A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL Gene
Identifieur interne : 000506 ( Istex/Corpus ); précédent : 000505; suivant : 000507A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL Gene
Auteurs : Sheila N. Jani Sait ; Susana C. Raimondi ; A. Thomas Look ; Heidi Gill ; Michael Thirman ; Manuel O. Diaz ; Thomas B. ShowsSource :
- Genes, Chromosomes and Cancer [ 1045-2257 ] ; 1993-05.
English descriptors
- Teeft :
- Acute leukemia, Acute leukemias, Acute lymphoblastic leukemia, Acute myeloid leukemia, Bamhi, Bamhi fragment, Bone marrow, Bone marrow cells, Breakpoint, Breakpoints, Cd3d, Cell hybrids, Chromosome, Chromosome band, Chromosome translocation, Clone, Drosophih trithorax, Drosophila trithorax protein, Homeotic gene regulation, Human gene mapping, Human genetics, Human homolog, Hybrid, Jani sait, Leukemia, Leukemic, Leukemic cells, Lymphoblastic, Lymphoblastic leukemia, Monocytic, Pbr3, Pbr6, Polyethylene glycol, Probe hybridized, Proc natl acad, Rearrangement, Roswell park cancer institute, Somatic cell hybrids pbr3, Southern blot analysis, Translocation, Translocation breakpoints.
Abstract
Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, MLL (myeloid/lymphoid or mixed‐lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene. © 1993 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/gcc.2870070105
Links to Exploration step
ISTEX:C2DDE5EB6CC14B57BCFC87240C175C308B8E247FLe document en format XML
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Jani Sait</name><affiliation><mods:affiliation>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Roswell Park Cancer Institute, Department of Human Genetics, Buffalo, NY 14263</mods:affiliation></affiliation></author><author><name sortKey="Raimondi, Susana C" sort="Raimondi, Susana C" uniqKey="Raimondi S" first="Susana C." last="Raimondi">Susana C. Raimondi</name><affiliation><mods:affiliation>St. Jude Children's Research Hospital, Memphis, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Look, A Thomas" sort="Look, A Thomas" uniqKey="Look A" first="A. Thomas" last="Look">A. Thomas Look</name><affiliation><mods:affiliation>St. Jude Children's Research Hospital, Memphis, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Gill, Heidi" sort="Gill, Heidi" uniqKey="Gill H" first="Heidi" last="Gill">Heidi Gill</name><affiliation><mods:affiliation>University of Chicago, Chicago, Illinois</mods:affiliation></affiliation></author><author><name sortKey="Thirman, Michael" sort="Thirman, Michael" uniqKey="Thirman M" first="Michael" last="Thirman">Michael Thirman</name><affiliation><mods:affiliation>University of Chicago, Chicago, Illinois</mods:affiliation></affiliation></author><author><name sortKey="Diaz, Manuel O" sort="Diaz, Manuel O" uniqKey="Diaz M" first="Manuel O." last="Diaz">Manuel O. Diaz</name><affiliation><mods:affiliation>University of Chicago, Chicago, Illinois</mods:affiliation></affiliation></author><author><name sortKey="Shows, Thomas B" sort="Shows, Thomas B" uniqKey="Shows T" first="Thomas B." last="Shows">Thomas B. Shows</name><affiliation><mods:affiliation>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Genes, Chromosomes and Cancer</title><title level="j" type="alt">GENES, CHROMOSOMES AND CANCER</title><idno type="ISSN">1045-2257</idno><idno type="eISSN">1098-2264</idno><imprint><biblScope unit="vol">7</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="28">28</biblScope><biblScope unit="page" to="31">31</biblScope><biblScope unit="page-count">4</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1993-05">1993-05</date></imprint><idno type="ISSN">1045-2257</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1045-2257</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute leukemia</term><term>Acute leukemias</term><term>Acute lymphoblastic leukemia</term><term>Acute myeloid leukemia</term><term>Bamhi</term><term>Bamhi fragment</term><term>Bone marrow</term><term>Bone marrow cells</term><term>Breakpoint</term><term>Breakpoints</term><term>Cd3d</term><term>Cell hybrids</term><term>Chromosome</term><term>Chromosome band</term><term>Chromosome translocation</term><term>Clone</term><term>Drosophih trithorax</term><term>Drosophila trithorax protein</term><term>Homeotic gene regulation</term><term>Human gene mapping</term><term>Human genetics</term><term>Human homolog</term><term>Hybrid</term><term>Jani sait</term><term>Leukemia</term><term>Leukemic</term><term>Leukemic cells</term><term>Lymphoblastic</term><term>Lymphoblastic leukemia</term><term>Monocytic</term><term>Pbr3</term><term>Pbr6</term><term>Polyethylene glycol</term><term>Probe hybridized</term><term>Proc natl acad</term><term>Rearrangement</term><term>Roswell park cancer institute</term><term>Somatic cell hybrids pbr3</term><term>Southern blot analysis</term><term>Translocation</term><term>Translocation breakpoints</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, MLL (myeloid/lymphoid or mixed‐lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene. © 1993 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>chromosome</json:string><json:string>translocation</json:string><json:string>breakpoints</json:string><json:string>breakpoint</json:string><json:string>pbr6</json:string><json:string>pbr3</json:string><json:string>rearrangement</json:string><json:string>leukemic</json:string><json:string>bamhi</json:string><json:string>cd3d</json:string><json:string>clone</json:string><json:string>monocytic</json:string><json:string>lymphoblastic</json:string><json:string>leukemia</json:string><json:string>bamhi fragment</json:string><json:string>proc natl acad</json:string><json:string>hybrid</json:string><json:string>cell hybrids</json:string><json:string>acute lymphoblastic leukemia</json:string><json:string>lymphoblastic leukemia</json:string><json:string>acute leukemia</json:string><json:string>southern blot analysis</json:string><json:string>leukemic cells</json:string><json:string>human genetics</json:string><json:string>polyethylene glycol</json:string><json:string>acute myeloid leukemia</json:string><json:string>human homolog</json:string><json:string>drosophila trithorax protein</json:string><json:string>homeotic gene regulation</json:string><json:string>bone marrow</json:string><json:string>roswell park cancer institute</json:string><json:string>somatic cell hybrids pbr3</json:string><json:string>probe hybridized</json:string><json:string>translocation breakpoints</json:string><json:string>human gene mapping</json:string><json:string>jani sait</json:string><json:string>chromosome translocation</json:string><json:string>acute leukemias</json:string><json:string>chromosome band</json:string><json:string>drosophih trithorax</json:string><json:string>bone marrow cells</json:string></teeft></keywords><author><json:item><name>Dr. Sheila N. Jani Sait</name><affiliations><json:string>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York</json:string><json:string>Correspondence address: Roswell Park Cancer Institute, Department of Human Genetics, Buffalo, NY 14263</json:string></affiliations></json:item><json:item><name>Susana C. Raimondi</name><affiliations><json:string>St. Jude Children's Research Hospital, Memphis, Tennessee</json:string></affiliations></json:item><json:item><name>A. Thomas Look</name><affiliations><json:string>St. Jude Children's Research Hospital, Memphis, Tennessee</json:string></affiliations></json:item><json:item><name>Heidi Gill</name><affiliations><json:string>University of Chicago, Chicago, Illinois</json:string></affiliations></json:item><json:item><name>Michael Thirman</name><affiliations><json:string>University of Chicago, Chicago, Illinois</json:string></affiliations></json:item><json:item><name>Manuel O. Diaz</name><affiliations><json:string>University of Chicago, Chicago, Illinois</json:string></affiliations></json:item><json:item><name>Thomas B. Shows</name><affiliations><json:string>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York</json:string></affiliations></json:item></author><articleId><json:string>GCC2870070105</json:string></articleId><arkIstex>ark:/67375/WNG-LX594BJP-9</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, MLL (myeloid/lymphoid or mixed‐lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene. © 1993 Wiley‐Liss, Inc.</abstract><qualityIndicators><score>5.309</score><pdfWordCount>2481</pdfWordCount><pdfCharCount>14620</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>4</pdfPageCount><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>69</abstractWordCount><abstractCharCount>513</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL Gene</title><pmid><json:string>7688552</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Genes, Chromosomes and Cancer</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1098-2264</json:string></doi><issn><json:string>1045-2257</json:string></issn><eissn><json:string>1098-2264</json:string></eissn><publisherId><json:string>GCC</json:string></publisherId><volume>7</volume><issue>1</issue><pages><first>28</first><last>31</last><total>4</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Research Article</value></json:item></subject></host><namedEntities><unitex><date><json:string>1993</json:string></date><geogName></geogName><orgName><json:string>Roswell Park Cancer Institute, Department of Human Genetics, Buffalo, NY</json:string><json:string>and American Lebanese Syrian Associated Charities</json:string><json:string>Jude Children's Research Hospital, Memphis, Tennessee</json:string><json:string>University of Chicago</json:string><json:string>Wiley-Liss, Inc</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Nancy Frame</json:string><json:string>Janet D. Rowley</json:string><json:string>Linda Haley</json:string><json:string>Heidi Gill</json:string><json:string>Susana C. Raimondi</json:string><json:string>M. Thirman</json:string><json:string>Thomas Look</json:string><json:string>Frederick Behm</json:string><json:string>Donna Ovak</json:string><json:string>Michael Thirman</json:string><json:string>Michael Henry</json:string><json:string>Cells</json:string><json:string>Sheila N. Jani</json:string><json:string>Norma Nowak</json:string></persName><placeName><json:string>American</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Sandoval et al., 1992</json:string><json:string>Das et al., 1992</json:string><json:string>Ziemin-van der Poel et al., 1991</json:string><json:string>Ziemin-van der Poel et al. (1991)</json:string><json:string>Rairnondi et al.</json:string><json:string>Hudson et al., 1991</json:string><json:string>Pui et al.</json:string><json:string>Trent et al., 1989</json:string><json:string>Mitelman, 1991</json:string><json:string>Cimino et al. (1992)</json:string><json:string>Radice and Tunacliffe, 1992</json:string><json:string>Davis et al., 1988</json:string><json:string>Junien and van Heyningen, 1991</json:string><json:string>McCabe et al.</json:string><json:string>Nagasaka et al., 1983</json:string><json:string>Chen et al., 1991</json:string><json:string>Krance et al., 1992</json:string><json:string>Djabali et al., 1992</json:string><json:string>Gibbons et al., 1990</json:string><json:string>Cimino et al., 1992</json:string><json:string>van den Elsen et al., 1984</json:string><json:string>Fan et al., 1990</json:string><json:string>Shows et al., 1984</json:string><json:string>Rowley et al., 1990</json:string><json:string>Church and Gilbert, 1984</json:string><json:string>Gu et al., 1992</json:string><json:string>Tkachuk et al., 1992</json:string><json:string>Stong et al., 1985</json:string><json:string>Sambrook et al., 1989</json:string><json:string>Feinberg and Vogelstein (1983)</json:string><json:string>Davidson and Gerald, 1976</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-LX594BJP-9</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - oncology</json:string><json:string>2 - genetics & heredity</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - oncology & carcinogenesis</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Cancer Research</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Genetics</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1993</publicationDate><copyrightDate>1993</copyrightDate><doi><json:string>10.1002/gcc.2870070105</json:string></doi><id>C2DDE5EB6CC14B57BCFC87240C175C308B8E247F</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/C2DDE5EB6CC14B57BCFC87240C175C308B8E247F/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/C2DDE5EB6CC14B57BCFC87240C175C308B8E247F/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C2DDE5EB6CC14B57BCFC87240C175C308B8E247F/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A t(11;12) 11q23 leukemic breakpoint that disrupts the <hi rend="italic">MLL</hi> Gene</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><availability><licence>Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company</licence></availability><date type="published" when="1993-05"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">A t(11;12) 11q23 leukemic breakpoint that disrupts the <hi rend="italic">MLL</hi> Gene</title><title level="a" type="short" xml:lang="en">t(11;12) LEUKEMIA THAT DISRUPTS THE MLL GENE</title><author xml:id="author-0000" role="corresp"><persName><addName>Dr.</addName><forename type="first">Sheila N. Jani</forename><surname>Sait</surname></persName><affiliation>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York<address><country key="US"></country></address></affiliation><affiliation>Roswell Park Cancer Institute, Department of Human Genetics, Buffalo, NY 14263</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Susana C.</forename><surname>Raimondi</surname></persName><affiliation>St. Jude Children's Research Hospital, Memphis, Tennessee<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">A. Thomas</forename><surname>Look</surname></persName><affiliation>St. Jude Children's Research Hospital, Memphis, Tennessee<address><country key="US"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Heidi</forename><surname>Gill</surname></persName><affiliation>University of Chicago, Chicago, Illinois<address><country key="US"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Michael</forename><surname>Thirman</surname></persName><affiliation>University of Chicago, Chicago, Illinois<address><country key="US"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Manuel O.</forename><surname>Diaz</surname></persName><affiliation>University of Chicago, Chicago, Illinois<address><country key="US"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Thomas B.</forename><surname>Shows</surname></persName><affiliation>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York<address><country key="US"></country></address></affiliation></author><idno type="istex">C2DDE5EB6CC14B57BCFC87240C175C308B8E247F</idno><idno type="ark">ark:/67375/WNG-LX594BJP-9</idno><idno type="DOI">10.1002/gcc.2870070105</idno><idno type="unit">GCC2870070105</idno><idno type="toTypesetVersion">file:GCC.GCC2870070105.pdf</idno></analytic><monogr><title level="j" type="main">Genes, Chromosomes and Cancer</title><title level="j" type="alt">GENES, CHROMOSOMES AND CANCER</title><idno type="pISSN">1045-2257</idno><idno type="eISSN">1098-2264</idno><idno type="book-DOI">10.1002/(ISSN)1098-2264</idno><idno type="book-part-DOI">10.1002/gcc.v7:1</idno><idno type="product">GCC</idno><imprint><biblScope unit="vol">7</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="28">28</biblScope><biblScope unit="page" to="31">31</biblScope><biblScope unit="page-count">4</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1993-05"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, <hi rend="italic">MLL</hi> (myeloid/lymphoid or mixed‐lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene. © 1993 Wiley‐Liss, Inc.</p></abstract><textClass><keywords rend="articleCategory"><term>Research Article</term></keywords><keywords rend="tocHeading1"><term>Research Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/C2DDE5EB6CC14B57BCFC87240C175C308B8E247F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1098-2264</doi><issn type="print">1045-2257</issn><issn type="electronic">1098-2264</issn><idGroup><id type="product" value="GCC"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="GENES, CHROMOSOMES AND CANCER">Genes, Chromosomes and Cancer</title><title type="short">Genes Chromosom. Cancer</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/gcc.v7:1</doi><numberingGroup><numbering type="journalVolume" number="7">7</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="1993-05">May 1993</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley" registered="yes">10.1002/gcc.2870070105</doi><idGroup><id type="unit" value="GCC2870070105"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company</copyright><eventGroup><event type="manuscriptReceived" date="1992-10-05"></event><event type="manuscriptAccepted" date="1992-12-10"></event><event type="firstOnline" date="2006-07-14"></event><event type="publishedOnlineFinalForm" date="2006-07-14"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-25"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst">28</numbering><numbering type="pageLast">31</numbering></numberingGroup><correspondenceTo>Roswell Park Cancer Institute, Department of Human Genetics, Buffalo, NY 14263</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:GCC.GCC2870070105.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="31"></count></countGroup><titleGroup><title type="main" xml:lang="en">A t(11;12) 11q23 leukemic breakpoint that disrupts the <i>MLL</i> Gene</title><title type="short" xml:lang="en">t(11;12) LEUKEMIA THAT DISRUPTS THE <fi>MLL</fi> GENE</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><honorifics>Dr.</honorifics><givenNames>Sheila N. Jani</givenNames><familyName>Sait</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Susana C.</givenNames><familyName>Raimondi</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>A. Thomas</givenNames><familyName>Look</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Heidi</givenNames><familyName>Gill</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Michael</givenNames><familyName>Thirman</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Manuel O.</givenNames><familyName>Diaz</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Thomas B.</givenNames><familyName>Shows</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>St. Jude Children's Research Hospital, Memphis, Tennessee</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>University of Chicago, Chicago, Illinois</unparsedAffiliation></affiliation></affiliationGroup><fundingInfo><fundingAgency>ACS</fundingAgency><fundingNumber>PDT445K</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>HG00359</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NCI</fundingAgency><fundingNumber>CA20180</fundingNumber></fundingInfo><fundingInfo><fundingAgency>American Lebanese Syrian Associated Charities</fundingAgency></fundingInfo><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>CA38725</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>CA42557</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, <i>MLL</i> (myeloid/lymphoid or mixed‐lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene. © 1993 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL Gene</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>t(11;12) LEUKEMIA THAT DISRUPTS THE MLL GENE</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL Gene</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Sheila N. Jani</namePart><namePart type="family">Sait</namePart><affiliation>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York</affiliation><affiliation>Correspondence address: Roswell Park Cancer Institute, Department of Human Genetics, Buffalo, NY 14263</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susana C.</namePart><namePart type="family">Raimondi</namePart><affiliation>St. Jude Children's Research Hospital, Memphis, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. Thomas</namePart><namePart type="family">Look</namePart><affiliation>St. Jude Children's Research Hospital, Memphis, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Heidi</namePart><namePart type="family">Gill</namePart><affiliation>University of Chicago, Chicago, Illinois</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Thirman</namePart><affiliation>University of Chicago, Chicago, Illinois</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Manuel O.</namePart><namePart type="family">Diaz</namePart><affiliation>University of Chicago, Chicago, Illinois</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas B.</namePart><namePart type="family">Shows</namePart><affiliation>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1993-05</dateIssued><dateCaptured encoding="w3cdtf">1992-10-05</dateCaptured><dateValid encoding="w3cdtf">1992-12-10</dateValid><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">3</extent><extent unit="tables">0</extent><extent unit="references">31</extent></physicalDescription><abstract lang="en">Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, MLL (myeloid/lymphoid or mixed‐lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene. © 1993 Wiley‐Liss, Inc.</abstract><note type="funding">ACS - No. PDT445K; </note><note type="funding">NIH - No. HG00359; </note><note type="funding">NCI - No. CA20180; </note><note type="funding">American Lebanese Syrian Associated Charities</note><note type="funding">NIH - No. CA38725; </note><note type="funding">NIH - No. CA42557; </note><relatedItem type="host"><titleInfo><title>Genes, Chromosomes and Cancer</title></titleInfo><titleInfo type="abbreviated"><title>Genes Chromosom. Cancer</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">1045-2257</identifier><identifier type="eISSN">1098-2264</identifier><identifier type="DOI">10.1002/(ISSN)1098-2264</identifier><identifier type="PublisherID">GCC</identifier><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>28</start><end>31</end><total>4</total></extent></part></relatedItem><identifier type="istex">C2DDE5EB6CC14B57BCFC87240C175C308B8E247F</identifier><identifier type="ark">ark:/67375/WNG-LX594BJP-9</identifier><identifier type="DOI">10.1002/gcc.2870070105</identifier><identifier type="ArticleID">GCC2870070105</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/C2DDE5EB6CC14B57BCFC87240C175C308B8E247F/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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