Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney
Identifieur interne : 000399 ( Istex/Corpus ); précédent : 000398; suivant : 000400Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney
Auteurs : Anthony Josephine ; Ganapathy Amudha ; Coothan Kandaswamy Veena ; Sreenivasan P. Preetha ; Arjunan Rajeswari ; Palaninathan VaralakshmiSource :
- Molecular Nutrition & Food Research [ 1613-4125 ] ; 2007-11.
English descriptors
- KwdEn :
Abstract
Sulfated polysaccharides from marine seaweeds are receiving continuous attention owing to their wide therapeutic applications and are known to inhibit free radical generation. It has been well known that mitochondria are the major sources as well as the target of free radicals. The renal tubules have high density of mitochondria and therefore show structural and functional defects in acute renal failure. Hence, the present study is designed to appraise the mitochondrial status during Cyclosporine A (CsA)‐induced nephrotoxicity and the effect of sulfated polysaccharides over it. Sulfated polysaccharides (5 mg/kg body weight, subcutaneously) treatment significantly prevented the CsA‐induced (25 mg/kg body weight, orally) mitochondrial damage. CsA‐induced mitochondrial oxidative stress in rat kidney was evident from increased reactive oxygen species level, decreased antioxidant defense system, coupled with enhanced lipid peroxidation. Further, the activities of tricarboxylic acid cycle and electron transport chain enzymes were decreased in CsA‐induced rats, along with a significant increase in the activities of urinary enzymes, thus indicating renal tubular injury. Ultrastructural changes were also in accord with the above aberrations. The above abnormalities were favorably modulated by sulfated polysaccharides supplementation, thus highlighting the significance of sulfated polysaccharides in preventing the renal mitochondrial dysfunction allied with CsA‐provoked nephrotoxicity.
Url:
DOI: 10.1002/mnfr.200700127
Links to Exploration step
ISTEX:878595168592A567E3CAD88E8FC7A3C93BE2C88FLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney</title><author><name sortKey="Josephine, Anthony" sort="Josephine, Anthony" uniqKey="Josephine A" first="Anthony" last="Josephine">Anthony Josephine</name><affiliation><mods:affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</mods:affiliation></affiliation></author><author><name sortKey="Amudha, Ganapathy" sort="Amudha, Ganapathy" uniqKey="Amudha G" first="Ganapathy" last="Amudha">Ganapathy Amudha</name><affiliation><mods:affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</mods:affiliation></affiliation></author><author><name sortKey="Veena, Coothan Kandaswamy" sort="Veena, Coothan Kandaswamy" uniqKey="Veena C" first="Coothan Kandaswamy" last="Veena">Coothan Kandaswamy Veena</name><affiliation><mods:affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</mods:affiliation></affiliation></author><author><name sortKey="Preetha, Sreenivasan P" sort="Preetha, Sreenivasan P" uniqKey="Preetha S" first="Sreenivasan P." last="Preetha">Sreenivasan P. Preetha</name><affiliation><mods:affiliation>Department of Zoology, Division of Biochemistry, University of Madras, Chennai, India</mods:affiliation></affiliation></author><author><name sortKey="Rajeswari, Arjunan" sort="Rajeswari, Arjunan" uniqKey="Rajeswari A" first="Arjunan" last="Rajeswari">Arjunan Rajeswari</name><affiliation><mods:affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</mods:affiliation></affiliation></author><author><name sortKey="Varalakshmi, Palaninathan" sort="Varalakshmi, Palaninathan" uniqKey="Varalakshmi P" first="Palaninathan" last="Varalakshmi">Palaninathan Varalakshmi</name><affiliation><mods:affiliation>E-mail: drvlakshmi@yahoo.com</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:878595168592A567E3CAD88E8FC7A3C93BE2C88F</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mnfr.200700127</idno><idno type="url">https://api.istex.fr/document/878595168592A567E3CAD88E8FC7A3C93BE2C88F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000399</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000399</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney</title><author><name sortKey="Josephine, Anthony" sort="Josephine, Anthony" uniqKey="Josephine A" first="Anthony" last="Josephine">Anthony Josephine</name><affiliation><mods:affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</mods:affiliation></affiliation></author><author><name sortKey="Amudha, Ganapathy" sort="Amudha, Ganapathy" uniqKey="Amudha G" first="Ganapathy" last="Amudha">Ganapathy Amudha</name><affiliation><mods:affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</mods:affiliation></affiliation></author><author><name sortKey="Veena, Coothan Kandaswamy" sort="Veena, Coothan Kandaswamy" uniqKey="Veena C" first="Coothan Kandaswamy" last="Veena">Coothan Kandaswamy Veena</name><affiliation><mods:affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</mods:affiliation></affiliation></author><author><name sortKey="Preetha, Sreenivasan P" sort="Preetha, Sreenivasan P" uniqKey="Preetha S" first="Sreenivasan P." last="Preetha">Sreenivasan P. Preetha</name><affiliation><mods:affiliation>Department of Zoology, Division of Biochemistry, University of Madras, Chennai, India</mods:affiliation></affiliation></author><author><name sortKey="Rajeswari, Arjunan" sort="Rajeswari, Arjunan" uniqKey="Rajeswari A" first="Arjunan" last="Rajeswari">Arjunan Rajeswari</name><affiliation><mods:affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</mods:affiliation></affiliation></author><author><name sortKey="Varalakshmi, Palaninathan" sort="Varalakshmi, Palaninathan" uniqKey="Varalakshmi P" first="Palaninathan" last="Varalakshmi">Palaninathan Varalakshmi</name><affiliation><mods:affiliation>E-mail: drvlakshmi@yahoo.com</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular Nutrition & Food Research</title><title level="j" type="abbrev">Mol. Nutr. Food Res.