The role of insulin-like growth factors and IGF-binding proteins in the physiological and pathological processes of the kidney
Identifieur interne : 001568 ( Main/Corpus ); précédent : 001567; suivant : 001569The role of insulin-like growth factors and IGF-binding proteins in the physiological and pathological processes of the kidney
Auteurs : Walter Zumkeller ; N. SchofieldSource :
- Virchows Archiv B [ 0340-6075 ] ; 1992-12-01.
Abstract
Summary: Insulin-like growth factors (IGFs) and their binding proteins are implicated in the growth regulation of the kidney during embryogenesis and differentiation. Recent evidence also suggests that IGFs play a role in kidney physiology (glomerular filtration rate, renal plasma flow) and pathology (diabetic renal hypertrophy, nephritis, glomerulosclerosis, kidney tumours, chronic renal failure). This review focuses on the biology of IGFs at the molecular, protein and receptor levels and considers their importance in renal physiology and pathology. The current data demonstrate a central role for the IGFs in the mediation of a wide variety of effects on renal growth, function and malignancy.
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DOI: 10.1007/BF02899684
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Schofield</name><affiliation><mods:affiliation>Department of Anatomy, University of Cambridge, Cambridge, UK</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B4B18F2AB33DBF2E46BB9348E9C447295CD50E02</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1007/BF02899684</idno><idno type="url">https://api.istex.fr/document/B4B18F2AB33DBF2E46BB9348E9C447295CD50E02/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001568</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The role of insulin-like growth factors and IGF-binding proteins in the physiological and pathological processes of the kidney</title><author><name sortKey="Zumkeller, Walter" sort="Zumkeller, Walter" uniqKey="Zumkeller W" first="Walter" last="Zumkeller">Walter Zumkeller</name><affiliation><mods:affiliation>Institute of Child Health, University of London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Anatomy, University of Cambridge, Cambridge, UK</mods:affiliation></affiliation></author><author><name sortKey="Schofield, N" sort="Schofield, N" uniqKey="Schofield N" first="N." last="Schofield">N. Schofield</name><affiliation><mods:affiliation>Department of Anatomy, University of Cambridge, Cambridge, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Virchows Archiv B</title><title level="j" type="sub">Cell Pathology</title><title level="j" type="abbrev">Virchows Archiv B Cell Pathol</title><idno type="ISSN">0340-6075</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1992-12-01">1992-12-01</date><biblScope unit="volume">62</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="207">207</biblScope><biblScope unit="page" to="220">220</biblScope></imprint><idno type="ISSN">0340-6075</idno></series><idno type="istex">B4B18F2AB33DBF2E46BB9348E9C447295CD50E02</idno><idno type="DOI">10.1007/BF02899684</idno><idno type="ArticleID">Art27</idno><idno type="ArticleID">BF02899684</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-6075</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Insulin-like growth factors (IGFs) and their binding proteins are implicated in the growth regulation of the kidney during embryogenesis and differentiation. Recent evidence also suggests that IGFs play a role in kidney physiology (glomerular filtration rate, renal plasma flow) and pathology (diabetic renal hypertrophy, nephritis, glomerulosclerosis, kidney tumours, chronic renal failure). This review focuses on the biology of IGFs at the molecular, protein and receptor levels and considers their importance in renal physiology and pathology. The current data demonstrate a central role for the IGFs in the mediation of a wide variety of effects on renal growth, function and malignancy.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>Walter Zumkeller</name><affiliations><json:string>Institute of Child Health, University of London, London, UK</json:string><json:string>Department of Anatomy, University of Cambridge, Cambridge, UK</json:string></affiliations></json:item><json:item><name>Paul N. Schofield</name><affiliations><json:string>Department of Anatomy, University of Cambridge, Cambridge, UK</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Insulin-like growth factors</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>IGF-binding proteins</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>IGF-receptors</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Renal physiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Renal pathology</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Summary: Insulin-like growth factors (IGFs) and their binding proteins are implicated in the growth regulation of the kidney during embryogenesis and differentiation. Recent evidence also suggests that IGFs play a role in kidney physiology (glomerular filtration rate, renal plasma flow) and pathology (diabetic renal hypertrophy, nephritis, glomerulosclerosis, kidney tumours, chronic renal failure). This review focuses on the biology of IGFs at the molecular, protein and receptor levels and considers their importance in renal physiology and pathology. 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Cambridge</OrgName><OrgAddress><City>Cambridge</City><Country>UK</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgName>Universitäts-Krankenhaus Eppendorf, Kinderklinik</OrgName><OrgAddress><Street>Martinistraße 52</Street><Postcode>W-2000</Postcode><City>Hamburg 20</City><Country>Federal Republic of Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>Insulin-like growth factors (IGFs) and their binding proteins are implicated in the growth regulation of the kidney during embryogenesis and differentiation. Recent evidence also suggests that IGFs play a role in kidney physiology (glomerular filtration rate, renal plasma flow) and pathology (diabetic renal hypertrophy, nephritis, glomerulosclerosis, kidney tumours, chronic renal failure).</Para><Para>This review focuses on the biology of IGFs at the molecular, protein and receptor levels and considers their importance in renal physiology and pathology. The current data demonstrate a central role for the IGFs in the mediation of a wide variety of effects on renal growth, function and malignancy.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Insulin-like growth factors</Keyword><Keyword>IGF-binding proteins</Keyword><Keyword>IGF-receptors</Keyword><Keyword>Renal physiology</Keyword><Keyword>Renal pathology</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The role of insulin-like growth factors and IGF-binding proteins in the physiological and pathological processes of the kidney</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The role of insulin-like growth factors and IGF-binding proteins in the physiological and pathological processes of the kidney</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Walter</namePart><namePart type="family">Zumkeller</namePart><affiliation>Institute of Child Health, University of London, London, UK</affiliation><affiliation>Department of Anatomy, University of Cambridge, Cambridge, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul</namePart><namePart type="given">N.</namePart><namePart type="family">Schofield</namePart><affiliation>Department of Anatomy, University of Cambridge, Cambridge, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="ReviewPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1991-10-24</dateCreated><dateIssued encoding="w3cdtf">1992-12-01</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: Insulin-like growth factors (IGFs) and their binding proteins are implicated in the growth regulation of the kidney during embryogenesis and differentiation. Recent evidence also suggests that IGFs play a role in kidney physiology (glomerular filtration rate, renal plasma flow) and pathology (diabetic renal hypertrophy, nephritis, glomerulosclerosis, kidney tumours, chronic renal failure). This review focuses on the biology of IGFs at the molecular, protein and receptor levels and considers their importance in renal physiology and pathology. 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