Effect of retinoic acid and interferon alpha on granulocyte-macrophage colony forming cells in chronic myeloid leukemia: Increased inhibition by all- trans - and 13- cis -retinoic acids in advanced stage disease
Identifieur interne : 000951 ( Main/Curation ); précédent : 000950; suivant : 000952Effect of retinoic acid and interferon alpha on granulocyte-macrophage colony forming cells in chronic myeloid leukemia: Increased inhibition by all- trans - and 13- cis -retinoic acids in advanced stage disease
Auteurs : Grace E. Sagayadan [États-Unis] ; Peter H. Wiernik [États-Unis] ; Nancy Sun [États-Unis] ; Greg Ahearn [États-Unis] ; Deborah Thompson [États-Unis] ; Steven J. Hallam [États-Unis] ; Xiao-Ping Hu [États-Unis] ; Janice P. Dutcher [États-Unis] ; Robert E. Gallagher [États-Unis]Source :
- Leukemia Research [ 0145-2126 ] ; 1994.
English descriptors
- Teeft :
- Acute promyelocytic leukemia, Albert einstein cancer center, Annealing temperature, Antisense primer, Assay, Blast cells, Blastic, Blastic crisis, Bone marrow, Cfc, Chain reaction, Chronic myeloid leukemia, Chronic phase, Clonal growth, Clonogenic, Clonogenic assays, Cmlcp cases, Colony formation, Colony morphology, Colony size, Current study, Differentiation therapy, Fetal calf serum, Individual points, Inftr, Inhibition, Inhibition curves, Interferon, Leukemia, Mrna, Myelogenous leukemia, Myeloid, Myeloproliferative disease, None none, Peripheral blood, Primer, Primer pair, Promyelocytic, Propositus case, Recombinant, Recombinant interferon, Retinoic, Retinoic acid, Retinoic acids, Sense primer, Single agent, Strong inhibition, Titration curves, Total clones, Various concentrations.
Abstract
Abstract: Granulocyte-macrophage colony forming units (CFU-GM) from patients with advanced stage chronic myelogenous leukemia (CML), i.e. in blastic crisis (BC) or accelerated phase (AP), were inhibited by all-trans-retinoic acid (tRA) approximately 1000-fold more potently than those from chronic phase (CP) CML patients (median ic50 = 10−9 M tRA for six CML-AP/BC cases vs > 10−6 M tRA for seven CML-CP cases). A similar activity pattern was observed for the stereoisomer 13-cis-RA (cRA). There was no apparent correlation of CFU-GM retinoid sensitivity with cloning efficiency or other colony characteristics. Interferon alpha-2a (INFα) alone strongly inhibited CFU-GM growth in all four CML-AP/BC cases (ic50 ⩽ 250 IU/ml) and three out of seven CML-CP cases (ic50 ⩽ 500 IU/ml), but there was little or no interactive effect between various concentrations of tRA and INFα (50 IU/ml) on CFU-GM from either CML-AP/BC or CML-CP cases. These results suggest that CML-AP/BC CFU-GM have some intrinsic molecular alteration(s) which markedly enhances their responsiveness to tRA and cRA, which may be clinically exploitable.
Url:
DOI: 10.1016/0145-2126(94)90055-8
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000873
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000872
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000648
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000960
Links to Exploration step
ISTEX:C5B9A77C81EB4B3891F7309A3235793023D7D6F6Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Effect of retinoic acid and interferon alpha on granulocyte-macrophage colony forming cells in chronic myeloid leukemia: Increased inhibition by all- trans - and 13- cis -retinoic acids in advanced stage disease</title>
<author><name sortKey="Sagayadan, Grace E" sort="Sagayadan, Grace E" uniqKey="Sagayadan G" first="Grace E." last="Sagayadan">Grace E. Sagayadan</name>
</author>
<author><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H." last="Wiernik">Peter H. Wiernik</name>
</author>
<author><name sortKey="Sun, Nancy" sort="Sun, Nancy" uniqKey="Sun N" first="Nancy" last="Sun">Nancy Sun</name>
</author>
<author><name sortKey="Ahearn, Greg" sort="Ahearn, Greg" uniqKey="Ahearn G" first="Greg" last="Ahearn">Greg Ahearn</name>
</author>
<author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name>
</author>
<author><name sortKey="Hallam, Steven J" sort="Hallam, Steven J" uniqKey="Hallam S" first="Steven J." last="Hallam">Steven J. Hallam</name>
</author>
<author><name sortKey="Hu, Xiao Ping" sort="Hu, Xiao Ping" uniqKey="Hu X" first="Xiao-Ping" last="Hu">Xiao-Ping Hu</name>
</author>
<author><name sortKey="Dutcher, Janice P" sort="Dutcher, Janice P" uniqKey="Dutcher J" first="Janice P." last="Dutcher">Janice P. Dutcher</name>
</author>
<author><name sortKey="Gallagher, Robert E" sort="Gallagher, Robert E" uniqKey="Gallagher R" first="Robert E." last="Gallagher">Robert E. Gallagher</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C5B9A77C81EB4B3891F7309A3235793023D7D6F6</idno>
<date when="1994" year="1994">1994</date>
<idno type="doi">10.1016/0145-2126(94)90055-8</idno>
<idno type="url">https://api.istex.fr/document/C5B9A77C81EB4B3891F7309A3235793023D7D6F6/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000873</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000873</idno>
<idno type="wicri:Area/Istex/Curation">000872</idno>
<idno type="wicri:Area/Istex/Checkpoint">000648</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000648</idno>
<idno type="wicri:doubleKey">0145-2126:1994:Sagayadan G:effect:of:retinoic</idno>
<idno type="wicri:Area/Main/Merge">000960</idno>
<idno type="wicri:Area/Main/Curation">000951</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Effect of retinoic acid and interferon alpha on granulocyte-macrophage colony forming cells in chronic myeloid leukemia: Increased inhibition by all- trans - and 13- cis -retinoic acids in advanced stage disease</title>