</title><idno type="ISSN">1613-4125</idno><idno type="eISSN">1613-4133</idno><imprint><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2007-11">2007-11</date><biblScope unit="volume">51</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1413">1413</biblScope><biblScope unit="page" to="1422">1422</biblScope></imprint><idno type="ISSN">1613-4125</idno></series><idno type="istex">878595168592A567E3CAD88E8FC7A3C93BE2C88F</idno><idno type="DOI">10.1002/mnfr.200700127</idno><idno type="ArticleID">MNFR200700127</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1613-4125</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants</term><term>Cyclosporine A</term><term>Mitochondrial enzymes</term><term>Mitochondrial swelling</term><term>Sulphated polysaccharides</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sulfated polysaccharides from marine seaweeds are receiving continuous attention owing to their wide therapeutic applications and are known to inhibit free radical generation. It has been well known that mitochondria are the major sources as well as the target of free radicals. The renal tubules have high density of mitochondria and therefore show structural and functional defects in acute renal failure. Hence, the present study is designed to appraise the mitochondrial status during Cyclosporine A (CsA)‐induced nephrotoxicity and the effect of sulfated polysaccharides over it. Sulfated polysaccharides (5 mg/kg body weight, subcutaneously) treatment significantly prevented the CsA‐induced (25 mg/kg body weight, orally) mitochondrial damage. CsA‐induced mitochondrial oxidative stress in rat kidney was evident from increased reactive oxygen species level, decreased antioxidant defense system, coupled with enhanced lipid peroxidation. Further, the activities of tricarboxylic acid cycle and electron transport chain enzymes were decreased in CsA‐induced rats, along with a significant increase in the activities of urinary enzymes, thus indicating renal tubular injury. Ultrastructural changes were also in accord with the above aberrations. The above abnormalities were favorably modulated by sulfated polysaccharides supplementation, thus highlighting the significance of sulfated polysaccharides in preventing the renal mitochondrial dysfunction allied with CsA‐provoked nephrotoxicity.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Anthony Josephine</name><affiliations><json:string>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</json:string></affiliations></json:item><json:item><name>Ganapathy Amudha</name><affiliations><json:string>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</json:string></affiliations></json:item><json:item><name>Coothan Kandaswamy Veena</name><affiliations><json:string>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</json:string></affiliations></json:item><json:item><name>Sreenivasan P. Preetha</name><affiliations><json:string>Department of Zoology, Division of Biochemistry, University of Madras, Chennai, India</json:string></affiliations></json:item><json:item><name>Arjunan Rajeswari</name><affiliations><json:string>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</json:string></affiliations></json:item><json:item><name>Palaninathan Varalakshmi</name><affiliations><json:string>E-mail: drvlakshmi@yahoo.com</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Antioxidants</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cyclosporine A</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mitochondrial enzymes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mitochondrial swelling</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Sulphated polysaccharides</value></json:item></subject><articleId><json:string>MNFR200700127</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Sulfated polysaccharides from marine seaweeds are receiving continuous attention owing to their wide therapeutic applications and are known to inhibit free radical generation. It has been well known that mitochondria are the major sources as well as the target of free radicals. The renal tubules have high density of mitochondria and therefore show structural and functional defects in acute renal failure. Hence, the present study is designed to appraise the mitochondrial status during Cyclosporine A (CsA)‐induced nephrotoxicity and the effect of sulfated polysaccharides over it. Sulfated polysaccharides (5 mg/kg body weight, subcutaneously) treatment significantly prevented the CsA‐induced (25 mg/kg body weight, orally) mitochondrial damage. CsA‐induced mitochondrial oxidative stress in rat kidney was evident from increased reactive oxygen species level, decreased antioxidant defense system, coupled with enhanced lipid peroxidation. Further, the activities of tricarboxylic acid cycle and electron transport chain enzymes were decreased in CsA‐induced rats, along with a significant increase in the activities of urinary enzymes, thus indicating renal tubular injury. Ultrastructural changes were also in accord with the above aberrations. The above abnormalities were favorably modulated by sulfated polysaccharides supplementation, thus highlighting the significance of sulfated polysaccharides in preventing the renal mitochondrial dysfunction allied with CsA‐provoked nephrotoxicity.