The role of personality factors and suggestion in placebo effect during mental stress test.
Identifieur interne : 000044 ( Pmc/Checkpoint ); précédent : 000043; suivant : 000045The role of personality factors and suggestion in placebo effect during mental stress test.
Auteurs : C C Mccann ; B. Goldfarb ; M. Frisk ; M A Quera-Salva ; P. MeyerSource :
- British Journal of Clinical Pharmacology [ 0306-5251 ] ; 1992.
Abstract
The aims of this study were first of all to document a placebo effect on systolic blood pressure and heart rate during mental arithmetic induced stress and secondly to assess the role of suggestion in producing this effect. Two types of placebo were used, a simple placebo and a placebo with an implied therapeutic action. Both were compared with alprazolam. A placebo response was seen in just over half of the volunteers when the cardiovascular changes to mental arithmetic induced stress in healthy volunteers were measured. This response appeared to be unaffected by the suggested therapeutic effect. Dominant, independent subjects, identified using the Cattell 16 PF personality test were less likely to respond to placebo. Alprazolam (0.5 mg) did not prevent, to a significantly greater degree than placebo, the systolic blood pressure or heart rate increases provoked by the mental stress.
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PubMed: 1540479
PubMed Central: 1381207
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PMC:1381207Le document en format XML
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<author><name sortKey="Quera Salva, M A" sort="Quera Salva, M A" uniqKey="Quera Salva M" first="M A" last="Quera-Salva">M A Quera-Salva</name>
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<series><title level="j">British Journal of Clinical Pharmacology</title>
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<front><div type="abstract" xml:lang="en"><p>The aims of this study were first of all to document a placebo effect on systolic blood pressure and heart rate during mental arithmetic induced stress and secondly to assess the role of suggestion in producing this effect. Two types of placebo were used, a simple placebo and a placebo with an implied therapeutic action. Both were compared with alprazolam. A placebo response was seen in just over half of the volunteers when the cardiovascular changes to mental arithmetic induced stress in healthy volunteers were measured. This response appeared to be unaffected by the suggested therapeutic effect. Dominant, independent subjects, identified using the Cattell 16 PF personality test were less likely to respond to placebo. Alprazolam (0.5 mg) did not prevent, to a significantly greater degree than placebo, the systolic blood pressure or heart rate increases provoked by the mental stress.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Clin Pharmacol</journal-id>
<journal-title>British Journal of Clinical Pharmacology</journal-title>
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<title-group><article-title>The role of personality factors and suggestion in placebo effect during mental stress test.</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>McCann</surname>
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<contrib contrib-type="author"><name><surname>Goldfarb</surname>
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<contrib contrib-type="author"><name><surname>Quera-Salva</surname>
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<aff>Clinical Pharmacology, Hôpital Necker, Paris, France.</aff>
<pub-date pub-type="ppub"><month>1</month>
<year>1992</year>
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<volume>33</volume>
<issue>1</issue>
<fpage>107</fpage>
<lpage>110</lpage>
<abstract><p>The aims of this study were first of all to document a placebo effect on systolic blood pressure and heart rate during mental arithmetic induced stress and secondly to assess the role of suggestion in producing this effect. Two types of placebo were used, a simple placebo and a placebo with an implied therapeutic action. Both were compared with alprazolam. A placebo response was seen in just over half of the volunteers when the cardiovascular changes to mental arithmetic induced stress in healthy volunteers were measured. This response appeared to be unaffected by the suggested therapeutic effect. Dominant, independent subjects, identified using the Cattell 16 PF personality test were less likely to respond to placebo. Alprazolam (0.5 mg) did not prevent, to a significantly greater degree than placebo, the systolic blood pressure or heart rate increases provoked by the mental stress.</p>
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<name sortKey="Meyer, P" sort="Meyer, P" uniqKey="Meyer P" first="P" last="Meyer">P. Meyer</name>
<name sortKey="Quera Salva, M A" sort="Quera Salva, M A" uniqKey="Quera Salva M" first="M A" last="Quera-Salva">M A Quera-Salva</name>
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