Cannabinoids in health and disease
Identifieur interne : 000024 ( Ncbi/Merge ); précédent : 000023; suivant : 000025Cannabinoids in health and disease
Auteurs : Natalya M. KoganSource :
- Dialogues in Clinical Neuroscience [ 1294-8322 ] ; 2007.
Abstract
Cannabis sativa L. preparations have been used in medicine for millenia. However, concern over the dangers of abuse led to the banning of the medicinal use of marijuana in most countries in the 1930s. Only recently, marijuana and individual natural and synthetic cannabinoid receptor agonists and antagonists, as well as chemically related compounds, whose mechanism of action is still obscure, have come back to being considered of therapeutic value. However, their use is highly restricted. Despite the mild addiction to cannabis and the possible enhancement of addiction to other substances of abuse, when combined with cannabis, the therapeutic value of cannabinoids is too high to be put aside. Numerous diseases, such as anorexia, emesis, pain, inflammation, multiple sclerosis, neurodegenerative disorders (Parkinson's disease, Huntington's disease, Tourette's syndrome, Alzheimer's disease), epilepsy, glaucoma, osteoporosis, schizophrenia, cardiovascular disorders, cancer, obesity, and metabolic syndrome-related disorders, to name just a few, are being treated or have the potential to be treated by cannabinoid agonists/antagonists/cannabinoid-related compounds. In view of the very low toxicity and the generally benign side effects of this group of compounds, neglecting or denying their clinical potential is unacceptable - instead, we need to work on the development of more selective cannabinoid receptor agonists/antagonists and related compounds, as well as on novel drugs of this family with better selectivity, distribution patterns, and pharmacokinetics, and - in cases where it is impossible to separate the desired clinical action and the psychoactivity - just to monitor these side effects carefully.
Url:
PubMed: 18286801
PubMed Central: 3202504
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000276
- to stream Pmc, to step Curation: 000164
- to stream Pmc, to step Checkpoint: 000180
Links to Exploration step
PMC:3202504Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cannabinoids in health and disease</title><author><name sortKey="Kogan, Natalya M" sort="Kogan, Natalya M" uniqKey="Kogan N" first="Natalya M." last="Kogan">Natalya M. Kogan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18286801</idno><idno type="pmc">3202504</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202504</idno><idno type="RBID">PMC:3202504</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">000276</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000276</idno><idno type="wicri:Area/Pmc/Curation">000164</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000164</idno><idno type="wicri:Area/Pmc/Checkpoint">000180</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000180</idno><idno type="wicri:Area/Ncbi/Merge">000024</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cannabinoids in health and disease</title><author><name sortKey="Kogan, Natalya M" sort="Kogan, Natalya M" uniqKey="Kogan N" first="Natalya M." last="Kogan">Natalya M. Kogan</name></author></analytic><series><title level="j">Dialogues in Clinical Neuroscience</title><idno type="ISSN">1294-8322</idno><idno type="eISSN">1958-5969</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cannabis sativa L. preparations have been used in medicine for millenia. However, concern over the dangers of abuse led to the banning of the medicinal use of marijuana in most countries in the 1930s. Only recently, marijuana and individual natural and synthetic cannabinoid receptor agonists and antagonists, as well as chemically related compounds, whose mechanism of action is still obscure, have come back to being considered of therapeutic value. However, their use is highly restricted. Despite the mild addiction to cannabis and the possible enhancement of addiction to other substances of abuse, when combined with cannabis, the therapeutic value of cannabinoids is too high to be put aside. Numerous diseases, such as anorexia, emesis, pain, inflammation, multiple sclerosis, neurodegenerative disorders (Parkinson's disease, Huntington's disease, Tourette's syndrome, Alzheimer's disease), epilepsy, glaucoma, osteoporosis, schizophrenia, cardiovascular disorders, cancer, obesity, and metabolic syndrome-related disorders, to name just a few, are being treated or have the potential to be treated by cannabinoid agonists/antagonists/cannabinoid-related compounds. In view of the very low toxicity and the generally benign side effects of this group of compounds, neglecting or denying their clinical potential is unacceptable - instead, we need to work on the development of more selective cannabinoid receptor agonists/antagonists and related compounds, as well as on novel drugs of this family with better selectivity, distribution patterns, and pharmacokinetics, and - in cases where it is impossible to separate the desired clinical action and the psychoactivity - just to monitor these side effects carefully.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zias, J" uniqKey="Zias J">J. Zias</name></author><author><name sortKey="Stark, H" uniqKey="Stark H">H. Stark</name></author><author><name sortKey="Sellgman, J" uniqKey="Sellgman J">J. Sellgman</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schlesinger, S" uniqKey="Schlesinger S">S. Schlesinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decourtive, E" uniqKey="Decourtive E">E. Decourtive</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mechoulam, R" uniqKey="Mechoulam R">R. Mechoulam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mechoulam, R" uniqKey="Mechoulam R">R. Mechoulam</name></author><author><name sortKey="Hanus, L" uniqKey="Hanus L">L. Hanus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaoni, Y" uniqKey="Gaoni Y">Y. Gaoni</name></author><author><name sortKey="Mechoulam, R" uniqKey="Mechoulam R">R. Mechoulam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waller, Cw Jj" uniqKey="Waller C">CW. JJ. Waller</name></author><author><name sortKey="Buelke, J" uniqKey="Buelke J">J. Buelke</name></author><author><name sortKey="Turner, Ce" uniqKey="Turner C">CE. Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fraser, Jd" uniqKey="Fraser J">JD. Fraser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grinspoon, L" uniqKey="Grinspoon L">L. Grinspoon</name></author><author><name sortKey="Bakalar, Jb" uniqKey="Bakalar J">JB. Bakalar</name></author><author><name sortKey="Zimmer, L" uniqKey="Zimmer L">L. Zimmer</name></author><author><name sortKey="Morgan, Jp" uniqKey="Morgan J">JP. Morgan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaymakcalan, S" uniqKey="Kaymakcalan S">S. Kaymakcalan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Rt" uniqKey="Jones R">RT. Jones</name></author><author><name sortKey="Benowitz, N" uniqKey="Benowitz N">N. Benowitz</name></author><author><name sortKey="Bachman, J" uniqKey="Bachman J">J. Bachman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nordstrom, Br" uniqKey="Nordstrom B">BR. Nordstrom</name></author><author><name sortKey="Levin, Fr" uniqKey="Levin F">FR. Levin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernoussi, A" uniqKey="Bernoussi A">A. Bernoussi</name></author><author><name sortKey="Brandibas, G" uniqKey="Brandibas G">G. Brandibas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Budney, Aj" uniqKey="Budney A">AJ. Budney</name></author><author><name sortKey="Moore, Ba" uniqKey="Moore B">BA. Moore</name></author><author><name sortKey="Rocha, Hl" uniqKey="Rocha H">HL. Rocha</name></author><author><name sortKey="Higgins, St" uniqKey="Higgins S">ST. Higgins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gardner, El" uniqKey="Gardner E">EL. Gardner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maldonado, R" uniqKey="Maldonado R">R. Maldonado</name></author><author><name sortKey="Rodriguez, De Fonseca F" uniqKey="Rodriguez D">de Fonseca F. Rodriguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mansbach, Rs" uniqKey="Mansbach R">RS. Mansbach</name></author><author><name sortKey="Nicholson, Kl" uniqKey="Nicholson K">KL. Nicholson</name></author><author><name sortKey="Martin, Br" uniqKey="Martin B">BR. Martin</name></author><author><name sortKey="Balster, Rl" uniqKey="Balster R">RL. Balster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colombo, G" uniqKey="Colombo G">G. Colombo</name></author><author><name sortKey="Serra, S" uniqKey="Serra S">S. Serra</name></author><author><name sortKey="Vacca, G" uniqKey="Vacca G">G. Vacca</name></author><author><name sortKey="Carai, Ma" uniqKey="Carai M">MA. Carai</name></author><author><name sortKey="Gessa, Gl" uniqKey="Gessa G">GL. Gessa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author><author><name sortKey="Harvey White, J" uniqKey="Harvey White J">J. Harvey-White</name></author><author><name sortKey="Zimmer, A" uniqKey="Zimmer A">A. Zimmer</name></author><author><name sortKey="Kunos, G" uniqKey="Kunos G">G. Kunos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, C" uniqKey="Cohen C">C. Cohen</name></author><author><name sortKey="Perrault, G" uniqKey="Perrault G">G. Perrault</name></author><author><name sortKey="Voltz, C" uniqKey="Voltz C">C. Voltz</name></author><author><name sortKey="Steinberg, R" uniqKey="Steinberg R">R. Steinberg</name></author><author><name sortKey="Soubrie, P" uniqKey="Soubrie P">P. Soubrie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Ns" uniqKey="Miller N">NS. Miller</name></author><author><name sortKey="Gold, Ms" uniqKey="Gold M">MS. Gold</name></author><author><name sortKey="Klahr, Al" uniqKey="Klahr A">AL. Klahr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Foltin, Rw" uniqKey="Foltin R">RW. Foltin</name></author><author><name sortKey="Fischman, Mw" uniqKey="Fischman M">MW. Fischman</name></author><author><name sortKey="Pippen, Pa" uniqKey="Pippen P">PA. Pippen</name></author><author><name sortKey="Kelly, Th" uniqKey="Kelly T">TH. Kelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lukas, Se" uniqKey="Lukas S">SE. Lukas</name></author><author><name sortKey="Sholar, M" uniqKey="Sholar M">M. Sholar</name></author><author><name sortKey="Kouri, E" uniqKey="Kouri E">E. Kouri</name></author><author><name sortKey="Fukuzako, H" uniqKey="Fukuzako H">H. Fukuzako</name></author><author><name sortKey="Mendelson, Jh" uniqKey="Mendelson J">JH. Mendelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ballon, N" uniqKey="Ballon N">N. Ballon</name></author><author><name sortKey="Leroy, S" uniqKey="Leroy S">S. Leroy</name></author><author><name sortKey="Roy, C" uniqKey="Roy C">C. Roy</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Filip, M" uniqKey="Filip M">M. Filip</name></author><author><name sortKey="Golda, A" uniqKey="Golda A">A. Golda</name></author><author><name sortKey="Zaniewska, M" uniqKey="Zaniewska M">M. Zaniewska</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Foll, B" uniqKey="Le Foll B">B. Le Foll</name></author><author><name sortKey="Goldberg, Sr" uniqKey="Goldberg S">SR. Goldberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, C" uniqKey="Cohen C">C. Cohen</name></author><author><name sortKey="Perrault, G" uniqKey="Perrault G">G. Perrault</name></author><author><name sortKey="Griebel, G" uniqKey="Griebel G">G. Griebel</name></author><author><name sortKey="Soubrie, P" uniqKey="Soubrie