Hepatologie Neuere Forschungsergebnisse in ihrer Bedeutung für das Verständnis von Leberkrankheiten
Identifieur interne : 000B93 ( Main/Corpus ); précédent : 000B92; suivant : 000B94Hepatologie Neuere Forschungsergebnisse in ihrer Bedeutung für das Verständnis von Leberkrankheiten
Auteurs : W. Gerok ; E. Blum ; W. Offensperger ; S. Offensperger ; T. Andus ; V. Gro ; C. HeinrichSource :
- Naturwissenschaften [ 0028-1042 ] ; 1991-06-01.
Abstract
Abstract: By two exemplary clinical situations — acute viral hepatitis, acute-phase reaction of the liver — the significance of basic research for the understanding of clinical phenomena and for the development of new diagnostic and therapeutic procedures is demonstrated. The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. The proteins confine the local injury and establish the homeostasis of the organism.
Url:
DOI: 10.1007/BF01134350
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Heinrich</name><affiliation><mods:affiliation>Medizinische Universitätsklinik, W-7800, Freiburg, Bundesrepublik Deutschland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Naturwissenschaften</title><title level="j" type="abbrev">Naturwissenschaften</title><idno type="ISSN">0028-1042</idno><idno type="eISSN">1432-1904</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1991-06-01">1991-06-01</date><biblScope unit="volume">78</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="241">241</biblScope><biblScope unit="page" to="249">249</biblScope></imprint><idno type="ISSN">0028-1042</idno></series><idno type="istex">583AC247174BA5CB8F28A293444FFA18D975958E</idno><idno type="DOI">10.1007/BF01134350</idno><idno type="ArticleID">Art1</idno><idno type="ArticleID">BF01134350</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-1042</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="de">de</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: By two exemplary clinical situations — acute viral hepatitis, acute-phase reaction of the liver — the significance of basic research for the understanding of clinical phenomena and for the development of new diagnostic and therapeutic procedures is demonstrated. The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. The proteins confine the local injury and establish the homeostasis of the organism.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>W. Gerok</name><affiliations><json:string>Medizinische Universitätsklinik, W-7800, Freiburg, Bundesrepublik Deutschland</json:string></affiliations></json:item><json:item><name>H. E. Blum</name><affiliations><json:string>Medizinische Universitätsklinik, W-7800, Freiburg, Bundesrepublik Deutschland</json:string></affiliations></json:item><json:item><name>W. 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The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. 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The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. The proteins confine the local injury and establish the homeostasis of the organism.</abstract><relatedItem type="host"><titleInfo><title>Naturwissenschaften</title></titleInfo><titleInfo type="abbreviated"><title>Naturwissenschaften</title></titleInfo><genre type="Journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1991-06-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><subject><genre>Life Sciences</genre><topic>Life Sciences, general</topic><topic>Environment, general</topic></subject><identifier type="ISSN">0028-1042</identifier><identifier type="eISSN">1432-1904</identifier><identifier type="JournalID">114</identifier><identifier type="IssueArticleCount">13</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>1991</date><detail type="volume"><number>78</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="pages"><start>241</start><end>249</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1991</recordOrigin></recordInfo></relatedItem><identifier type="istex">583AC247174BA5CB8F28A293444FFA18D975958E</identifier><identifier type="DOI">10.1007/BF01134350</identifier><identifier type="ArticleID">Art1</identifier><identifier type="ArticleID">BF01134350</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1991</recordOrigin></recordInfo></mods></metadata><enrichments><istex:refBibTEI uri="https://api.istex.fr/document/583AC247174BA5CB8F28A293444FFA18D975958E/enrichments/refBib"><teiHeader></teiHeader><text><front></front><body></body><back><listBibl><biblStruct xml:id="b0"><analytic><title level="a" type="main">New Engl</title><author><persName><forename type="first">J</forename><forename type="middle">H</forename><surname>Hoofnagle</surname></persName></author></analytic><monogr><title level="j">J. 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