Phosphines and metal phosphine complexes: Relationship of chemistry to anticancer and other biological activity
Identifieur interne : 000223 ( Istex/Corpus ); précédent : 000222; suivant : 000224Phosphines and metal phosphine complexes: Relationship of chemistry to anticancer and other biological activity
Auteurs : Susan J. Berners-Price ; Peter J. SadlerSource :
- Structure and Bonding [ 0081-5993 ] ; 1988.
Abstract
Abstract: Current interest in the biological chemistry of phosphines and their metal complexes ranges from the widespread application of PH3 as a fumigant, to the clinical use of a Au(I)PEt3 complex as an anti-arthritic drug. Metal phosphine complexes also offer potential as heart-imaging agents and anti-cancer drugs. Data on cytotoxicity and anticancer activity are surveyed in detail with particular emphasis on diphosphines and their copper, silver and gold complexes. Chemistry of likely relevance to pharmacology is discussed: especially redox reactions (disulphide reduction, oxygen abstraction), radical reactions and metal binding. Much phosphine chemistry of relevance to biology has yet to be explored.
Url:
DOI: 10.1007/3-540-50130-4_2
Links to Exploration step
ISTEX:B51A4A95F529FA4165F2EA93A7299FA48EFA32A7Le document en format XML
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Metal phosphine complexes also offer potential as heart-imaging agents and anti-cancer drugs. Data on cytotoxicity and anticancer activity are surveyed in detail with particular emphasis on diphosphines and their copper, silver and gold complexes. Chemistry of likely relevance to pharmacology is discussed: especially redox reactions (disulphide reduction, oxygen abstraction), radical reactions and metal binding. Much phosphine chemistry of relevance to biology has yet to be explored.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>Susan J. Berners-Price</name><affiliations><json:string>Department of Chemistry, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK</json:string></affiliations></json:item><json:item><name>Peter J. 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Metal phosphine complexes also offer potential as heart-imaging agents and anti-cancer drugs. Data on cytotoxicity and anticancer activity are surveyed in detail with particular emphasis on diphosphines and their copper, silver and gold complexes. Chemistry of likely relevance to pharmacology is discussed: especially redox reactions (disulphide reduction, oxygen abstraction), radical reactions and metal binding. 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7HX</Postcode><City>London</City><Country>UK</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Current interest in the biological chemistry of phosphines and their metal complexes ranges from the widespread application of PH<Subscript>3</Subscript> as a fumigant, to the clinical use of a Au(I)PEt<Subscript>3</Subscript> complex as an anti-arthritic drug. Metal phosphine complexes also offer potential as heart-imaging agents and anti-cancer drugs. Data on cytotoxicity and anticancer activity are surveyed in detail with particular emphasis on diphosphines and their copper, silver and gold complexes. Chemistry of likely relevance to pharmacology is discussed: especially redox reactions (disulphide reduction, oxygen abstraction), radical reactions and metal binding. Much phosphine chemistry of relevance to biology has yet to be explored.</Para></Abstract></ChapterHeader><NoBody></NoBody></Chapter></Book></Series></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Phosphines and metal phosphine complexes: Relationship of chemistry to anticancer and other biological activity</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Phosphines and metal phosphine complexes: Relationship of chemistry to anticancer and other biological activity</title></titleInfo><name type="personal"><namePart type="given">Susan</namePart><namePart type="given">J.</namePart><namePart type="family">Berners-Price</namePart><affiliation>Department of Chemistry, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter</namePart><namePart type="given">J.</namePart><namePart type="family">Sadler</namePart><affiliation>Department of Chemistry, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="conference" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer Berlin Heidelberg</publisher><place><placeTerm type="text">Berlin, Heidelberg</placeTerm></place><dateIssued encoding="w3cdtf">2005-03-03</dateIssued><copyrightDate encoding="w3cdtf">1988</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Current interest in the biological chemistry of phosphines and their metal complexes ranges from the widespread application of PH3 as a fumigant, to the clinical use of a Au(I)PEt3 complex as an anti-arthritic drug. Metal phosphine complexes also offer potential as heart-imaging agents and anti-cancer drugs. Data on cytotoxicity and anticancer activity are surveyed in detail with particular emphasis on diphosphines and their copper, silver and gold complexes. Chemistry of likely relevance to pharmacology is discussed: especially redox reactions (disulphide reduction, oxygen abstraction), radical reactions and metal binding. Much phosphine chemistry of relevance to biology has yet to be explored.</abstract><relatedItem type="host"><titleInfo><title>Bioinorganic Chemistry</title></titleInfo><genre type="book-series" displayLabel="Proceedings"></genre><originInfo><copyrightDate encoding="w3cdtf">1988</copyrightDate><issuance>monographic</issuance></originInfo><subject><genre>Book-Subject-Collection</genre><topic authority="SpringerSubjectCodes" authorityURI="SUCO11644">Chemistry and Materials Science</topic></subject><subject><genre>Book-Subject-Group</genre><topic authority="SpringerSubjectCodes" authorityURI="B">Biomedicine</topic><topic authority="SpringerSubjectCodes" authorityURI="B11001">Cancer Research</topic><topic authority="SpringerSubjectCodes" authorityURI="L14005">Biochemistry, general</topic><topic authority="SpringerSubjectCodes" authorityURI="C16008">Inorganic Chemistry</topic><topic authority="SpringerSubjectCodes" authorityURI="F00008">Pharmacy</topic><topic authority="SpringerSubjectCodes" authorityURI="H43008">Oncology</topic></subject><identifier type="DOI">10.1007/3-540-50130-4</identifier><identifier type="ISBN">978-3-540-50130-5</identifier><identifier type="eISBN">978-3-540-45936-1</identifier><identifier type="ISSN">0081-5993</identifier><identifier type="eISSN">1616-8550</identifier><identifier type="BookTitleID">21480</identifier><identifier type="BookID">3540501304</identifier><identifier type="BookChapterCount">3</identifier><identifier type="BookVolumeNumber">70</identifier><part><date>1988</date><detail type="volume"><number>70</number><caption>vol.</caption></detail><extent unit="pages"><start>27</start><end>102</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1988</recordOrigin></recordInfo></relatedItem><relatedItem type="series"><titleInfo><title>Structure and Bonding</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="given">J.</namePart><namePart type="family">Clarke</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="given">B.</namePart><namePart type="family">Goodenough</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="given">A.</namePart><namePart type="family">Ibers</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="given">K.</namePart><namePart type="family">Jørgensen</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="given">M.</namePart><namePart type="given">P.</namePart><namePart type="family">Mingos</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="given">B.</namePart><namePart type="family">Neilands</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="given">A.</namePart><namePart type="family">Palmer</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Reinen</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="given">J.</namePart><namePart type="family">Sadler</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Weiss</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="given">J.</namePart><namePart type="given">P.</namePart><namePart type="family">Williams</namePart><role><roleTerm type="text">editor</roleTerm></role></name><originInfo><copyrightDate encoding="w3cdtf">1988</copyrightDate><issuance>serial</issuance></originInfo><identifier type="ISSN">0081-5993</identifier><identifier type="eISSN">1616-8550</identifier><identifier type="SeriesID">430</identifier><recordInfo><recordOrigin>Springer-Verlag, 1988</recordOrigin></recordInfo></relatedItem><identifier type="istex">B51A4A95F529FA4165F2EA93A7299FA48EFA32A7</identifier><identifier type="DOI">10.1007/3-540-50130-4_2</identifier><identifier type="ChapterID">2</identifier><identifier type="ChapterID">Chap2</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1988</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1988</recordOrigin></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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