Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)
Identifieur interne : 000D97 ( Main/Corpus ); précédent : 000D96; suivant : 000D98Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)
Auteurs : P. Schuff Erner ; E. Schütz ; W. C. Seyde ; Th. Eisenhauer ; G. Janning ; V. W. Armstrong ; D. SeidelSource :
- European Journal of Clinical Investigation [ 0014-2972 ] ; 1989-01.
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Abstract
Abstract. Heparin‐induced Extracorporeal LDL‐Pre‐cipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen. In 10 adult patients with severe type II hyperlipoproteinemia, a single HELP treatment of 3 1 plasma led to an acute decrease in the average plasma viscosity (PV) from 1.30 to 1.1 mPas. At the same time, an even more marked decrease in the mean erythrocyte aggregation rate from a pathological value of 7.9% to a value of 3.7% (normal range <5%) was observed. Long‐term studies on five patients demonstrated a lasting improvement in these two haemorheological variables. The acute rheological changes were also accompanied by an improvement in polarographically determined muscle oxygen tension. Mean oxygen tension values measured in both the m.biceps brachii and the m.tibia‐lis anterior in five patients before and after a single HELP treatment increased from 30.4 to 37.7 mmHg and from 27.2 to 31.3 mmHg respectively. These results may provide an explanation for the rapid improvement in patients' clinical symptoms such as angina pectoris and in stress electrocardiogram which have been observed during HELP therapy.
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DOI: 10.1111/j.1365-2362.1989.tb00192.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)</title><author><name sortKey="Schuff Erner, P" sort="Schuff Erner, P" uniqKey="Schuff Erner P" first="P." last="Schuff Erner">P. Schuff Erner</name><affiliation><mods:affiliation>†Department of Clinical Chemistry</mods:affiliation></affiliation></author><author><name sortKey="Schutz, E" sort="Schutz, E" uniqKey="Schutz E" first="E." last="Schütz">E. Schütz</name><affiliation><mods:affiliation>†Department of Clinical Chemistry</mods:affiliation></affiliation></author><author><name sortKey="Seyde, W C" sort="Seyde, W C" uniqKey="Seyde W" first="W. C." last="Seyde">W. C. Seyde</name><affiliation><mods:affiliation>‡Department of Anesthesiology, University Clinics, Robert‐Koch‐Strasse 40, D‐3400 Goettingen, FRG</mods:affiliation></affiliation></author><author><name sortKey="Eisenhauer, Th" sort="Eisenhauer, Th" uniqKey="Eisenhauer T" first="Th." last="Eisenhauer">Th. Eisenhauer</name><affiliation><mods:affiliation>§Department of Nephrology and Rheumatology</mods:affiliation></affiliation></author><author><name sortKey="Janning, G" sort="Janning, G" uniqKey="Janning G" first="G." last="Janning">G. Janning</name><affiliation><mods:affiliation>§Department of Nephrology and Rheumatology</mods:affiliation></affiliation></author><author><name sortKey="Armstrong, V W" sort="Armstrong, V W" uniqKey="Armstrong V" first="V. W." last="Armstrong">V. W. Armstrong</name><affiliation><mods:affiliation>†Department of Clinical Chemistry</mods:affiliation></affiliation></author><author><name sortKey="Seidel, D" sort="Seidel, D" uniqKey="Seidel D" first="D." last="Seidel">D. Seidel</name><affiliation><mods:affiliation>†Department of Clinical Chemistry</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2843A2A567A124211A9B43C60586158C110E197C</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1111/j.1365-2362.1989.tb00192.x</idno><idno type="url">https://api.istex.fr/document/2843A2A567A124211A9B43C60586158C110E197C/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000D97</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)</title><author><name sortKey="Schuff Erner, P" sort="Schuff Erner, P" uniqKey="Schuff Erner P" first="P." last="Schuff Erner">P. Schuff Erner</name><affiliation><mods:affiliation>†Department of Clinical Chemistry</mods:affiliation></affiliation></author><author><name sortKey="Schutz, E" sort="Schutz, E" uniqKey="Schutz E" first="E." last="Schütz">E. Schütz</name><affiliation><mods:affiliation>†Department of Clinical Chemistry</mods:affiliation></affiliation></author><author><name sortKey="Seyde, W C" sort="Seyde, W C" uniqKey="Seyde W" first="W. C." last="Seyde">W. C. Seyde</name><affiliation><mods:affiliation>‡Department of Anesthesiology, University Clinics, Robert‐Koch‐Strasse 40, D‐3400 Goettingen, FRG</mods:affiliation></affiliation></author><author><name sortKey="Eisenhauer, Th" sort="Eisenhauer, Th" uniqKey="Eisenhauer T" first="Th." last="Eisenhauer">Th. Eisenhauer</name><affiliation><mods:affiliation>§Department of Nephrology and Rheumatology</mods:affiliation></affiliation></author><author><name sortKey="Janning, G" sort="Janning, G" uniqKey="Janning