Minireview: Dopaminergic Regulation of Insulin Secretion from the Pancreatic Islet
Identifieur interne : 000098 ( Main/Exploration ); précédent : 000097; suivant : 000099Minireview: Dopaminergic Regulation of Insulin Secretion from the Pancreatic Islet
Auteurs : Alessandro Ustione ; David W. Piston ; Paul E. HarrisSource :
- Molecular Endocrinology [ 0888-8809 ] ; 2013.
Abstract
Exogenous dopamine inhibits insulin secretion from pancreatic β-cells, but the lack of dopaminergic neurons in pancreatic islets has led to controversy regarding the importance of this effect. Recent data, however, suggest a plausible physiologic role for dopamine in the regulation of insulin secretion. We review the literature underlying our current understanding of dopaminergic signaling that can down-regulate glucose-stimulated insulin secretion from pancreatic islets. In this negative feedback loop, dopamine is synthesized in the β-cells from circulating
Url:
DOI: 10.1210/me.2013-1083
PubMed: 23744894
PubMed Central: 3725340
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Exogenous dopamine inhibits insulin secretion from pancreatic β-cells, but the lack of dopaminergic neurons in pancreatic islets has led to controversy regarding the importance of this effect. Recent data, however, suggest a plausible physiologic role for dopamine in the regulation of insulin secretion. We review the literature underlying our current understanding of dopaminergic signaling that can down-regulate glucose-stimulated insulin secretion from pancreatic islets. In this negative feedback loop, dopamine is synthesized in the β-cells from circulating <sc>l</sc>
-dopa, serves as an autocrine signal that is cosecreted with insulin, and causes a tonic inhibition on glucose-stimulated insulin secretion. On the whole animal scale, <sc>l</sc>
-dopa is produced by cells in the gastrointestinal tract, and its concentration in the blood plasma increases following a mixed meal. By reviewing the outcome of certain types of bariatric surgery that result in rapid amelioration of glucose tolerance, we hypothesize that dopamine serves as an “antiincretin” signal that counterbalances the stimulatory effect of glucagon-like peptide 1.</p>
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<name sortKey="Ustione, Alessandro" sort="Ustione, Alessandro" uniqKey="Ustione A" first="Alessandro" last="Ustione">Alessandro Ustione</name>
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