Fotemustine plus dacarbazine for malignant melanoma
Identifieur interne : 000845 ( Istex/Corpus ); précédent : 000844; suivant : 000846Fotemustine plus dacarbazine for malignant melanoma
Auteurs : Marie-F Avril ; Jean Bonneterre ; Didier Cupissol ; Jean-J Grob ; Bernard Kalis ; Pierre Fumoleau ; Pierre Kerbrat ; Lucien Israel ; Pierre Fargeot ; Daniel Lambert ; Michelle Delaunay ; Brigitte Dreno ; Catherine Vilmer ; Jean-P Bizzari ; Véronique CourSource :
- European Journal of Cancer [ 0959-8049 ] ; 1992.
English descriptors
- Teeft :
- Alkaline phosphatases, Biometric parameters, Cancer chemother, Centre, Cerebral lesions, Cerebral metastases, Chemotherapy, Clinical trials, Combination chemotherapy, Complete response, Complete responses, Dacarbazine, Disease progression, Dominant metastatic site, Early death, Eurj cancer, Evaluable, Evaluable patients, Final evaluation, Fotemustine, Grade leukopenia, Haematological, Haematological toxicity, High performance, Hopital, Induction cycle, Lesion, Limb perfusion, Maintenance cycle, Malignant, Malignant melanoma, Median, Median days, Median duration, Median durations, Median nadir, Median survival time, Melanoma, Melphalan, Metastasis, Metastatic, Metastatic melanoma, Monotherapy, Natural history, Objective responses, Overall response rate, Partial response, Partial responses, Present series, Prognostic factors, Regimen, Response range, Response rate, Response rates, Toxicity, Visceral lesions, Visceral metastases.
Abstract
Abstract: 119 patients with metastatic melanoma received fotemustine 100 mg/m2 on days 1 and 8 and dacarbazine 250 mg/m2 on days 15–18. After a 5-week rest, fotemustine 100 mg/m2 on day 1 and dacarbazine 250 mg/m2 on days 2–5 was given every 3–4 weeks. 12 complete responses (11.6%) and 16 partial responses were observed in 103 evaluable patients (response rate 27.2%). The median duration of response was 21.5+ weeks (8+ to 53+). The response rate was 26.3% in CNS, 18.2% in visceral sites and 37.5% in non-visceral sites. The toxicity was mainly haematological: grade III–IV leukopenia in 27.4% and thrombocytopenia in 23.4%. The response rate was lower than that in 63 patients previously reported. The present series had a higher median age (54 vs. 40 years) without any differences in other population variables. However, activity on CNS metastases and on non-visceral sites was confirmed. Haematological toxicity was about 50% lower than that with fotemustine alone. Hence, this is an active outpatient regiment for metastatic melanoma, especially against cerebral and non-visceral metastases.
Url:
DOI: 10.1016/0959-8049(92)90008-P
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Abstract: 119 patients with metastatic melanoma received fotemustine 100 mg/m2 on days 1 and 8 and dacarbazine 250 mg/m2 on days 15–18. After a 5-week rest, fotemustine 100 mg/m2 on day 1 and dacarbazine 250 mg/m2 on days 2–5 was given every 3–4 weeks. 12 complete responses (11.6%) and 16 partial responses were observed in 103 evaluable patients (response rate 27.2%). The median duration of response was 21.5+ weeks (8+ to 53+). The response rate was 26.3% in CNS, 18.2% in visceral sites and 37.5% in non-visceral sites. The toxicity was mainly haematological: grade III–IV leukopenia in 27.4% and thrombocytopenia in 23.4%. The response rate was lower than that in 63 patients previously reported. The present series had a higher median age (54 vs. 40 years) without any differences in other population variables. However, activity on CNS metastases and on non-visceral sites was confirmed. Haematological toxicity was about 50% lower than that with fotemustine alone. Hence, this is an active outpatient regiment for metastatic melanoma, especially against cerebral and non-visceral metastases.</div>
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<abstract xml:lang="en"><p>119 patients with metastatic melanoma received fotemustine 100 mg/m2 on days 1 and 8 and dacarbazine 250 mg/m2 on days 15–18. After a 5-week rest, fotemustine 100 mg/m2 on day 1 and dacarbazine 250 mg/m2 on days 2–5 was given every 3–4 weeks. 12 complete responses (11.6%) and 16 partial responses were observed in 103 evaluable patients (response rate 27.2%). The median duration of response was 21.5+ weeks (8+ to 53+). The response rate was 26.3% in CNS, 18.2% in visceral sites and 37.5% in non-visceral sites. The toxicity was mainly haematological: grade III–IV leukopenia in 27.4% and thrombocytopenia in 23.4%. The response rate was lower than that in 63 patients previously reported. The present series had a higher median age (54 vs. 40 years) without any differences in other population variables. However, activity on CNS metastases and on non-visceral sites was confirmed. Haematological toxicity was about 50% lower than that with fotemustine alone. Hence, this is an active outpatient regiment for metastatic melanoma, especially against cerebral and non-visceral metastases.</p>
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<head><ce:dochead><ce:textfn>Paper</ce:textfn>
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<ce:title>Fotemustine plus dacarbazine for malignant melanoma</ce:title>
<ce:author-group><ce:author><ce:given-name>Marie-F</ce:given-name>
<ce:surname>Avril</ce:surname>
<ce:cross-ref refid="COR1"><ce:sup>1</ce:sup>
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<ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup>
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<ce:author><ce:given-name>Jean</ce:given-name>
<ce:surname>Bonneterre</ce:surname>
<ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Didier</ce:given-name>
<ce:surname>Cupissol</ce:surname>
<ce:cross-ref refid="AFF3"><ce:sup>3</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Jean-J</ce:given-name>
<ce:surname>Grob</ce:surname>
<ce:cross-ref refid="AFF4"><ce:sup>4</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Bernard</ce:given-name>
<ce:surname>Kalis</ce:surname>
<ce:cross-ref refid="AFF5"><ce:sup>5</ce:sup>
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</ce:author>
<ce:author><ce:given-name>Pierre</ce:given-name>
<ce:surname>Fumoleau</ce:surname>
<ce:cross-ref refid="AFF6"><ce:sup>6</ce:sup>
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</ce:author>
<ce:author><ce:given-name>Pierre</ce:given-name>
<ce:surname>Kerbrat</ce:surname>
<ce:cross-ref refid="AFF7"><ce:sup>7</ce:sup>
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</ce:author>
<ce:author><ce:given-name>Lucien</ce:given-name>
<ce:surname>Israel</ce:surname>
<ce:cross-ref refid="AFF8"><ce:sup>8</ce:sup>
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</ce:author>
<ce:author><ce:given-name>Pierre</ce:given-name>
<ce:surname>Fargeot</ce:surname>
<ce:cross-ref refid="AFF9"><ce:sup>9</ce:sup>
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</ce:author>
<ce:author><ce:given-name>Daniel</ce:given-name>
<ce:surname>Lambert</ce:surname>
<ce:cross-ref refid="AFF10"><ce:sup>10</ce:sup>
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</ce:author>
<ce:author><ce:given-name>Michelle</ce:given-name>
<ce:surname>Delaunay</ce:surname>
<ce:cross-ref refid="AFF11"><ce:sup>11</ce:sup>
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</ce:author>
<ce:author><ce:given-name>Brigitte</ce:given-name>
<ce:surname>Dreno</ce:surname>
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<ce:author><ce:given-name>Catherine</ce:given-name>
<ce:surname>Vilmer</ce:surname>
<ce:cross-ref refid="AFF13"><ce:sup>13</ce:sup>
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</ce:author>
<ce:author><ce:given-name>Jean-P</ce:given-name>
<ce:surname>Bizzari</ce:surname>
<ce:cross-ref refid="AFF14"><ce:sup>14</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Véronique</ce:given-name>
<ce:surname>Cour</ce:surname>
<ce:cross-ref refid="AFF14"><ce:sup>14</ce:sup>
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<ce:affiliation id="AFF1"><ce:label>1</ce:label>
<ce:textfn>Institut Gustave Roussy, Service de Dermatologie, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF2"><ce:label>2</ce:label>
<ce:textfn>Centre Oscar Lambret, Lille, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF3"><ce:label>3</ce:label>
<ce:textfn>Centre Val d'Aurelle, Montpellier, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF4"><ce:label>4</ce:label>
<ce:textfn>Hôpital Sainte-Marguerite, Marseille, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF5"><ce:label>5</ce:label>
<ce:textfn>Hôpital Sébastopol, Reims, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF6"><ce:label>6</ce:label>
<ce:textfn>Centre René Gauducheau, Nantes, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF7"><ce:label>7</ce:label>
<ce:textfn>Centre Eugène Marquis, Rennes, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF8"><ce:label>8</ce:label>
<ce:textfn>Hôpital Avicenne, Bobigny, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF9"><ce:label>9</ce:label>