<author><name sortKey="Sagayadan, Grace E" sort="Sagayadan, Grace E" uniqKey="Sagayadan G" first="Grace E." last="Sagayadan">Grace E. Sagayadan</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY 10467</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H." last="Wiernik">Peter H. Wiernik</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY 10467</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, Nancy" sort="Sun, Nancy" uniqKey="Sun N" first="Nancy" last="Sun">Nancy Sun</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY 10467</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ahearn, Greg" sort="Ahearn, Greg" uniqKey="Ahearn G" first="Greg" last="Ahearn">Greg Ahearn</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY 10467</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY 10467</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hallam, Steven J" sort="Hallam, Steven J" uniqKey="Hallam S" first="Steven J." last="Hallam">Steven J. Hallam</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY 10467</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Xiao Ping" sort="Hu, Xiao Ping" uniqKey="Hu X" first="Xiao-Ping" last="Hu">Xiao-Ping Hu</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY 10467</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dutcher, Janice P" sort="Dutcher, Janice P" uniqKey="Dutcher J" first="Janice P." last="Dutcher">Janice P. Dutcher</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY 10467</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gallagher, Robert E" sort="Gallagher, Robert E" uniqKey="Gallagher R" first="Robert E." last="Gallagher">Robert E. Gallagher</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY 10467</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Leukemia Research</title>
<title level="j" type="abbrev">LR</title>
<idno type="ISSN">0145-2126</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1994">1994</date>
<biblScope unit="volume">18</biblScope>
<biblScope unit="issue">10</biblScope>
<biblScope unit="page" from="741">741</biblScope>
<biblScope unit="page" to="748">748</biblScope>
</imprint>
<idno type="ISSN">0145-2126</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0145-2126</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute promyelocytic leukemia</term>
<term>Albert einstein cancer center</term>
<term>Annealing temperature</term>
<term>Antisense primer</term>
<term>Assay</term>
<term>Blast cells</term>
<term>Blastic</term>
<term>Blastic crisis</term>
<term>Bone marrow</term>
<term>Cfc</term>
<term>Chain reaction</term>
<term>Chronic myeloid leukemia</term>
<term>Chronic phase</term>
<term>Clonal growth</term>
<term>Clonogenic</term>
<term>Clonogenic assays</term>
<term>Cmlcp cases</term>
<term>Colony formation</term>
<term>Colony morphology</term>
<term>Colony size</term>
<term>Current study</term>
<term>Differentiation therapy</term>
<term>Fetal calf serum</term>
<term>Individual points</term>
<term>Inftr</term>
<term>Inhibition</term>
<term>Inhibition curves</term>
<term>Interferon</term>
<term>Leukemia</term>
<term>Mrna</term>
<term>Myelogenous leukemia</term>
<term>Myeloid</term>
<term>Myeloproliferative disease</term>
<term>None none</term>
<term>Peripheral blood</term>
<term>Primer</term>
<term>Primer pair</term>
<term>Promyelocytic</term>
<term>Propositus case</term>
<term>Recombinant</term>
<term>Recombinant interferon</term>
<term>Retinoic</term>
<term>Retinoic acid</term>
<term>Retinoic acids</term>
<term>Sense primer</term>
<term>Single agent</term>
<term>Strong inhibition</term>
<term>Titration curves</term>
<term>Total clones</term>
<term>Various concentrations</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Granulocyte-macrophage colony forming units (CFU-GM) from patients with advanced stage chronic myelogenous leukemia (CML), i.e. in blastic crisis (BC) or accelerated phase (AP), were inhibited by all-trans-retinoic acid (tRA) approximately 1000-fold more potently than those from chronic phase (CP) CML patients (median ic50 = 10−9 M tRA for six CML-AP/BC cases vs > 10−6 M tRA for seven CML-CP cases). A similar activity pattern was observed for the stereoisomer 13-cis-RA (cRA). There was no apparent correlation of CFU-GM retinoid sensitivity with cloning efficiency or other colony characteristics. Interferon alpha-2a (INFα) alone strongly inhibited CFU-GM growth in all four CML-AP/BC cases (ic50 ⩽ 250 IU/ml) and three out of seven CML-CP cases (ic50 ⩽ 500 IU/ml), but there was little or no interactive effect between various concentrations of tRA and INFα (50 IU/ml) on CFU-GM from either CML-AP/BC or CML-CP cases. These results suggest that CML-AP/BC CFU-GM have some intrinsic molecular alteration(s) which markedly enhances their responsiveness to tRA and cRA, which may be clinically exploitable.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/BernheimV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000951 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000951 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Psychologie |area= BernheimV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:C5B9A77C81EB4B3891F7309A3235793023D7D6F6 |texte= Effect of retinoic acid and interferon alpha on granulocyte-macrophage colony forming cells in chronic myeloid leukemia: Increased inhibition by all- trans - and 13- cis -retinoic acids in advanced stage disease }}
This area was generated with Dilib version V0.6.33. |