Structure, Chromosomal Localization, and Expression Analysis of the Mouse Inhibin/Activin βC( Inhbc ) Gene
Identifieur interne : 000B53 ( Main/Corpus ); précédent : 000B52; suivant : 000B54Structure, Chromosomal Localization, and Expression Analysis of the Mouse Inhibin/Activin βC( Inhbc ) Gene
Auteurs : Jacky Schmitt ; Gertrud Hötten ; Nancy A. Jenkins ; Debra J. Gilbert ; Neal G. Copeland ; Jens Pohl ; Heinrich SchreweSource :
- Genomics [ 0888-7543 ] ; 1995.
Abstract
The mouse inhibin/activin βCgene (Inhbc), a member of the transforming growth factor-β (TGF-β) superfamily, was cloned, mapped, and characterized. The gene spans approximately 14 kb, is composed of two exons, and maps to the distal region of mouse chromosome 10, which is syntenic to chromosome 12q13.1, where the human inhibin/activin βCgene (INHBC) maps. The primary translation product is a preproprotein of 352 amino acids. The mature C-terminal domain of 116 amino acids shares 94% identity with its human homolog. Primer extension analysis shows that transcription starts approximately 130 bp upstream of the translation initiation site, and no TATA box was found in the promoter. Ribonuclease protection analyses reveal that mouseInhbcis predominantly expressed in adult liver. Embryonic expression is detected beginning from Day 14.5 of gestation.
Url:
DOI: 10.1006/geno.1996.0130
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The gene spans approximately 14 kb, is composed of two exons, and maps to the distal region of mouse chromosome 10, which is syntenic to chromosome 12q13.1, where the human inhibin/activin βCgene (INHBC) maps. The primary translation product is a preproprotein of 352 amino acids. The mature C-terminal domain of 116 amino acids shares 94% identity with its human homolog. Primer extension analysis shows that transcription starts approximately 130 bp upstream of the translation initiation site, and no TATA box was found in the promoter. Ribonuclease protection analyses reveal that mouseInhbcis predominantly expressed in adult liver. Embryonic expression is detected beginning from Day 14.5 of gestation.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Jacky Schmitt</name><affiliations><json:string>Max-Planck-Institute of Immunobiology, Department of Developmental Biology, Stübeweg 51, 79108, Freiburg, Germany</json:string></affiliations></json:item><json:item><name>Gertrud Hötten</name><affiliations><json:string>Biopharm GmbH, Czernyring 22, 69115, Heidelberg, Germany</json:string></affiliations></json:item><json:item><name>Nancy A. Jenkins</name><affiliations><json:string>Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland, 21702</json:string></affiliations></json:item><json:item><name>Debra J. 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mouse inhibin/activin βCgene (Inhbc), a member of the transforming growth factor-β (TGF-β) superfamily, was cloned, mapped, and characterized. The gene spans approximately 14 kb, is composed of two exons, and maps to the distal region of mouse chromosome 10, which is syntenic to chromosome 12q13.1, where the human inhibin/activin βCgene (INHBC) maps. The primary translation product is a preproprotein of 352 amino acids. The mature C-terminal domain of 116 amino acids shares 94% identity with its human homolog. Primer extension analysis shows that transcription starts approximately 130 bp upstream of the translation initiation site, and no TATA box was found in the promoter. Ribonuclease protection analyses reveal that mouseInhbcis predominantly expressed in adult liver. Embryonic expression is detected beginning from Day 14.5 of gestation.</p></abstract></profileDesc><revisionDesc><change when="1995-12-21">Registration</change><change when="1995">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-4">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/FE00CD5BF1086BDC8DE865CFD0DE064EE2A0775D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier converted-article found"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YGENO</jid><aid>90130</aid><ce:pii>S0888-7543(96)90130-5</ce:pii><ce:doi>10.1006/geno.1996.0130</ce:doi><ce:copyright type="full-transfer" year="1996">Academic Press</ce:copyright></item-info><head><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>Structure, Chromosomal Localization, and Expression Analysis of the Mouse Inhibin/Activin β<ce:inf>C</ce:inf>(<ce:italic>Inhbc</ce:italic>) Gene</ce:title><ce:author-group><ce:author><ce:given-name>Jacky</ce:given-name><ce:surname>Schmitt</ce:surname><ce:cross-ref refid="A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Gertrud</ce:given-name><ce:surname>Hötten</ce:surname><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Nancy A.</ce:given-name><ce:surname>Jenkins</ce:surname><ce:cross-ref refid="A3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Debra J.</ce:given-name><ce:surname>Gilbert</ce:surname><ce:cross-ref refid="A3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Neal G.