Histiocytic lymphoma cell lines: Immunologic and cytogenetic studies
Identifieur interne : 000874 ( Istex/Corpus ); précédent : 000873; suivant : 000875Histiocytic lymphoma cell lines: Immunologic and cytogenetic studies
Auteurs : Barbara Kaiser-Mccaw Hecht ; Alan L. Epstein ; Carol S. Berger ; Henry S. Kaplan ; Frederick HechtSource :
- Cancer Genetics and Cytogenetics [ 0165-4608 ] ; 1984.
English descriptors
- Teeft :
- Abnormality, Biomedical research institute, Cell line, Cell lines, Cell lymphomas, Cell type, Chain genes, Chromosomal, Chromosome, Cytogenetic, Cytogenetic studies, Diffuse, Diffuse histiocytic, Epstein, Hecht, Histiocytic, Histiocytic lymphoma cell lines, Human chromosomes, Human immunoglobulin, Immunoglobulin, Intermediate grade, Kaplan, Karyotype, Large cell, Large cell immunoblastic, Leukemia, Lymphocytic, Lymphoma, Lymphoma cell lines, Malignant, Malignant lymphoma, Malignant lymphomas, Marker chromosome, Null cell, Oncogene, Proc natl acad, Rearrangement, Translocation.
Abstract
Abstract: Cell lines were established from 15 patients with diffuse histiocytic lymphoma (DHL) of the intermediate grade, diffuse large cell (class G), and high-grade, large cell immunoblastic (class H) types. Immunologic studies indicated that 11 of the 15 DHL cell lines were B cell in origin, 2 were histiocytic, and 2 were null cell. Cytogenetic studies revealed 1 hypodiploid, 11 hyperdiploid, and 3 near-tetraploid cell lines. Chromosome #7 was trisomic in 3 lines, chromosomes #12 in 4 lines, and chromosome #13 in 3 lines. Chromosome #2 was monosomic in 3 lines, chromosome #8 was monosomic in 5 lines, chromosome #14 in 4 lines, and chromosome #22 in 6 cell lines. This is of special interest, as chromosomes #2, #8, #14, and #22 are clearly concerned with rearrangements in Burkitt's lymphoma and immunoglobulin expression. The most common rearrangement in the DHL cell lines involved chromosome #14 at band 14q32. However, in contrast to Burkitt's lymphoma, the pattern of translocation in DHL is between chromosome #14 and usually chromosome #11 or chromosome #18. The 14;18 translocation is not restricted to patients with low-grade follicular, small cleaved cell lymphomas, as has been reported. The 14q+ chromosome is characteristic of lymphoid malignancies in general. It is due, invariably, to a translocation with the breakpoint in band 14q32, which is the locus of the immunoglobulin heavy chain genes. We propose that in each translocation, for example, chromosomes #11 or #18, an oncogene may be transposed onto chromosome #14, and that each 14q+ translocation in DHL represents an event that transposes an oncogene from another chromosome to chromosome #14.
Url:
DOI: 10.1016/0165-4608(85)90186-4
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Abstract: Cell lines were established from 15 patients with diffuse histiocytic lymphoma (DHL) of the intermediate grade, diffuse large cell (class G), and high-grade, large cell immunoblastic (class H) types. Immunologic studies indicated that 11 of the 15 DHL cell lines were B cell in origin, 2 were histiocytic, and 2 were null cell. Cytogenetic studies revealed 1 hypodiploid, 11 hyperdiploid, and 3 near-tetraploid cell lines. Chromosome #7 was trisomic in 3 lines, chromosomes #12 in 4 lines, and chromosome #13 in 3 lines. Chromosome #2 was monosomic in 3 lines, chromosome #8 was monosomic in 5 lines, chromosome #14 in 4 lines, and chromosome #22 in 6 cell lines. This is of special interest, as chromosomes #2, #8, #14, and #22 are clearly concerned with rearrangements in Burkitt's lymphoma and immunoglobulin expression. The most common rearrangement in the DHL cell lines involved chromosome #14 at band 14q32. However, in contrast to Burkitt's lymphoma, the pattern of translocation in DHL is between chromosome #14 and usually chromosome #11 or chromosome #18. The 14;18 translocation is not restricted to patients with low-grade follicular, small cleaved cell lymphomas, as has been reported. The 14q+ chromosome is characteristic of lymphoid malignancies in general. It is due, invariably, to a translocation with the breakpoint in band 14q32, which is the locus of the immunoglobulin heavy chain genes. We propose that in each translocation, for example, chromosomes #11 or #18, an oncogene may be transposed onto chromosome #14, and that each 14q+ translocation in DHL represents an event that transposes an oncogene from another chromosome to chromosome #14.</div>
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<notesStmt><note>This work was supported in part by Research Grants CA-25055 and RO1-CA 30621 and Contract NO1-CP-43228 from the National Cancer Institute; Research Grant HD-12601 from the National Institutes of Child Health and Human Development; and by gifts to the Malcolm Hecht, Jr., Leukemia Research Fund, the Carolyn and Lena Kaiser Cancer Research Fund, and the Joseph Edward Luetje Lymphoma Research Fund.</note>
