Serveur d'exploration Hippolyte Bernheim

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Effect of primary phase feline immunodeficiency virus infection on cats with chronic toxoplasmosis

Identifieur interne : 000A14 ( Main/Exploration ); précédent : 000A13; suivant : 000A15

Effect of primary phase feline immunodeficiency virus infection on cats with chronic toxoplasmosis

Auteurs : Michael R. Lappin [États-Unis] ; Peter W. Gasper [États-Unis] ; Barbara J. Rose [États-Unis] ; Cynthia C. Powell [États-Unis]

Source :

RBID : ISTEX:46B0853F12FE8C1AAAFD6ED3C541113D2129EBED

English descriptors

Abstract

Abstract: The effect of primary phase feline immunodeficiency virus (FIV) infection on clinical signs, hematological values, Toxoplasma gondii oocyst shedding, T. gondii-specific serology, T. gondii-specific cell-mediated immune responses, non-specific cell-mediated immune responses, and lymphocyte subpopulations from cats with experimentally induced chronic toxoplasmosis was studied. No significant clinical or hematologic abnormalities were noted following inoculation with FIV. T. gondii-specific IgM was significantly increased, concanavalin A, T. gondii tachyzoite antigen and T. gondii secretory antigen induction of lymphocyte transformation were significantly suppressed, and CD4+ cell numbers were significantly decreased following inoculation with FIV. The changes were attributed to FIV effects on the immune system and resultant activated toxoplasmosis.

Url:
DOI: 10.1016/0165-2427(92)90125-A


Affiliations:


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Le document en format XML

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<term>Absolute number</term>
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<term>Ackley</term>
<term>Acute phase</term>
<term>Antibody</term>
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<term>Days post challenge</term>
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<term>Fauci</term>
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<term>Granulocytic dysplasia</term>
<term>Granulocytic myelodysplasia</term>
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<term>Hematologic abnormalities</term>
<term>Herpes</term>
<term>Herpesvirus</term>
<term>High levels</term>
<term>Human immunodeficiency virus</term>
<term>Human immunodeficiency virus infection</term>
<term>Humoral</term>
<term>Hybridization</term>
<term>Immune</term>
<term>Immune dysfunction</term>
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<term>Immune responses</term>
<term>Immune system</term>
<term>Immunodeficiency</term>
<term>Immunodeficiency syndrome</term>
<term>Immunodeficiency virus</term>
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<term>Intravenous administration</term>
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<term>Leukemia</term>
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<term>Leukopenia</term>
<term>Linenberger</term>
<term>Lipoprotein</term>
<term>Littermate</term>
<term>Long term</term>
<term>Lutz</term>
<term>Lymphadenopathy</term>
<term>Lymphocyte</term>
<term>Lymphocyte blastogenesis</term>
<term>Lymphocyte counts</term>
<term>Lymphocyte numbers</term>
<term>Lymphocyte ratios</term>
<term>Lymphocyte responses</term>
<term>Lymphocyte subsets</term>
<term>Lymphoid</term>
<term>Lymphopenia</term>
<term>Macrophage</term>
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<term>Megakaryocyte</term>
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<term>Mitogen response</term>
<term>Mitogen responsiveness</term>
<term>Monoclonal</term>
<term>Monoclonal antibodies</term>
<term>Monoclonal antibody</term>
<term>Monocyte</term>
<term>Mononuclear</term>
<term>Mononuclear cells</term>
<term>Murine</term>
<term>National institutes</term>
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<term>Neural cells</term>
<term>Neurologic</term>
<term>Neurotropism</term>
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<term>Neutralizing antibodies</term>
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<term>Neutrophil</term>
<term>Neutrophilia</term>
<term>Node</term>
<term>Observation period</term>
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<term>Pokeweed mitogen</term>
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<term>Positive cells</term>
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<term>Post inoculation</term>
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<term>Relative susceptibility</term>
<term>Replication</term>
<term>Retrovirus</term>
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<term>Secondary antibodies</term>
<term>Secondary antibody</term>
<term>Secondary stages</term>
<term>Serology</term>
<term>Serum samples</term>
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<term>Short term</term>
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<term>Signal transduction</term>
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<term>Simian immunodeficiency virus</term>
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<term>Specific antibodies</term>
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<term>Spleen cells</term>
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<term>Supernatant</term>
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<term>Syncytium formation</term>
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<term>Target cells</term>
<term>Thymidine</term>
<term>Thymidine incorporation</term>
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<term>Tnfa</term>
<term>Tnfct</term>
<term>Tnfot</term>
<term>Tnfot levels</term>
<term>Tomoda</term>
<term>Tompkins</term>
<term>Torten</term>
<term>Toxoplasma</term>
<term>Toxoplasmosis</term>
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<term>Vaccine</term>
<term>Veterinary immunology</term>
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<term>Viral</term>
<term>Viremia</term>
<term>Virol</term>
<term>Virus</term>
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<div type="abstract" xml:lang="en">Abstract: The effect of primary phase feline immunodeficiency virus (FIV) infection on clinical signs, hematological values, Toxoplasma gondii oocyst shedding, T. gondii-specific serology, T. gondii-specific cell-mediated immune responses, non-specific cell-mediated immune responses, and lymphocyte subpopulations from cats with experimentally induced chronic toxoplasmosis was studied. No significant clinical or hematologic abnormalities were noted following inoculation with FIV. T. gondii-specific IgM was significantly increased, concanavalin A, T. gondii tachyzoite antigen and T. gondii secretory antigen induction of lymphocyte transformation were significantly suppressed, and CD4+ cell numbers were significantly decreased following inoculation with FIV. The changes were attributed to FIV effects on the immune system and resultant activated toxoplasmosis.</div>
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