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Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: A possible complication of chronic hypoxia and carbon monoxide toxicity?

Identifieur interne : 000219 ( Istex/Corpus ); précédent : 000218; suivant : 000220

Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: A possible complication of chronic hypoxia and carbon monoxide toxicity?

Auteurs : Brian K. Lassinger ; Carolyn Kwak ; Roy L. Walford ; Joseph Jankovic

Source :

RBID : ISTEX:B8F92DA332035692074CC35029BBD38E53F8B2B1

English descriptors

Abstract

Exogenous toxins and chronic hypoxia have been implicated in the etiopathogenesis of a variety of neurological disorders, but it is not always possible to establish a cause–effect relationships. We describe a patient who presented with an unusual gait disorder and progressive motor neuron disease after residing for 2 years within Biosphere 2, a scientifically engineered dome, tightly sealed to allow miniscule exchange of air between its atmosphere and the earth's atmosphere. We postulate that this unusual syndrome resulted from chronic hypoxia possibly coupled with carbon monoxide and nitrous oxide exposure. © 2004 Movement Disorder Society

Url:
DOI: 10.1002/mds.20076

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ISTEX:B8F92DA332035692074CC35029BBD38E53F8B2B1

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<p>A videotape accompanies this article.</p>
</note>
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<title>Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: A possible complication of chronic hypoxia and carbon monoxide toxicity?</title>
</titleInfo>
<titleInfo type="abbreviated" lang="en">
<title>Parkinsonism in a Biosphere Participant</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en">
<title>Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: A possible complication of chronic hypoxia and carbon monoxide toxicity?</title>
</titleInfo>
<name type="personal">
<namePart type="given">Brian K.</namePart>
<namePart type="family">Lassinger</namePart>
<namePart type="termsOfAddress">PA</namePart>
<affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Carolyn</namePart>
<namePart type="family">Kwak</namePart>
<namePart type="termsOfAddress">MS, PA‐C</namePart>
<affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Roy L.</namePart>
<namePart type="family">Walford</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Pathology and Laboratory Medicine, University of California School of Medicine, Los Angeles, California, USA</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Joseph</namePart>
<namePart type="family">Jankovic</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation>
<affiliation>Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
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<originInfo>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place>
<placeTerm type="text">Hoboken</placeTerm>
</place>
<dateIssued encoding="w3cdtf">2004-04</dateIssued>
<dateCaptured encoding="w3cdtf">2003-01-24</dateCaptured>
<dateValid encoding="w3cdtf">2004-01-08</dateValid>
<copyrightDate encoding="w3cdtf">2004</copyrightDate>
</originInfo>
<language>
<languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
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<extent unit="references">40</extent>
<extent unit="words">3351</extent>
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<abstract lang="en">Exogenous toxins and chronic hypoxia have been implicated in the etiopathogenesis of a variety of neurological disorders, but it is not always possible to establish a cause–effect relationships. We describe a patient who presented with an unusual gait disorder and progressive motor neuron disease after residing for 2 years within Biosphere 2, a scientifically engineered dome, tightly sealed to allow miniscule exchange of air between its atmosphere and the earth's atmosphere. We postulate that this unusual syndrome resulted from chronic hypoxia possibly coupled with carbon monoxide and nitrous oxide exposure. © 2004 Movement Disorder Society</abstract>
<note type="content">*A videotape accompanies this article.</note>
<subject lang="en">
<genre>keywords</genre>
<topic>biosphere</topic>
<topic>parkinsonism</topic>
<topic>gait disorder</topic>
<topic>motor neuron disease</topic>
<topic>hypoxia</topic>
</subject>
<relatedItem type="host">
<titleInfo>
<title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
</titleInfo>
<titleInfo type="abbreviated">
<title>Mov. Disord.</title>
</titleInfo>
<genre type="journal">journal</genre>
<note type="content"> This article includes Supplementary Video Clips available at http://www.interscience.wiley.com/jpages/0360‐4012/suppmat/69/v69.810.htmlSupporting Info Item: Supporting Information file suppmat_465.mpg - </note>
<subject>
<genre>article-category</genre>
<topic>Brief Report with Video</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part>
<date>2004</date>
<detail type="volume">
<caption>vol.</caption>
<number>19</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>4</number>
</detail>
<extent unit="pages">
<start>465</start>
<end>469</end>
<total>5</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">B8F92DA332035692074CC35029BBD38E53F8B2B1</identifier>
<identifier type="DOI">10.1002/mds.20076</identifier>
<identifier type="ArticleID">MDS20076</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2004 Movement Disorder Society</accessCondition>
<recordInfo>
<recordContentSource>WILEY</recordContentSource>
<recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
</recordInfo>
</mods>
</metadata>
<serie></serie>
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