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<abstract xml:lang="en"><p>Cell lines were established from 15 patients with diffuse histiocytic lymphoma (DHL) of the intermediate grade, diffuse large cell (class G), and high-grade, large cell immunoblastic (class H) types. Immunologic studies indicated that 11 of the 15 DHL cell lines were B cell in origin, 2 were histiocytic, and 2 were null cell. Cytogenetic studies revealed 1 hypodiploid, 11 hyperdiploid, and 3 near-tetraploid cell lines. Chromosome #7 was trisomic in 3 lines, chromosomes #12 in 4 lines, and chromosome #13 in 3 lines. Chromosome #2 was monosomic in 3 lines, chromosome #8 was monosomic in 5 lines, chromosome #14 in 4 lines, and chromosome #22 in 6 cell lines. This is of special interest, as chromosomes #2, #8, #14, and #22 are clearly concerned with rearrangements in Burkitt's lymphoma and immunoglobulin expression. The most common rearrangement in the DHL cell lines involved chromosome #14 at band 14q32. However, in contrast to Burkitt's lymphoma, the pattern of translocation in DHL is between chromosome #14 and usually chromosome #11 or chromosome #18. The 14;18 translocation is not restricted to patients with low-grade follicular, small cleaved cell lymphomas, as has been reported. The 14q+ chromosome is characteristic of lymphoid malignancies in general. It is due, invariably, to a translocation with the breakpoint in band 14q32, which is the locus of the immunoglobulin heavy chain genes. We propose that in each translocation, for example, chromosomes #11 or #18, an oncogene may be transposed onto chromosome #14, and that each 14q+ translocation in DHL represents an event that transposes an oncogene from another chromosome to chromosome #14.</p>
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<head><ce:article-footnote><ce:label>☆</ce:label>
<ce:note-para>This work was supported in part by Research Grants CA-25055 and RO1-CA 30621 and Contract NO1-CP-43228 from the National Cancer Institute; Research Grant HD-12601 from the National Institutes of Child Health and Human Development; and by gifts to the Malcolm Hecht, Jr., Leukemia Research Fund, the Carolyn and Lena Kaiser Cancer Research Fund, and the Joseph Edward Luetje Lymphoma Research Fund.</ce:note-para>
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<ce:title>Histiocytic lymphoma cell lines: Immunologic and cytogenetic studies</ce:title>
<ce:author-group><ce:author><ce:given-name>Barbara Kaiser-McCaw</ce:given-name>
<ce:surname>Hecht</ce:surname>
<ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup>
</ce:cross-ref>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
</ce:cross-ref>
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<ce:author><ce:given-name>Alan L.</ce:given-name>
<ce:surname>Epstein</ce:surname>
<ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup>
</ce:cross-ref>
<ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup>
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<ce:author><ce:given-name>Carol S.</ce:given-name>
<ce:surname>Berger</ce:surname>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Henry S.</ce:given-name>
<ce:surname>Kaplan</ce:surname>
<ce:cross-ref refid="AFF4"><ce:sup>d</ce:sup>
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<ce:cross-ref refid="AFF5"><ce:sup>e</ce:sup>
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<ce:author><ce:given-name>Frederick</ce:given-name>
<ce:surname>Hecht</ce:surname>
<ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup>
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<ce:affiliation id="AFF1"><ce:label>a</ce:label>
<ce:textfn>Genetics Center and Cancer Research Center, Southwest Biomedical Research Institute, Tempe, AZ, USA</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF2"><ce:label>b</ce:label>
<ce:textfn>Department of Medicine, Northwestern University, Chicago, IL, USA</ce:textfn>
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<ce:affiliation id="AFF3"><ce:label>c</ce:label>
<ce:textfn>Cancer Center, Northwestern University, Chicago, IL, USA</ce:textfn>
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<ce:affiliation id="AFF4"><ce:label>d</ce:label>
<ce:textfn>Cancer Biology Research Laboratory, Stanford University School of Medicine, Stanford, CA, USA</ce:textfn>
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<ce:affiliation id="AFF5"><ce:label>e</ce:label>
<ce:textfn>Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA</ce:textfn>
</ce:affiliation>
