Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease
Identifieur interne : 000165 ( Istex/Corpus ); précédent : 000164; suivant : 000166Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease
Auteurs : Yi Guo ; Wei-Dong Le ; Joseph Jankovic ; Hua-Rong Yang ; Hong-Bo Xu ; Wen-Jie Xie ; Zhi Song ; Hao DengSource :
- Movement Disorders [ 0885-3185 ] ; 2011-08-01.
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Abstract
Paired‐like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons.
To determine whether genetic variation in the coding region of the paired‐like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease.
We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early‐onset Parkinson's disease and familial Parkinson's disease. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23693
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<front><div type="abstract">Paired‐like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons.</div>
<div type="abstract">To determine whether genetic variation in the coding region of the paired‐like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease.</div>
<div type="abstract">We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early‐onset Parkinson's disease and familial Parkinson's disease. © 2011 Movement Disorder Society</div>
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<titleGroup><title type="main" xml:lang="en">Systematic genetic analysis of the <i>PITX3</i>
gene in patients with Parkinson disease<link href="#fn1"></link>
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<title type="short" xml:lang="en">Brief Report</title>
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<supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p>
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<p>To determine whether genetic variation in the coding region of the paired‐like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease.</p>
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<section xml:id="abs1-3"><title type="main">Results:</title>
<p>We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early‐onset Parkinson's disease and familial Parkinson's disease. © 2011 Movement Disorder Society</p>
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<noteGroup><note xml:id="fn1"><p>Relevant conflicts of interest/financial disclosures: Nothing to report.</p>
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<note xml:id="fn3"><p>Full financial disclosures and author roles may be found in the online version of this article.</p>
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<abstract>Paired‐like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons.</abstract>
<abstract>To determine whether genetic variation in the coding region of the paired‐like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease.</abstract>
<abstract>We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early‐onset Parkinson's disease and familial Parkinson's disease. © 2011 Movement Disorder Society</abstract>
<note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note>
<note type="content">*This work was supported by Central South University, Changsha, China, and Baylor College of Medicine, Houston, Texas.</note>
<note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note>
<subject lang="en"><genre>keywords</genre>
<topic>Parkinson disease</topic>
<topic>transcription factor</topic>
<topic>paired‐like homodomain transcription factor 3</topic>
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<identifier type="ISSN">0885-3185</identifier>
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