Excitatory effects of muscarine on septohippocampal neurons: involvement of M3 receptors
Identifieur interne : 000544 ( Istex/Checkpoint ); précédent : 000543; suivant : 000545Excitatory effects of muscarine on septohippocampal neurons: involvement of M3 receptors
Auteurs : Weimin Liu [États-Unis] ; Ashok Kumar [États-Unis] ; Meenakshi Alreja [États-Unis]Source :
- Brain Research [ 0006-8993 ] ; 1998.
English descriptors
- KwdEn :
- Teeft :
- Acetylcholine, Agonist, Antagonist, Antidromic, Antidromically, Atropine, Basal, Basal forebrain, Bath application, Binding studies, Brain research, Carbachol, Chart record trace, Cholinergic, Conduction, Conduction velocities, Conduction velocity, Dorsal fornix, Electrophysiological, Electrophysiological studies, Excitation, Excitatory, Excitatory effect, Excitatory effects, Excitatory response, Excitatory responses, Extracellular recordings, Gabaergic, Gabaergic neurons, High affinity, Hippocampal, Hippocampus, Inhibitory responses, Irreversible antagonist, Maximal response, Medial, Medial septum, Methoctramine, Mrna, Msdb, Msdb neuron, Msdb neurons, Muscarine, Muscarine curve, Muscarinic, Muscarinic agonists, Muscarinic receptor, Muscarinic receptor subtypes, Muscarinic receptors, Muscarinic response, Muscarinic responses, Neuron, Neurosci, Pharmacol, Physiol, Pirenzepine, Present study, Receptor, Receptor antagonist, Septal, Septohippocampal, Septohippocampal gabaergic neurons, Septohippocampal neurons, Septum, Shns, Subtypes, Telenzepine, Wide range.
Abstract
Abstract: Cholinergic mechanisms in the septohippocampal pathway contribute to several cognitive functions and impaired cholinergic transmission in this pathway may be related to the memory loss and dementia that accompanies normal aging and Alzheimer's disease and behavioral studies suggest that muscarinic mechanisms in the medial septum/diagonal band of Broca (MSDB) may contribute to these functions. The goal of the present study was to begin a characterization of the physiological and pharmacological effects of muscarine on antidromically identified septohippocampal neurons (SHNs). Muscarinic agonists produced a concentration-dependent excitation in >90% of SHNs tested using extracellular recordings in an in vitro rat brain slice preparation. The SHNs excited by muscarine had a broad range of conduction velocities (0.2 to 3.7 m/s; mean: 1.6±0.06 m/s; n=110), suggesting involvement of neurons with both slow (possibly cholinergic) and fast (possibly GABAergic) conducting fibers. The muscarine-induced excitations in SHNs were found not to be mediated via M1, M2 or M4 receptors, as they were not blocked by the M1-selective antagonists, pirenzepine or telenzepine or by the M2/M4-selective antagonist, methoctramine. In contrast, the M3-selective antagonist, 4-DAMP-mustard, blocked muscarinic excitations in a majority of SHNs, indicating the presence of M3 as well as non-M3-type responses. McN-A-343, an M1 and M5-selective agonist, excited 33% of neurons tested, confirming involvement of non-M3 receptors (possibly M5) and M3 receptors. Since the cholinergic and GABAergic MSDB neurons together innervate almost every type of hippocampal neuron, the effects of muscarine on SHNs would also have a profound effect on hippocampal circuitry.
Url:
DOI: 10.1016/S0006-8993(98)00729-X
Affiliations:
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when="1998">1998</date><biblScope unit="volume">805</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="220">220</biblScope><biblScope unit="page" to="233">233</biblScope></imprint><idno type="ISSN">0006-8993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholine</term><term>Basal forebrain</term><term>Cholinergic</term><term>Diagonal band</term><term>M3 receptor</term><term>Medial septum</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acetylcholine</term><term>Agonist</term><term>Antagonist</term><term>Antidromic</term><term>Antidromically</term><term>Atropine</term><term>Basal</term><term>Basal forebrain</term><term>Bath application</term><term>Binding studies</term><term>Brain research</term><term>Carbachol</term><term>Chart record trace</term><term>Cholinergic</term><term>Conduction</term><term>Conduction velocities</term><term>Conduction velocity</term><term>Dorsal fornix</term><term>Electrophysiological</term><term>Electrophysiological studies</term><term>Excitation</term><term>Excitatory</term><term>Excitatory effect</term><term>Excitatory effects</term><term>Excitatory response</term><term>Excitatory responses</term><term>Extracellular recordings</term><term>Gabaergic</term><term>Gabaergic neurons</term><term>High affinity</term><term>Hippocampal</term><term>Hippocampus</term><term>Inhibitory responses</term><term>Irreversible antagonist</term><term>Maximal response</term><term>Medial</term><term>Medial septum</term><term>Methoctramine</term><term>Mrna</term><term>Msdb</term><term>Msdb neuron</term><term>Msdb neurons</term><term>Muscarine</term><term>Muscarine curve</term><term>Muscarinic</term><term>Muscarinic agonists</term><term>Muscarinic receptor</term><term>Muscarinic receptor subtypes</term><term>Muscarinic receptors</term><term>Muscarinic response</term><term>Muscarinic responses</term><term>Neuron</term><term>Neurosci</term><term>Pharmacol</term><term>Physiol</term><term>Pirenzepine</term><term>Present study</term><term>Receptor</term><term>Receptor antagonist</term><term>Septal</term><term>Septohippocampal</term><term>Septohippocampal gabaergic neurons</term><term>Septohippocampal neurons</term><term>Septum</term><term>Shns</term><term>Subtypes</term><term>Telenzepine</term><term>Wide range</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Cholinergic mechanisms in the septohippocampal pathway contribute to several cognitive functions and impaired cholinergic transmission in this pathway may be related to the memory loss and dementia that accompanies normal aging and Alzheimer's disease and behavioral studies suggest that muscarinic mechanisms in the medial septum/diagonal band of Broca (MSDB) may contribute to these functions. The goal of the present study was to begin a characterization of the physiological and pharmacological effects of muscarine on antidromically identified septohippocampal neurons (SHNs). Muscarinic agonists produced a concentration-dependent excitation in >90% of SHNs tested using extracellular recordings in an in vitro rat brain slice preparation. The SHNs excited by muscarine had a broad range of conduction velocities (0.2 to 3.7 m/s; mean: 1.6±0.06 m/s; n=110), suggesting involvement of neurons with both slow (possibly cholinergic) and fast (possibly GABAergic) conducting fibers. The muscarine-induced excitations in SHNs were found not to be mediated via M1, M2 or M4 receptors, as they were not blocked by the M1-selective antagonists, pirenzepine or telenzepine or by the M2/M4-selective antagonist, methoctramine. In contrast, the M3-selective antagonist, 4-DAMP-mustard, blocked muscarinic excitations in a majority of SHNs, indicating the presence of M3 as well as non-M3-type responses. McN-A-343, an M1 and M5-selective agonist, excited 33% of neurons tested, confirming involvement of non-M3 receptors (possibly M5) and M3 receptors. Since the cholinergic and GABAergic MSDB neurons together innervate almost every type of hippocampal neuron, the effects of muscarine on SHNs would also have a profound effect on hippocampal circuitry.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Liu, Weimin" sort="Liu, Weimin" uniqKey="Liu W" first="Weimin" last="Liu">Weimin Liu</name></region><name sortKey="Alreja, Meenakshi" sort="Alreja, Meenakshi" uniqKey="Alreja M" first="Meenakshi" last="Alreja">Meenakshi Alreja</name><name sortKey="Kumar, Ashok" sort="Kumar, Ashok" uniqKey="Kumar A" first="Ashok" last="Kumar">Ashok Kumar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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