<ce:correspondence id="COR1"><ce:label>∗</ce:label>
<ce:text>Address requests for reprints to Dr. Barbara Kaiser-McCaw Hecht, Genetics Center and Cancer Research Center, Southwest Biomedical Research Institute, 123 East University Drive, Tempe, AZ 85281.</ce:text>
</ce:correspondence>
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<ce:date-received day="20" month="7" year="1983"></ce:date-received>
<ce:date-accepted day="21" month="12" year="1983"></ce:date-accepted>
<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>Cell lines were established from 15 patients with diffuse histiocytic lymphoma (DHL) of the intermediate grade, diffuse large cell (class G), and high-grade, large cell immunoblastic (class H) types. Immunologic studies indicated that 11 of the 15 DHL cell lines were B cell in origin, 2 were histiocytic, and 2 were null cell. Cytogenetic studies revealed 1 hypodiploid, 11 hyperdiploid, and 3 near-tetraploid cell lines. Chromosome #7 was trisomic in 3 lines, chromosomes #12 in 4 lines, and chromosome #13 in 3 lines. Chromosome #2 was monosomic in 3 lines, chromosome #8 was monosomic in 5 lines, chromosome #14 in 4 lines, and chromosome #22 in 6 cell lines. This is of special interest, as chromosomes #2, #8, #14, and #22 are clearly concerned with rearrangements in Burkitt's lymphoma and immunoglobulin expression. The most common rearrangement in the DHL cell lines involved chromosome #14 at band 14q32. However, in contrast to Burkitt's lymphoma, the pattern of translocation in DHL is between chromosome #14 and usually chromosome #11 or chromosome #18. The 14;18 translocation is not restricted to patients with low-grade follicular, small cleaved cell lymphomas, as has been reported. The 14q+ chromosome is characteristic of lymphoid malignancies in general. It is due, invariably, to a translocation with the breakpoint in band 14q32, which is the locus of the immunoglobulin heavy chain genes. We propose that in each translocation, for example, chromosomes #11 or #18, an oncogene may be transposed onto chromosome #14, and that each 14q+ translocation in DHL represents an event that transposes an oncogene from another chromosome to chromosome #14.</ce:simple-para>
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<name type="personal"><namePart type="given">Barbara Kaiser-McCaw</namePart>
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<affiliation>Genetics Center and Cancer Research Center, Southwest Biomedical Research Institute, Tempe, AZ, USA</affiliation>
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<abstract lang="en">Abstract: Cell lines were established from 15 patients with diffuse histiocytic lymphoma (DHL) of the intermediate grade, diffuse large cell (class G), and high-grade, large cell immunoblastic (class H) types. Immunologic studies indicated that 11 of the 15 DHL cell lines were B cell in origin, 2 were histiocytic, and 2 were null cell. Cytogenetic studies revealed 1 hypodiploid, 11 hyperdiploid, and 3 near-tetraploid cell lines. Chromosome #7 was trisomic in 3 lines, chromosomes #12 in 4 lines, and chromosome #13 in 3 lines. Chromosome #2 was monosomic in 3 lines, chromosome #8 was monosomic in 5 lines, chromosome #14 in 4 lines, and chromosome #22 in 6 cell lines. This is of special interest, as chromosomes #2, #8, #14, and #22 are clearly concerned with rearrangements in Burkitt's lymphoma and immunoglobulin expression. The most common rearrangement in the DHL cell lines involved chromosome #14 at band 14q32. However, in contrast to Burkitt's lymphoma, the pattern of translocation in DHL is between chromosome #14 and usually chromosome #11 or chromosome #18. The 14;18 translocation is not restricted to patients with low-grade follicular, small cleaved cell lymphomas, as has been reported. The 14q+ chromosome is characteristic of lymphoid malignancies in general. It is due, invariably, to a translocation with the breakpoint in band 14q32, which is the locus of the immunoglobulin heavy chain genes. We propose that in each translocation, for example, chromosomes #11 or #18, an oncogene may be transposed onto chromosome #14, and that each 14q+ translocation in DHL represents an event that transposes an oncogene from another chromosome to chromosome #14.</abstract>
<note>This work was supported in part by Research Grants CA-25055 and RO1-CA 30621 and Contract NO1-CP-43228 from the National Cancer Institute; Research Grant HD-12601 from the National Institutes of Child Health and Human Development; and by gifts to the Malcolm Hecht, Jr., Leukemia Research Fund, the Carolyn and Lena Kaiser Cancer Research Fund, and the Joseph Edward Luetje Lymphoma Research Fund.</note>
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