Liver Regeneration
Identifieur interne : 001429 ( Main/Corpus ); précédent : 001428; suivant : 001430Liver Regeneration
Auteurs : K. Michalopoulos ; Marie DefrancesSource :
- Advances in Biochemical Engineering [ 0724-6145 ] ; 2005.
Abstract
Abstract: This review summarizes the functional aspects, cellular kinetics and molecular mechanisms related to liver regeneration. Liver regeneration is a model of regenerative growth of tissues in adult animals. Rapid biochemical and gene expression changes following initiation of regeneration are mediated by specific stimuli, including growth factors and cytokines. The whole process involves multiple feedback loops between same or different types of cells. The end result is restoration of hepatic mass and preservation of the normal histology of the liver. All of this complex phenomenology occurs while the liver continues to provide all the metabolic support required to sustain life of the organism.
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DOI: 10.1007/b99968
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Michalopoulos</name><affiliation><mods:affiliation>Department of Pathology, University of Pittsburgh School of Medicine, 15241, Pittsburgh, PA, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: michalopoulosgk@upmc.edu</mods:affiliation></affiliation></author><author><name sortKey="Defrances, Marie" sort="Defrances, Marie" uniqKey="Defrances M" first="Marie" last="Defrances">Marie Defrances</name><affiliation><mods:affiliation>Department of Pathology, University of Pittsburgh School of Medicine, 15241, Pittsburgh, PA, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: defrancesmc@upmc.edu</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0117548E975FB40867A9F0066F5D6620AF6B8291</idno><date when="????">????</date><idno type="doi">10.1007/b99968</idno><idno type="url">https://api.istex.fr/document/0117548E975FB40867A9F0066F5D6620AF6B8291/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001429</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Liver Regeneration</title><author><name sortKey="Michalopoulos, K" sort="Michalopoulos, K" uniqKey="Michalopoulos K" first="K." last="Michalopoulos">K. Michalopoulos</name><affiliation><mods:affiliation>Department of Pathology, University of Pittsburgh School of Medicine, 15241, Pittsburgh, PA, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: michalopoulosgk@upmc.edu</mods:affiliation></affiliation></author><author><name sortKey="Defrances, Marie" sort="Defrances, Marie" uniqKey="Defrances M" first="Marie" last="Defrances">Marie Defrances</name><affiliation><mods:affiliation>Department of Pathology, University of Pittsburgh School of Medicine, 15241, Pittsburgh, PA, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: defrancesmc@upmc.edu</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="s">Advances in Biochemical Engineering</title><imprint><date>2005</date></imprint><idno type="ISSN">0724-6145</idno><idno type="eISSN">1616-8542</idno><idno type="ISSN">0724-6145</idno></series><idno type="istex">0117548E975FB40867A9F0066F5D6620AF6B8291</idno><idno type="DOI">10.1007/b99968</idno><idno type="ChapterID">Chap5</idno><idno type="ChapterID">5</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0724-6145</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: This review summarizes the functional aspects, cellular kinetics and molecular mechanisms related to liver regeneration. Liver regeneration is a model of regenerative growth of tissues in adult animals. Rapid biochemical and gene expression changes following initiation of regeneration are mediated by specific stimuli, including growth factors and cytokines. The whole process involves multiple feedback loops between same or different types of cells. The end result is restoration of hepatic mass and preservation of the normal histology of the liver. All of this complex phenomenology occurs while the liver continues to provide all the metabolic support required to sustain life of the organism.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>George K. 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Liver regeneration is a model of regenerative growth of tissues in adult animals. Rapid biochemical and gene expression changes following initiation of regeneration are mediated by specific stimuli, including growth factors and cytokines. The whole process involves multiple feedback loops between same or different types of cells. The end result is restoration of hepatic mass and preservation of the normal histology of the liver. 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Liver regeneration is a model of regenerative growth of tissues in adult animals. Rapid biochemical and gene expression changes following initiation of regeneration are mediated by specific stimuli, including growth factors and cytokines. The whole process involves multiple feedback loops between same or different types of cells. The end result is restoration of hepatic mass and preservation of the normal histology of the liver. 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when="1997"></date></imprint></monogr></biblStruct><biblStruct xml:id="b261"><analytic><title></title><author><persName><forename type="first">H</forename><surname>Hikita</surname></persName></author><author><persName><forename type="first">J</forename><surname>Vaughan</surname></persName></author><author><persName><forename type="first">K</forename><surname>Babcock</surname></persName></author><author><persName><forename type="first">Hc</forename><surname>Pitot</surname></persName></author></analytic><monogr><title level="j">Toxicol Sci</title><imprint><biblScope unit="volume">52</biblScope><biblScope unit="page">17</biblScope><date type="published" when="1999-04"></date></imprint></monogr></biblStruct></listBibl></back></text></istex:refBibTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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