</abstract><qualityIndicators><score>7.876</score><pdfVersion>1.4</pdfVersion><pdfPageSize>604 x 791 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1500</abstractCharCount><pdfWordCount>6903</pdfWordCount><pdfCharCount>43590</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>198</abstractWordCount></qualityIndicators><title>Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney</title><genre><json:string>article</json:string></genre><host><volume>51</volume><publisherId><json:string>MNFR</json:string></publisherId><pages><total>10</total><last>1422</last><first>1413</first></pages><issn><json:string>1613-4125</json:string></issn><issue>11</issue><author><json:item><name>Edzard Ernst</name></json:item></author><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1613-4133</json:string></eissn><title>Molecular Nutrition & Food Research</title><doi><json:string>10.1002/(ISSN)1613-4133</json:string></doi></host><categories><wos><json:string>science</json:string><json:string>food science & technology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>biomedical research</json:string><json:string>nutrition & dietetics</json:string></scienceMetrix></categories><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1002/mnfr.200700127</json:string></doi><id>878595168592A567E3CAD88E8FC7A3C93BE2C88F</id><score>0.119686455</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/878595168592A567E3CAD88E8FC7A3C93BE2C88F/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/878595168592A567E3CAD88E8FC7A3C93BE2C88F/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/878595168592A567E3CAD88E8FC7A3C93BE2C88F/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><availability><p>Copyright © 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</p></availability><date>2007</date></publicationStmt><notesStmt><note>Council of Scientific and Industrial Research (CSIR), New Delhi, India</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney</title><author xml:id="author-1"><persName><forename type="first">Anthony</forename><surname>Josephine</surname></persName><affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</affiliation></author><author xml:id="author-2"><persName><forename type="first">Ganapathy</forename><surname>Amudha</surname></persName><affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</affiliation></author><author xml:id="author-3"><persName><forename type="first">Coothan Kandaswamy</forename><surname>Veena</surname></persName><affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</affiliation></author><author xml:id="author-4"><persName><forename type="first">Sreenivasan P.</forename><surname>Preetha</surname></persName><affiliation>Department of Zoology, Division of Biochemistry, University of Madras, Chennai, India</affiliation></author><author xml:id="author-5"><persName><forename type="first">Arjunan</forename><surname>Rajeswari</surname></persName><affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</affiliation></author><author xml:id="author-6"><persName><forename type="first">Palaninathan</forename><surname>Varalakshmi</surname></persName><email>drvlakshmi@yahoo.com</email></author></analytic><monogr><title level="j">Molecular Nutrition & Food Research</title><title level="j" type="abbrev">Mol. Nutr. Food Res.</title><idno type="pISSN">1613-4125</idno><idno type="eISSN">1613-4133</idno><idno type="DOI">10.1002/(ISSN)1613-4133</idno><imprint><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2007-11"></date><biblScope unit="volume">51</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1413">1413</biblScope><biblScope unit="page" to="1422">1422</biblScope></imprint></monogr><idno type="istex">878595168592A567E3CAD88E8FC7A3C93BE2C88F</idno><idno type="DOI">10.1002/mnfr.200700127</idno><idno type="ArticleID">MNFR200700127</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Sulfated polysaccharides from marine seaweeds are receiving continuous attention owing to their wide therapeutic applications and are known to inhibit free radical generation. It has been well known that mitochondria are the major sources as well as the target of free radicals. The renal tubules have high density of mitochondria and therefore show structural and functional defects in acute renal failure. Hence, the present study is designed to appraise the mitochondrial status during Cyclosporine A (CsA)‐induced nephrotoxicity and the effect of sulfated polysaccharides over it. Sulfated polysaccharides (5 mg/kg body weight, subcutaneously) treatment significantly prevented the CsA‐induced (25 mg/kg body weight, orally) mitochondrial damage. CsA‐induced mitochondrial oxidative stress in rat kidney was evident from increased reactive oxygen species level, decreased antioxidant defense system, coupled with enhanced lipid peroxidation. Further, the activities of tricarboxylic acid cycle and electron transport chain enzymes were decreased in CsA‐induced rats, along with a significant increase in the activities of urinary enzymes, thus indicating renal tubular injury. Ultrastructural changes were also in accord with the above aberrations. The above abnormalities were favorably modulated by sulfated polysaccharides supplementation, thus highlighting the significance of sulfated polysaccharides in preventing the renal mitochondrial dysfunction allied with CsA‐provoked nephrotoxicity.