Occupational endotoxin‐exposure and possible health effects on humans (review)
Identifieur interne : 000D59 ( Main/Corpus ); précédent : 000D58; suivant : 000D60Occupational endotoxin‐exposure and possible health effects on humans (review)
Auteurs : Verena Liebers ; Thomas Brüning ; Monika Raulf EimsothSource :
- American Journal of Industrial Medicine [ 0271-3586 ] ; 2006-06.
English descriptors
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Abstract
Background: Endotoxins are commonly found at workplaces where large amounts of bioaerosols are generated. In Germany, especially since the Ordinance on Safety and Health Protection related to work involving biological agents (Biostoff‐Verordnung) became effective (1999), threshold limit values are widely discussed. Up to the present, endotoxin values are measured with non‐uniform methods and therefore values are of limited benefit for classification of exposure groups. In Germany there is no threshold limit value for endotoxin. Methods: Relevant literature of the last 20 years was selected from Medline and discussed. Results: In this review we focused on the impact of endotoxin exposure on human health with special respect to the measurements on workplace and methodological aspects of endotoxin determination. Methods for sampling and endotoxin determination have to be validated, optimized, and standardized first. Conclusion: The adverse health effects of endotoxins are known, standardization of measurements is a necessary goal and protection measures should be established immediately. Am. J. Ind. Med. 2006. © 2006 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ajim.20310
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ISTEX:46BF7E9025FFE7A17671F9926D050A6B99184621Le document en format XML
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Med.</title><idno type="ISSN">0271-3586</idno><idno type="eISSN">1097-0274</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-06">2006-06</date><biblScope unit="volume">49</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="474">474</biblScope><biblScope unit="page" to="491">491</biblScope></imprint><idno type="ISSN">0271-3586</idno></series><idno type="istex">46BF7E9025FFE7A17671F9926D050A6B99184621</idno><idno type="DOI">10.1002/ajim.20310</idno><idno type="ArticleID">AJIM20310</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0271-3586</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>LAL‐test</term><term>bioaerosols</term><term>endotoxin</term><term>health effects</term><term>occupational exposure</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Endotoxins are commonly found at workplaces where large amounts of bioaerosols are generated. In Germany, especially since the Ordinance on Safety and Health Protection related to work involving biological agents (Biostoff‐Verordnung) became effective (1999), threshold limit values are widely discussed. Up to the present, endotoxin values are measured with non‐uniform methods and therefore values are of limited benefit for classification of exposure groups. In Germany there is no threshold limit value for endotoxin. Methods: Relevant literature of the last 20 years was selected from Medline and discussed. Results: In this review we focused on the impact of endotoxin exposure on human health with special respect to the measurements on workplace and methodological aspects of endotoxin determination. Methods for sampling and endotoxin determination have to be validated, optimized, and standardized first. Conclusion: The adverse health effects of endotoxins are known, standardization of measurements is a necessary goal and protection measures should be established immediately. Am. J. Ind. Med. 2006. © 2006 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Verena Liebers PhD</name><affiliations><json:string>Research Institute for Occupational Medicine of the Berufsgenossenschaften (BGFA), Institute of the Ruhr‐University Bochum, Bochum, Germany</json:string></affiliations></json:item><json:item><name>Thomas Brüning MD</name><affiliations><json:string>Research Institute for Occupational Medicine of the Berufsgenossenschaften (BGFA), Institute of the Ruhr‐University Bochum, Bochum, Germany</json:string></affiliations></json:item><json:item><name>Monika Raulf‐Heimsoth PhD</name><affiliations><json:string>Research Institute for Occupational Medicine of the Berufsgenossenschaften (BGFA), Institute of the Ruhr‐University Bochum, Bochum, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>bioaerosols</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>endotoxin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>health effects</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LAL‐test</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>occupational exposure</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Background: Endotoxins are commonly found at workplaces where large amounts of bioaerosols are generated. In Germany, especially since the Ordinance on Safety and Health Protection related to work involving biological agents (Biostoff‐Verordnung) became effective (1999), threshold limit values are widely discussed. Up to the present, endotoxin values are measured with non‐uniform methods and therefore values are of limited benefit for classification of exposure groups. In Germany there is no threshold limit value for endotoxin. Methods: Relevant literature of the last 20 years was selected from Medline and discussed. Results: In this review we focused on the impact of endotoxin exposure on human health with special respect to the measurements on workplace and methodological aspects of endotoxin determination. Methods for sampling and endotoxin determination have to be validated, optimized, and standardized first. Conclusion: The adverse health effects of endotoxins are known, standardization of measurements is a necessary goal and protection measures should be established immediately. Am. 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In Germany, especially since the Ordinance on Safety and Health Protection related to work involving biological agents (Biostoff‐Verordnung) became effective (1999), threshold limit values are widely discussed. Up to the present, endotoxin values are measured with non‐uniform methods and therefore values are of limited benefit for classification of exposure groups. In Germany there is no threshold limit value for endotoxin.</p></section><section xml:id="abs1-2"><title type="main">Methods</title><p>Relevant literature of the last 20 years was selected from Medline and discussed.</p></section><section xml:id="abs1-3"><title type="main">Results</title><p>In this review we focused on the impact of endotoxin exposure on human health with special respect to the measurements on workplace and methodological aspects of endotoxin determination. Methods for sampling and endotoxin determination have to be validated, optimized, and standardized first.</p></section><section xml:id="abs1-4"><title type="main">Conclusion</title><p>The adverse health effects of endotoxins are known, standardization of measurements is a necessary goal and protection measures should be established immediately. Am. J. Ind. 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In Germany, especially since the Ordinance on Safety and Health Protection related to work involving biological agents (Biostoff‐Verordnung) became effective (1999), threshold limit values are widely discussed. Up to the present, endotoxin values are measured with non‐uniform methods and therefore values are of limited benefit for classification of exposure groups. In Germany there is no threshold limit value for endotoxin. Methods: Relevant literature of the last 20 years was selected from Medline and discussed. Results: In this review we focused on the impact of endotoxin exposure on human health with special respect to the measurements on workplace and methodological aspects of endotoxin determination. Methods for sampling and endotoxin determination have to be validated, optimized, and standardized first. Conclusion: The adverse health effects of endotoxins are known, standardization of measurements is a necessary goal and protection measures should be established immediately. Am. 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