P">P. Soubrie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castane, A" uniqKey="Castane A">A. Castane</name></author><author><name sortKey="Berrendero, F" uniqKey="Berrendero F">F. Berrendero</name></author><author><name sortKey="Maldonado, R" uniqKey="Maldonado R">R. Maldonado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Einecke, D" uniqKey="Einecke D">D. Einecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Foulds, J" uniqKey="Foulds J">J. Foulds</name></author><author><name sortKey="Burke, M" uniqKey="Burke M">M. Burke</name></author><author><name sortKey="Steinberg, M" uniqKey="Steinberg M">M. Steinberg</name></author><author><name sortKey="Williams, Jm" uniqKey="Williams J">JM. Williams</name></author><author><name sortKey="Ziedonis, Dm" uniqKey="Ziedonis D">DM. Ziedonis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gelfand, Ev" uniqKey="Gelfand E">EV. Gelfand</name></author><author><name sortKey="Cannon, Cp" uniqKey="Cannon C">CP. Cannon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yao, L" uniqKey="Yao L">L. Yao</name></author><author><name sortKey="Mcfarland, K" uniqKey="Mcfarland K">K. McFarland</name></author><author><name sortKey="Fan, P" uniqKey="Fan P">P. Fan</name></author><author><name sortKey="Jiang, Z" uniqKey="Jiang Z">Z. Jiang</name></author><author><name sortKey="Ueda, T" uniqKey="Ueda T">T. Ueda</name></author><author><name sortKey="Diamond, I" uniqKey="Diamond I">I. Diamond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ledent, C" uniqKey="Ledent C">C. Ledent</name></author><author><name sortKey="Valverde, O" uniqKey="Valverde O">O. Valverde</name></author><author><name sortKey="Cossu, G" uniqKey="Cossu G">G. Cossu</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laviolette, Sr" uniqKey="Laviolette S">SR. Laviolette</name></author><author><name sortKey="Grace, Aa" uniqKey="Grace A">AA. Grace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Foll, B" uniqKey="Le Foll B">B. Le Foll</name></author><author><name sortKey="Goldberg, Sr" uniqKey="Goldberg S">SR. Goldberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Solowij, N" uniqKey="Solowij N">N. Solowij</name></author><author><name sortKey="Stephens, Rs" uniqKey="Stephens R">RS. Stephens</name></author><author><name sortKey="Roffman, Ra" uniqKey="Roffman R">RA. Roffman</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klugman, A" uniqKey="Klugman A">A. Klugman</name></author><author><name sortKey="Gruzelier, J" uniqKey="Gruzelier J">J. Gruzelier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wadsworth, Ej" uniqKey="Wadsworth E">EJ. Wadsworth</name></author><author><name sortKey="Moss, Sc" uniqKey="Moss S">SC. Moss</name></author><author><name sortKey="Simpson, Sa" uniqKey="Simpson S">SA. Simpson</name></author><author><name sortKey="Smith, Ap" uniqKey="Smith A">AP. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jager, G" uniqKey="Jager G">G. Jager</name></author><author><name sortKey="Kahn, Rs" uniqKey="Kahn R">RS. Kahn</name></author><author><name sortKey="Van Den Brink, W" uniqKey="Van Den Brink W">W. Van Den Brink</name></author><author><name sortKey="Van Ree, Jm" uniqKey="Van Ree J">JM. Van Ree</name></author><author><name sortKey="Ramsey, Nf" uniqKey="Ramsey N">NF. Ramsey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maj, Pf" uniqKey="Maj P">PF. Maj</name></author><author><name sortKey="Collu, M" uniqKey="Collu M">M. Collu</name></author><author><name sortKey="Fadda, P" uniqKey="Fadda P">P. Fadda</name></author><author><name sortKey="Cattaneo, A" uniqKey="Cattaneo A">A. Cattaneo</name></author><author><name sortKey="Racagni, G" uniqKey="Racagni G">G. Racagni</name></author><author><name sortKey="Riva, Ma" uniqKey="Riva M">MA. Riva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huizink, Ac" uniqKey="Huizink A">AC. Huizink</name></author><author><name sortKey="Mulder, Ej" uniqKey="Mulder E">EJ. Mulder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fried, Pa" uniqKey="Fried P">PA. Fried</name></author><author><name sortKey="Smith, Am" uniqKey="Smith A">AM. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, Rm" uniqKey="Murray R">RM. Murray</name></author><author><name sortKey="Morrison, Pd" uniqKey="Morrison P">PD. Morrison</name></author><author><name sortKey="Henquet, C" uniqKey="Henquet C">C. Henquet</name></author><author><name sortKey="Di Forti, M" uniqKey="Di Forti M">M. Di Forti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Solowij, N" uniqKey="Solowij N">N. Solowij</name></author><author><name sortKey="Michie, Pt" uniqKey="Michie P">PT. Michie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Favrat, B" uniqKey="Favrat B">B. Favrat</name></author><author><name sortKey="Menetrey, A" uniqKey="Menetrey A">A. Menetrey</name></author><author><name sortKey="Augsburger, M" uniqKey="Augsburger M">M. Augsburger</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Souza, Dc" uniqKey="D Souza D">DC. D'Souza</name></author><author><name sortKey="Perry, E" uniqKey="Perry E">E. Perry</name></author><author><name sortKey="Macdougall, L" uniqKey="Macdougall L">L. MacDougall</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozaki, S" uniqKey="Ozaki S">S. Ozaki</name></author><author><name sortKey="Wada, K" uniqKey="Wada K">K. Wada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujiwara, M" uniqKey="Fujiwara M">M. Fujiwara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tunving, K" uniqKey="Tunving K">K. Tunving</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laqueille, X" uniqKey="Laqueille X">X. Laqueille</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mendelson, Jh" uniqKey="Mendelson J">JH. Mendelson</name></author><author><name sortKey="Kuehnle, Jc" uniqKey="Kuehnle J">JC. Kuehnle</name></author><author><name sortKey="Greenberg, I" uniqKey="Greenberg I">I. Greenberg</name></author><author><name sortKey="Mello, Nk" uniqKey="Mello N">NK. Mello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnwell, Ss" uniqKey="Barnwell S">SS. Barnwell</name></author><author><name sortKey="Earleywine, M" uniqKey="Earleywine M">M. Earleywine</name></author><author><name sortKey="Wilcox, R" uniqKey="Wilcox R">R. Wilcox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wargo, Ka" uniqKey="Wargo K">KA. Wargo</name></author><author><name sortKey="Geveden, Bn" uniqKey="Geveden B">BN. Geveden</name></author><author><name sortKey="Mcconnell, Vj" uniqKey="Mcconnell V">VJ. McConnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirkham, Tc" uniqKey="Kirkham T">TC. Kirkham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirkham, Tc" uniqKey="Kirkham T">TC. Kirkham</name></author><author><name sortKey="Tucci, Sa" uniqKey="Tucci S">SA. Tucci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Russo, P" uniqKey="Russo P">P. Russo</name></author><author><name sortKey="Strazzullo, P" uniqKey="Strazzullo P">P. Strazzullo</name></author><author><name sortKey="Cappuccio, Fp" uniqKey="Cappuccio F">FP. Cappuccio</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gessa, Gl" uniqKey="Gessa G">GL. Gessa</name></author><author><name sortKey="Orru, A" uniqKey="Orru A">A. Orru</name></author><author><name sortKey="Lai, P" uniqKey="Lai P">P. Lai</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ward, Sj" uniqKey="Ward S">SJ. Ward</name></author><author><name sortKey="Dykstra, La" uniqKey="Dykstra L">LA. Dykstra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simiand, J" uniqKey="Simiand J">J. Simiand</name></author><author><name sortKey="Keane, M" uniqKey="Keane M">M. Keane</name></author><author><name sortKey="Keane, Pe" uniqKey="Keane P">PE. Keane</name></author><author><name sortKey="Soubrie, P" uniqKey="Soubrie P">P. Soubrie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carai, Ma" uniqKey="Carai M">MA. Carai</name></author><author><name sortKey="Colombo, G" uniqKey="Colombo G">G Colombo</name></author><author><name sortKey="Maccioni, P" uniqKey="Maccioni P">P. Maccioni</name></author><author><name sortKey="Gessa, Gl" uniqKey="Gessa G">GL. Gessa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pagotto, U" uniqKey="Pagotto U">U. Pagotto</name></author><author><name sortKey="Pasquali, R" uniqKey="Pasquali R">R. Pasquali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Despres, Jp" uniqKey="Despres J">JP. Despres</name></author><author><name sortKey="Golay, A" uniqKey="Golay A">A. Golay</name></author><author><name sortKey="Sjostrom, L" uniqKey="Sjostrom L">L. Sjostrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pi Sunyer, Fx" uniqKey="Pi Sunyer F">FX. Pi-Sunyer</name></author><author><name sortKey="Aronne, Lj" uniqKey="Aronne L">LJ. Aronne</name></author><author><name sortKey="Heshmati, Hm" uniqKey="Heshmati H">HM. Heshmati</name></author><author><name sortKey="Devin, J" uniqKey="Devin J">J. Devin</name></author><author><name sortKey="Rosenstock, J" uniqKey="Rosenstock J">J. Rosenstock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Gaal, Lf" uniqKey="Van Gaal L">LF. Van Gaal</name></author><author><name sortKey="Rissanen, Am" uniqKey="Rissanen A">AM. Rissanen</name></author><author><name sortKey="Scheen, Aj" uniqKey="Scheen A">AJ. Scheen</name></author><author><name sortKey="Ziegler, O" uniqKey="Ziegler O">O. Ziegler</name></author><author><name sortKey="Rossner, S" uniqKey="Rossner S">S. Rossner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cleland, Jg" uniqKey="Cleland J">JG. Cleland</name></author><author><name sortKey="Ghosh, J" uniqKey="Ghosh J">J. Ghosh</name></author><author><name sortKey="Freemantle, N" uniqKey="Freemantle N">N. Freemantle</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scheen, Aj" uniqKey="Scheen A">AJ. Scheen</name></author><author><name sortKey="Van Gaal, Lg" uniqKey="Van Gaal L">LG. Van Gaal</name></author><author><name sortKey="Despres, Jp" uniqKey="Despres J">JP. Despres</name></author><author><name sortKey="Pi Sunyer, X" uniqKey="Pi Sunyer X">X. Pi-Sunyer</name></author><author><name sortKey="Golay, A" uniqKey="Golay A">A. Golay</name></author><author><name sortKey="Hanotin, C" uniqKey="Hanotin C">C. Hanotin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shapiro, H" uniqKey="Shapiro H">H. Shapiro</name></author><author><name sortKey="Singer, P" uniqKey="Singer P">P. Singer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, Pn" uniqKey="Patel P">PN. Patel</name></author><author><name sortKey="Pathak, R" uniqKey="Pathak R">R. Pathak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beal, Je" uniqKey="Beal J">JE. Beal</name></author><author><name sortKey="Olson, R" uniqKey="Olson R">R. Olson</name></author><author><name sortKey="Lefkowitz, L" uniqKey="Lefkowitz L">L. Lefkowitz</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beal, Je" uniqKey="Beal J">JE. Beal</name></author><author><name sortKey="Olson, R" uniqKey="Olson R">R. Olson</name></author><author><name sortKey="Laubenstein, L" uniqKey="Laubenstein L">L. Laubenstein</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorter, R" uniqKey="Gorter R">R. Gorter</name></author><author><name sortKey="Seefried, M" uniqKey="Seefried M">M. Seefried</name></author><author><name sortKey="Volberding, P" uniqKey="Volberding P">P. Volberding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Timpone, Jg" uniqKey="Timpone J">JG. Timpone</name></author><author><name sortKey="Wright, Dj" uniqKey="Wright D">DJ. Wright</name></author><author><name sortKey="Li, N" uniqKey="Li N">N. Li</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nauck, F" uniqKey="Nauck F">F. Nauck</name></author><author><name sortKey="Klaschik, E" uniqKey="Klaschik E">E. Klaschik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, K" uniqKey="Nelson K">K. Nelson</name></author><author><name sortKey="Walsh, D" uniqKey="Walsh D">D. Walsh</name></author><author><name sortKey="Deeter, P" uniqKey="Deeter P">P. Deeter</name></author><author><name sortKey="Sheehan, F" uniqKey="Sheehan F">F. Sheehan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Br" uniqKey="Martin B">BR. Martin</name></author><author><name sortKey="Wiley, Jl" uniqKey="Wiley J">JL. Wiley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abrahamov, A" uniqKey="Abrahamov A">A. Abrahamov</name></author><author><name sortKey="Abrahamov, A" uniqKey="Abrahamov A">A. Abrahamov</name></author><author><name sortKey="Mechoulam, R" uniqKey="Mechoulam R">R. Mechoulam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tramer, Mr" uniqKey="Tramer M">MR. Tramer</name></author><author><name sortKey="Carroll, D" uniqKey="Carroll D">D. Carroll</name></author><author><name sortKey="Campbell, Fa" uniqKey="Campbell F">FA. Campbell</name></author><author><name sortKey="Reynolds, Dj" uniqKey="Reynolds D">DJ. Reynolds</name></author><author><name sortKey="Moore, Ra" uniqKey="Moore R">RA. Moore</name></author><author><name sortKey="Mcquay, Hj" uniqKey="Mcquay H">HJ. McQuay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, Yc" uniqKey="Liang Y">YC. Liang</name></author><author><name sortKey="Huang, Cc" uniqKey="Huang C">CC. Huang</name></author><author><name sortKey="Hsu, Ks" uniqKey="Hsu K">KS. Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volfe, Z" uniqKey="Volfe Z">Z. Volfe</name></author><author><name sortKey="Dvilansky, A" uniqKey="Dvilansky A">A. Dvilansky</name></author><author><name sortKey="Nathan, I" uniqKey="Nathan I">I. Nathan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Attal, N" uniqKey="Attal N">N. Attal</name></author><author><name sortKey="Brasseur, L" uniqKey="Brasseur L">L. Brasseur</name></author><author><name sortKey="Guirimand, D" uniqKey="Guirimand D">D. Guirimand</name></author><author><name sortKey="Clermond Gnamien, S" uniqKey="Clermond Gnamien S">S. Clermond-Gnamien</name></author><author><name sortKey="Atlami, S" uniqKey="Atlami S">S. Atlami</name></author><author><name sortKey="Bouhassira, D" uniqKey="Bouhassira D">D. Bouhassira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buggy, Dj" uniqKey="Buggy D">DJ. Buggy</name></author><author><name sortKey="Toogood, L" uniqKey="Toogood L">L. Toogood</name></author><author><name sortKey="Marie, S" uniqKey="Marie S">S. Marie</name></author><author><name sortKey="Sharpe, P" uniqKey="Sharpe P">P. Sharpe</name></author><author><name sortKey="Lambert, Dg" uniqKey="Lambert D">DG. Lambert</name></author><author><name sortKey="Rowbotham, Dj" uniqKey="Rowbotham D">DJ. Rowbotham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holdcroft, A" uniqKey="Holdcroft A">A. Holdcroft</name></author><author><name sortKey="Smith, M" uniqKey="Smith M">M. Smith</name></author><author><name sortKey="Jacklin, A" uniqKey="Jacklin A">A. Jacklin</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berman, Js" uniqKey="Berman J">JS. Berman</name></author><author><name sortKey="Symonds, C" uniqKey="Symonds C">C. Symonds</name></author><author><name sortKey="Birch, R" uniqKey="Birch R">R. Birch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Svendsen, Kb" uniqKey="Svendsen K">KB. Svendsen</name></author><author><name sortKey="Jensen, Ts" uniqKey="Jensen T">TS. Jensen</name></author><author><name sortKey="Bach, Fw" uniqKey="Bach F">FW. Bach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Svendsen, Kb" uniqKey="Svendsen K">KB. Svendsen</name></author><author><name sortKey="Jensen, Ts" uniqKey="Jensen T">TS. Jensen</name></author><author><name sortKey="Bach, Fw" uniqKey="Bach F">FW. Bach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noyes, R" uniqKey="Noyes R">R. Noyes</name></author><author><name sortKey="Jr" uniqKey="Jr">Jr.</name></author><author><name sortKey="Brunk, Sf" uniqKey="Brunk S">SF. Brunk</name></author><author><name sortKey="Avery, Da" uniqKey="Avery D">DA. Avery</name></author><author><name sortKey="Canter, Ac" uniqKey="Canter A">AC. Canter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noyes, R" uniqKey="Noyes R">R. Noyes</name></author><author><name sortKey="Jr" uniqKey="Jr">Jr.</name></author><author><name sortKey="Brunk, Sf" uniqKey="Brunk S">SF. Brunk</name></author><author><name sortKey="Baram, Da" uniqKey="Baram D">DA. Baram</name></author><author><name sortKey="Canter, A" uniqKey="Canter A">A. Canter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ware, Ma" uniqKey="Ware M">MA. Ware</name></author><author><name sortKey="Doyle, Cr" uniqKey="Doyle C">CR. Doyle</name></author><author><name sortKey="Woods, R" uniqKey="Woods R">R. Woods</name></author><author><name sortKey="Lynch, Me" uniqKey="Lynch M">ME. Lynch</name></author><author><name sortKey="Clark, Aj" uniqKey="Clark A">AJ. Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woolridge, E" uniqKey="Woolridge E">E. Woolridge</name></author><author><name sortKey="Barton, S" uniqKey="Barton S">S. Barton</name></author><author><name sortKey="Samuel, J" uniqKey="Samuel J">J. Samuel</name></author><author><name sortKey="Osorio, J" uniqKey="Osorio J">J. Osorio</name></author><author><name sortKey="Dougherty, A" uniqKey="Dougherty A">A. Dougherty</name></author><author><name sortKey="Holdcroft, A" uniqKey="Holdcroft A">A. Holdcroft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berlach, Dm" uniqKey="Berlach D">DM. Berlach</name></author><author><name sortKey="Shir, Y" uniqKey="Shir Y">Y. Shir</name></author><author><name sortKey="Ware, Ma" uniqKey="Ware M">MA. Ware</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wissel, J" uniqKey="Wissel J">J. Wissel</name></author><author><name sortKey="Haydn, T" uniqKey="Haydn T">T. Haydn</name></author><author><name sortKey="Muiier, J" uniqKey="Muiier J">J. MuIIer</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karst, M" uniqKey="Karst M">M. Karst</name></author><author><name sortKey="Salim, K" uniqKey="Salim K">K. Salim</name></author><author><name sortKey="Burstein, S" uniqKey="Burstein S">S. Burstein</name></author><author><name sortKey="Conrad, I" uniqKey="Conrad I">I. Conrad</name></author><author><name sortKey="Hoy, L" uniqKey="Hoy L">L. Hoy</name></author><author><name sortKey="Schneider, U" uniqKey="Schneider U">U. Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vann, Re" uniqKey="Vann R">RE. Vann</name></author><author><name sortKey="Cook, Cd" uniqKey="Cook C">CD. Cook</name></author><author><name sortKey="Martin, Br" uniqKey="Martin B">BR. Martin</name></author><author><name sortKey="Jenny, L" uniqKey="Jenny L">L. Jenny</name></author><author><name sortKey="Wiley, Jl" uniqKey="Wiley J">JL. Wiley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Russo, E" uniqKey="Russo E">E. Russo</name></author><author><name sortKey="Guy, Gw" uniqKey="Guy G">GW. Guy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iskedjian, M" uniqKey="Iskedjian M">M. Iskedjian</name></author><author><name sortKey="Bereza, B" uniqKey="Bereza B">B. Bereza</name></author><author><name sortKey="Gordon, A" uniqKey="Gordon A">A. Gordon</name></author><author><name sortKey="Piwko, C" uniqKey="Piwko C">C. Piwko</name></author><author><name sortKey="Einarson, Tr" uniqKey="Einarson T">TR. Einarson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Notcutt, W" uniqKey="Notcutt W">W. Notcutt</name></author><author><name sortKey="Price, M" uniqKey="Price M">M. Price</name></author><author><name sortKey="Miller, R" uniqKey="Miller R">R. Miller</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rog, Dj" uniqKey="Rog D">DJ. Rog</name></author><author><name sortKey="Nurmikko, Tj" uniqKey="Nurmikko T">TJ. Nurmikko</name></author><author><name sortKey="Friede, T" uniqKey="Friede T">T. Friede</name></author><author><name sortKey="Young, Ca" uniqKey="Young C">CA. Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnes, Mp" uniqKey="Barnes M">MP. Barnes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez, J" uniqKey="Perez J">J. Perez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ware, M" uniqKey="Ware M">M. Ware</name></author><author><name sortKey="Beaulieu, P" uniqKey="Beaulieu P">P. Beaulieu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Achiron, A" uniqKey="Achiron A">A. Achiron</name></author><author><name sortKey="Miron, S" uniqKey="Miron S">S. Miron</name></author><author><name sortKey="Lavie, V" uniqKey="Lavie V">V. Lavie</name></author><author><name sortKey="Margalit, R" uniqKey="Margalit R">R. Margalit</name></author><author><name sortKey="Biegon, A" uniqKey="Biegon A">A. Biegon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyman, Wd" uniqKey="Lyman W">WD. Lyman</name></author><author><name sortKey="Sonett, Jr" uniqKey="Sonett J">JR. Sonett</name></author><author><name sortKey="Brosnan, Cf" uniqKey="Brosnan C">CF. Brosnan</name></author><author><name sortKey="Elkin, R" uniqKey="Elkin R">R. Elkin</name></author><author><name sortKey="Bornstein, Mb" uniqKey="Bornstein M">MB. Bornstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez, Aj" uniqKey="Sanchez A">AJ. Sanchez</name></author><author><name sortKey="Gonzalez Perez, P" uniqKey="Gonzalez Perez P">P. Gonzalez-Perez</name></author><author><name sortKey="Galve Roperh, I" uniqKey="Galve Roperh I">I. Galve-Roperh</name></author><author><name sortKey="Garcia Merino, A" uniqKey="Garcia Merino A">A. Garcia-Merino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Docagne, F" uniqKey="Docagne F">F. Docagne</name></author><author><name sortKey="Muneton, V" uniqKey="Muneton V">V. Muneton</name></author><author><name sortKey="Clemente, D" uniqKey="Clemente D">D. Clemente</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benito, C" uniqKey="Benito C">C. Benito</name></author><author><name sortKey="Romero, Jp" uniqKey="Romero J">JP. Romero</name></author><author><name sortKey="Tolon, Rm" uniqKey="Tolon R">RM. Tolon</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cabranes, A" uniqKey="Cabranes A">A. Cabranes</name></author><author><name sortKey="Pryce, G" uniqKey="Pryce G">G. Pryce</name></author><author><name sortKey="Baker, D" uniqKey="Baker D">D. Baker</name></author><author><name sortKey="Fernandez Ruiz, J" uniqKey="Fernandez Ruiz J">J. Fernandez-Ruiz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petro, Dj" uniqKey="Petro D">DJ. Petro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pryce, G" uniqKey="Pryce G">G. Pryce</name></author><author><name sortKey="Baker, D" uniqKey="Baker D">D. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ungerieider, Jt" uniqKey="Ungerieider J">JT. UngerIeider</name></author><author><name sortKey="Andyrsiak, T" uniqKey="Andyrsiak T">T. Andyrsiak</name></author><author><name sortKey="Fairbanks, L" uniqKey="Fairbanks L">L. Fairbanks</name></author><author><name sortKey="Ellison, Gw" uniqKey="Ellison G">GW. Ellison</name></author><author><name sortKey="Myers, Lw" uniqKey="Myers L">LW. Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martyn, Cn" uniqKey="Martyn C">CN. Martyn</name></author><author><name sortKey="Lllis, Ls" uniqKey="Lllis L">LS. lllis</name></author><author><name sortKey="Thom, J" uniqKey="Thom J">J. Thom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meinck, Hm" uniqKey="Meinck H">HM. Meinck</name></author><author><name sortKey="Schonle, Pw" uniqKey="Schonle P">PW. Schonle</name></author><author><name sortKey="Conrad, B" uniqKey="Conrad B">B. Conrad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petro, Dj" uniqKey="Petro D">DJ. Petro</name></author><author><name sortKey="Ellenberger, C" uniqKey="Ellenberger C">C. Ellenberger</name></author><author><name sortKey="Jr" uniqKey="Jr">Jr.