance (MeSH)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Cerebral Cortex (physiopathology)</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognition Disorders (psychology)</term>
<term>Comprehension (physiology)</term>
<term>Data Interpretation, Statistical (MeSH)</term>
<term>Educational Status (MeSH)</term>
<term>Electroencephalography (MeSH)</term>
<term>Evoked Potentials, Motor (physiology)</term>
<term>Female (MeSH)</term>
<term>Hand (physiology)</term>
<term>Humans (MeSH)</term>
<term>Image Processing, Computer-Assisted (MeSH)</term>
<term>Language (MeSH)</term>
<term>Magnetic Resonance Imaging (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Motor Cortex (physiopathology)</term>
<term>Movement (physiology)</term>
<term>Nervous System Diseases (physiopathology)</term>
<term>Nervous System Diseases (psychology)</term>
<term>Neurodegenerative Diseases (physiopathology)</term>
<term>Neurodegenerative Diseases (psychology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Reaction Time (physiology)</term>
<term>Transcranial Magnetic Stimulation (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse de variance (MeSH)</term>
<term>Antiparkinsoniens (usage thérapeutique)</term>
<term>Compréhension (physiologie)</term>
<term>Cortex cérébral (physiopathologie)</term>
<term>Cortex moteur (physiopathologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Imagerie par résonance magnétique (MeSH)</term>
<term>Interprétation statistique de données (MeSH)</term>
<term>Langage (MeSH)</term>
<term>Main (physiologie)</term>
<term>Maladie de Parkinson (physiopathologie)</term>
<term>Maladie de Parkinson (psychologie)</term>
<term>Maladies du système nerveux (physiopathologie)</term>
<term>Maladies du système nerveux (psychologie)</term>
<term>Maladies neurodégénératives (physiopathologie)</term>
<term>Maladies neurodégénératives (psychologie)</term>
<term>Mouvement (physiologie)</term>
<term>Mâle (MeSH)</term>
<term>Niveau d'instruction (MeSH)</term>
<term>Potentiels évoqués moteurs (physiologie)</term>
<term>Stimulation magnétique transcrânienne (MeSH)</term>
<term>Temps de réaction (physiologie)</term>
<term>Traitement d'image par ordinateur (MeSH)</term>
<term>Troubles de la cognition (psychologie)</term>
<term>Troubles de la cognition (étiologie)</term>
<term>Électroencéphalographie (MeSH)</term>
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<term>Mouvement</term>
<term>Potentiels évoqués moteurs</term>
<term>Temps de réaction</term>
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<term>Evoked Potentials, Motor</term>
<term>Hand</term>
<term>Movement</term>
<term>Reaction Time</term>
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<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Cortex cérébral</term>
<term>Cortex moteur</term>
<term>Maladie de Parkinson</term>
<term>Maladies du système nerveux</term>
<term>Maladies neurodégénératives</term>
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<term>Motor Cortex</term>
<term>Nervous System Diseases</term>
<term>Neurodegenerative Diseases</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Maladies du système nerveux</term>
<term>Maladies neurodégénératives</term>
<term>Troubles de la cognition</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cognition Disorders</term>
<term>Nervous System Diseases</term>
<term>Neurodegenerative Diseases</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term>
<term>Data Interpretation, Statistical</term>
<term>Educational Status</term>
<term>Electroencephalography</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
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<term>Magnetic Resonance Imaging</term>
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<term>Transcranial Magnetic Stimulation</term>
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<term>Analyse de variance</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Interprétation statistique de données</term>
<term>Langage</term>
<term>Mâle</term>
<term>Niveau d'instruction</term>
<term>Stimulation magnétique transcrânienne</term>
<term>Traitement d'image par ordinateur</term>
<term>Électroencéphalographie</term>
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<front><div type="abstract" xml:lang="en">Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease - EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.</div>
</front>
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<Abstract><AbstractText>Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease - EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.</AbstractText>
<CopyrightInformation>Copyright © 2012 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ibáñez</LastName>
<ForeName>Agustín</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University, Buenos Aires, Argentina. aibanez@ineco.org.ar</Affiliation>
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<Author ValidYN="Y"><LastName>Cardona</LastName>
<ForeName>Juan F</ForeName>
<Initials>JF</Initials>
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<Author ValidYN="Y"><LastName>Dos Santos</LastName>
<ForeName>Yamil Vidal</ForeName>
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<ForeName>Alejandro</ForeName>
<Initials>A</Initials>
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<affiliations><list><country><li>Argentine</li>
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