Serveur d'exploration Hippolyte Bernheim

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Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function

Identifieur interne : 000C48 ( Main/Exploration ); précédent : 000C47; suivant : 000C49

Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function

Auteurs : Jan Carmichael [États-Unis] ; Stewart W. Shankel [États-Unis]

Source :

RBID : ISTEX:629858DDFF64713A59592E6D129427C9329DF66D

English descriptors

Abstract

Abstract: In the past 15 years, there has been an explosion in the number of nonsteroidal anti-Inflammatory drugs on the market. Along with this explosion have come increasing reports of the physiologic and pathologic changes seen in the kidneys. This report reviews the effects of prostaglandins on the kidney and the physiologic changes that result when prostaglandin synthesis Is blocked. The world literature on renal complications of nonsteroldal anti-inflammatory drugs is reviewed and 274 cases of acute renal disease associated with their use are reported. The following cases are described: nephrotic syndrome (34); acute interstitial nephritis (51); acute tubular necrosis (29); papillary necrosis (53); poor perfusion with renal failure (40); acute glomerulitis or vasculitis (13); and unspecified renal failure (102). Fenoprofen appeared to be more nephrotoxic than other nonsteroidal anti-Inflammatory drugs and resulted in multiple renal lesions in the same patient.

Url:
DOI: 10.1016/0002-9343(85)90223-2


Affiliations:


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Le document en format XML

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<term>Arachidonic acid</term>
<term>Arch intern</term>
<term>Arthritis rheum</term>
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<term>Cyclic endoperoxides</term>
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<term>Fenoprofen</term>
<term>Filtration</term>
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<term>Interstitial nephritis</term>
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<term>Prostacycline</term>
<term>Prostaglandin</term>
<term>Prostaglandin synthesis</term>
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<term>Renin release</term>
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