G" first="G." last="Janning">G. Janning</name><affiliation><mods:affiliation>§Department of Nephrology and Rheumatology</mods:affiliation></affiliation></author><author><name sortKey="Armstrong, V W" sort="Armstrong, V W" uniqKey="Armstrong V" first="V. W." last="Armstrong">V. W. Armstrong</name><affiliation><mods:affiliation>†Department of Clinical Chemistry</mods:affiliation></affiliation></author><author><name sortKey="Seidel, D" sort="Seidel, D" uniqKey="Seidel D" first="D." last="Seidel">D. Seidel</name><affiliation><mods:affiliation>†Department of Clinical Chemistry</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Clinical Investigation</title><idno type="ISSN">0014-2972</idno><idno type="eISSN">1365-2362</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1989-01">1989-01</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="30">30</biblScope><biblScope unit="page" to="37">37</biblScope></imprint><idno type="ISSN">0014-2972</idno></series><idno type="istex">2843A2A567A124211A9B43C60586158C110E197C</idno><idno type="DOI">10.1111/j.1365-2362.1989.tb00192.x</idno><idno type="ArticleID">ECI30</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2972</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atherosclerosis</term><term>LDL‐cholesterol</term><term>blood fluidity</term><term>erythrocyte aggregation</term><term>haemorheology</term><term>heparin‐induced‐LDL‐apheresis</term><term>plasma viscosity</term><term>tissue oxygen tension</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract. Heparin‐induced Extracorporeal LDL‐Pre‐cipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen. In 10 adult patients with severe type II hyperlipoproteinemia, a single HELP treatment of 3 1 plasma led to an acute decrease in the average plasma viscosity (PV) from 1.30 to 1.1 mPas. At the same time, an even more marked decrease in the mean erythrocyte aggregation rate from a pathological value of 7.9% to a value of 3.7% (normal range <5%) was observed. Long‐term studies on five patients demonstrated a lasting improvement in these two haemorheological variables. The acute rheological changes were also accompanied by an improvement in polarographically determined muscle oxygen tension. Mean oxygen tension values measured in both the m.biceps brachii and the m.tibia‐lis anterior in five patients before and after a single HELP treatment increased from 30.4 to 37.7 mmHg and from 27.2 to 31.3 mmHg respectively. These results may provide an explanation for the rapid improvement in patients' clinical symptoms such as angina pectoris and in stress electrocardiogram which have been observed during HELP therapy.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>P. SCHUFF‐WERNER</name><affiliations><json:string>†Department of Clinical Chemistry</json:string></affiliations></json:item><json:item><name>E. SCHÜTZ</name><affiliations><json:string>†Department of Clinical Chemistry</json:string></affiliations></json:item><json:item><name>W. C. SEYDE</name><affiliations><json:string>‡Department of Anesthesiology, University Clinics, Robert‐Koch‐Strasse 40, D‐3400 Goettingen, FRG</json:string></affiliations></json:item><json:item><name>TH. EISENHAUER</name><affiliations><json:string>§Department of Nephrology and Rheumatology</json:string></affiliations></json:item><json:item><name>G. JANNING</name><affiliations><json:string>§Department of Nephrology and Rheumatology</json:string></affiliations></json:item><json:item><name>V. W. ARMSTRONG</name><affiliations><json:string>†Department of Clinical Chemistry</json:string></affiliations></json:item><json:item><name>D. SEIDEL</name><affiliations><json:string>†Department of Clinical Chemistry</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Atherosclerosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>haemorheology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LDL‐cholesterol</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>heparin‐induced‐LDL‐apheresis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>plasma viscosity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>erythrocyte aggregation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>blood fluidity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tissue oxygen tension</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Abstract. Heparin‐induced Extracorporeal LDL‐Pre‐cipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen. In 10 adult patients with severe type II hyperlipoproteinemia, a single HELP treatment of 3 1 plasma led to an acute decrease in the average plasma viscosity (PV) from 1.30 to 1.1 mPas. At the same time, an even more marked decrease in the mean erythrocyte aggregation rate from a pathological value of 7.9% to a value of 3.7% (normal range >5%) was observed. Long‐term studies on five patients demonstrated a lasting improvement in these two haemorheological variables. The acute rheological changes were also accompanied by an improvement in polarographically determined muscle oxygen tension. Mean oxygen tension values measured in both the m.biceps brachii and the m.tibia‐lis anterior in five patients before and after a single HELP treatment increased from 30.4 to 37.7 mmHg and from 27.2 to 31.3 mmHg respectively. These results may provide an explanation for the rapid improvement in patients' clinical symptoms such as angina pectoris and in stress electrocardiogram which have been observed during HELP therapy.</abstract><qualityIndicators><score>6.535</score><pdfVersion>1.4</pdfVersion><pdfPageSize>630 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>8</keywordCount><abstractCharCount>1169</abstractCharCount><pdfWordCount>3899</pdfWordCount><pdfCharCount>26843</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>178</abstractWordCount></qualityIndicators><title>Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)</title><genre><json:string>article</json:string></genre><host><volume>19</volume><pages><total>8</total><last>37</last><first>30</first></pages><issn><json:string>0014-2972</json:string></issn><issue>1</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1365-2362</json:string></eissn><title>European Journal of Clinical Investigation</title><doi><json:string>10.1111/(ISSN)1365-2362</json:string></doi></host><publicationDate>1989</publicationDate><copyrightDate>1989</copyrightDate><doi><json:string>10.1111/j.1365-2362.1989.tb00192.x</json:string></doi><id>2843A2A567A124211A9B43C60586158C110E197C</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/2843A2A567A124211A9B43C60586158C110E197C/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/2843A2A567A124211A9B43C60586158C110E197C/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/2843A2A567A124211A9B43C60586158C110E197C/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>1989</date></publicationStmt><notesStmt><note type="content">**This paper includes part of the dissertation of E. Schültz.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)</title><author><persName><forename type="first">P.</forename><surname>SCHUFF‐WERNER</surname></persName><note type="correspondence"><p>Correspondence: **Department of Clinical Chemistry, University Clinics, Robert‐Koch‐Strasse 40, D‐3400 Goettingen, FRG.</p></note><affiliation>†Department of Clinical Chemistry</affiliation></author><author><persName><forename type="first">E.</forename><surname>SCHÜTZ</surname></persName><note type="biography">*This paper includes part of the dissertation of E. Schültz.</note><affiliation>*This paper includes part of the dissertation of E. Schültz.</affiliation><affiliation>†Department of Clinical Chemistry</affiliation></author><author><persName><forename type="first">W. C.</forename><surname>SEYDE</surname></persName><affiliation>‡Department of Anesthesiology, University Clinics, Robert‐Koch‐Strasse 40, D‐3400 Goettingen, FRG</affiliation></author><author><persName><forename type="first">TH.</forename><surname>EISENHAUER</surname></persName><affiliation>§Department of Nephrology and Rheumatology</affiliation></author><author><persName><forename type="first">G.</forename><surname>JANNING</surname></persName><affiliation>§Department of Nephrology and Rheumatology</affiliation></author><author><persName><forename type="first">V. W.</forename><surname>ARMSTRONG</surname></persName><affiliation>†Department of Clinical Chemistry</affiliation></author><author><persName><forename type="first">D.</forename><surname>SEIDEL</surname></persName><affiliation>†Department of Clinical Chemistry</affiliation></author></analytic><monogr><title level="j">European Journal of Clinical Investigation</title><idno type="pISSN">0014-2972</idno><idno type="eISSN">1365-2362</idno><idno type="DOI">10.1111/(ISSN)1365-2362</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1989-01"></date><biblScope unit="volume">19</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="30">30</biblScope><biblScope unit="page" to="37">37</biblScope></imprint></monogr><idno type="istex">2843A2A567A124211A9B43C60586158C110E197C</idno><idno type="DOI">10.1111/j.1365-2362.1989.tb00192.x</idno><idno type="ArticleID">ECI30</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1989</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract. Heparin‐induced Extracorporeal LDL‐Pre‐cipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen. In 10 adult patients with severe type II hyperlipoproteinemia, a single HELP treatment of 3 1 plasma led to an acute decrease in the average plasma viscosity (PV) from 1.30 to 1.1 mPas. At the same time, an even more marked decrease in the mean erythrocyte aggregation rate from a pathological value of 7.9% to a value of 3.7% (normal range <5%) was observed. Long‐term studies on five patients demonstrated a lasting improvement in these two haemorheological variables. The acute rheological changes were also accompanied by an improvement in polarographically determined muscle oxygen tension. Mean oxygen tension values measured in both the m.biceps brachii and the m.tibia‐lis anterior in five patients before and after a single HELP treatment increased from 30.4 to 37.7 mmHg and from 27.2 to 31.3 mmHg respectively. These results may provide an explanation for the rapid improvement in patients' clinical symptoms such as angina pectoris and in stress electrocardiogram which have been observed during HELP therapy.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Atherosclerosis</term></item><item><term>haemorheology</term></item><item><term>LDL‐cholesterol</term></item><item><term>heparin‐induced‐LDL‐apheresis</term></item><item><term>plasma viscosity</term></item><item><term>erythrocyte aggregation</term></item><item><term>blood fluidity</term></item><item><term>tissue oxygen tension</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1989-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/2843A2A567A124211A9B43C60586158C110E197C/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2362</doi><issn type="print">0014-2972</issn><issn type="electronic">1365-2362</issn><idGroup><id type="product" value="ECI"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF CLINICAL INVESTIGATION">European Journal of Clinical Investigation</title></titleGroup></publicationMeta><publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/eci.1989.19.issue-1</doi><numberingGroup><numbering type="journalVolume" number="19">19</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="1989-01">January 1989</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0003000" status="forIssue"><doi origin="wiley">10.1111/j.1365-2362.1989.tb00192.x</doi><idGroup><id type="unit" value="ECI30"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">Original Article</title></titleGroup><eventGroup><event type="firstOnline" date="2008-03-20"></event><event type="publishedOnlineFinalForm" date="2008-03-20"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-05"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-20"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="30">30</numbering><numbering type="pageLast" number="37">37</numbering></numberingGroup><correspondenceTo>**Department of Clinical Chemistry, University Clinics, Robert‐Koch‐Strasse 40, D‐3400 Goettingen, FRG.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ECI.ECI30.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 15 April 1988 and in revised form 16 August 1988</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="51"></count><count type="linksCrossRef" number="10"></count></countGroup><titleGroup><title type="main">Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)<link href="#fn1">*</link></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>P.</givenNames><familyName>SCHUFF‐WERNER</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>E.</givenNames><familyName>SCHÜTZ</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>W. C.</givenNames><familyName>SEYDE</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>TH.</givenNames><familyName>EISENHAUER</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>G.</givenNames><familyName>JANNING</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>V. W.</givenNames><familyName>ARMSTRONG</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>D.</givenNames><familyName>SEIDEL</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>†Department of Clinical Chemistry</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>§Department of Nephrology and Rheumatology</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>‡Department of Anesthesiology, University Clinics, Robert‐Koch‐Strasse 40, D‐3400 Goettingen, FRG</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Atherosclerosis</keyword><keyword xml:id="k2">haemorheology</keyword><keyword xml:id="k3">LDL‐cholesterol</keyword><keyword xml:id="k4">heparin‐induced‐LDL‐apheresis</keyword><keyword xml:id="k5">plasma viscosity</keyword><keyword xml:id="k6">erythrocyte aggregation</keyword><keyword xml:id="k7">blood fluidity</keyword><keyword xml:id="k8">tissue oxygen tension</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Abstract. </b> Heparin‐induced Extracorporeal LDL‐Pre‐cipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen.</p><p>In 10 adult patients with severe type II hyperlipoproteinemia, a single HELP treatment of 3 1 plasma led to an acute decrease in the average plasma viscosity (PV) from 1.30 to 1.1 mPas. At the same time, an even more marked decrease in the mean erythrocyte aggregation rate from a pathological value of 7.9% to a value of 3.7% (normal range <5%) was observed. Long‐term studies on five patients demonstrated a lasting improvement in these two haemorheological variables. The acute rheological changes were also accompanied by an improvement in polarographically determined muscle oxygen tension. Mean oxygen tension values measured in both the m.biceps brachii and the m.tibia‐lis anterior in five patients before and after a single HELP treatment increased from 30.4 to 37.7 mmHg and from 27.2 to 31.3 mmHg respectively.</p><p>These results may provide an explanation for the rapid improvement in patients' clinical symptoms such as angina pectoris and in stress electrocardiogram which have been observed during HELP therapy.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1" numbered="no"><p>*This paper includes part of the dissertation of E. Schültz.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)</title></titleInfo><name type="personal"><namePart type="given">P.</namePart><namePart type="family">SCHUFF‐WERNER</namePart><affiliation>†Department of Clinical Chemistry</affiliation><description>Correspondence: **Department of Clinical Chemistry, University Clinics, Robert‐Koch‐Strasse 40, D‐3400 Goettingen, FRG.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">SCHÜTZ</namePart><affiliation>†Department of Clinical Chemistry</affiliation><description>*This paper includes part of the dissertation of E. Schültz.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. C.</namePart><namePart type="family">SEYDE</namePart><affiliation>‡Department of Anesthesiology, University Clinics, Robert‐Koch‐Strasse 40, D‐3400 Goettingen, FRG</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TH.</namePart><namePart type="family">EISENHAUER</namePart><affiliation>§Department of Nephrology and Rheumatology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">JANNING</namePart><affiliation>§Department of Nephrology and Rheumatology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. W.</namePart><namePart type="family">ARMSTRONG</namePart><affiliation>†Department of Clinical Chemistry</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">SEIDEL</namePart><affiliation>†Department of Clinical Chemistry</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1989-01</dateIssued><edition>Received 15 April 1988 and in revised form 16 August 1988</edition><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">51</extent></physicalDescription><abstract lang="en">Abstract. Heparin‐induced Extracorporeal LDL‐Pre‐cipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen. In 10 adult patients with severe type II hyperlipoproteinemia, a single HELP treatment of 3 1 plasma led to an acute decrease in the average plasma viscosity (PV) from 1.30 to 1.1 mPas. At the same time, an even more marked decrease in the mean erythrocyte aggregation rate from a pathological value of 7.9% to a value of 3.7% (normal range <5%) was observed. Long‐term studies on five patients demonstrated a lasting improvement in these two haemorheological variables. The acute rheological changes were also accompanied by an improvement in polarographically determined muscle oxygen tension. Mean oxygen tension values measured in both the m.biceps brachii and the m.tibia‐lis anterior in five patients before and after a single HELP treatment increased from 30.4 to 37.7 mmHg and from 27.2 to 31.3 mmHg respectively. These results may provide an explanation for the rapid improvement in patients' clinical symptoms such as angina pectoris and in stress electrocardiogram which have been observed during HELP therapy.</abstract><note type="content">**This paper includes part of the dissertation of E. Schültz.</note><subject lang="en"><genre>Keywords</genre><topic>Atherosclerosis</topic><topic>haemorheology</topic><topic>LDL‐cholesterol</topic><topic>heparin‐induced‐LDL‐apheresis</topic><topic>plasma viscosity</topic><topic>erythrocyte aggregation</topic><topic>blood fluidity</topic><topic>tissue oxygen tension</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Clinical Investigation</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0014-2972</identifier><identifier type="eISSN">1365-2362</identifier><identifier type="DOI">10.1111/(ISSN)1365-2362</identifier><identifier type="PublisherID">ECI</identifier><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>30</start><end>37</end><total>8</total></extent></part></relatedItem><identifier type="istex">2843A2A567A124211A9B43C60586158C110E197C</identifier><identifier type="DOI">10.1111/j.1365-2362.1989.tb00192.x</identifier><identifier type="ArticleID">ECI30</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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