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenneisen, R" uniqKey="Brenneisen R">R. Brenneisen</name></author><author><name sortKey="Egli, A" uniqKey="Egli A">A. Egli</name></author><author><name sortKey="Elsohly, Ma" uniqKey="Elsohly M">MA. Elsohly</name></author><author><name sortKey="Henn, V" uniqKey="Henn V">V. Henn</name></author><author><name sortKey="Spiess, Y" uniqKey="Spiess Y">Y. Spiess</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koch, M" uniqKey="Koch M">M. Koch</name></author><author><name sortKey="Mostert, J" uniqKey="Mostert J">J. Mostert</name></author><author><name sortKey="Heersema, D" uniqKey="Heersema D">D. Heersema</name></author><author><name sortKey="De Keyser, J" uniqKey="De Keyser J">J. De Keyser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Killestein, J" uniqKey="Killestein J">J. Killestein</name></author><author><name sortKey="Hoogervorst, El" uniqKey="Hoogervorst E">EL. Hoogervorst</name></author><author><name sortKey="Reif, M" uniqKey="Reif M">M. Reif</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenberg, Hs" uniqKey="Greenberg H">HS. Greenberg</name></author><author><name sortKey="Werness, Sa" uniqKey="Werness S">SA. Werness</name></author><author><name sortKey="Pugh, Je" uniqKey="Pugh J">JE. Pugh</name></author><author><name sortKey="Andrus, Ro" uniqKey="Andrus R">RO. Andrus</name></author><author><name sortKey="Anderson, Dj" uniqKey="Anderson D">DJ. Anderson</name></author><author><name sortKey="Domino, Ef" uniqKey="Domino E">EF. Domino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clifford, Db" uniqKey="Clifford D">DB. Clifford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, P" uniqKey="Fox P">P. Fox</name></author><author><name sortKey="Bain, Pg" uniqKey="Bain P">PG. Bain</name></author><author><name sortKey="Glickman, S" uniqKey="Glickman S">S. Glickman</name></author><author><name sortKey="Carroll, C" uniqKey="Carroll C">C. Carroll</name></author><author><name sortKey="Zajicek, J" uniqKey="Zajicek J">J. Zajicek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schon, F" uniqKey="Schon F">F. Schon</name></author><author><name sortKey="Hart, Pe" uniqKey="Hart P">PE. Hart</name></author><author><name sortKey="Hodgson, Tl" uniqKey="Hodgson T">TL. Hodgson</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freeman, Rm" uniqKey="Freeman R">RM. Freeman</name></author><author><name sortKey="Adekanmi, O" uniqKey="Adekanmi O">O. Adekanmi</name></author><author><name sortKey="Waterfield, Mr" uniqKey="Waterfield M">MR. Waterfield</name></author><author><name sortKey="Waterfield, Ae" uniqKey="Waterfield A">AE. Waterfield</name></author><author><name sortKey="Wright, D" uniqKey="Wright D">D. Wright</name></author><author><name sortKey="Zajicek, J" uniqKey="Zajicek J">J. Zajicek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Pf" uniqKey="Smith P">PF. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaney, C" uniqKey="Vaney C">C. Vaney</name></author><author><name sortKey="Heinzel Gutenbrunner, M" uniqKey="Heinzel Gutenbrunner M">M. Heinzel-Gutenbrunner</name></author><author><name sortKey="Jobin, P" uniqKey="Jobin P">P. Jobin</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wade, Dt" uniqKey="Wade D">DT. Wade</name></author><author><name sortKey="Makela, P" uniqKey="Makela P">P. Makela</name></author><author><name sortKey="Robson, P" uniqKey="Robson P">P. Robson</name></author><author><name sortKey="House, H" uniqKey="House H">H. House</name></author><author><name sortKey="Bateman, C" uniqKey="Bateman C">C. Bateman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wade, Dt" uniqKey="Wade D">DT. Wade</name></author><author><name sortKey="Makela, Pm" uniqKey="Makela P">PM. Makela</name></author><author><name sortKey="House, H" uniqKey="House H">H. House</name></author><author><name sortKey="Bateman, C" uniqKey="Bateman C">C. Bateman</name></author><author><name sortKey="Robson, P" uniqKey="Robson P">P. Robson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zajicek, J" uniqKey="Zajicek J">J. Zajicek</name></author><author><name sortKey="Fox, P" uniqKey="Fox P">P. Fox</name></author><author><name sortKey="Sanders, H" uniqKey="Sanders H">H. Sanders</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zajicek, Jp" uniqKey="Zajicek J">JP. Zajicek</name></author><author><name sortKey="Sanders, Hp" uniqKey="Sanders H">HP. Sanders</name></author><author><name sortKey="Wright, De" uniqKey="Wright D">DE. Wright</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bifuico, M" uniqKey="Bifuico M">M. BifuIco</name></author><author><name sortKey="Laezza, C" uniqKey="Laezza C">C. Laezza</name></author><author><name sortKey="Malfitano, Am" uniqKey="Malfitano A">AM. Malfitano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bowiing, A" uniqKey="Bowiing A">A. BowIing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maccarrone, M" uniqKey="Maccarrone M">M. Maccarrone</name></author><author><name sortKey="Battista, N" uniqKey="Battista N">N. Battista</name></author><author><name sortKey="Centonze, D" uniqKey="Centonze D">D. Centonze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mestre, L" uniqKey="Mestre L">L. Mestre</name></author><author><name sortKey="Correa, F" uniqKey="Correa F">F. Correa</name></author><author><name sortKey="Docagne, F" uniqKey="Docagne F">F. Docagne</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lastres Becker, I" uniqKey="Lastres Becker I">I. Lastres-Becker</name></author><author><name sortKey="Molina Holgado, F" uniqKey="Molina Holgado F">F. Molina-Holgado</name></author><author><name sortKey="Ramos, Ja" uniqKey="Ramos J">JA. Ramos</name></author><author><name sortKey="Mechoulam, R" uniqKey="Mechoulam R">R. Mechoulam</name></author><author><name sortKey="Fernandez Ruiz, J" uniqKey="Fernandez Ruiz J">J. Fernandez-Ruiz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sommer, C" uniqKey="Sommer C">C. Sommer</name></author><author><name sortKey="Schomacher, M" uniqKey="Schomacher M">M. Schomacher</name></author><author><name sortKey="Berger, C" uniqKey="Berger C">C. Berger</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knoiler, N" uniqKey="Knoiler N">N. KnoIler</name></author><author><name sortKey="Levi, L" uniqKey="Levi L">L. Levi</name></author><author><name sortKey="Shoshan, I" uniqKey="Shoshan I">I. Shoshan</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maas, Ai" uniqKey="Maas A">AI. Maas</name></author><author><name sortKey="Murray, G" uniqKey="Murray G">G. Murray</name></author><author><name sortKey="Henney, H" uniqKey="Henney H">H. Henney</name></author><author><name sortKey="3rd" uniqKey="3rd">3rd.</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, Tw" uniqKey="Klein T">TW. Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walter, L" uniqKey="Walter L">L. Walter</name></author><author><name sortKey="Stella, N" uniqKey="Stella N">N. Stella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marchalant, Y" uniqKey="Marchalant Y">Y. Marchalant</name></author><author><name sortKey="Rosi, S" uniqKey="Rosi S">S. Rosi</name></author><author><name sortKey="Wenk, Gl" uniqKey="Wenk G">GL. Wenk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maresz, K" uniqKey="Maresz K">K. Maresz</name></author><author><name sortKey="Pryce, G" uniqKey="Pryce G">G. Pryce</name></author><author><name sortKey="Ponomarev, Ed" uniqKey="Ponomarev E">ED. Ponomarev</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steffens, S" uniqKey="Steffens S">S. Steffens</name></author><author><name sortKey="Veillard, Nr" uniqKey="Veillard N">NR. Veillard</name></author><author><name sortKey="Arnaud, C" uniqKey="Arnaud C">C. Arnaud</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darmani, Na" uniqKey="Darmani N">NA. Darmani</name></author><author><name sortKey="Izzo, Aa" uniqKey="Izzo A">AA. Izzo</name></author><author><name sortKey="Degenhardt, B" uniqKey="Degenhardt B">B. Degenhardt</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rajesh, M" uniqKey="Rajesh M">M. Rajesh</name></author><author><name sortKey="Mukhopadhyay, P" uniqKey="Mukhopadhyay P">P. Mukhopadhyay</name></author><author><name sortKey="Batkai, S" uniqKey="Batkai S">S. Batkai</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Croci, T" uniqKey="Croci T">T. Croci</name></author><author><name sortKey="Zarini, E" uniqKey="Zarini E">E. Zarini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brotchie, Jm" uniqKey="Brotchie J">JM. Brotchie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maneuf, Yp" uniqKey="Maneuf Y">YP. Maneuf</name></author><author><name sortKey="Crossman, Ar" uniqKey="Crossman A">AR. Crossman</name></author><author><name sortKey="Brotchie, Jm" uniqKey="Brotchie J">JM. Brotchie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrer, B" uniqKey="Ferrer B">B. Ferrer</name></author><author><name sortKey="Asbrock, N" uniqKey="Asbrock N">N. Asbrock</name></author><author><name sortKey="Kathuria, S" uniqKey="Kathuria S">S. Kathuria</name></author><author><name sortKey="Piomelli, D" uniqKey="Piomelli D">D. Piomelli</name></author><author><name sortKey="Giuffrida, A" uniqKey="Giuffrida A">A. Giuffrida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez, S" uniqKey="Gonzalez S">S. Gonzalez</name></author><author><name sortKey="Scorticati, C" uniqKey="Scorticati C">C. Scorticati</name></author><author><name sortKey="Garcia Arencibia, M" uniqKey="Garcia Arencibia M">M. Garcia-Arencibia</name></author><author><name sortKey="De Miguel, R" uniqKey="De Miguel R">R. de Miguel</name></author><author><name sortKey="Ramos, Ja" uniqKey="Ramos J">JA. Ramos</name></author><author><name sortKey="Fernandez Ruiz, J" uniqKey="Fernandez Ruiz J">J. Fernandez-Ruiz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lastres Becker, I" uniqKey="Lastres Becker I">I. Lastres-Becker</name></author><author><name sortKey="Cebeira, M" uniqKey="Cebeira M">M. Cebeira</name></author><author><name sortKey="De Ceballos, Ml" uniqKey="De Ceballos M">ML. de Ceballos</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pisani, A" uniqKey="Pisani A">A. Pisani</name></author><author><name sortKey="Fezza, F" uniqKey="Fezza F">F. Fezza</name></author><author><name sortKey="Galati, S" uniqKey="Galati S">S. Galati</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreitzer, Ac" uniqKey="Kreitzer A">AC. Kreitzer</name></author><author><name sortKey="Malenka, Rc" uniqKey="Malenka R">RC. Malenka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sieradzan, Ka" uniqKey="Sieradzan K">KA. Sieradzan</name></author><author><name sortKey="Fox, Sh" uniqKey="Fox S">SH. Fox</name></author><author><name sortKey="Hill, M" uniqKey="Hill M">M. Hill</name></author><author><name sortKey="Dick, Jp" uniqKey="Dick J">JP. Dick</name></author><author><name sortKey="Crossman, Ar" uniqKey="Crossman A">AR. Crossman</name></author><author><name sortKey="Brotchie, Jm" uniqKey="Brotchie J">JM. Brotchie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jabusch, Hc" uniqKey="Jabusch H">HC. Jabusch</name></author><author><name sortKey="Schneider, U" uniqKey="Schneider U">U. Schneider</name></author><author><name sortKey="Altenmuiier, E" uniqKey="Altenmuiier E">E. AltenmuIIer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carroll, Cb" uniqKey="Carroll