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>Antioxidants</term></item><item><term>Cyclosporine A</term></item><item><term>Mitochondrial enzymes</term></item><item><term>Mitochondrial swelling</term></item><item><term>Sulphated polysaccharides</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-03-30">Received</change><change when="2007-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/878595168592A567E3CAD88E8FC7A3C93BE2C88F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>WILEY‐VCH Verlag</publisherName><publisherLoc>Weinheim</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1613-4133</doi><issn type="print">1613-4125</issn><issn type="electronic">1613-4133</issn><idGroup><id type="product" value="MNFR"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOLECULAR NUTRITION FOOD RESEARCH">Molecular Nutrition & Food Research</title><title type="short">Mol. Nutr. Food Res.</title></titleGroup></publicationMeta><publicationMeta level="part" position="110"><doi origin="wiley" registered="yes">10.1002/mnfr.v51:11</doi><titleGroup><title type="specialIssueTitle">Garlic</title></titleGroup><numberingGroup><numbering type="journalVolume" number="51">51</numbering><numbering type="journalIssue">11</numbering></numberingGroup><creators><creator xml:id="sped1" creatorRole="sponsoringEditor"><personName><givenNames>Edzard</givenNames><familyName>Ernst</familyName></personName></creator></creators><coverDate startDate="2007-11">November 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="14" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mnfr.200700127</doi><idGroup><id type="unit" value="MNFR200700127"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</copyright><eventGroup><event type="manuscriptReceived" date="2007-03-30"></event><event type="manuscriptRevised" date="2007-05-24"></event><event type="firstOnline" date="2007-10-04"></event><event type="publishedOnlineFinalForm" date="2007-10-26"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1413</numbering><numbering type="pageLast">1422</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:MNFR.MNFR200700127.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="67"></count></countGroup><titleGroup><title type="main" xml:lang="en">Beneficial effects of sulfated polysaccharides from <i>Sargassum wightii</i> against mitochondrial alterations induced by Cyclosporine A in rat kidney</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#a1"><personName><givenNames>Anthony</givenNames><familyName>Josephine</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#a1"><personName><givenNames>Ganapathy</givenNames><familyName>Amudha</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#a1"><personName><givenNames>Coothan Kandaswamy</givenNames><familyName>Veena</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#a2"><personName><givenNames>Sreenivasan P.</givenNames><familyName>Preetha</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#a1"><personName><givenNames>Arjunan</givenNames><familyName>Rajeswari</familyName></personName></creator><creator xml:id="au6" creatorRole="author"><personName><givenNames>Palaninathan</givenNames><familyName>Varalakshmi</familyName></personName><contactDetails><email>drvlakshmi@yahoo.com</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="IN" type="organization"><unparsedAffiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="IN" type="organization"><unparsedAffiliation>Department of Zoology, Division of Biochemistry, University of Madras, Chennai, India</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Antioxidants</keyword><keyword xml:id="kwd2">Cyclosporine A</keyword><keyword xml:id="kwd3">Mitochondrial enzymes</keyword><keyword xml:id="kwd4">Mitochondrial swelling</keyword><keyword xml:id="kwd5">Sulphated polysaccharides</keyword></keywordGroup><fundingInfo><fundingAgency>Council of Scientific and Industrial Research (CSIR), New Delhi, India</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Sulfated polysaccharides from marine seaweeds are receiving continuous attention owing to their wide therapeutic applications and are known to inhibit free radical generation. It has been well known that mitochondria are the major sources as well as the target of free radicals. The renal tubules have high density of mitochondria and therefore show structural and functional defects in acute renal failure. Hence, the present study is designed to appraise the mitochondrial status during Cyclosporine A (CsA)‐induced nephrotoxicity and the effect of sulfated polysaccharides over it. Sulfated polysaccharides (5 mg/kg body weight, subcutaneously) treatment significantly prevented the CsA‐induced (25 mg/kg body weight, orally) mitochondrial damage. CsA‐induced mitochondrial oxidative stress in rat kidney was evident from increased reactive oxygen species level, decreased antioxidant defense system, coupled with enhanced lipid peroxidation. Further, the activities of tricarboxylic acid cycle and electron transport chain enzymes were decreased in CsA‐induced rats, along with a significant increase in the activities of urinary enzymes, thus indicating renal tubular injury. Ultrastructural changes were also in accord with the above aberrations. The above abnormalities were favorably modulated by sulfated polysaccharides supplementation, thus highlighting the significance of sulfated polysaccharides in preventing the renal mitochondrial dysfunction allied with CsA‐provoked nephrotoxicity.