Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function
Identifieur interne : 000C48 ( Main/Exploration ); précédent : 000C47; suivant : 000C49Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function
Auteurs : Jan Carmichael [États-Unis] ; Stewart W. Shankel [États-Unis]Source :
- The American Journal of Medicine [ 0002-9343 ] ; 1985.
English descriptors
- Teeft :
- American journal, Analgesic, Analgesic nephropathy, Arachidonic, Arachidonic acid, Arch intern, Arthritis rheum, Aspirin, Clin, Cyclic endoperoxides, Engl, Fenoprofen, Filtration, Glomerular filtration rate, Ibuprofen, Indomethacin, Intern, Interstitial nephritis, June, Medicine volume, Naproxen, Necrosis, Nephritis, Nephropathy, Nephrotic, Nephrotic syndrome, Nephrotlc syndrome, Nonsteroidal, Nonsteroidal drugs, Other nonsteroidal drugs, Papillary, Papillary necrosis, Phenylbutazone, Prostacycline, Prostaglandin, Prostaglandin synthesis, Renal, Renal blood flow, Renal disease, Renal effects, Renal failure, Renal function, Renin, Renin release, Renin secretion, Rheumatoid arthritis, Shankel, Sulindac, Syndrome, Tubule, Water reabsorption.
Abstract
Abstract: In the past 15 years, there has been an explosion in the number of nonsteroidal anti-Inflammatory drugs on the market. Along with this explosion have come increasing reports of the physiologic and pathologic changes seen in the kidneys. This report reviews the effects of prostaglandins on the kidney and the physiologic changes that result when prostaglandin synthesis Is blocked. The world literature on renal complications of nonsteroldal anti-inflammatory drugs is reviewed and 274 cases of acute renal disease associated with their use are reported. The following cases are described: nephrotic syndrome (34); acute interstitial nephritis (51); acute tubular necrosis (29); papillary necrosis (53); poor perfusion with renal failure (40); acute glomerulitis or vasculitis (13); and unspecified renal failure (102). Fenoprofen appeared to be more nephrotoxic than other nonsteroidal anti-Inflammatory drugs and resulted in multiple renal lesions in the same patient.
Url:
DOI: 10.1016/0002-9343(85)90223-2
Affiliations:
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Le document en format XML
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<term>Arthritis rheum</term>
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<front><div type="abstract" xml:lang="en">Abstract: In the past 15 years, there has been an explosion in the number of nonsteroidal anti-Inflammatory drugs on the market. Along with this explosion have come increasing reports of the physiologic and pathologic changes seen in the kidneys. This report reviews the effects of prostaglandins on the kidney and the physiologic changes that result when prostaglandin synthesis Is blocked. The world literature on renal complications of nonsteroldal anti-inflammatory drugs is reviewed and 274 cases of acute renal disease associated with their use are reported. The following cases are described: nephrotic syndrome (34); acute interstitial nephritis (51); acute tubular necrosis (29); papillary necrosis (53); poor perfusion with renal failure (40); acute glomerulitis or vasculitis (13); and unspecified renal failure (102). Fenoprofen appeared to be more nephrotoxic than other nonsteroidal anti-Inflammatory drugs and resulted in multiple renal lesions in the same patient.</div>
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