A Molecular Genetic Linkage Map of Mouse Chromosome 9 with Regional Localizations for the Gsta, T3g, Ets-1 and Ldlr Loci
Identifieur interne : 000139 ( Pmc/Corpus ); précédent : 000138; suivant : 000140A Molecular Genetic Linkage Map of Mouse Chromosome 9 with Regional Localizations for the Gsta, T3g, Ets-1 and Ldlr Loci
Auteurs : D. M. Kingsley ; N. A. Jenkins ; N. G. CopelandSource :
- Genetics [ 0016-6731 ] ; 1989.
Abstract
A 64-centiMorgan linkage map of mouse chromosome 9 was developed using cloned DNA markers and an interspecific backcross between Mus spretus and the C57BL/6J inbred strain. This map was compared to conventional genetic maps using six markers previously localized in laboratory mouse strains. These markers included thymus cell antigen-1, cytochrome P450-3, dilute, transferrin, cholecystokinin, and the G-protein alpha inhibitory subunit. No evidence was seen for segregation distortion, chromosome rearrangements, or altered genetic distances in the results from interspecific backcross mapping. Regional map locations were determined for four genes that were previously assigned to chromosome 9 using somatic cell hybrids. These genes were glutathione S-transferase Ya subunit (Gsta), the T3 gamma subunit, the low density lipoprotein receptor, and the Ets-1 oncogene. The map locations for these genes establish new regions of synteny between mouse chromosome 9 and human chromosomes 6, 11, and 19. In addition, the close linkage detected between the dilute and Gsta loci suggests that the Gsta locus may be part of the dilute/short ear complex, one of the most extensively studied genetic regions of the mouse.
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PubMed: 2572508
PubMed Central: 1203779
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<author><name sortKey="Copeland, N G" sort="Copeland, N G" uniqKey="Copeland N" first="N. G." last="Copeland">N. G. Copeland</name>
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<front><div type="abstract" xml:lang="en"><p>A 64-centiMorgan linkage map of mouse chromosome 9 was developed using cloned DNA markers and an interspecific backcross between Mus spretus and the C57BL/6J inbred strain. This map was compared to conventional genetic maps using six markers previously localized in laboratory mouse strains. These markers included thymus cell antigen-1, cytochrome P450-3, dilute, transferrin, cholecystokinin, and the G-protein alpha inhibitory subunit. No evidence was seen for segregation distortion, chromosome rearrangements, or altered genetic distances in the results from interspecific backcross mapping. Regional map locations were determined for four genes that were previously assigned to chromosome 9 using somatic cell hybrids. These genes were glutathione S-transferase Ya subunit (Gsta), the T3 gamma subunit, the low density lipoprotein receptor, and the Ets-1 oncogene. The map locations for these genes establish new regions of synteny between mouse chromosome 9 and human chromosomes 6, 11, and 19. In addition, the close linkage detected between the dilute and Gsta loci suggests that the Gsta locus may be part of the dilute/short ear complex, one of the most extensively studied genetic regions of the mouse.</p>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Genetics</journal-id>
<journal-title>Genetics</journal-title>
<issn pub-type="ppub">0016-6731</issn>
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<article-id pub-id-type="publisher-id">1231165</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Investigations</subject>
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<title-group><article-title>A Molecular Genetic Linkage Map of Mouse Chromosome 9 with Regional Localizations for the Gsta, T3g, Ets-1 and Ldlr Loci</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Kingsley</surname>
<given-names>D. M.</given-names>
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<contrib contrib-type="author"><name><surname>Jenkins</surname>
<given-names>N. A.</given-names>
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<contrib contrib-type="author"><name><surname>Copeland</surname>
<given-names>N. G.</given-names>
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<aff>Mammalian Genetics Laboratory, BRI-Basic Research Program, NCI-Frederick Cancer Research Facility, Frederick, Maryland 21701</aff>
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<pub-date pub-type="ppub"><month>09</month>
<year>1989</year>
</pub-date>
<volume>123</volume>
<issue>1</issue>
<fpage>165</fpage>
<lpage>172</lpage>
<abstract><p>A 64-centiMorgan linkage map of mouse chromosome 9 was developed using cloned DNA markers and an interspecific backcross between Mus spretus and the C57BL/6J inbred strain. This map was compared to conventional genetic maps using six markers previously localized in laboratory mouse strains. These markers included thymus cell antigen-1, cytochrome P450-3, dilute, transferrin, cholecystokinin, and the G-protein alpha inhibitory subunit. No evidence was seen for segregation distortion, chromosome rearrangements, or altered genetic distances in the results from interspecific backcross mapping. Regional map locations were determined for four genes that were previously assigned to chromosome 9 using somatic cell hybrids. These genes were glutathione S-transferase Ya subunit (Gsta), the T3 gamma subunit, the low density lipoprotein receptor, and the Ets-1 oncogene. The map locations for these genes establish new regions of synteny between mouse chromosome 9 and human chromosomes 6, 11, and 19. In addition, the close linkage detected between the dilute and Gsta loci suggests that the Gsta locus may be part of the dilute/short ear complex, one of the most extensively studied genetic regions of the mouse.</p>
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