Pentobarbitone stimulation of protein phosphorylation in rat brain in vitro
Identifieur interne : 000B50 ( Main/Exploration ); précédent : 000B49; suivant : 000B51Pentobarbitone stimulation of protein phosphorylation in rat brain in vitro
Auteurs : S. Kumar [Inde] ; R. Shankar [Inde]Source :
- Pharmacological Research Communications [ 0031-6989 ] ; 1987.
English descriptors
- Teeft :
- Barbiturate, Cerebral cortex slices, Different concentrations, Different time periods, Incorporation, Incubation, Incubation time, Lipid, Lipid peroxidation, Pentobarbitone, Peroxidation, Pharmacological, Pharmacological research communications, Phosphoprotein, Phosphorylation, Protein phosphorylation, Shankar.
Abstract
Abstract: Effect of pentobarbitone on protein phosphorylation in rat brain in vitro was investigated. It was observed that at short term incubations pentobarbitone greatly enhanced incorporation of 32P into cerebral phosphoproteins which came to lower level after prolonged incubation. Dose response curve of the drug on protein phosphorylation was unconventional. The drug did not appreciably affect lipid peroxidation in brain homogenates. Effect of pentobarbitone on protein phosphorylation is not due to its inhibition of mitochondrial electron flow which would have given opposite results.
Url:
DOI: 10.1016/0031-6989(87)90006-3
Affiliations:
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Le document en format XML
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