Minireview: Dopaminergic Regulation of Insulin Secretion from the Pancreatic Islet
Identifieur interne : 000098 ( Main/Exploration ); précédent : 000097; suivant : 000099Minireview: Dopaminergic Regulation of Insulin Secretion from the Pancreatic Islet
Auteurs : Alessandro Ustione ; David W. Piston ; Paul E. HarrisSource :
- Molecular Endocrinology [ 0888-8809 ] ; 2013.
Abstract
Exogenous dopamine inhibits insulin secretion from pancreatic β-cells, but the lack of dopaminergic neurons in pancreatic islets has led to controversy regarding the importance of this effect. Recent data, however, suggest a plausible physiologic role for dopamine in the regulation of insulin secretion. We review the literature underlying our current understanding of dopaminergic signaling that can down-regulate glucose-stimulated insulin secretion from pancreatic islets. In this negative feedback loop, dopamine is synthesized in the β-cells from circulating
Url:
DOI: 10.1210/me.2013-1083
PubMed: 23744894
PubMed Central: 3725340
Affiliations:
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