BernheimV1, Pmc, Corpus, bibRecord, 000139

A Molecular Genetic Linkage Map of Mouse Chromosome 9 with Regional Localizations for the Gsta, T3g, Ets-1 and Ldlr Loci

Identifieur interne : 000139 ( Pmc/Corpus ); précédent : 000138; suivant : 000140

A Molecular Genetic Linkage Map of Mouse Chromosome 9 with Regional Localizations for the Gsta, T3g, Ets-1 and Ldlr Loci

Auteurs : D. M. Kingsley ; N. A. Jenkins ; N. G. Copeland

Source :

Genetics [ 0016-6731 ] ; 1989.

RBID : PMC:1203779

Abstract

A 64-centiMorgan linkage map of mouse chromosome 9 was developed using cloned DNA markers and an interspecific backcross between Mus spretus and the C57BL/6J inbred strain. This map was compared to conventional genetic maps using six markers previously localized in laboratory mouse strains. These markers included thymus cell antigen-1, cytochrome P450-3, dilute, transferrin, cholecystokinin, and the G-protein alpha inhibitory subunit. No evidence was seen for segregation distortion, chromosome rearrangements, or altered genetic distances in the results from interspecific backcross mapping. Regional map locations were determined for four genes that were previously assigned to chromosome 9 using somatic cell hybrids. These genes were glutathione S-transferase Ya subunit (Gsta), the T3 gamma subunit, the low density lipoprotein receptor, and the Ets-1 oncogene. The map locations for these genes establish new regions of synteny between mouse chromosome 9 and human chromosomes 6, 11, and 19. In addition, the close linkage detected between the dilute and Gsta loci suggests that the Gsta locus may be part of the dilute/short ear complex, one of the most extensively studied genetic regions of the mouse.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1203779

PubMed: 2572508
PubMed Central: 1203779

Links to Exploration step

PMC:1203779

Le document en format XML

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<author><name sortKey="Kingsley, D M" sort="Kingsley, D M" uniqKey="Kingsley D" first="D. M." last="Kingsley">D. M. Kingsley</name>
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<author><name sortKey="Jenkins, N A" sort="Jenkins, N A" uniqKey="Jenkins N" first="N. A." last="Jenkins">N. A. Jenkins</name>
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<author><name sortKey="Copeland, N G" sort="Copeland, N G" uniqKey="Copeland N" first="N. G." last="Copeland">N. G. Copeland</name>
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<author><name sortKey="Jenkins, N A" sort="Jenkins, N A" uniqKey="Jenkins N" first="N. A." last="Jenkins">N. A. Jenkins</name>
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<author><name sortKey="Copeland, N G" sort="Copeland, N G" uniqKey="Copeland N" first="N. G." last="Copeland">N. G. Copeland</name>
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<series><title level="j">Genetics</title>
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<front><div type="abstract" xml:lang="en"><p>A 64-centiMorgan linkage map of mouse chromosome 9 was developed using cloned DNA markers and an interspecific backcross between Mus spretus and the C57BL/6J inbred strain. This map was compared to conventional genetic maps using six markers previously localized in laboratory mouse strains. These markers included thymus cell antigen-1, cytochrome P450-3, dilute, transferrin, cholecystokinin, and the G-protein alpha inhibitory subunit. No evidence was seen for segregation distortion, chromosome rearrangements, or altered genetic distances in the results from interspecific backcross mapping. Regional map locations were determined for four genes that were previously assigned to chromosome 9 using somatic cell hybrids. These genes were glutathione S-transferase Ya subunit (Gsta), the T3 gamma subunit, the low density lipoprotein receptor, and the Ets-1 oncogene. The map locations for these genes establish new regions of synteny between mouse chromosome 9 and human chromosomes 6, 11, and 19. In addition, the close linkage detected between the dilute and Gsta loci suggests that the Gsta locus may be part of the dilute/short ear complex, one of the most extensively studied genetic regions of the mouse.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Genetics</journal-id>
<journal-title>Genetics</journal-title>
<issn pub-type="ppub">0016-6731</issn>
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<article-meta><article-id pub-id-type="pmid">2572508</article-id>
<article-id pub-id-type="pmc">1203779</article-id>
<article-id pub-id-type="publisher-id">1231165</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Investigations</subject>
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<title-group><article-title>A Molecular Genetic Linkage Map of Mouse Chromosome 9 with Regional Localizations for the Gsta, T3g, Ets-1 and Ldlr Loci</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kingsley</surname>
<given-names>D. M.</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Jenkins</surname>
<given-names>N. A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Copeland</surname>
<given-names>N. G.</given-names>
</name>
</contrib>
<aff>Mammalian Genetics Laboratory, BRI-Basic Research Program, NCI-Frederick Cancer Research Facility, Frederick, Maryland 21701</aff>
</contrib-group>
<pub-date pub-type="ppub"><month>09</month>
<year>1989</year>
</pub-date>
<volume>123</volume>
<issue>1</issue>
<fpage>165</fpage>
<lpage>172</lpage>
<abstract><p>A 64-centiMorgan linkage map of mouse chromosome 9 was developed using cloned DNA markers and an interspecific backcross between Mus spretus and the C57BL/6J inbred strain. This map was compared to conventional genetic maps using six markers previously localized in laboratory mouse strains. These markers included thymus cell antigen-1, cytochrome P450-3, dilute, transferrin, cholecystokinin, and the G-protein alpha inhibitory subunit. No evidence was seen for segregation distortion, chromosome rearrangements, or altered genetic distances in the results from interspecific backcross mapping. Regional map locations were determined for four genes that were previously assigned to chromosome 9 using somatic cell hybrids. These genes were glutathione S-transferase Ya subunit (Gsta), the T3 gamma subunit, the low density lipoprotein receptor, and the Ets-1 oncogene. The map locations for these genes establish new regions of synteny between mouse chromosome 9 and human chromosomes 6, 11, and 19. In addition, the close linkage detected between the dilute and Gsta loci suggests that the Gsta locus may be part of the dilute/short ear complex, one of the most extensively studied genetic regions of the mouse.</p>
</abstract>
</article-meta>
</front>
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Serveur d'exploration Hippolyte Bernheim

A Molecular Genetic Linkage Map of Mouse Chromosome 9 with Regional Localizations for the Gsta, T3g, Ets-1 and Ldlr Loci

A Molecular Genetic Linkage Map of Mouse Chromosome 9 with Regional Localizations for the Gsta, T3g, Ets-1 and Ldlr Loci

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki