Antihypertensive effects of Terminalia superba Engler & Diels (Combretaceae) : in vivo et in vitro study
Identifieur interne : 000013 ( Hal/Corpus ); précédent : 000012; suivant : 000014Antihypertensive effects of Terminalia superba Engler & Diels (Combretaceae) : in vivo et in vitro study
Auteurs : Esther Ngo Lemba TomSource :
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Abstract
Terminalia superba Engler & Diels (Combretaceae) is used in cameroonian traditional medicine for thé treatment of hypertension (HT). The aim of this thesis was to provide scientifical of it traditional use. We evaluated thé effects of an aqueous extract (AQUE) of T. superba in normal rats or in glucose or ethanol induced hypertensive rats. The AQUE had an hypotensive, antihypertensive and antioxydative effect. Four extracts of T. superba: aqueous (AQU), méthanol (MET), méthylène chloride (MC) and methanol/methylene chloride (MCM) extracts showed vasorelaxant effects on rat aortic rings endothelium stripped or not, contracted with phénylephrine or potassium chloride. The MC extract was thé most potent. It reduced thé calcium fluxes in vascular smooth muscle cells. The MC extract had an antihypertensive effect in spontaneously hypertensive rat, associated with a decreased in oxidative stress assessed by measuring thé rate of urine 8-iso-PGF2a and reduced endothelial dysfunction. This extract did not affect diuresis, or thé activity of hepatic cytochrome P450 3A. The AQU and MC extracts appeared slightly toxic, with LDso respectively greater than 5000 mg/kg and 2000 mg/kg. The MC extract at doses of 300 and 600 mg/kg induced areas of vascular congestion and inflammation réversible after discontinuation. In conclusion, our study validâtes thé pharmacological traditional use of T. superba as a treatment for hypertension. The prospects of this work will aim at identifying thé pure compounds that cause thé cardiovascular activity of this plant, and further toxicological studies to ensure their safety.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antihypertensive effects of Terminalia superba Engler & Diels (Combretaceae) : in vivo et in vitro study</title><title xml:lang="fr">Effets antihypertenseurs des extraits de Terminalia superba Engler & Diels (Combretaceae) : étude in vivo et in vitro</title><author><name sortKey="Ngo Lemba Tom, Esther" sort="Ngo Lemba Tom, Esther" uniqKey="Ngo Lemba Tom E" first="Esther" last="Ngo Lemba Tom">Esther Ngo Lemba Tom</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-219557" status="OLD"><idno type="IdRef">166218014</idno><idno type="RNSR">200815504X</idno><orgName>Fonctions et dysfonctions épithéliales - UFC (EA 4267)</orgName><orgName type="acronym">FDE</orgName><date type="end">2017-05-17</date><desc><address><addrLine>UFR des Sciences Médicales et Pharmaceutiques (UFR SMP) 19 rue Ambroise Paré les Hauts du Chazal 25041 Besançon cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-fcomte.fr/pages/fr/menu1/recherche/la-recherche-a-l-ufc/ea-4267-fonctions-et-dysfonctions-epitheliales-18229-16144.html</ref></desc><listRelation><relation name="EA4267" active="#struct-458810" type="direct"></relation></listRelation><tutelles><tutelle name="EA4267" active="#struct-458810" type="direct"><org type="institution" xml:id="struct-458810" status="VALID"><idno type="IdRef">026403188</idno><idno type="ISNI">0000 0001 2188 3779 </idno><orgName>Université de Franche-Comté</orgName><orgName type="acronym">UFC</orgName><desc><address><country key="FR"></country></address><ref type="url">http://www.univ-fcomte.fr</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:tel-01227197</idno><idno type="halId">tel-01227197</idno><idno type="halUri">https://tel.archives-ouvertes.fr/tel-01227197</idno><idno type="url">https://tel.archives-ouvertes.fr/tel-01227197</idno><date when="2011-03-07">2011-03-07</date><idno type="wicri:Area/Hal/Corpus">000013</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antihypertensive effects of Terminalia superba Engler & Diels (Combretaceae) : in vivo et in vitro study</title><title xml:lang="fr">Effets antihypertenseurs des extraits de Terminalia superba Engler & Diels (Combretaceae) : étude in vivo et in vitro</title><author><name sortKey="Ngo Lemba Tom, Esther" sort="Ngo Lemba Tom, Esther" uniqKey="Ngo Lemba Tom E" first="Esther" last="Ngo Lemba Tom">Esther Ngo Lemba Tom</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-219557" status="OLD"><idno type="IdRef">166218014</idno><idno type="RNSR">200815504X</idno><orgName>Fonctions et dysfonctions épithéliales - UFC (EA 4267)</orgName><orgName type="acronym">FDE</orgName><date type="end">2017-05-17</date><desc><address><addrLine>UFR des Sciences Médicales et Pharmaceutiques (UFR SMP) 19 rue Ambroise Paré les Hauts du Chazal 25041 Besançon cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-fcomte.fr/pages/fr/menu1/recherche/la-recherche-a-l-ufc/ea-4267-fonctions-et-dysfonctions-epitheliales-18229-16144.html</ref></desc><listRelation><relation name="EA4267" active="#struct-458810" type="direct"></relation></listRelation><tutelles><tutelle name="EA4267" active="#struct-458810" type="direct"><org type="institution" xml:id="struct-458810" status="VALID"><idno type="IdRef">026403188</idno><idno type="ISNI">0000 0001 2188 3779 </idno><orgName>Université de Franche-Comté</orgName><orgName type="acronym">UFC</orgName><desc><address><country key="FR"></country></address><ref type="url">http://www.univ-fcomte.fr</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Antihypertensive</term><term>Antioxidant</term><term>Extracts</term><term>Toxicity</term></keywords><keywords scheme="mix" xml:lang="fr"><term>Antihypertenseurs</term><term>Antioxydant</term><term>Endothéluim</term><term>Extraits</term><term>Terminalia superba</term><term>Toxicité</term><term>Vasorelaxant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Terminalia superba Engler & Diels (Combretaceae) is used in cameroonian traditional medicine for thé treatment of hypertension (HT). The aim of this thesis was to provide scientifical of it traditional use. We evaluated thé effects of an aqueous extract (AQUE) of T. superba in normal rats or in glucose or ethanol induced hypertensive rats. The AQUE had an hypotensive, antihypertensive and antioxydative effect. Four extracts of T. superba: aqueous (AQU), méthanol (MET), méthylène chloride (MC) and methanol/methylene chloride (MCM) extracts showed vasorelaxant effects on rat aortic rings endothelium stripped or not, contracted with phénylephrine or potassium chloride. The MC extract was thé most potent. It reduced thé calcium fluxes in vascular smooth muscle cells. The MC extract had an antihypertensive effect in spontaneously hypertensive rat, associated with a decreased in oxidative stress assessed by measuring thé rate of urine 8-iso-PGF2a and reduced endothelial dysfunction. This extract did not affect diuresis, or thé activity of hepatic cytochrome P450 3A. The AQU and MC extracts appeared slightly toxic, with LDso respectively greater than 5000 mg/kg and 2000 mg/kg. The MC extract at doses of 300 and 600 mg/kg induced areas of vascular congestion and inflammation réversible after discontinuation. In conclusion, our study validâtes thé pharmacological traditional use of T. superba as a treatment for hypertension. The prospects of this work will aim at identifying thé pure compounds that cause thé cardiovascular activity of this plant, and further toxicological studies to ensure their safety.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Antihypertensive effects of Terminalia superba Engler & Diels (Combretaceae) : in vivo et in vitro study</title><title xml:lang="fr">Effets antihypertenseurs des extraits de Terminalia superba Engler & Diels (Combretaceae) : étude in vivo et in vitro</title><author role="aut"><persName><forename type="first">Esther</forename><surname>Ngo Lemba Tom</surname></persName><idno type="halauthorid">1245387</idno><affiliation ref="#struct-219557"></affiliation><affiliation ref="#struct-219558"></affiliation></author><editor role="depositor"><persName><forename>ABES</forename><surname>STAR</surname></persName><email type="md5">f5aa7f563b02bb6adbba7496989af39a</email><email type="domain">abes.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2015-11-10 15:22:57</date><date type="whenModified">2018-02-15 08:48:15</date><date type="whenReleased">2015-11-16 10:13:20</date><date type="whenProduced">2011-03-07</date><date type="whenEndEmbargoed">2015-11-10</date><ref type="file" target="https://tel.archives-ouvertes.fr/tel-01227197/document"><date notBefore="2015-11-10"></date></ref><ref type="file" subtype="author" n="1" target="https://tel.archives-ouvertes.fr/tel-01227197/file/these_A_NGOLEMBATOM_Esther_2011.pdf"><date notBefore="2015-11-10"></date></ref></edition><respStmt><resp>contributor</resp><name key="131274"><persName><forename>ABES</forename><surname>STAR</surname></persName><email type="md5">f5aa7f563b02bb6adbba7496989af39a</email><email type="domain">abes.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">tel-01227197</idno><idno type="halUri">https://tel.archives-ouvertes.fr/tel-01227197</idno><idno type="halBibtex">ngolembatom:tel-01227197</idno><idno type="halRefHtml">Pharmacologie. Université de Franche-Comté, 2011. Français. 〈NNT : 2011BESA3003〉</idno><idno type="halRef">Pharmacologie. Université de Franche-Comté, 2011. Français. 〈NNT : 2011BESA3003〉</idno></publicationStmt><seriesStmt><idno type="stamp" n="STAR">STAR - Dépôt national des thèses électroniques</idno><idno type="stamp" n="UNIV-FCOMTE">Université de Franche-Comté</idno></seriesStmt><notesStmt></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antihypertensive effects of Terminalia superba Engler & Diels (Combretaceae) : in vivo et in vitro study</title><title xml:lang="fr">Effets antihypertenseurs des extraits de Terminalia superba Engler & Diels (Combretaceae) : étude in vivo et in vitro</title><author role="aut"><persName><forename type="first">Esther</forename><surname>Ngo Lemba Tom</surname></persName><idno type="halauthorid">1245387</idno><affiliation ref="#struct-219557"></affiliation><affiliation ref="#struct-219558"></affiliation></author></analytic><monogr><idno type="nnt">2011BESA3003</idno><imprint><date type="dateDefended">2011-03-07</date></imprint><authority type="institution">Université de Franche-Comté</authority><authority type="school">École doctorale Homme, environnement, santé (Besançon ; 2000-2012)</authority><authority type="supervisor">Céline Demougeot</authority><authority type="supervisor">Corinne Girard</authority><authority type="supervisor">Théophile Dimo</authority><authority type="jury">Pierre Kamtchouing [Président]</authority><authority type="jury">Alain Berthelot</authority><authority type="jury">Dieudonné Njamen</authority></monogr></biblStruct></sourceDesc><profileDesc><langUsage><language ident="fr">French</language></langUsage><textClass><keywords scheme="author"><term xml:lang="en">Antihypertensive</term><term xml:lang="en">Extracts</term><term xml:lang="en">Antioxidant</term><term xml:lang="en">Toxicity</term><term xml:lang="fr">Toxicité</term><term xml:lang="fr">Antioxydant</term><term xml:lang="fr">Endothéluim</term><term xml:lang="fr">Vasorelaxant</term><term xml:lang="fr">Antihypertenseurs</term><term xml:lang="fr">Extraits</term><term xml:lang="fr">Terminalia superba</term></keywords><classCode scheme="halDomain" n="sdv.sp.pharma">Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</classCode><classCode scheme="halTypology" n="THESE">Theses</classCode></textClass><abstract xml:lang="en">Terminalia superba Engler & Diels (Combretaceae) is used in cameroonian traditional medicine for thé treatment of hypertension (HT). The aim of this thesis was to provide scientifical of it traditional use. We evaluated thé effects of an aqueous extract (AQUE) of T. superba in normal rats or in glucose or ethanol induced hypertensive rats. The AQUE had an hypotensive, antihypertensive and antioxydative effect. Four extracts of T. superba: aqueous (AQU), méthanol (MET), méthylène chloride (MC) and methanol/methylene chloride (MCM) extracts showed vasorelaxant effects on rat aortic rings endothelium stripped or not, contracted with phénylephrine or potassium chloride. The MC extract was thé most potent. It reduced thé calcium fluxes in vascular smooth muscle cells. The MC extract had an antihypertensive effect in spontaneously hypertensive rat, associated with a decreased in oxidative stress assessed by measuring thé rate of urine 8-iso-PGF2a and reduced endothelial dysfunction. This extract did not affect diuresis, or thé activity of hepatic cytochrome P450 3A. The AQU and MC extracts appeared slightly toxic, with LDso respectively greater than 5000 mg/kg and 2000 mg/kg. The MC extract at doses of 300 and 600 mg/kg induced areas of vascular congestion and inflammation réversible after discontinuation. In conclusion, our study validâtes thé pharmacological traditional use of T. superba as a treatment for hypertension. The prospects of this work will aim at identifying thé pure compounds that cause thé cardiovascular activity of this plant, and further toxicological studies to ensure their safety.</abstract><abstract xml:lang="fr">Terminalia superba Engler & Diels (Combretaceae) est utilisée en médecine traditionnelle au Cameroun pour les soins d'hypertension artérielle (HTA). L'objectif du travail de cette thèse a été d'apporter des bases scientifiques à son utilisation traditionnelle. Nous avons évalué les effets d'un extrait aqueux de T. superba chez des rats normaux ou soumis à deux modèles d'HTA secondaire : l'HTA induite par le glucose et l'HTA induite par l'éthanol. L'extrait aqueux exerce un effet hypotenseur, antihypertenseur et antioxydant. Quatre extraits de T. superba : l'extrait aqueux (AQU), au méthanol (MET), au chlorure de méthylène (MC) et au méthanol/chlorure de méthylène (MCM) ont des effets vasodilatateurs les anneaux aortiques isolés de rat, dénués ou non d'endothélium vasculaire et contractés à la phénylephrine ou au chlorure de potassium. L'extrait MC est le plus actif et réduit les flux calciques. L'extrait MC a exercé un effet anti-hypertenseur chez le rat spontanément hypertendu, une diminution du stress oxydatif, une amélioration de la fonction endothéliale. Il n'a affecté ni la diurèse, ni l'activité des cytochromes P450 3A hépatiques. Les extraits AQU et au MC se sont révélés faiblement toxiques, avec des DLso respectivement supérieures à 5000 mg/kg et 2000 mg/kg. L'extrait MC aux doses de 300 et de 600 mg/kg a révélé des zones de congestion vasculaires et d'inflammations réversibles après arrêt du traitement. Ce travail a validé sur le plan pharmacologique l'utilisation de T. superba comme traitement alternatif à l'HTA. Il sera question d'identifier les composés purs à l'origine de l'activité cardio-vasculaire de la plante, et à poursuivre les études toxicologiques.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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