C">CB. Carroll</name></author><author><name sortKey="Bain, Pg" uniqKey="Bain P">PG. Bain</name></author><author><name sortKey="Teare, L" uniqKey="Teare L">L. Teare</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, Sh" uniqKey="Fox S">SH. Fox</name></author><author><name sortKey="Kellett, M" uniqKey="Kellett M">M. Kellett</name></author><author><name sortKey="Moore, Ap" uniqKey="Moore A">AP. Moore</name></author><author><name sortKey="Crossman, Ar" uniqKey="Crossman A">AR. Crossman</name></author><author><name sortKey="Brotchie, Jm" uniqKey="Brotchie J">JM. Brotchie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mesnage, V" uniqKey="Mesnage V">V. Mesnage</name></author><author><name sortKey="Houeto, Jl" uniqKey="Houeto J">JL. Houeto</name></author><author><name sortKey="Bonnet, Am" uniqKey="Bonnet A">AM. Bonnet</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Venderova, K" uniqKey="Venderova K">K. Venderova</name></author><author><name sortKey="Ruzicka, E" uniqKey="Ruzicka E">E. Ruzicka</name></author><author><name sortKey="Vorisek, V" uniqKey="Vorisek V">V. Vorisek</name></author><author><name sortKey="Visnovsky, P" uniqKey="Visnovsky P">P. Visnovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aisasua, Del Valle A" uniqKey="Aisasua D">del Valle A. AIsasua</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lastres Becker, I" uniqKey="Lastres Becker I">I. Lastres-Becker</name></author><author><name sortKey="Fernandez Ruiz, J" uniqKey="Fernandez Ruiz J">J. Fernandez-Ruiz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sevcik, J" uniqKey="Sevcik J">J. Sevcik</name></author><author><name sortKey="Masek, K" uniqKey="Masek K">K. Masek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glass, M" uniqKey="Glass M">M. Glass</name></author><author><name sortKey="Dragunow, M" uniqKey="Dragunow M">M. Dragunow</name></author><author><name sortKey="Faull, Rl" uniqKey="Faull R">RL. Faull</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richfield, Ek" uniqKey="Richfield E">EK. Richfield</name></author><author><name sortKey="Herkenham, M" uniqKey="Herkenham M">M. Herkenham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glass, M" uniqKey="Glass M">M. Glass</name></author><author><name sortKey="Faull, Rl" uniqKey="Faull R">RL. Faull</name></author><author><name sortKey="Dragunow, M" uniqKey="Dragunow M">M. Dragunow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Lago, E" uniqKey="De Lago E">E. de Lago</name></author><author><name sortKey="Urbani, P" uniqKey="Urbani P">P. Urbani</name></author><author><name sortKey="Ramos, Ja" uniqKey="Ramos J">JA. Ramos</name></author><author><name sortKey="Di Marzo, V" uniqKey="Di Marzo V">V. Di Marzo</name></author><author><name sortKey="Fernandez Ruiz, J" uniqKey="Fernandez Ruiz J">J. Fernandez-Ruiz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lastres Becker, I" uniqKey="Lastres Becker I">I. Lastres-Becker</name></author><author><name sortKey="De Miguel, R" uniqKey="De Miguel R">R. de Miguel</name></author><author><name sortKey="De Petrocellis, L" uniqKey="De Petrocellis L">L. De Petrocellis</name></author><author><name sortKey="Makriyannis, A" uniqKey="Makriyannis A">A. Makriyannis</name></author><author><name sortKey="Di Marzo, V" uniqKey="Di Marzo V">V. Di Marzo</name></author><author><name sortKey="Fernandez Ruiz, J" uniqKey="Fernandez Ruiz J">J. Fernandez-Ruiz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pintor, A" uniqKey="Pintor A">A. Pintor</name></author><author><name sortKey="Tebano, Mt" uniqKey="Tebano M">MT. Tebano</name></author><author><name sortKey="Martire, A" uniqKey="Martire A">A. Martire</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Consroe, P" uniqKey="Consroe P">P. Consroe</name></author><author><name sortKey="Laguna, J" uniqKey="Laguna J">J. Laguna</name></author><author><name sortKey="Ahender, J" uniqKey="Ahender J">J. AHender</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulier Vahl, Kr" uniqKey="Mulier Vahl K">KR. MulIer-Vahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller Vahl, Kr" uniqKey="Muller Vahl K">KR. Muller-Vahl</name></author><author><name sortKey="Prevedel, H" uniqKey="Prevedel H">H. Prevedel</name></author><author><name sortKey="Theloe, K" uniqKey="Theloe K">K. Theloe</name></author><author><name sortKey="Kolbe, H" uniqKey="Kolbe H">H. Kolbe</name></author><author><name sortKey="Emrich, Hm" uniqKey="Emrich H">HM. Emrich</name></author><author><name sortKey="Schneider, U" uniqKey="Schneider U">U. Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muiier Vahi, Kr" uniqKey="Muiier Vahi K">KR. MuIIer-VahI</name></author><author><name sortKey="Schneider, U" uniqKey="Schneider U">U. Schneider</name></author><author><name sortKey="Koblenz, A" uniqKey="Koblenz A">A. Koblenz</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muiier Vahl, Kr" uniqKey="Muiier Vahl K">KR. MuIIer-Vahl</name></author><author><name sortKey="Schneider, U" uniqKey="Schneider U">U. Schneider</name></author><author><name sortKey="Prevedel, H" uniqKey="Prevedel H">H. Prevedel</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gadzicki, D" uniqKey="Gadzicki D">D. Gadzicki</name></author><author><name sortKey="Muiier Vahl, Kr" uniqKey="Muiier Vahl K">KR. MuIIer-Vahl</name></author><author><name sortKey="Heller, D" uniqKey="Heller D">D. Heller</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carter, Gt" uniqKey="Carter G">GT. Carter</name></author><author><name sortKey="Rosen, Bs" uniqKey="Rosen B">BS. Rosen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bilsland, Lg" uniqKey="Bilsland L">LG. Bilsland</name></author><author><name sortKey="Dick, Jr" uniqKey="Dick J">JR. Dick</name></author><author><name sortKey="Pryce, G" uniqKey="Pryce G">G. Pryce</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raman, C" uniqKey="Raman C">C. Raman</name></author><author><name sortKey="Mcallister, Sd" uniqKey="Mcallister S">SD. McAllister</name></author><author><name sortKey="Rizvi, G" uniqKey="Rizvi G">G. Rizvi</name></author><author><name sortKey="Patel, Sg" uniqKey="Patel S">SG. Patel</name></author><author><name sortKey="Moore, Dh" uniqKey="Moore D">DH. Moore</name></author><author><name sortKey="Abood, Me" uniqKey="Abood M">ME. Abood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weydt, P" uniqKey="Weydt P">P. Weydt</name></author><author><name sortKey="Hong, S" uniqKey="Hong S">S. Hong</name></author><author><name sortKey="Witting, A" uniqKey="Witting A">A. Witting</name></author><author><name sortKey="Moiier, T" uniqKey="Moiier T">T. MoIIer</name></author><author><name sortKey="Stella, N" uniqKey="Stella N">N. Stella</name></author><author><name sortKey="Kliot, M" uniqKey="Kliot M">M. Kliot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, K" uniqKey="Kim K">K. Kim</name></author><author><name sortKey="Moore, Dh" uniqKey="Moore D">DH. Moore</name></author><author><name sortKey="Makriyannis, A" uniqKey="Makriyannis A">A. Makriyannis</name></author><author><name sortKey="Abood, Me" uniqKey="Abood M">ME. Abood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shoemaker, Jl" uniqKey="Shoemaker J">JL. Shoemaker</name></author><author><name sortKey="Seely, Ka" uniqKey="Seely K">KA. Seely</name></author><author><name sortKey="Reed, Rl" uniqKey="Reed R">RL. Reed</name></author><author><name sortKey="Crow, Jp" uniqKey="Crow J">JP. Crow</name></author><author><name sortKey="Prather, Pl" uniqKey="Prather P">PL. Prather</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amtmann, D" uniqKey="Amtmann D">D. Amtmann</name></author><author><name sortKey="Weydt, P" uniqKey="Weydt P">P. Weydt</name></author><author><name sortKey="Johnson, Kl" uniqKey="Johnson K">KL. Johnson</name></author><author><name sortKey="Jensen, Mp" uniqKey="Jensen M">MP. Jensen</name></author><author><name sortKey="Carter, Gt" uniqKey="Carter G">GT. Carter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eubanks, Lm" uniqKey="Eubanks L">LM. Eubanks</name></author><author><name sortKey="Rogers, Cj" uniqKey="Rogers C">CJ. Rogers</name></author><author><name sortKey="Beuscher, Ae Th" uniqKey="Beuscher A">AE. 4th. Beuscher</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voiicer, L" uniqKey="Voiicer L">L. VoIicer</name></author><author><name sortKey="Stelly, M" uniqKey="Stelly M">M. Stelly</name></author><author><name sortKey="Morris, J" uniqKey="Morris J">J. Morris</name></author><author><name sortKey="Mclaughlin, J" uniqKey="Mclaughlin J">J. McLaughlin</name></author><author><name sortKey="Volicer, Bj" uniqKey="Volicer B">BJ. Volicer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waither, S" uniqKey="Waither S">S. WaIther</name></author><author><name sortKey="Mahlberg, R" uniqKey="Mahlberg R">R. Mahlberg</name></author><author><name sortKey="Eichmann, U" uniqKey="Eichmann U">U. Eichmann</name></author><author><name sortKey="Kunz, D" uniqKey="Kunz D">D. Kunz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carlini, Ea" uniqKey="Carlini E">EA. Carlini</name></author><author><name sortKey="Mechoulam, R" uniqKey="Mechoulam R">R. Mechoulam</name></author><author><name sortKey="Lander, N" uniqKey="Lander N">N. Lander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Consroe, P" uniqKey="Consroe P">P. Consroe</name></author><author><name sortKey="Martin, A" uniqKey="Martin A">A. Martin</name></author><author><name sortKey="Singh, V" uniqKey="Singh V">V. Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Ar" uniqKey="Martin A">AR. Martin</name></author><author><name sortKey="Consroe, P" uniqKey="Consroe P">P. Consroe</name></author><author><name sortKey="Kane, W" uniqKey="Kane W">W. Kane</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ames, Fr" uniqKey="Ames F">FR. Ames</name></author><author><name sortKey="Cridland, S" uniqKey="Cridland S">S. Cridland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Consroe, P" uniqKey="Consroe P">P. Consroe</name></author><author><name sortKey="Wolkin, A" uniqKey="Wolkin A">A. Wolkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Consroe, Pf" uniqKey="Consroe P">PF. Consroe</name></author><author><name sortKey="Wolkin, Al" uniqKey="Wolkin A">AL. Wolkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cortesi, M" uniqKey="Cortesi M">M. Cortesi</name></author><author><name sortKey="Fusar Poli, P" uniqKey="Fusar Poli P">P. Fusar-Poli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deshpande, Ls" uniqKey="Deshpande L">LS. Deshpande</name></author><author><name sortKey="Sombati, S" uniqKey="Sombati S">S. Sombati</name></author><author><name sortKey="Blair, Re" uniqKey="Blair R">RE. Blair</name></author><author><name sortKey="Carter, Ds" uniqKey="Carter D">DS. Carter</name></author><author><name sortKey="Martin, Br" uniqKey="Martin B">BR. Martin</name></author><author><name sortKey="Delorenzo, Rj" uniqKey="Delorenzo R">RJ. DeLorenzo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luszczki, Jj" uniqKey="Luszczki J">JJ. Luszczki</name></author><author><name sortKey="Czuczwar, P" uniqKey="Czuczwar P">P. Czuczwar</name></author><author><name sortKey="Cioczek Czuczwar, A" uniqKey="Cioczek Czuczwar A">A. Cioczek-Czuczwar</name></author><author><name sortKey="Czuczwar, Sj" uniqKey="Czuczwar S">SJ. Czuczwar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gordon, E" uniqKey="Gordon E">E. Gordon</name></author><author><name sortKey="Devinsky, O" uniqKey="Devinsky O">O. Devinsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keeler, Mh" uniqKey="Keeler M">MH. Keeler</name></author><author><name sortKey="Reifler, Cb" uniqKey="Reifler C">CB. Reifler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cunha, Jm" uniqKey="Cunha J">JM. Cunha</name></author><author><name sortKey="Carlini, Ea" uniqKey="Carlini E">EA. Carlini</name></author><author><name sortKey="Pereira, Ae" uniqKey="Pereira A">AE. Pereira</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashton, Ch" uniqKey="Ashton C">CH. Ashton</name></author><author><name sortKey="Moore, Pb" uniqKey="Moore P">PB. Moore</name></author><author><name sortKey="Gallagher, P" uniqKey="Gallagher P">P. Gallagher</name></author><author><name sortKey="Young, Ah" uniqKey="Young A">AH. Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grinspoon, L" uniqKey="Grinspoon L">L. Grinspoon</name></author><author><name sortKey="Bakalar, Jb" uniqKey="Bakalar J">JB. Bakalar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emrich, Hm" uniqKey="Emrich H">HM. Emrich</name></author><author><name sortKey="Leweke, Fm" uniqKey="Leweke F">FM. Leweke</name></author><author><name sortKey="Schneider, U" uniqKey="Schneider U">U. Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leweke, Fm" uniqKey="Leweke F">FM. Leweke</name></author><author><name sortKey="Giuffrida, A" uniqKey="Giuffrida A">A. Giuffrida</name></author><author><name sortKey="Koethe, D" uniqKey="Koethe D">D. Koethe</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kenchadze, Vg" uniqKey="Kenchadze V">VG. Kenchadze</name></author><author><name sortKey="Chkoniia, Ed" uniqKey="Chkoniia E">ED. Chkoniia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcguire, Pk" uniqKey="Mcguire P">PK. McGuire</name></author><author><name sortKey="Jones, P" uniqKey="Jones P">P. Jones</name></author><author><name sortKey="Harvey, I" uniqKey="Harvey I">I. Harvey</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jockers Scherubl, Mc" uniqKey="Jockers Scherubl M">MC. Jockers-Scherubl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boydeii, J" uniqKey="Boydeii J">J. BoydeII</name></author><author><name sortKey="Dean, K" uniqKey="Dean K">K. Dean</name></author><author><name sortKey="Dutta, R" uniqKey="Dutta R">R. Dutta</name></author><author><name sortKey="Giouroukou, E" uniqKey="Giouroukou E">E. Giouroukou</name></author><author><name sortKey="Fearon, P" uniqKey="Fearon P">P. Fearon</name></author><author><name sortKey="Murray, R" uniqKey="Murray R">R. Murray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dubertret, C" uniqKey="Dubertret C">C. Dubertret</name></author><author><name sortKey="Bidard, I" uniqKey="Bidard I">I. Bidard</name></author><author><name sortKey="Ades, J" uniqKey="Ades J">J. Ades</name></author><author><name sortKey="Gorwood, P" uniqKey="Gorwood P">P. Gorwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meltzer, Hy" uniqKey="Meltzer H">HY. Meltzer</name></author><author><name sortKey="Arvanitis, L" uniqKey="Arvanitis L">L. Arvanitis</name></author><author><name sortKey="Bauer, D" uniqKey="Bauer D">D. Bauer</name></author><author><name sortKey="Rein, W" uniqKey="Rein W">W. Rein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zuardi, Aw" uniqKey="Zuardi A">AW. Zuardi</name></author><author><name sortKey="Morais, Sl" uniqKey="Morais S">SL. Morais</name></author><author><name sortKey="Guimaraes, Fs" uniqKey="Guimaraes F">FS. Guimaraes</name></author><author><name sortKey="Mechoulam, R" uniqKey="Mechoulam R">R. Mechoulam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zuardi, Aw" uniqKey="Zuardi A">AW. Zuardi</name></author><author><name sortKey="Crippa, Ja" uniqKey="Crippa J">JA. Crippa</name></author><author><name sortKey="Hallak, Je" uniqKey="Hallak J">JE. Hallak</name></author><author><name sortKey="Moreira, Fa" uniqKey="Moreira F">FA. Moreira</name></author><author><name sortKey="Guimaraes, Fs" uniqKey="Guimaraes F">FS. Guimaraes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zuardi, Aw" uniqKey="Zuardi A">AW. Zuardi</name></author><author><name sortKey="Hallak, Je" uniqKey="Hallak J">JE. Hallak</name></author><author><name sortKey="Dursun, Sm" uniqKey="Dursun S">SM. Dursun</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chhatwal, Jp" uniqKey="Chhatwal J">JP. Chhatwal</name></author><author><name sortKey="Davis, M" uniqKey="Davis M">M. Davis</name></author><author><name sortKey="Maguschak, Ka" uniqKey="Maguschak K">KA. Maguschak</name></author><author><name sortKey="Ressler, Kj" uniqKey="Ressler K">KJ. Ressler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varvel, Sa" uniqKey="Varvel S">SA. Varvel</name></author><author><name sortKey="Wise, Le" uniqKey="Wise L">LE. Wise</name></author><author><name sortKey="Niyuhire, F" uniqKey="Niyuhire F">F. Niyuhire</name></author><author><name sortKey="Cravatt, Bf" uniqKey="Cravatt B">BF. Cravatt</name></author><author><name sortKey="Lichtman, Ah" uniqKey="Lichtman A">AH. Lichtman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fride, E" uniqKey="Fride E">E. Fride</name></author><author><name sortKey="Suris, R" uniqKey="Suris R">R. Suris</name></author><author><name sortKey="Weidenfeld, J" uniqKey="Weidenfeld J">J. Weidenfeld</name></author><author><name sortKey="Mechoulam, R" uniqKey="Mechoulam R">R. Mechoulam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calhoun, Ps" uniqKey="Calhoun P">PS. Calhoun</name></author><author><name sortKey="Sampson, Ws" uniqKey="Sampson W">WS. Sampson</name></author><author><name sortKey="Bosworth, Hb" uniqKey="Bosworth H">HB. Bosworth</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barrero, Fj" uniqKey="Barrero F">FJ. Barrero</name></author><author><name sortKey="Ampuero, I" uniqKey="Ampuero I">I. Ampuero</name></author><author><name sortKey="Morales, B" uniqKey="Morales B">B. Morales</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guimaraes, Fs" uniqKey="Guimaraes F">FS. Guimaraes</name></author><author><name sortKey="Chiaretti, Tm" uniqKey="Chiaretti T">TM. Chiaretti</name></author><author><name sortKey="Graeff, Fg" uniqKey="Graeff F">FG. Graeff</name></author><author><name sortKey="Zuardi, Aw" uniqKey="Zuardi A">AW. Zuardi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guimaraes, Fs" uniqKey="Guimaraes F">FS. Guimaraes</name></author><author><name sortKey="De Aguiar, Jc" uniqKey="De Aguiar J">JC. de Aguiar</name></author><author><name sortKey="Mechoulam, R" uniqKey="Mechoulam R">R. Mechoulam</name></author><author><name sortKey="Breuer, A" uniqKey="Breuer A">A. Breuer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glass, Rm" uniqKey="Glass R">RM. Glass</name></author><author><name sortKey="Uhlenhuth, Eh" uniqKey="Uhlenhuth E">EH. Uhlenhuth</name></author><author><name sortKey="Hartel, Fw" uniqKey="Hartel F">FW. Hartel</name></author><author><name sortKey="Schuster, Cr" uniqKey="Schuster C">CR. Schuster</name></author><author><name sortKey="Fischman, Mw" uniqKey="Fischman M">MW. Fischman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fabre, Lf" uniqKey="Fabre L">LF. Fabre</name></author><author><name sortKey="Mclendon, D" uniqKey="Mclendon D">D. McLendon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barratt, Es" uniqKey="Barratt E">ES. Barratt</name></author><author><name sortKey="Beaver, W" uniqKey="Beaver W">W. Beaver</name></author><author><name sortKey="White, R" uniqKey="White R">R. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freemon, Fr" uniqKey="Freemon F">FR. Freemon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pivik, Rt" uniqKey="Pivik R">RT. Pivik</name></author><author><name sortKey="Zarcone, V" uniqKey="Zarcone V">V. Zarcone</name></author><author><name sortKey="Dement, Wc" uniqKey="Dement W">WC. Dement</name></author><author><name sortKey="Hollister, Le" uniqKey="Hollister L">LE. Hollister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feinberg, I" uniqKey="Feinberg I">I. Feinberg</name></author><author><name sortKey="Jones, R" uniqKey="Jones R">R. Jones</name></author><author><name sortKey="Walker, J" uniqKey="Walker J">J. Walker</name></author><author><name sortKey="Cavness, C" uniqKey="Cavness C">C. Cavness</name></author><author><name sortKey="Floyd, T" uniqKey="Floyd T">T. Floyd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feinberg, I" uniqKey="Feinberg I">I. Feinberg</name></author><author><name sortKey="Jones, R" uniqKey="Jones R">R. Jones</name></author><author><name sortKey="Walker, Jm" uniqKey="Walker J">JM. Walker</name></author><author><name sortKey="Cavness, C" uniqKey="Cavness C">C. Cavness</name></author><author><name sortKey="March, J" uniqKey="March J">J. March</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholson, An" uniqKey="Nicholson A">AN. Nicholson</name></author><author><name sortKey="Turner, C" uniqKey="Turner C">C. Turner</name></author><author><name sortKey="Stone, Bm" uniqKey="Stone B">BM. Stone</name></author><author><name sortKey="Robson, Pj" uniqKey="Robson P">PJ. Robson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tashkin, Dp" uniqKey="Tashkin D">DP. Tashkin</name></author><author><name sortKey="Shapiro, Bj" uniqKey="Shapiro B">BJ. Shapiro</name></author><author><name sortKey="Lee, Ye" uniqKey="Lee Y">YE. Lee</name></author><author><name sortKey="Harper, Ce" uniqKey="Harper C">CE. Harper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tashkin, Dp" uniqKey="Tashkin D">DP. Tashkin</name></author><author><name sortKey="Calvarese, Bm" uniqKey="Calvarese B">BM. Calvarese</name></author><author><name sortKey="Simmons, Ms" uniqKey="Simmons M">MS. Simmons</name></author><author><name sortKey="Shapiro, Bj" uniqKey="Shapiro B">BJ. Shapiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abboud, Rt" uniqKey="Abboud R">RT. Abboud</name></author><author><name sortKey="Sanders, Hd" uniqKey="Sanders H">HD. Sanders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tashkin, Dp" uniqKey="Tashkin D">DP. Tashkin</name></author><author><name sortKey="Shapiro, Bj" uniqKey="Shapiro B">BJ. Shapiro</name></author><author><name sortKey="Frank, Im" uniqKey="Frank I">IM. Frank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tashkin, Dp" uniqKey="Tashkin D">DP. Tashkin</name></author><author><name sortKey="Shapiro, Bj" uniqKey="Shapiro B">BJ. Shapiro</name></author><author><name sortKey="Frank, Im" uniqKey="Frank I">IM. Frank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gong, H" uniqKey="Gong H">H. Gong</name></author><author><name sortKey="Jr" uniqKey="Jr">Jr.</name></author><author><name sortKey="Tashkin, Dp" uniqKey="Tashkin D">DP. Tashkin</name></author><author><name sortKey="Simmons, Ms" uniqKey="Simmons M">MS. Simmons</name></author><author><name sortKey="Calvarese, B" uniqKey="Calvarese B">B. Calvarese</name></author><author><name sortKey="Shapiro, Bj" uniqKey="Shapiro B">BJ. Shapiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartley, Jp" uniqKey="Hartley J">JP. Hartley</name></author><author><name sortKey="Nogrady, Sg" uniqKey="Nogrady S">SG. Nogrady</name></author><author><name sortKey="Seaton, A" uniqKey="Seaton A">A. Seaton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Sj" uniqKey="Williams S">SJ. Williams</name></author><author><name sortKey="Hartley, Jp" uniqKey="Hartley J">JP. Hartley</name></author><author><name sortKey="Graham, Jd" uniqKey="Graham J">JD. Graham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benowitz, Nl" uniqKey="Benowitz N">NL. Benowitz</name></author><author><name sortKey="Rosenberg, J" uniqKey="Rosenberg J">J. Rosenberg</name></author><author><name sortKey="Rogers, W" uniqKey="Rogers W">W. Rogers</name></author><author><name sortKey="Bachman, J" uniqKey="Bachman J">J. Bachman</name></author><author><name sortKey="Jones, Rt" uniqKey="Jones R">RT. