BernheimV1, Main, Exploration, bibRecord, 000079

Caracterisation of signaling pathways controled by androgens in mouse striated muscle

Identifieur interne : 000079 ( Main/Exploration ); précédent : 000078; suivant : 000080

Caracterisation of signaling pathways controled by androgens in mouse striated muscle

Auteurs : Me Lanie Schuh [France]

Source :

RBID : Hal:tel-01236155

Descripteurs français

mix :
- Anabolisme, Androgènes, Autophagie, Catabolisme, Cellules satellites, Force, Muscle squelettique, Myofibres, Récepteur des androgènes.
Wicri :
- topic : Glucose.

English descriptors

mix :
- Anabolism, Androgen, Androgen receptor, Autophagy, Catabolism, Glucose, Myofibers, Polyamines, Satellite cells, Skeletal muscle, Strength.

Abstract

Muscles generate strength and movement, and have important metabolic functions. The aim of my work was to characterize the role and mechanisms of action of androgen receptor in skeletal muscle. We show that ablation of the androgen receptor in skeletal muscle myofibers does not affect muscle mass as both anabolic (IGF1) and catabolic pathways (myostatin) are deregulated. However, the absence of this receptor in myofibers decreases muscle hypertrophy induced by mechanical overload and limits glucocorticoids-induced muscle atrophy. Its ablation also increases autophagy, leading to sacromeres destructuration, resulting in decreased muscle strength. Moreover, its deletion reduced the rate of glucose absorption during a glucidic overload. Thus, myofibres androgen receptor regulates muscle mass and strength, as well as glucose import.

Url:

https://tel.archives-ouvertes.fr/tel-01236155

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000022
to stream Hal, to step Curation: 000022
to stream Hal, to step Checkpoint: 000073
to stream Main, to step Merge: 000079
to stream Main, to step Curation: 000079

Le document en format XML

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<term>Polyamines</term>
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<front><div type="abstract" xml:lang="en">Muscles generate strength and movement, and have important metabolic functions. The aim of my work was to characterize the role and mechanisms of action of androgen receptor in skeletal muscle. We show that ablation of the androgen receptor in skeletal muscle myofibers does not affect muscle mass as both anabolic (IGF1) and catabolic pathways (myostatin) are deregulated. However, the absence of this receptor in myofibers decreases muscle hypertrophy induced by mechanical overload and limits glucocorticoids-induced muscle atrophy. Its ablation also increases autophagy, leading to sacromeres destructuration, resulting in decreased muscle strength. Moreover, its deletion reduced the rate of glucose absorption during a glucidic overload. Thus, myofibres androgen receptor regulates muscle mass and strength, as well as glucose import.</div>
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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Psychologie
   |area=    BernheimV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Hal:tel-01236155
   |texte=   Caracterisation of signaling pathways controled by androgens in mouse striated muscle
}}

This area was generated with Dilib version V0.6.33.
Data generation: Mon Mar 5 17:33:33 2018. Site generation: Thu Apr 29 15:49:51 2021

	Serveur d'exploration Hippolyte Bernheim
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Hippolyte Bernheim

Caracterisation of signaling pathways controled by androgens in mouse striated muscle

Caracterisation of signaling pathways controled by androgens in mouse striated muscle

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri