A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial
Identifieur interne : 000657 ( Istex/Corpus ); précédent : 000656; suivant : 000658A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial
Auteurs : Mihai Gheorghiade ; Peter S. Pang ; Andrew P. Ambrosy ; Gloria Lan ; Philip Schmidt ; Gerasimos Filippatos ; Marvin Konstam ; Karl Swedberg ; Thomas Cook ; Brian Traver ; Aldo Maggioni ; John Burnett ; Liliana Grinfeld ; James Udelson ; Faiez ZannadSource :
- Heart Failure Reviews [ 1382-4147 ] ; 2012-05-01.
English descriptors
Abstract
Abstract: Hospitalization for worsening chronic heart failure results in high post-discharge mortality, morbidity, and cost. However, thorough characterization, soon after discharge of patients with early post-discharge events has not been previously performed. The objectives of this study were to describe the baseline, in-hospital, and post-discharge clinical, laboratory, and neurohormonal profiles of patients hospitalized for worsening heart failure with reduced ejection fraction (EF) who die or are re-admitted for cardiovascular (CV) causes within 90 days of initial hospitalization. Retrospective analysis of 4,133 patients hospitalized for worsening heart failure with EF ≤40% in the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial, which randomized patients to tolvaptan or placebo, both in addition to standard therapy. Clinical and laboratory parameters were obtained within 48 h of admission, during hospitalization, and post-discharge weeks 1, 4, 8, and every 8 weeks thereafter for a median of 9.9 months. Patients with events within 90 days were compared with those with later/no events. All-cause mortality (ACM) and CV re-hospitalization were independently adjudicated. Within 90 days of admission, 395 patients (9.6%) died and 801 patients (19.4%) were re-hospitalized for CV causes. Significant baseline and longitudinal differences were seen between groups with early versus later (>90 days) or no events at 12 months post-randomization. Post-discharge outcomes were similar in the tolvaptan and placebo groups. Patients with early post-discharge events experienced clinically significant worsening in signs and symptoms, laboratory values, and neurohormonal parameters soon after discharge. Identifying these abnormalities may facilitate efforts to reduce post-discharge mortality and re-hospitalization.
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DOI: 10.1007/s10741-011-9280-0
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Michigan Avenue, Suite 1006, 60611, Chicago, IL, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: m-gheorghiade@northwestern.edu</mods:affiliation></affiliation></author><author><name sortKey="Pang, Peter S" sort="Pang, Peter S" uniqKey="Pang P" first="Peter S." last="Pang">Peter S. Pang</name><affiliation><mods:affiliation>Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N. Michigan Avenue, Suite 1006, 60611, Chicago, IL, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA</mods:affiliation></affiliation></author><author><name sortKey="Ambrosy, Andrew P" sort="Ambrosy, Andrew P" uniqKey="Ambrosy A" first="Andrew P." last="Ambrosy">Andrew P. Ambrosy</name><affiliation><mods:affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Lan, Gloria" sort="Lan, Gloria" uniqKey="Lan G" first="Gloria" last="Lan">Gloria Lan</name><affiliation><mods:affiliation>Northwestern University Feinberg School of Medicine, Chicago, IL, USA</mods:affiliation></affiliation></author><author><name sortKey="Schmidt, Philip" sort="Schmidt, Philip" uniqKey="Schmidt P" first="Philip" last="Schmidt">Philip Schmidt</name><affiliation><mods:affiliation>Department of Medicine, Northwestern Memorial Hospital, Chicago, IL, USA</mods:affiliation></affiliation></author><author><name sortKey="Filippatos, Gerasimos" sort="Filippatos, Gerasimos" uniqKey="Filippatos G" first="Gerasimos" last="Filippatos">Gerasimos Filippatos</name><affiliation><mods:affiliation>Athens University Hospital, Attikon, Greece</mods:affiliation></affiliation></author><author><name sortKey="Konstam, Marvin" sort="Konstam, Marvin" uniqKey="Konstam M" first="Marvin" last="Konstam">Marvin Konstam</name><affiliation><mods:affiliation>New England Medical Center, Tufts University School of Medicine, Boston, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Swedberg, Karl" sort="Swedberg, Karl" uniqKey="Swedberg K" first="Karl" last="Swedberg">Karl Swedberg</name><affiliation><mods:affiliation>Sahlgrenska University Hospital/Östra, Gothenburg, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Cook, Thomas" sort="Cook, Thomas" uniqKey="Cook T" first="Thomas" last="Cook">Thomas Cook</name><affiliation><mods:affiliation>University of Wisconsin, Madison, WI, USA</mods:affiliation></affiliation></author><author><name sortKey="Traver, Brian" sort="Traver, Brian" uniqKey="Traver B" first="Brian" last="Traver">Brian Traver</name><affiliation><mods:affiliation>University of Wisconsin, Madison, WI, USA</mods:affiliation></affiliation></author><author><name sortKey="Maggioni, Aldo" sort="Maggioni, Aldo" uniqKey="Maggioni A" first="Aldo" last="Maggioni">Aldo Maggioni</name><affiliation><mods:affiliation>Associazione Nazionale Medici Cardiologi Ospedalieri Research Center, Florence, Italy</mods:affiliation></affiliation></author><author><name sortKey="Burnett, John" sort="Burnett, John" uniqKey="Burnett J" first="John" last="Burnett">John Burnett</name><affiliation><mods:affiliation>Mayo Clinic, Rochester, MN, USA</mods:affiliation></affiliation></author><author><name sortKey="Grinfeld, Liliana" sort="Grinfeld, Liliana" uniqKey="Grinfeld L" first="Liliana" last="Grinfeld">Liliana Grinfeld</name><affiliation><mods:affiliation>Hospital Italiano, Buenos Aires, Argentina</mods:affiliation></affiliation></author><author><name sortKey="Udelson, James" sort="Udelson, James" uniqKey="Udelson J" first="James" last="Udelson">James Udelson</name><affiliation><mods:affiliation>New England Medical Center, Tufts University School of Medicine, Boston, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name><affiliation><mods:affiliation>Centre d’Investigations Cliniques, Institut National de la Santé et de la Recherche Médicale (INSERM), Nancy, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Heart Failure Reviews</title><title level="j" type="abbrev">Heart Fail Rev</title><idno type="ISSN">1382-4147</idno><idno type="eISSN">1573-7322</idno><imprint><publisher>Springer US; http://www.springer-ny.com</publisher><pubPlace>Boston</pubPlace><date type="published" when="2012-05-01">2012-05-01</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="485">485</biblScope><biblScope unit="page" to="509">509</biblScope></imprint><idno type="ISSN">1382-4147</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1382-4147</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute heart failure</term><term>Characterization</term><term>Mortality</term><term>Patient profiles</term><term>Re-hospitalization</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Hospitalization for worsening chronic heart failure results in high post-discharge mortality, morbidity, and cost. However, thorough characterization, soon after discharge of patients with early post-discharge events has not been previously performed. The objectives of this study were to describe the baseline, in-hospital, and post-discharge clinical, laboratory, and neurohormonal profiles of patients hospitalized for worsening heart failure with reduced ejection fraction (EF) who die or are re-admitted for cardiovascular (CV) causes within 90 days of initial hospitalization. Retrospective analysis of 4,133 patients hospitalized for worsening heart failure with EF ≤40% in the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial, which randomized patients to tolvaptan or placebo, both in addition to standard therapy. Clinical and laboratory parameters were obtained within 48 h of admission, during hospitalization, and post-discharge weeks 1, 4, 8, and every 8 weeks thereafter for a median of 9.9 months. Patients with events within 90 days were compared with those with later/no events. All-cause mortality (ACM) and CV re-hospitalization were independently adjudicated. Within 90 days of admission, 395 patients (9.6%) died and 801 patients (19.4%) were re-hospitalized for CV causes. Significant baseline and longitudinal differences were seen between groups with early versus later (>90 days) or no events at 12 months post-randomization. Post-discharge outcomes were similar in the tolvaptan and placebo groups. Patients with early post-discharge events experienced clinically significant worsening in signs and symptoms, laboratory values, and neurohormonal parameters soon after discharge. Identifying these abnormalities may facilitate efforts to reduce post-discharge mortality and re-hospitalization.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Mihai Gheorghiade</name><affiliations><json:string>Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N. Michigan Avenue, Suite 1006, 60611, Chicago, IL, USA</json:string><json:string>E-mail: m-gheorghiade@northwestern.edu</json:string></affiliations></json:item><json:item><name>Peter S. Pang</name><affiliations><json:string>Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N. Michigan Avenue, Suite 1006, 60611, Chicago, IL, USA</json:string><json:string>Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA</json:string></affiliations></json:item><json:item><name>Andrew P. Ambrosy</name><affiliations><json:string>Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA</json:string></affiliations></json:item><json:item><name>Gloria Lan</name><affiliations><json:string>Northwestern University Feinberg School of Medicine, Chicago, IL, USA</json:string></affiliations></json:item><json:item><name>Philip Schmidt</name><affiliations><json:string>Department of Medicine, Northwestern Memorial Hospital, Chicago, IL, USA</json:string></affiliations></json:item><json:item><name>Gerasimos Filippatos</name><affiliations><json:string>Athens University Hospital, Attikon, Greece</json:string></affiliations></json:item><json:item><name>Marvin Konstam</name><affiliations><json:string>New England Medical Center, Tufts University School of Medicine, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Karl Swedberg</name><affiliations><json:string>Sahlgrenska University Hospital/Östra, Gothenburg, Sweden</json:string></affiliations></json:item><json:item><name>Thomas Cook</name><affiliations><json:string>University of Wisconsin, Madison, WI, USA</json:string></affiliations></json:item><json:item><name>Brian Traver</name><affiliations><json:string>University of Wisconsin, Madison, WI, USA</json:string></affiliations></json:item><json:item><name>Aldo Maggioni</name><affiliations><json:string>Associazione Nazionale Medici Cardiologi Ospedalieri Research Center, Florence, Italy</json:string></affiliations></json:item><json:item><name>John Burnett</name><affiliations><json:string>Mayo Clinic, Rochester, MN, USA</json:string></affiliations></json:item><json:item><name>Liliana Grinfeld</name><affiliations><json:string>Hospital Italiano, Buenos Aires, Argentina</json:string></affiliations></json:item><json:item><name>James Udelson</name><affiliations><json:string>New England Medical Center, Tufts University School of Medicine, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Faiez Zannad</name><affiliations><json:string>Centre d’Investigations Cliniques, Institut National de la Santé et de la Recherche Médicale (INSERM), Nancy, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Acute heart failure</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Patient profiles</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Characterization</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mortality</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Re-hospitalization</value></json:item></subject><articleId><json:string>9280</json:string><json:string>s10741-011-9280-0</json:string></articleId><arkIstex>ark:/67375/VQC-F1WJNH1H-P</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Hospitalization for worsening chronic heart failure results in high post-discharge mortality, morbidity, and cost. However, thorough characterization, soon after discharge of patients with early post-discharge events has not been previously performed. The objectives of this study were to describe the baseline, in-hospital, and post-discharge clinical, laboratory, and neurohormonal profiles of patients hospitalized for worsening heart failure with reduced ejection fraction (EF) who die or are re-admitted for cardiovascular (CV) causes within 90 days of initial hospitalization. Retrospective analysis of 4,133 patients hospitalized for worsening heart failure with EF ≤40% in the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial, which randomized patients to tolvaptan or placebo, both in addition to standard therapy. Clinical and laboratory parameters were obtained within 48 h of admission, during hospitalization, and post-discharge weeks 1, 4, 8, and every 8 weeks thereafter for a median of 9.9 months. Patients with events within 90 days were compared with those with later/no events. All-cause mortality (ACM) and CV re-hospitalization were independently adjudicated. Within 90 days of admission, 395 patients (9.6%) died and 801 patients (19.4%) were re-hospitalized for CV causes. Significant baseline and longitudinal differences were seen between groups with early versus later (>90 days) or no events at 12 months post-randomization. Post-discharge outcomes were similar in the tolvaptan and placebo groups. Patients with early post-discharge events experienced clinically significant worsening in signs and symptoms, laboratory values, and neurohormonal parameters soon after discharge. Identifying these abnormalities may facilitate efforts to reduce post-discharge mortality and re-hospitalization.</abstract><qualityIndicators><score>9.952</score><pdfWordCount>5420</pdfWordCount><pdfCharCount>37911</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>25</pdfPageCount><pdfPageSize>595.276 x 790.866 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>246</abstractWordCount><abstractCharCount>1878</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial</title><genre><json:string>research-article</json:string></genre><host><title>Heart Failure Reviews</title><language><json:string>unknown</json:string></language><publicationDate>2012</publicationDate><copyrightDate>2012</copyrightDate><issn><json:string>1382-4147</json:string></issn><eissn><json:string>1573-7322</json:string></eissn><journalId><json:string>10741</json:string></journalId><volume>17</volume><issue>3</issue><pages><first>485</first><last>509</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Cardiology</value></json:item></subject></host><ark><json:string>ark:/67375/VQC-F1WJNH1H-P</json:string></ark><publicationDate>2012</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1007/s10741-011-9280-0</json:string></doi><id>6C52EEFF1590EB312ED65221AD4F04B9CDA6B4F8</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/6C52EEFF1590EB312ED65221AD4F04B9CDA6B4F8/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/6C52EEFF1590EB312ED65221AD4F04B9CDA6B4F8/fulltext/zip</uri></json:item><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/6C52EEFF1590EB312ED65221AD4F04B9CDA6B4F8/fulltext/txt</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/6C52EEFF1590EB312ED65221AD4F04B9CDA6B4F8/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://publisher-list.data.istex.fr">Springer US; http://www.springer-ny.com</publisher><pubPlace>Boston</pubPlace><availability><licence><p>Springer Science+Business Media, LLC, 2011</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>2011</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">Mihai</forename><surname>Gheorghiade</surname></persName><email>m-gheorghiade@northwestern.edu</email><affiliation>Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N. Michigan Avenue, Suite 1006, 60611, Chicago, IL, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Peter</forename><surname>Pang</surname></persName><affiliation>Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N. Michigan Avenue, Suite 1006, 60611, Chicago, IL, USA</affiliation><affiliation>Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Andrew</forename><surname>Ambrosy</surname></persName><affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Gloria</forename><surname>Lan</surname></persName><affiliation>Northwestern University Feinberg School of Medicine, Chicago, IL, USA</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Philip</forename><surname>Schmidt</surname></persName><affiliation>Department of Medicine, Northwestern Memorial Hospital, Chicago, IL, USA</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Gerasimos</forename><surname>Filippatos</surname></persName><affiliation>Athens University Hospital, Attikon, Greece</affiliation></author><author xml:id="author-0006"><persName><forename type="first">Marvin</forename><surname>Konstam</surname></persName><affiliation>New England Medical Center, Tufts University School of Medicine, Boston, MA, USA</affiliation></author><author xml:id="author-0007"><persName><forename type="first">Karl</forename><surname>Swedberg</surname></persName><affiliation>Sahlgrenska University Hospital/Östra, Gothenburg, Sweden</affiliation></author><author xml:id="author-0008"><persName><forename type="first">Thomas</forename><surname>Cook</surname></persName><affiliation>University of Wisconsin, Madison, WI, USA</affiliation></author><author xml:id="author-0009"><persName><forename type="first">Brian</forename><surname>Traver</surname></persName><affiliation>University of Wisconsin, Madison, WI, USA</affiliation></author><author xml:id="author-0010"><persName><forename type="first">Aldo</forename><surname>Maggioni</surname></persName><affiliation>Associazione Nazionale Medici Cardiologi Ospedalieri Research Center, Florence, Italy</affiliation></author><author xml:id="author-0011"><persName><forename type="first">John</forename><surname>Burnett</surname></persName><affiliation>Mayo Clinic, Rochester, MN, USA</affiliation></author><author xml:id="author-0012"><persName><forename type="first">Liliana</forename><surname>Grinfeld</surname></persName><affiliation>Hospital Italiano, Buenos Aires, Argentina</affiliation></author><author xml:id="author-0013"><persName><forename type="first">James</forename><surname>Udelson</surname></persName><affiliation>New England Medical Center, Tufts University School of Medicine, Boston, MA, USA</affiliation></author><author xml:id="author-0014"><persName><forename type="first">Faiez</forename><surname>Zannad</surname></persName><affiliation>Centre d’Investigations Cliniques, Institut National de la Santé et de la Recherche Médicale (INSERM), Nancy, France</affiliation></author><idno type="istex">6C52EEFF1590EB312ED65221AD4F04B9CDA6B4F8</idno><idno type="ark">ark:/67375/VQC-F1WJNH1H-P</idno><idno type="DOI">10.1007/s10741-011-9280-0</idno><idno type="article-id">9280</idno><idno type="article-id">s10741-011-9280-0</idno></analytic><monogr><title level="j">Heart Failure Reviews</title><title level="j" type="abbrev">Heart Fail Rev</title><idno type="pISSN">1382-4147</idno><idno type="eISSN">1573-7322</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">13</idno><idno type="volume-issue-count">6</idno><imprint><publisher>Springer US; http://www.springer-ny.com</publisher><pubPlace>Boston</pubPlace><date type="published" when="2012-05-01"></date><biblScope unit="volume">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="485">485</biblScope><biblScope unit="page" to="509">509</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Hospitalization for worsening chronic heart failure results in high post-discharge mortality, morbidity, and cost. However, thorough characterization, soon after discharge of patients with early post-discharge events has not been previously performed. The objectives of this study were to describe the baseline, in-hospital, and post-discharge clinical, laboratory, and neurohormonal profiles of patients hospitalized for worsening heart failure with reduced ejection fraction (EF) who die or are re-admitted for cardiovascular (CV) causes within 90 days of initial hospitalization. Retrospective analysis of 4,133 patients hospitalized for worsening heart failure with EF ≤40% in the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial, which randomized patients to tolvaptan or placebo, both in addition to standard therapy. Clinical and laboratory parameters were obtained within 48 h of admission, during hospitalization, and post-discharge weeks 1, 4, 8, and every 8 weeks thereafter for a median of 9.9 months. Patients with events within 90 days were compared with those with later/no events. All-cause mortality (ACM) and CV re-hospitalization were independently adjudicated. Within 90 days of admission, 395 patients (9.6%) died and 801 patients (19.4%) were re-hospitalized for CV causes. Significant baseline and longitudinal differences were seen between groups with early versus later (>90 days) or no events at 12 months post-randomization. Post-discharge outcomes were similar in the tolvaptan and placebo groups. Patients with early post-discharge events experienced clinically significant worsening in signs and symptoms, laboratory values, and neurohormonal parameters soon after discharge. Identifying these abnormalities may facilitate efforts to reduce post-discharge mortality and re-hospitalization.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Acute heart failure</term></item><item><term>Patient profiles</term></item><item><term>Characterization</term></item><item><term>Mortality</term></item><item><term>Re-hospitalization</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Cardiology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-05-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-12-1">References added</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" 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TocLevels="0"><ArticleID>9280</ArticleID><ArticleDOI>10.1007/s10741-011-9280-0</ArticleDOI><ArticleSequenceNumber>12</ArticleSequenceNumber><ArticleTitle Language="En" OutputMedium="All">A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial</ArticleTitle><ArticleFirstPage>485</ArticleFirstPage><ArticleLastPage>509</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2011</Year><Month>8</Month><Day>25</Day></RegistrationDate><OnlineDate><Year>2011</Year><Month>9</Month><Day>20</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer Science+Business Media, LLC</CopyrightHolderName><CopyrightYear>2011</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Mihai</GivenName><FamilyName>Gheorghiade</FamilyName></AuthorName><Contact><Phone>+1-312-6950052</Phone><Fax>+1-312-6951434</Fax><Email>m-gheorghiade@northwestern.edu</Email></Contact></Author><Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><GivenName>Peter</GivenName><GivenName>S.</GivenName><FamilyName>Pang</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Andrew</GivenName><GivenName>P.</GivenName><FamilyName>Ambrosy</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff4"><AuthorName DisplayOrder="Western"><GivenName>Gloria</GivenName><FamilyName>Lan</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff5"><AuthorName DisplayOrder="Western"><GivenName>Philip</GivenName><FamilyName>Schmidt</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff6"><AuthorName DisplayOrder="Western"><GivenName>Gerasimos</GivenName><FamilyName>Filippatos</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff7"><AuthorName DisplayOrder="Western"><GivenName>Marvin</GivenName><FamilyName>Konstam</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff8"><AuthorName DisplayOrder="Western"><GivenName>Karl</GivenName><FamilyName>Swedberg</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff9"><AuthorName DisplayOrder="Western"><GivenName>Thomas</GivenName><FamilyName>Cook</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff9"><AuthorName DisplayOrder="Western"><GivenName>Brian</GivenName><FamilyName>Traver</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff10"><AuthorName DisplayOrder="Western"><GivenName>Aldo</GivenName><FamilyName>Maggioni</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff11"><AuthorName DisplayOrder="Western"><GivenName>John</GivenName><FamilyName>Burnett</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff12"><AuthorName DisplayOrder="Western"><GivenName>Liliana</GivenName><FamilyName>Grinfeld</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff7"><AuthorName DisplayOrder="Western"><GivenName>James</GivenName><FamilyName>Udelson</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff13"><AuthorName DisplayOrder="Western"><GivenName>Faiez</GivenName><FamilyName>Zannad</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Center for Cardiovascular Innovation</OrgDivision><OrgName>Northwestern University Feinberg School of Medicine</OrgName><OrgAddress><Street>645 N. Michigan Avenue, Suite 1006</Street><City>Chicago</City><State>IL</State><Postcode>60611</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Emergency Medicine</OrgDivision><OrgName>Northwestern University Feinberg School of Medicine</OrgName><OrgAddress><City>Chicago</City><State>IL</State><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Department of Medicine</OrgDivision><OrgName>Stanford University School of Medicine</OrgName><OrgAddress><City>Stanford</City><State>CA</State><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgName>Northwestern University Feinberg School of Medicine</OrgName><OrgAddress><City>Chicago</City><State>IL</State><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff5"><OrgDivision>Department of Medicine</OrgDivision><OrgName>Northwestern Memorial Hospital</OrgName><OrgAddress><City>Chicago</City><State>IL</State><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff6"><OrgName>Athens University Hospital</OrgName><OrgAddress><City>Attikon</City><Country Code="GR">Greece</Country></OrgAddress></Affiliation><Affiliation ID="Aff7"><OrgDivision>New England Medical Center</OrgDivision><OrgName>Tufts University School of Medicine</OrgName><OrgAddress><City>Boston</City><State>MA</State><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff8"><OrgName>Sahlgrenska University Hospital/Östra</OrgName><OrgAddress><City>Gothenburg</City><Country Code="SE">Sweden</Country></OrgAddress></Affiliation><Affiliation ID="Aff9"><OrgName>University of Wisconsin</OrgName><OrgAddress><City>Madison</City><State>WI</State><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff10"><OrgName>Associazione Nazionale Medici Cardiologi Ospedalieri Research Center</OrgName><OrgAddress><City>Florence</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff11"><OrgName>Mayo Clinic</OrgName><OrgAddress><City>Rochester</City><State>MN</State><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff12"><OrgName>Hospital Italiano</OrgName><OrgAddress><City>Buenos Aires</City><Country Code="AR">Argentina</Country></OrgAddress></Affiliation><Affiliation ID="Aff13"><OrgDivision>Centre d’Investigations Cliniques</OrgDivision><OrgName>Institut National de la Santé et de la Recherche Médicale (INSERM)</OrgName><OrgAddress><City>Nancy</City><Country Code="FR">France</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para>Hospitalization for worsening chronic heart failure results in high post-discharge mortality, morbidity, and cost. However, thorough characterization, soon after discharge of patients with early post-discharge events has not been previously performed. The objectives of this study were to describe the baseline, in-hospital, and post-discharge clinical, laboratory, and neurohormonal profiles of patients hospitalized for worsening heart failure with reduced ejection fraction (EF) who die or are re-admitted for cardiovascular (CV) causes within 90 days of initial hospitalization. Retrospective analysis of 4,133 patients hospitalized for worsening heart failure with EF ≤40% in the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial, which randomized patients to tolvaptan or placebo, both in addition to standard therapy. Clinical and laboratory parameters were obtained within 48 h of admission, during hospitalization, and post-discharge weeks 1, 4, 8, and every 8 weeks thereafter for a median of 9.9 months. Patients with events within 90 days were compared with those with later/no events. All-cause mortality (ACM) and CV re-hospitalization were independently adjudicated. Within 90 days of admission, 395 patients (9.6%) died and 801 patients (19.4%) were re-hospitalized for CV causes. Significant baseline and longitudinal differences were seen between groups with early versus later (>90 days) or no events at 12 months post-randomization. Post-discharge outcomes were similar in the tolvaptan and placebo groups. Patients with early post-discharge events experienced clinically significant worsening in signs and symptoms, laboratory values, and neurohormonal parameters soon after discharge. Identifying these abnormalities may facilitate efforts to reduce post-discharge mortality and re-hospitalization.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Acute heart failure</Keyword><Keyword>Patient profiles</Keyword><Keyword>Characterization</Keyword><Keyword>Mortality</Keyword><Keyword>Re-hospitalization</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>This work was presented as a Late-Breaking Clinical Trial at the European Society of Cardiology in Munich, Germany, September 2008.</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Mihai</namePart><namePart type="family">Gheorghiade</namePart><affiliation>Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N. Michigan Avenue, Suite 1006, 60611, Chicago, IL, USA</affiliation><affiliation>E-mail: m-gheorghiade@northwestern.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter</namePart><namePart type="given">S.</namePart><namePart type="family">Pang</namePart><affiliation>Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N. Michigan Avenue, Suite 1006, 60611, Chicago, IL, USA</affiliation><affiliation>Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew</namePart><namePart type="given">P.</namePart><namePart type="family">Ambrosy</namePart><affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gloria</namePart><namePart type="family">Lan</namePart><affiliation>Northwestern University Feinberg School of Medicine, Chicago, IL, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philip</namePart><namePart type="family">Schmidt</namePart><affiliation>Department of Medicine, Northwestern Memorial Hospital, Chicago, IL, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gerasimos</namePart><namePart type="family">Filippatos</namePart><affiliation>Athens University Hospital, Attikon, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marvin</namePart><namePart type="family">Konstam</namePart><affiliation>New England Medical Center, Tufts University School of Medicine, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karl</namePart><namePart type="family">Swedberg</namePart><affiliation>Sahlgrenska University Hospital/Östra, Gothenburg, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas</namePart><namePart type="family">Cook</namePart><affiliation>University of Wisconsin, Madison, WI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brian</namePart><namePart type="family">Traver</namePart><affiliation>University of Wisconsin, Madison, WI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aldo</namePart><namePart type="family">Maggioni</namePart><affiliation>Associazione Nazionale Medici Cardiologi Ospedalieri Research Center, Florence, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John</namePart><namePart