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Adrenergic mechanisms in the control of gastrointestinal motility: From basic science to clinical applications

Identifieur interne : 001330 ( Main/Corpus ); précédent : 001329; suivant : 001331

Adrenergic mechanisms in the control of gastrointestinal motility: From basic science to clinical applications

Auteurs : Fabrizio De Ponti ; Cristina Giaroni ; Marco Cosentino ; Sergio Lecchini ; Gianmario Frigo

Source :

RBID : ISTEX:C1ADC6378FA9D0565685B7C0CE41845DED6BF75E

Abstract

Over the years, a vast literature has accumulated on the adrenergic mechanisms controlling gut motility, blood flow, and mucosal transport. The present review is intended as a survey of key information on the relevance of adrenergic mechanisms modulating gut motility and will provide an outline of our knowledge on the distribution and functional role of adrenoceptor subtypes mediating motor responses. α1-Adrenoceptors are located postsynaptically on smooth muscle cells and, to a lesser extent, on intrinsic neurons; α2-adrenoceptors may be present both pre- and postsynaptically, with presynaptic auto- and hetero-receptors playing an important role in the modulation of neurotransmitter release; gb-adrenoceptors are found mainly on smooth muscle cells. From a clinical standpoint, adrenoceptor agonists/antagonists have been investigated as potential motility inhibiting (antidiarrheal/anti-spasmodic) or prokinetic agents, although at present their field of application is limited to select patient groups.

Url:
DOI: 10.1016/0163-7258(95)02031-4

Links to Exploration step

ISTEX:C1ADC6378FA9D0565685B7C0CE41845DED6BF75E

Le document en format XML

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<abstract lang="en">Over the years, a vast literature has accumulated on the adrenergic mechanisms controlling gut motility, blood flow, and mucosal transport. The present review is intended as a survey of key information on the relevance of adrenergic mechanisms modulating gut motility and will provide an outline of our knowledge on the distribution and functional role of adrenoceptor subtypes mediating motor responses. α1-Adrenoceptors are located postsynaptically on smooth muscle cells and, to a lesser extent, on intrinsic neurons; α2-adrenoceptors may be present both pre- and postsynaptically, with presynaptic auto- and hetero-receptors playing an important role in the modulation of neurotransmitter release; gb-adrenoceptors are found mainly on smooth muscle cells. From a clinical standpoint, adrenoceptor agonists/antagonists have been investigated as potential motility inhibiting (antidiarrheal/anti-spasmodic) or prokinetic agents, although at present their field of application is limited to select patient groups.</abstract>
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<genre>Keywords</genre>
<topic>Adrenoceptors</topic>
<topic>sympathetic nervous system</topic>
<topic>gastrointestinal motility</topic>
<topic>antidiarrheal agents</topic>
<topic>antispasmodic agents</topic>
<topic>prokinetic agents</topic>
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<title>Pharmacology and Therapeutics</title>
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<dateIssued encoding="w3cdtf">1996</dateIssued>
</originInfo>
<identifier type="ISSN">0163-7258</identifier>
<identifier type="PII">S0163-7258(00)X0004-6</identifier>
<part>
<date>1996</date>
<detail type="volume">
<number>69</number>
<caption>vol.</caption>
</detail>
<detail type="issue">
<number>1</number>
<caption>no.</caption>
</detail>
<extent unit="issue pages">
<start>1</start>
<end>83</end>
</extent>
<extent unit="pages">
<start>59</start>
<end>78</end>
</extent>
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<identifier type="istex">C1ADC6378FA9D0565685B7C0CE41845DED6BF75E</identifier>
<identifier type="DOI">10.1016/0163-7258(95)02031-4</identifier>
<identifier type="PII">0163-7258(95)02031-4</identifier>
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