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney</title></titleInfo><name type="personal"><namePart type="given">Anthony</namePart><namePart type="family">Josephine</namePart><affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ganapathy</namePart><namePart type="family">Amudha</namePart><affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Coothan Kandaswamy</namePart><namePart type="family">Veena</namePart><affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sreenivasan P.</namePart><namePart type="family">Preetha</namePart><affiliation>Department of Zoology, Division of Biochemistry, University of Madras, Chennai, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arjunan</namePart><namePart type="family">Rajeswari</namePart><affiliation>Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India. Fax: +91‐44‐2454‐0709</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Palaninathan</namePart><namePart type="family">Varalakshmi</namePart><affiliation>E-mail: drvlakshmi@yahoo.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2007-11</dateIssued><dateCaptured encoding="w3cdtf">2007-03-30</dateCaptured><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">4</extent><extent unit="references">67</extent></physicalDescription><abstract lang="en">Sulfated polysaccharides from marine seaweeds are receiving continuous attention owing to their wide therapeutic applications and are known to inhibit free radical generation. It has been well known that mitochondria are the major sources as well as the target of free radicals. The renal tubules have high density of mitochondria and therefore show structural and functional defects in acute renal failure. Hence, the present study is designed to appraise the mitochondrial status during Cyclosporine A (CsA)‐induced nephrotoxicity and the effect of sulfated polysaccharides over it. Sulfated polysaccharides (5 mg/kg body weight, subcutaneously) treatment significantly prevented the CsA‐induced (25 mg/kg body weight, orally) mitochondrial damage. CsA‐induced mitochondrial oxidative stress in rat kidney was evident from increased reactive oxygen species level, decreased antioxidant defense system, coupled with enhanced lipid peroxidation. Further, the activities of tricarboxylic acid cycle and electron transport chain enzymes were decreased in CsA‐induced rats, along with a significant increase in the activities of urinary enzymes, thus indicating renal tubular injury. Ultrastructural changes were also in accord with the above aberrations. The above abnormalities were favorably modulated by sulfated polysaccharides supplementation, thus highlighting the significance of sulfated polysaccharides in preventing the renal mitochondrial dysfunction allied with CsA‐provoked nephrotoxicity.</abstract><note type="funding">Council of Scientific and Industrial Research (CSIR), New Delhi, India</note><subject lang="en"><genre>keywords</genre><topic>Antioxidants</topic><topic>Cyclosporine A</topic><topic>Mitochondrial enzymes</topic><topic>Mitochondrial swelling</topic><topic>Sulphated polysaccharides</topic></subject><relatedItem type="host"><titleInfo><title>Molecular Nutrition & Food Research</title></titleInfo><titleInfo type="abbreviated"><title>Mol. Nutr. Food Res.</title></titleInfo><name type="personal"><namePart type="given">Edzard</namePart><namePart type="family">Ernst</namePart></name><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">1613-4125</identifier><identifier type="eISSN">1613-4133</identifier><identifier type="DOI">10.1002/(ISSN)1613-4133</identifier><identifier type="PublisherID">MNFR</identifier><part><date>2007</date><detail type="title"><title>Garlic</title></detail><detail type="volume"><caption>vol.</caption><number>51</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1413</start><end>1422</end><total>10</total></extent></part></relatedItem><identifier type="istex">878595168592A567E3CAD88E8FC7A3C93BE2C88F</identifier><identifier type="DOI">10.1002/mnfr.200700127</identifier><identifier type="ArticleID">MNFR200700127</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>WILEY‐VCH Verlag</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/DanceTherParkinsonV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000399 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000399 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Psychologie
|area= DanceTherParkinsonV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:878595168592A567E3CAD88E8FC7A3C93BE2C88F
|texte= Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney
}}
| This area was generated with Dilib version V0.6.35. |  |