Chromosome analysis of 63 cases of secondary nonlymphoid blood disorders: A cooperative study
Identifieur interne : 000C77 ( Main/Merge ); précédent : 000C76; suivant : 000C78Chromosome analysis of 63 cases of secondary nonlymphoid blood disorders: A cooperative study
Auteurs : Nancy S. Groupe Français De Cytogénétique HématologiqueSource :
- Cancer Genetics and Cytogenetics [ 0165-4608 ] ; 1984.
English descriptors
- Teeft :
- Abnormality, Acute leukemia, Acute nonlymphocytic leukemia, Anll, Blast cells, Blood disorder, Cancer genet cytogenet, Carcinogenic agents, Carcinoma, Chemotherapy, Chromosome, Chromosome abnormalities, Chromosome variation, Cooperative study, Cytogenetic study, Cytologic, Cytologic study, Cytologic variation, Groupe, High proportion, Irradiation chemotherapy chemotherapy, Karyotype, Leukemia, Localized radiotherapy, Lymphoma, Malignant lymphoma, Medullary blasts, Micromegakaryocytes macroplatelets, Monosomy, Myeloma, Occupational exposure, Primary leukemia, Professional hazards, Radiotherapy, Refractory anemia, Secondary anll, Secondary blood disorders, Secondary leukemia, Secondary nonlymphoid blood disorders, Structural abnormalities, Structural defects, Umds.
Abstract
Abstract: A cooperative study of secondary nonlymphoid blood disorders [dysmyelopoietic syndrome and acute nonlymphoblastic leukemia (ANLL)] was carried out on 63 patients, 8 after professional exposure to carcinogenic agents and 55 following exposure to therapeutical hazards. Clonal chromosome abnormalities were observed in 56 cases (88.9%). The most common abnormalities were hypodiploidy and structural defects. The chromosomes most often involved were #7, #5, and #17. Monosomy 7 was seen more often following malignant lymphoma than after cancer, whereas monosomy 17 seemed more common in patients formerly exposed to professional hazards. Cytogenetic “variation” is often accompanied by cytologic “variation,” which could explain the high proportion of ANLL cases that are difficult to classify into the FAB system. A correlation was found between complete monosomy 7 and the presence of micromegakaryocytes and/or macroplatelets.
Url:
DOI: 10.1016/0165-4608(84)90120-1
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