Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases
Identifieur interne : 001045 ( Main/Corpus ); précédent : 001044; suivant : 001046Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases
Auteurs : T. Hanada ; I. Kinjyo ; K. Inagaki-Ohara ; A. YoshimuraSource :
- Reviews of Physiology, Biochemistry and Pharmacology [ 0303-4240 ] ; 2004.
Abstract
Abstract: Hematopoiesis, the process of Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.
Url:
DOI: 10.1007/s10254-003-0015-z
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Kinjyo</name><affiliation><mods:affiliation>Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, 812-8582, Higashi-ku, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Inagaki Ohara, K" sort="Inagaki Ohara, K" uniqKey="Inagaki Ohara K" first="K." last="Inagaki-Ohara">K. Inagaki-Ohara</name><affiliation><mods:affiliation>Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, 812-8582, Higashi-ku, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Yoshimura, A" sort="Yoshimura, A" uniqKey="Yoshimura A" first="A." last="Yoshimura">A. 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These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>T. 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TocLevels="0"><ChapterID>4</ChapterID><ChapterDOI>10.1007/s10254-003-0015-z</ChapterDOI><ChapterSequenceNumber>4</ChapterSequenceNumber><ChapterTitle Language="En">Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases</ChapterTitle><ChapterFirstPage>72</ChapterFirstPage><ChapterLastPage>86</ChapterLastPage><ChapterCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>2003</CopyrightYear></ChapterCopyright><ChapterHistory><RegistrationDate><Year>2003</Year><Month>10</Month><Day>30</Day></RegistrationDate><OnlineDate><Year>2003</Year><Month>10</Month><Day>29</Day></OnlineDate></ChapterHistory><ChapterGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ChapterGrants><ChapterContext><SeriesID>112</SeriesID><BookID>978-3-540-45205-8</BookID><BookTitle>Reviews of Physiology, Biochemistry and Pharmacology</BookTitle></ChapterContext></ChapterInfo><ChapterHeader><AuthorGroup><Author AffiliationIDS="Aff11"><AuthorName DisplayOrder="Western"><GivenName>T.</GivenName><FamilyName>Hanada</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff11"><AuthorName DisplayOrder="Western"><GivenName>I.</GivenName><FamilyName>Kinjyo</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff11"><AuthorName DisplayOrder="Western"><GivenName>K.</GivenName><FamilyName>Inagaki-Ohara</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff11" CorrespondingAffiliationID="Aff11"><AuthorName DisplayOrder="Western"><GivenName>A.</GivenName><FamilyName>Yoshimura</FamilyName></AuthorName><Contact><Phone>+81-92-6426823</Phone><Fax>+81-92-6426825</Fax><Email>yakihiko@bioreg.kyushu-u.ac.jp</Email></Contact></Author><Affiliation ID="Aff11"><OrgDivision>Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation</OrgDivision><OrgName>Kyushu University</OrgName><OrgAddress><Street>Maidashi</Street><Postcode>812-8582</Postcode><City>Higashi-ku, Fukuoka</City><Country>Japan</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Hematopoiesis, the process of Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through <Emphasis Type="Italic">Janus</Emphasis> tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.</Para></Abstract></ChapterHeader><NoBody></NoBody></Chapter></Book></Series></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Hanada</namePart><affiliation>Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, 812-8582, Higashi-ku, Fukuoka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Kinjyo</namePart><affiliation>Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, 812-8582, Higashi-ku, Fukuoka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Inagaki-Ohara</namePart><affiliation>Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, 812-8582, Higashi-ku, Fukuoka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">A.</namePart><namePart type="family">Yoshimura</namePart><affiliation>Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, 812-8582, Higashi-ku, Fukuoka, Japan</affiliation><affiliation>E-mail: yakihiko@bioreg.kyushu-u.ac.jp</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer Berlin Heidelberg</publisher><place><placeTerm type="text">Berlin, Heidelberg</placeTerm></place><dateIssued encoding="w3cdtf">2003</dateIssued><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Hematopoiesis, the process of Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.</abstract><relatedItem type="host"><titleInfo><title>Reviews of Physiology, Biochemistry and Pharmacology</title></titleInfo><genre type="Book Series" displayLabel="Monograph"></genre><originInfo><copyrightDate encoding="w3cdtf">2004</copyrightDate><issuance>monographic</issuance></originInfo><subject><genre>Book Subject Collection</genre><topic authority="SpringerSubjectCodes" authorityURI="SUCO11642">Biomedical and Life Sciences</topic></subject><subject><genre>Book Subject Group</genre><topic authority="SpringerSubjectCodes" authorityURI="B">Biomedicine</topic><topic authority="SpringerSubjectCodes" authorityURI="B0000X">Biomedicine general</topic></subject><identifier type="DOI">10.1007/978-3-540-45205-8</identifier><identifier type="ISBN">978-3-540-20213-4</identifier><identifier type="eISBN">978-3-540-45205-8</identifier><identifier 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type="personal"><namePart type="given">A.</namePart><namePart type="family">Miyahima</namePart><affiliation>Tokyo</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Murer</namePart><affiliation>Zürich</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Offermanns</namePart><affiliation>Heidelberg</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Pfanner</namePart><affiliation>Freiburg</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Schultz</namePart><affiliation>Berlin</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Schweiger</namePart><affiliation>Berlin</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><originInfo><copyrightDate encoding="w3cdtf">2004</copyrightDate><issuance>serial</issuance></originInfo><identifier type="ISSN">0303-4240</identifier><identifier type="SeriesID">112</identifier><recordInfo><recordOrigin>Springer-Verlag Berlin Heidelberg, 2004</recordOrigin></recordInfo></relatedItem><identifier type="istex">26FFE5C15AFD32A9CB31EB78B9444C56F6B8E541</identifier><identifier type="DOI">10.1007/s10254-003-0015-z</identifier><identifier type="ChapterID">Chap4</identifier><identifier type="ChapterID">4</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag Berlin Heidelberg</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 2003</recordOrigin></recordInfo></mods></metadata><enrichments><istex:refBibTEI 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