</ce:given-name><ce:surname>Copeland</ce:surname><ce:cross-ref refid="A3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jens</ce:given-name><ce:surname>Pohl</ce:surname><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Heinrich</ce:given-name><ce:surname>Schrewe</ce:surname><ce:cross-ref refid="A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="A1"><ce:label>a</ce:label><ce:textfn>Max-Planck-Institute of Immunobiology, Department of Developmental Biology, Stübeweg 51, 79108, Freiburg, Germany</ce:textfn></ce:affiliation><ce:affiliation id="A2"><ce:label>b</ce:label><ce:textfn>Biopharm GmbH, Czernyring 22, 69115, Heidelberg, Germany</ce:textfn></ce:affiliation><ce:affiliation id="A3"><ce:label>c</ce:label><ce:textfn>Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland, 21702</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="12" month="9" year="1995"></ce:date-received><ce:date-accepted day="21" month="12" year="1995"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The mouse inhibin/activin β<ce:inf>C</ce:inf>gene (<ce:italic>Inhbc</ce:italic>), a member of the transforming growth factor-β (TGF-β) superfamily, was cloned, mapped, and characterized. The gene spans approximately 14 kb, is composed of two exons, and maps to the distal region of mouse chromosome 10, which is syntenic to chromosome 12q13.1, where the human inhibin/activin β<ce:inf>C</ce:inf>gene (INHBC) maps. The primary translation product is a preproprotein of 352 amino acids. The mature C-terminal domain of 116 amino acids shares 94% identity with its human homolog. Primer extension analysis shows that transcription starts approximately 130 bp upstream of the translation initiation site, and no TATA box was found in the promoter. Ribonuclease protection analyses reveal that mouse<ce:italic>Inhbc</ce:italic>is predominantly expressed in adult liver. Embryonic expression is detected beginning from Day 14.5 of gestation.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Structure, Chromosomal Localization, and Expression Analysis of the Mouse Inhibin/Activin βC( Inhbc ) Gene</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Structure, Chromosomal Localization, and Expression Analysis of the Mouse Inhibin/Activin β</title></titleInfo><name type="personal"><namePart type="given">Jacky</namePart><namePart type="family">Schmitt</namePart><affiliation>Max-Planck-Institute of Immunobiology, Department of Developmental Biology, Stübeweg 51, 79108, Freiburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gertrud</namePart><namePart type="family">Hötten</namePart><affiliation>Biopharm GmbH, Czernyring 22, 69115, Heidelberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nancy A.</namePart><namePart type="family">Jenkins</namePart><affiliation>Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland, 21702</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Debra J.</namePart><namePart type="family">Gilbert</namePart><affiliation>Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland, 21702</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Neal G.</namePart><namePart type="family">Copeland</namePart><affiliation>Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland, 21702</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jens</namePart><namePart type="family">Pohl</namePart><affiliation>Biopharm GmbH, Czernyring 22, 69115, Heidelberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Heinrich</namePart><namePart type="family">Schrewe</namePart><affiliation>Max-Planck-Institute of Immunobiology, Department of Developmental Biology, Stübeweg 51, 79108, Freiburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><dateValid encoding="w3cdtf">1995-12-21</dateValid><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The mouse inhibin/activin βCgene (Inhbc), a member of the transforming growth factor-β (TGF-β) superfamily, was cloned, mapped, and characterized. The gene spans approximately 14 kb, is composed of two exons, and maps to the distal region of mouse chromosome 10, which is syntenic to chromosome 12q13.1, where the human inhibin/activin βCgene (INHBC) maps. The primary translation product is a preproprotein of 352 amino acids. The mature C-terminal domain of 116 amino acids shares 94% identity with its human homolog. Primer extension analysis shows that transcription starts approximately 130 bp upstream of the translation initiation site, and no TATA box was found in the promoter. Ribonuclease protection analyses reveal that mouseInhbcis predominantly expressed in adult liver. Embryonic expression is detected beginning from Day 14.5 of gestation.</abstract><note type="content">Section title: Regular Article</note><relatedItem type="host"><titleInfo><title>Genomics</title></titleInfo><titleInfo type="abbreviated"><title>YGENO</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19960315</dateIssued></originInfo><identifier type="ISSN">0888-7543</identifier><identifier type="PII">S0888-7543(00)X0127-9</identifier><part><date>19960315</date><detail type="volume"><number>32</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>301</start><end>493</end></extent><extent unit="pages"><start>358</start><end>366</end></extent></part></relatedItem><identifier type="istex">FE00CD5BF1086BDC8DE865CFD0DE064EE2A0775D</identifier><identifier type="DOI">10.1006/geno.1996.0130</identifier><identifier type="PII">S0888-7543(96)90130-5</identifier><accessCondition type="use and reproduction" contentType="">© 1996Academic Press</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Academic Press, ©1996</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/FE00CD5BF1086BDC8DE865CFD0DE064EE2A0775D/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">BIOTECHNOLOGY & APPLIED MICROBIOLOGY</classCode><classCode scheme="WOS">GENETICS & HEREDITY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI><istex:refBibTEI uri="https://api.istex.fr/document/FE00CD5BF1086BDC8DE865CFD0DE064EE2A0775D/enrichments/refBib"><teiHeader></teiHeader><text><front></front><body></body><back><listBibl><biblStruct><analytic><title level="a" type="main">the testes of mice genetically deficient in germ cells tor-deficient mice could be</title></analytic><monogr><title level="j">Biol. 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