<ce:textfn>Centre Georges François Leclerc, Dijon, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF10"><ce:label>10</ce:label>
<ce:textfn>C.H.R.U.—Hôpital du bocage, Dijon, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF11"><ce:label>11</ce:label>
<ce:textfn>Hôpital Pellegrin Tripode, Bordeaux, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF12"><ce:label>12</ce:label>
<ce:textfn>C.H.U. Hotel-Dieu, Nantes, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF13"><ce:label>13</ce:label>
<ce:textfn>Centre René Huguenin, Saint-Cloud, France</ce:textfn>
</ce:affiliation>
<ce:affiliation id="AFF14"><ce:label>14</ce:label>
<ce:textfn>Institut de Recherches Internationales Servier, Courbevoie, France</ce:textfn>
</ce:affiliation>
<ce:correspondence id="COR1"><ce:label>1</ce:label>
<ce:text>Correspondence to M.F. Avril.</ce:text>
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<ce:date-accepted day="27" month="1" year="1992"></ce:date-accepted>
<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>119 patients with metastatic melanoma received fotemustine 100 mg/m<ce:sup>2</ce:sup>
on days 1 and 8 and dacarbazine 250 mg/m<ce:sup>2</ce:sup>
on days 15–18. After a 5-week rest, fotemustine 100 mg/m<ce:sup>2</ce:sup>
on day 1 and dacarbazine 250 mg/m<ce:sup>2</ce:sup>
on days 2–5 was given every 3–4 weeks. 12 complete responses (11.6%) and 16 partial responses were observed in 103 evaluable patients (response rate 27.2%). The median duration of response was 21.5+ weeks (8+ to 53+). The response rate was 26.3% in CNS, 18.2% in visceral sites and 37.5% in non-visceral sites. The toxicity was mainly haematological: grade III–IV leukopenia in 27.4% and thrombocytopenia in 23.4%. The response rate was lower than that in 63 patients previously reported. The present series had a higher median age (54 vs. 40 years) without any differences in other population variables. However, activity on CNS metastases and on non-visceral sites was confirmed. Haematological toxicity was about 50% lower than that with fotemustine alone. Hence, this is an active outpatient regiment for metastatic melanoma, especially against cerebral and non-visceral metastases.</ce:simple-para>
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<abstract lang="en">Abstract: 119 patients with metastatic melanoma received fotemustine 100 mg/m2 on days 1 and 8 and dacarbazine 250 mg/m2 on days 15–18. After a 5-week rest, fotemustine 100 mg/m2 on day 1 and dacarbazine 250 mg/m2 on days 2–5 was given every 3–4 weeks. 12 complete responses (11.6%) and 16 partial responses were observed in 103 evaluable patients (response rate 27.2%). The median duration of response was 21.5+ weeks (8+ to 53+). The response rate was 26.3% in CNS, 18.2% in visceral sites and 37.5% in non-visceral sites. The toxicity was mainly haematological: grade III–IV leukopenia in 27.4% and thrombocytopenia in 23.4%. The response rate was lower than that in 63 patients previously reported. The present series had a higher median age (54 vs. 40 years) without any differences in other population variables. However, activity on CNS metastases and on non-visceral sites was confirmed. Haematological toxicity was about 50% lower than that with fotemustine alone. Hence, this is an active outpatient regiment for metastatic melanoma, especially against cerebral and non-visceral metastases.</abstract>
<note type="content">Section title: Paper</note>
<relatedItem type="host"><titleInfo><title>European Journal of Cancer</title>
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<titleInfo type="abbreviated"><title>EJC</title>
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<dateIssued encoding="w3cdtf">1992</dateIssued>
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<identifier type="ISSN">0959-8049</identifier>
<identifier type="PII">S0959-8049(00)X0170-0</identifier>
<part><date>1992</date>
<detail type="volume"><number>28</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>11</number>
<caption>no.</caption>
</detail>
<extent unit="issue-pages"><start>1777</start>
<end>1935</end>
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<extent unit="pages"><start>1807</start>
<end>1811</end>
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<identifier type="ark">ark:/67375/6H6-NN62TZTW-Z</identifier>
<identifier type="DOI">10.1016/0959-8049(92)90008-P</identifier>
<identifier type="PII">0959-8049(92)90008-P</identifier>
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