Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
Identifieur interne : 000E74 ( Istex/Corpus ); précédent : 000E73; suivant : 000E75Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
Auteurs : Nancy J. Rothwell ; Giamal Luheshi ; Sylvie ToulmondSource :
- Pharmacology and Therapeutics [ 0163-7258 ] ; 1996.
English descriptors
- Teeft :
- Antagonist, Astrocyte, Biol, Bram, Cytokine, Dinarello, Endogenous, Endotoxin, Febrile responses, Giulian, Glia, Glial, Glial cells, Growth factors, Immunol, Interleukin, Ischaemia, Kluger, Krueger, Lipopolysaccharide, Luheshi, Mediator, Mrna, Necrosis, Nerve growth factor, Neurodegeneration, Neuronal, Neuronal damage, Neurones, Neurosci, Neurotrophic, Neurotrophins, Nmda, Pharmacol, Physiol, Pyrogen, Pyrogenic, Receptor, Receptor antagonist, Recombinant, Relton, Rothwell, Strijbos, Thermogenesis, Toulmond, Trends pharmacol, Tumor necrosis factor.
Abstract
Abstract: Numerous cytokines and their receptors have been identified in the brain, where they act as mediators of host defence responses and have direct effects on neuronal and glial function. Experimental tools for studying cytokine actions, their source and control of synthesis in the brain, actions and mechanisms of action will be reviewed here. In particular, the cytokines interleukin-1, interleukin-6, and tumour necrosis factor-α have been implicated in the central control of responses to systemic disease and injury and activation of fever, neuroendocrine, immune, and behavioural responses. The recent discovery of specific inhibitors of cytokine synthesis, release, or action may offer significant therapeutic benefit.
Url:
DOI: 10.1016/0163-7258(95)02033-0
Links to Exploration step
ISTEX:F71ABC29CADA72E56A6BE9B5AADAD8AD0E6D1A8ELe document en format XML
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Experimental tools for studying cytokine actions, their source and control of synthesis in the brain, actions and mechanisms of action will be reviewed here. In particular, the cytokines interleukin-1, interleukin-6, and tumour necrosis factor-α have been implicated in the central control of responses to systemic disease and injury and activation of fever, neuroendocrine, immune, and behavioural responses. 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Experimental tools for studying cytokine actions, their source and control of synthesis in the brain, actions and mechanisms of action will be reviewed here. In particular, the cytokines interleukin-1, interleukin-6, and tumour necrosis factor-α have been implicated in the central control of responses to systemic disease and injury and activation of fever, neuroendocrine, immune, and behavioural responses. 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Experimental tools for studying cytokine actions, their source and control of synthesis in the brain, actions and mechanisms of action will be reviewed here. In particular, the cytokines interleukin-1, interleukin-6, and tumour necrosis factor-α have been implicated in the central control of responses to systemic disease and injury and activation of fever, neuroendocrine, immune, and behavioural responses. The recent discovery of specific inhibitors of cytokine synthesis, release, or action may offer significant therapeutic benefit.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Cytokines</term></item><item><term>brain</term></item><item><term>neuroimmunology</term></item><item><term>neurodegeneration</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/F71ABC29CADA72E56A6BE9B5AADAD8AD0E6D1A8E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="rev"><item-info><jid>JPT</jid><aid>95020330</aid><ce:pii>0163-7258(95)02033-0</ce:pii><ce:doi>10.1016/0163-7258(95)02033-0</ce:doi><ce:copyright type="unknown" year="1996"></ce:copyright></item-info><head><ce:title>Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology</ce:title><ce:author-group><ce:author><ce:given-name>Nancy J.</ce:given-name><ce:surname>Rothwell</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Giamal</ce:given-name><ce:surname>Luheshi</ce:surname></ce:author><ce:author><ce:given-name>Sylvie</ce:given-name><ce:surname>Toulmond</ce:surname></ce:author><ce:affiliation><ce:textfn>School of Biological Sciences, Room 1.124, Stopford Building, University of Manchester, Oxford road, Manchester M13 9PT, UK</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author.</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Numerous cytokines and their receptors have been identified in the brain, where they act as mediators of host defence responses and have direct effects on neuronal and glial function. Experimental tools for studying cytokine actions, their source and control of synthesis in the brain, actions and mechanisms of action will be reviewed here. In particular, the cytokines interleukin-1, interleukin-6, and tumour necrosis factor-α have been implicated in the central control of responses to systemic disease and injury and activation of fever, neuroendocrine, immune, and behavioural responses. The recent discovery of specific inhibitors of cytokine synthesis, release, or action may offer significant therapeutic benefit.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Cytokines</ce:text></ce:keyword><ce:keyword><ce:text>brain</ce:text></ce:keyword><ce:keyword><ce:text>neuroimmunology</ce:text></ce:keyword><ce:keyword><ce:text>neurodegeneration</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology</title></titleInfo><name type="personal"><namePart type="given">Nancy J.</namePart><namePart type="family">Rothwell</namePart><affiliation>School of Biological Sciences, Room 1.124, Stopford Building, University of Manchester, Oxford road, Manchester M13 9PT, UK</affiliation><description>Corresponding author.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giamal</namePart><namePart type="family">Luheshi</namePart><affiliation>School of Biological Sciences, Room 1.124, Stopford Building, University of Manchester, Oxford road, Manchester M13 9PT, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sylvie</namePart><namePart type="family">Toulmond</namePart><affiliation>School of Biological Sciences, Room 1.124, Stopford Building, University of Manchester, Oxford road, Manchester M13 9PT, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="Review article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Numerous cytokines and their receptors have been identified in the brain, where they act as mediators of host defence responses and have direct effects on neuronal and glial function. Experimental tools for studying cytokine actions, their source and control of synthesis in the brain, actions and mechanisms of action will be reviewed here. In particular, the cytokines interleukin-1, interleukin-6, and tumour necrosis factor-α have been implicated in the central control of responses to systemic disease and injury and activation of fever, neuroendocrine, immune, and behavioural responses. The recent discovery of specific inhibitors of cytokine synthesis, release, or action may offer significant therapeutic benefit.</abstract><subject><genre>Keywords</genre><topic>Cytokines</topic><topic>brain</topic><topic>neuroimmunology</topic><topic>neurodegeneration</topic></subject><relatedItem type="host"><titleInfo><title>Pharmacology and Therapeutics</title></titleInfo><titleInfo type="abbreviated"><title>JPT</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued></originInfo><identifier type="ISSN">0163-7258</identifier><identifier type="PII">S0163-7258(00)X0003-4</identifier><part><date>1996</date><detail type="volume"><number>69</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue-pages"><start>85</start><end>151</end></extent><extent unit="pages"><start>85</start><end>95</end></extent></part></relatedItem><identifier type="istex">F71ABC29CADA72E56A6BE9B5AADAD8AD0E6D1A8E</identifier><identifier type="ark">ark:/67375/6H6-WDZJK7K0-9</identifier><identifier type="DOI">10.1016/0163-7258(95)02033-0</identifier><identifier type="PII">0163-7258(95)02033-0</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/F71ABC29CADA72E56A6BE9B5AADAD8AD0E6D1A8E/metadata/json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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