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanakis, C" uniqKey="Kanakis C">C. Kanakis</name></author><author><name sortKey="Jr" uniqKey="Jr">Jr.</name></author><author><name sortKey="Pouget, Jm" uniqKey="Pouget J">JM. Pouget</name></author><author><name sortKey="Rosen, Km" uniqKey="Rosen K">KM. Rosen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tashkin, Dp" uniqKey="Tashkin D">DP. Tashkin</name></author><author><name sortKey="Levisman, Ja" uniqKey="Levisman J">JA. Levisman</name></author><author><name sortKey="Abbasi, As" uniqKey="Abbasi A">AS. Abbasi</name></author><author><name sortKey="Shapiro, Bj" uniqKey="Shapiro B">BJ. Shapiro</name></author><author><name sortKey="Ellis, Nm" uniqKey="Ellis N">NM. Ellis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benowitz, Nl" uniqKey="Benowitz N">NL. Benowitz</name></author><author><name sortKey="Jones, Rt" uniqKey="Jones R">RT. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benowitz, Nl" uniqKey="Benowitz N">NL. Benowitz</name></author><author><name sortKey="Jones, Rt" uniqKey="Jones R">RT. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goreiick, Da" uniqKey="Goreiick D">DA. GoreIick</name></author><author><name sortKey="Heishman, Sj" uniqKey="Heishman S">SJ. Heishman</name></author><author><name sortKey="Preston, Kl" uniqKey="Preston K">KL. Preston</name></author><author><name sortKey="Nelson, Ra" uniqKey="Nelson R">RA. Nelson</name></author><author><name sortKey="Moolchan, Et" uniqKey="Moolchan E">ET. Moolchan</name></author><author><name sortKey="Huestis, Ma" uniqKey="Huestis M">MA. Huestis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisohiy, Ma" uniqKey="Eisohiy M">MA. EisohIy</name></author><author><name sortKey="Harland, E" uniqKey="Harland E">E. Harland</name></author><author><name sortKey="Murphy, Jc" uniqKey="Murphy J">JC. Murphy</name></author><author><name sortKey="Wirth, P" uniqKey="Wirth P">P. Wirth</name></author><author><name sortKey="Waller, Cw" uniqKey="Waller C">CW. Waller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elsohly, Ma" uniqKey="Elsohly M">MA. ElSohly</name></author><author><name sortKey="Harland, Ec" uniqKey="Harland E">EC. Harland</name></author><author><name sortKey="Benigni, Da" uniqKey="Benigni D">DA. Benigni</name></author><author><name sortKey="Waller, Cw" uniqKey="Waller C">CW. Waller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchwaid, A" uniqKey="Buchwaid A">A. BuchwaId</name></author><author><name sortKey="Derendorf, H" uniqKey="Derendorf H">H. Derendorf</name></author><author><name sortKey="Ji, F" uniqKey="Ji F">F. Ji</name></author><author><name sortKey="Nagaraja, Ny" uniqKey="Nagaraja N">NY. Nagaraja</name></author><author><name sortKey="Wu, Wm" uniqKey="Wu W">WM. Wu</name></author><author><name sortKey="Bodor, N" uniqKey="Bodor N">N. Bodor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laine, K" uniqKey="Laine K">K. Laine</name></author><author><name sortKey="Jarvinen, K" uniqKey="Jarvinen K">K. Jarvinen</name></author><author><name sortKey="Mechoulam, R" uniqKey="Mechoulam R">R. Mechoulam</name></author><author><name sortKey="Breuer, A" uniqKey="Breuer A">A. Breuer</name></author><author><name sortKey="Jarvinen, T" uniqKey="Jarvinen T">T. Jarvinen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laine, K" uniqKey="Laine K">K. Laine</name></author><author><name sortKey="Jarvinen, K" uniqKey="Jarvinen K">K. Jarvinen</name></author><author><name sortKey="Pate, Dw" uniqKey="Pate D">DW. Pate</name></author><author><name sortKey="Urtti, A" uniqKey="Urtti A">A. Urtti</name></author><author><name sortKey="Jarvinen, T" uniqKey="Jarvinen T">T. Jarvinen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pate, Dw" uniqKey="Pate D">DW. Pate</name></author><author><name sortKey="Jarvinen, K" uniqKey="Jarvinen K">K. Jarvinen</name></author><author><name sortKey="Urtti, A" uniqKey="Urtti A">A. Urtti</name></author><author><name sortKey="Jarho, P" uniqKey="Jarho P">P. Jarho</name></author><author><name sortKey="Jarvinen, T" uniqKey="Jarvinen T">T. Jarvinen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Porcella, A" uniqKey="Porcella A">A. Porcella</name></author><author><name sortKey="Casellas, P" uniqKey="Casellas P">P. Casellas</name></author><author><name sortKey="Gessa, Gl" uniqKey="Gessa G">GL. Gessa</name></author><author><name sortKey="Pani, L" uniqKey="Pani L">L. Pani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colasanti, Bk" uniqKey="Colasanti B">BK. Colasanti</name></author><author><name sortKey="Brown, Re" uniqKey="Brown R">RE. Brown</name></author><author><name sortKey="Craig, Cr" uniqKey="Craig C">CR. Craig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colasanti, Bk" uniqKey="Colasanti B">BK. Colasanti</name></author><author><name sortKey="Craig, Cr" uniqKey="Craig C">CR. Craig</name></author><author><name sortKey="Allara, Rd" uniqKey="Allara R">RD. Allara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coiasanti, Bk" uniqKey="Coiasanti B">BK. CoIasanti</name></author><author><name sortKey="Powell, Sr" uniqKey="Powell S">SR. Powell</name></author><author><name sortKey="Craig, Cr" uniqKey="Craig C">CR. Craig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hepier, Rs" uniqKey="Hepier R">RS. HepIer</name></author><author><name sortKey="Frank, Ir" uniqKey="Frank I">IR. Frank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Merritt, Jc" uniqKey="Merritt J">JC. Merritt</name></author><author><name sortKey="Olsen, Jl" uniqKey="Olsen J">JL. Olsen</name></author><author><name sortKey="Armstrong, Jr" uniqKey="Armstrong J">JR. Armstrong</name></author><author><name sortKey="Mckinnon, Sm" uniqKey="Mckinnon S">SM. McKinnon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Merritt, Jc" uniqKey="Merritt J">JC. Merritt</name></author><author><name sortKey="Perry, Dd" uniqKey="Perry D">DD. Perry</name></author><author><name sortKey="Russell, Dn" uniqKey="Russell D">DN. Russell</name></author><author><name sortKey="Jones, Bf" uniqKey="Jones B">BF. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Merritt, Jc" uniqKey="Merritt J">JC. Merritt</name></author><author><name sortKey="Crawford, Wj" uniqKey="Crawford W">WJ. Crawford</name></author><author><name sortKey="Alexander, Pc" uniqKey="Alexander P">PC. Alexander</name></author><author><name sortKey="Anduze, Al" uniqKey="Anduze A">AL. Anduze</name></author><author><name sortKey="Gelbart, Ss" uniqKey="Gelbart S">SS. Gelbart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Purneii, Wd" uniqKey="Purneii W">WD. PurneII</name></author><author><name sortKey="Gregg, Jm" uniqKey="Gregg J">JM. Gregg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crawford, Wj" uniqKey="Crawford W">WJ. Crawford</name></author><author><name sortKey="Merritt, Jc" uniqKey="Merritt J">JC. Merritt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tomida, I" uniqKey="Tomida I">I. Tomida</name></author><author><name sortKey="Azuara Bianco, A" uniqKey="Azuara Bianco A">A. Azuara-BIanco</name></author><author><name sortKey="House, H" uniqKey="House H">H. House</name></author><author><name sortKey="Flint, M" uniqKey="Flint M">M. Flint</name></author><author><name sortKey="Pertwee, Rg" uniqKey="Pertwee R">RG. Pertwee</name></author><author><name sortKey="Robson, Pj" uniqKey="Robson P">PJ. Robson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, W" uniqKey="Hall W">W. Hall</name></author><author><name sortKey="Christie, M" uniqKey="Christie M">M. Christie</name></author><author><name sortKey="Currow, D" uniqKey="Currow D">D. Currow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kogan, Nm" uniqKey="Kogan N">NM. Kogan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bifulco, M" uniqKey="Bifulco M">M. Bifulco</name></author><author><name sortKey="Laezza, C" uniqKey="Laezza C">C. Laezza</name></author><author><name sortKey="Gazzerro, P" uniqKey="Gazzerro P">P. Gazzerro</name></author><author><name sortKey="Pentimalli, F" uniqKey="Pentimalli F">F. Pentimalli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aguado, T" uniqKey="Aguado T">T. Aguado</name></author><author><name sortKey="Carracedo, A" uniqKey="Carracedo A">A. Carracedo</name></author><author><name sortKey="Julien, B" uniqKey="Julien B">B. Julien</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massi, P" uniqKey="Massi P">P. Massi</name></author><author><name sortKey="Vaccani, A" uniqKey="Vaccani A">A. Vaccani</name></author><author><name sortKey="Bianchessi, S" uniqKey="Bianchessi S">S. Bianchessi</name></author><author><name sortKey="Costa, B" uniqKey="Costa B">B. Costa</name></author><author><name sortKey="Macchi, P" uniqKey="Macchi P">P. Macchi</name></author><author><name sortKey="Parolaro, D" uniqKey="Parolaro D">D. Parolaro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biazquez, C" uniqKey="Biazquez C">C. BIazquez</name></author><author><name sortKey="Carracedo, A" uniqKey="Carracedo A">A. Carracedo</name></author><author><name sortKey="Barrado, L" uniqKey="Barrado L">L. Barrado</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caffarel, Mm" uniqKey="Caffarel M">MM. Caffarel</name></author><author><name sortKey="Sarrio, D" uniqKey="Sarrio D">D. Sarrio</name></author><author><name sortKey="Palacios, J" uniqKey="Palacios J">J. Palacios</name></author><author><name sortKey="Guzman, M" uniqKey="Guzman M">M. Guzman</name></author><author><name sortKey="Sanchez, C" uniqKey="Sanchez C">C. Sanchez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carracedo, A" uniqKey="Carracedo A">A. Carracedo</name></author><author><name sortKey="Gironella, M" uniqKey="Gironella M">M. Gironella</name></author><author><name sortKey="Lorente, M" uniqKey="Lorente M">M. Lorente</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, W" uniqKey="Jia W">W. Jia</name></author><author><name sortKey="Hegde, Vl" uniqKey="Hegde V">VL. Hegde</name></author><author><name sortKey="Singh, Np" uniqKey="Singh N">NP. Singh</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mckallip, Rj" uniqKey="Mckallip R">RJ. McKallip</name></author><author><name sortKey="Jia, W" uniqKey="Jia W">W. Jia</name></author><author><name sortKey="Schlomer, J" uniqKey="Schlomer J">J. Schlomer</name></author><author><name sortKey="Warren, Jw" uniqKey="Warren J">JW. Warren</name></author><author><name sortKey="Nagarkatti, Ps" uniqKey="Nagarkatti P">PS. Nagarkatti</name></author><author><name sortKey="Nagarkatti, M" uniqKey="Nagarkatti M">M. Nagarkatti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarfaraz, S" uniqKey="Sarfaraz S">S. Sarfaraz</name></author><author><name sortKey="Afaq, F" uniqKey="Afaq F">F. Afaq</name></author><author><name sortKey="Adhami, Vm" uniqKey="Adhami V">VM. Adhami</name></author><author><name sortKey="Malik, A" uniqKey="Malik A">A. Malik</name></author><author><name sortKey="Mukhtar, H" uniqKey="Mukhtar H">H. Mukhtar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarnataro, D" uniqKey="Sarnataro D">D. Sarnataro</name></author><author><name sortKey="Pisanti, S" uniqKey="Pisanti S">S. Pisanti</name></author><author><name sortKey="Santoro, A" uniqKey="Santoro A">A. Santoro</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guzman, M" uniqKey="Guzman M">M. Guzman</name></author><author><name sortKey="Duarte, Mj" uniqKey="Duarte M">MJ. Duarte</name></author><author><name sortKey="Blazquez, C" uniqKey="Blazquez C">C. Blazquez</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcclung, Ca" uniqKey="Mcclung C">CA. McClung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harper, Sj" uniqKey="Harper S">SJ. Harper</name></author><author><name sortKey="Jones, Ns" uniqKey="Jones N">NS. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Brien, C P" uniqKey="O Brien C">C. P. O'Brien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lader, M" uniqKey="Lader M">M. Lader</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luetje, Cm" uniqKey="Luetje C">CM. Luetje</name></author><author><name sortKey="Wooten, J" uniqKey="Wooten J">J. Wooten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jansen, Kl" uniqKey="Jansen K">KL. Jansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jansen, Kl" uniqKey="Jansen K">KL. Jansen</name></author><author><name sortKey="Darracot Cankovic, R" uniqKey="Darracot Cankovic R">R. Darracot-Cankovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Linazaroso, G" uniqKey="Linazaroso G">G. Linazaroso</name></author><author><name sortKey="Van Blercom, N" uniqKey="Van Blercom N">N. van Blercom</name></author><author><name sortKey="Lasa, A" uniqKey="Lasa A">A. Lasa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenhill, Ll" uniqKey="Greenhill L">LL. Greenhill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karsak, M" uniqKey="Karsak M">M. Karsak</name></author><author><name sortKey="Cohen Solal, M" uniqKey="Cohen Solal M">M. Cohen-Solal</name></author><author><name sortKey="Freudenberg, J" uniqKey="Freudenberg J">J. Freudenberg</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ofek, O" uniqKey="Ofek O">O. Ofek</name></author><author><name sortKey="Karsak, M" uniqKey="Karsak M">M. Karsak</name></author><author><name sortKey="Leclerc, N" uniqKey="Leclerc N">N. Leclerc</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Begg, M" uniqKey="Begg M">M. Begg</name></author><author><name sortKey="Pacher, P" uniqKey="Pacher P">P. Pacher</name></author><author><name sortKey="Batkai, S" uniqKey="Batkai S">S. Batkai</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fride, E" uniqKey="Fride E">E. Fride</name></author><author><name sortKey="Foox, A" uniqKey="Foox A">A. Foox</name></author><author><name sortKey="Rosenberg, E" uniqKey="Rosenberg E">E. Rosenberg</name></author><author><name sortKey="Et Al" uniqKey="Et Al">et al.</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, D" uniqKey="Baker D">D. Baker</name></author><author><name sortKey="Pryce, G" uniqKey="Pryce G">G. Pryce</name></author><author><name sortKey="Davies, Wl" uniqKey="Davies W">WL. Davies</name></author><author><name sortKey="Hiley, Cr" uniqKey="Hiley C">CR. Hiley</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Dialogues Clin Neurosci</journal-id><journal-id journal-id-type="pmc">Dialogues Clin Neurosci</journal-id><journal-title-group><journal-title>Dialogues in Clinical Neuroscience</journal-title></journal-title-group><issn pub-type="ppub">1294-8322</issn><issn pub-type="epub">1958-5969</issn><publisher><publisher-name>Les Laboratoires Servier</publisher-name><publisher-loc>France</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18286801</article-id><article-id pub-id-type="pmc">3202504</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Research</subject></subj-group></article-categories><title-group><article-title>Cannabinoids in health and disease</article-title><trans-title-group xml:lang="es"><trans-title>Cannabinoides en la salud y en la enfermedad</trans-title></trans-title-group><trans-title-group xml:lang="fr"><trans-title>Cannabinoïdes: effets chez le sujet sain et utilisation en thérapeutique</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kogan</surname><given-names>Natalya M.</given-names></name><degrees>MSc</degrees><aff>Medicinal Chemistry and Natural Products Dept, Pharmacy School, Ein-Kerem Medical Campus, the Hebrew University of Jerusalem, Israel</aff></contrib></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Mechoulam</surname><given-names>Raphael</given-names></name><degrees>PhD</degrees><xref ref-type="corresp" rid="COR2">*</xref><aff>Medicinal Chemistry and Natural Products Dept, Pharmacy School, Ein-Kerem Medical Campus, the Hebrew University of Jerusalem, Israel</aff></contrib></contrib-group><author-notes><corresp id="COR2"><label>*</label>E-mail: <email>mechou@cc.huji.ac.il</email></corresp></author-notes><pub-date pub-type="epub-ppub"><month>12</month><year>2007</year></pub-date><pmc-comment>Fake ppub date generated by PMC from publisher pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>12</month><year>2007</year></pub-date><volume>9</volume><issue>4</issue><fpage>413</fpage><lpage>430</lpage><permissions><copyright-statement>Copyright: © 2007 LLS</copyright-statement><copyright-year>2007</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/">http://creativecommons.org/licenses/by-nc-nd/3.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Cannabis sativa L. preparations have been used in medicine for millenia. However, concern over the dangers of abuse led to the banning of the medicinal use of marijuana in most countries in the 1930s. Only recently, marijuana and individual natural and synthetic cannabinoid receptor agonists and antagonists, as well as chemically related compounds, whose mechanism of action is still obscure, have come back to being considered of therapeutic value. However, their use is highly restricted. Despite the mild addiction to cannabis and the possible enhancement of addiction to other substances of abuse, when combined with cannabis, the therapeutic value of cannabinoids is too high to be put aside. Numerous diseases, such as anorexia, emesis, pain, inflammation, multiple sclerosis, neurodegenerative disorders (Parkinson's disease, Huntington's disease, Tourette's syndrome, Alzheimer's disease), epilepsy, glaucoma, osteoporosis, schizophrenia, cardiovascular disorders, cancer, obesity, and metabolic syndrome-related disorders, to name just a few, are being treated or have the potential to be treated by cannabinoid agonists/antagonists/cannabinoid-related compounds. In view of the very low toxicity and the generally benign side effects of this group of compounds, neglecting or denying their clinical potential is unacceptable - instead, we need to work on the development of more selective cannabinoid receptor agonists/antagonists and related compounds, as well as on novel drugs of this family with better selectivity, distribution patterns, and pharmacokinetics, and - in cases where it is impossible to separate the desired clinical action and the psychoactivity - just to monitor these side effects carefully.</p></abstract><trans-abstract xml:lang="es"><p>Las preparaciones de Cannabis sativa L. se han empleado en medicina desde hace milenios. Sin embargo, la preocupación acerca de los peligros del abuso condujo a la prohibición de la utilización médica de la marihuana en la mayoría de los países en la década de 1930. Sólo recientemente, los agonistas y antagonistas naturales y sintéticos de los receptores de marihuana, como también compuestos químicamente relacionados, cuyo mecanismo de acción todavía es confuso, han vuelto a reconsiderar el valor terapéutico. Pero su empleo está estrictamente limitado. A pesar de la adicción leve a cannnabis y el posible incremento de la adicción a otras sustancias de abuso, cuando se combinan con cannabis, el valor terapéutico de los cannabinoides es muy alto como para no tomarlo en cuenta. Numerosas enfermedades como la anorexia, la emesis, el dolor, la inflamación, la esclerosis múltiple, trastornos neurodegenerativos (Enfermedad de Parkinson, Enfermedad de Huntington, Síndrome de Tourette, Enfermedad de Alzheimer), epilepsia, glaucoma, osteoporosis, esquizofrenia, trastornos cardiovasculares, cáncer, obesidad, y trastornos relacionados con el síndrome metabólico, por nombrar sólo algunas, están siendo tratadas o tienen el potencial de tratarse por agonistas o antagonistas de los cannabinoides o compuestos relacionados con ellos. Dada la muy baja toxicidad y los efectos secundarios generalmente benignos de este grupo de compuestos, desatender o negar su potencial clínico es inaceptable; hay que trabajar en el desarrollo de agonistas y antagonistas, y compuestos relacionados que sean más selectivos para el receptor de cannabinoides, como también de nuevos fármacos de esta familia con mejor selectividad, patrones de distribución y fármaco-cinética, y - en casos donde sea imposible separar la acción clinica deseada y la psicoactividad - igual monitorear estos efectos secundarios cuidadosamente.</p></trans-abstract><trans-abstract xml:lang="fr"><p>Depuis des millénaires, des préparations à base de Cannabis sativa L. ont été utilisées en médecine. Dans les années 1930 cependant, des inquiétudes concernant le danger lié à l'abus de cette substance ont conduit à l'interdiction de l'utilisation médicale de la marijuana dans la plupart des pays. Ce n'est que depuis peu que la marijuana et les agonistes et antagonistes des récepteurs cannabinoïdes synthétiques et naturels, ainsi que les composés chimiquement apparentés dont le mécanisme d'action est encore obscur, sont à nouveau considérés comme ayant un intérêt thérapeutique. Leur usage est cependant très limité. Malgré la dépendance modérée au cannabis et la possible stimulation de la dépendance à d'autres drogues lorsqu'elles sont associées au cannabis, la valeur thérapeutique des cannabinoïdes est trop élevée pour être négligée. De nombreuses pathologies, telles que l'anorexie, les vomissements, la douleur, l'inflammation, la sclérose en plaques, les troubles neurodégénératifs (maladie de Parkinson, chorée de Huntington, syndrome de Gilles de la Tourette, maladie d'Alzheimer), l'épilepsie, le glaucome, l'ostéoporose, la schizophrénie, les troubles cardiovasculaires, le cancer, l'obésité et les troubles liés au syndrome métabolique, pour n'en nommer que quelques-unes, sont traitées ou pourraient être traitées par des agonistes/antagonistes des cannabinoïdes, ou substances apparentées. Au regard de la très faible toxicité et des effets secondaires généralement bénins de cette classe de produits, il serait inacceptable de négliger ou de nier leur potentiel clinique. Il faut au contraire travailler au développement de récepteurs agonistes/antagonistes des cannabinoïdes et de composés apparentés sélectifs, ainsi qu'à de nouveaux médicaments de cette famille plus sélectifs, avec un mode de distribution et une pharmacocinétique meilleurs. Et lorsqu'il est impossible de séparer l'action clinique désirée et les effets psychoactifs, il est simplement nécessaire de surveiller attentivement les effets indésirables.</p></trans-abstract><kwd-group><kwd><italic>cannabinoids</italic></kwd><kwd><italic>therapeutics</italic></kwd><kwd><italic>medicinal</italic></kwd><kwd><italic>addiction</italic></kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Kogan, Natalya M" sort="Kogan, Natalya M" uniqKey="Kogan N" first="Natalya M." last="Kogan">Natalya M. Kogan</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/DanceTherParkinsonV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000024 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000024 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Psychologie
|area= DanceTherParkinsonV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:3202504
|texte= Cannabinoids in health and disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:18286801" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a DanceTherParkinsonV1
| This area was generated with Dilib version V0.6.35. |  |