type="family">Burnett</namePart><affiliation>Mayo Clinic, Rochester, MN, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Liliana</namePart><namePart type="family">Grinfeld</namePart><affiliation>Hospital Italiano, Buenos Aires, Argentina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James</namePart><namePart type="family">Udelson</namePart><affiliation>New England Medical Center, Tufts University School of Medicine, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Faiez</namePart><namePart type="family">Zannad</namePart><affiliation>Centre d’Investigations Cliniques, Institut National de la Santé et de la Recherche Médicale (INSERM), Nancy, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer US; http://www.springer-ny.com</publisher><place><placeTerm type="text">Boston</placeTerm></place><dateIssued encoding="w3cdtf">2012-05-01</dateIssued><dateIssued encoding="w3cdtf">2011</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Hospitalization for worsening chronic heart failure results in high post-discharge mortality, morbidity, and cost. However, thorough characterization, soon after discharge of patients with early post-discharge events has not been previously performed. The objectives of this study were to describe the baseline, in-hospital, and post-discharge clinical, laboratory, and neurohormonal profiles of patients hospitalized for worsening heart failure with reduced ejection fraction (EF) who die or are re-admitted for cardiovascular (CV) causes within 90 days of initial hospitalization. Retrospective analysis of 4,133 patients hospitalized for worsening heart failure with EF ≤40% in the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial, which randomized patients to tolvaptan or placebo, both in addition to standard therapy. Clinical and laboratory parameters were obtained within 48 h of admission, during hospitalization, and post-discharge weeks 1, 4, 8, and every 8 weeks thereafter for a median of 9.9 months. Patients with events within 90 days were compared with those with later/no events. All-cause mortality (ACM) and CV re-hospitalization were independently adjudicated. Within 90 days of admission, 395 patients (9.6%) died and 801 patients (19.4%) were re-hospitalized for CV causes. Significant baseline and longitudinal differences were seen between groups with early versus later (>90 days) or no events at 12 months post-randomization. Post-discharge outcomes were similar in the tolvaptan and placebo groups. Patients with early post-discharge events experienced clinically significant worsening in signs and symptoms, laboratory values, and neurohormonal parameters soon after discharge. Identifying these abnormalities may facilitate efforts to reduce post-discharge mortality and re-hospitalization.</abstract><subject lang="en"><genre>Keywords</genre><topic>Acute heart failure</topic><topic>Patient profiles</topic><topic>Characterization</topic><topic>Mortality</topic><topic>Re-hospitalization</topic></subject><relatedItem type="host"><titleInfo><title>Heart Failure Reviews</title></titleInfo><titleInfo type="abbreviated"><title>Heart Fail Rev</title></titleInfo><genre type="journal" displayLabel="Archive Journal" authority="ISTEX" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2012-04-12</dateIssued><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Cardiology</topic></subject><identifier type="ISSN">1382-4147</identifier><identifier type="eISSN">1573-7322</identifier><identifier type="JournalID">10741</identifier><identifier type="IssueArticleCount">13</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>2012</date><detail type="volume"><number>17</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="pages"><start>485</start><end>509</end></extent></part><recordInfo><recordOrigin>Springer Science+Business Media, LLC, 2012</recordOrigin></recordInfo></relatedItem><identifier type="istex">6C52EEFF1590EB312ED65221AD4F04B9CDA6B4F8</identifier><identifier type="ark">ark:/67375/VQC-F1WJNH1H-P</identifier><identifier type="DOI">10.1007/s10741-011-9280-0</identifier><identifier type="ArticleID">9280</identifier><identifier type="ArticleID">s10741-011-9280-0</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer Science+Business Media, LLC, 2011</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer Science+Business Media, LLC, 2011</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/6C52EEFF1590EB312ED65221AD4F04B9CDA6B4F8/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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