Cadmium and children: Exposure and health effects
Identifieur interne : 000827 ( Main/Corpus ); précédent : 000826; suivant : 000828Cadmium and children: Exposure and health effects
Auteurs : Greet Schoeters ; Elly Den Hond ; Moniek Zuurbier ; Rima Naginiene ; Peter Van Den Hazel ; Nikolaos Stilianakis ; Roberto Ronchetti ; Janna G. KoppeSource :
- Acta Pædiatrica [ 0803-5253 ] ; 2006-10.
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- KwdEn :
Abstract
Cadmium exposure and accumulation in the body start at young age. Exposure routes in children are mainly via food, environmental tobacco smoke and house dust. Excretion from the body is limited. Cadmium accumulation in the kidney is responsible for effects such as nephrotoxicity and osteoporosis which are observed at adult age. Cadmium exposure through inhalation is also associated with lung cancer in adulthood. Although transfer to the neonate through the placenta and through breast milk is limited, teratogenic and developmental effects were observed in experimental animals. The database on human studies involving children is limited, yet effects on motoric and perceptual behaviour in children have been associated with elevated in utero cadmium exposure. In school age children urinary cadmium levels were associated with immune suppressive effects. More studies are needed to confirm these results. Experimental data in vitro and in animals refer to effects of cadmium on the hypothalamus‐pituitary axis at different levels. This may lead to disorders of the endocrine and/or immune system. Cadmium exposure at early age should be limited as much as possible to prevent direct effects on children and to prevent accumulation of cadmium which may have serious health effects only becoming manifest at older age.
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DOI: 10.1080/08035320600886232
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ISTEX:97C94856F3A4ED3A9B4B0C8A4934003F9A0BB880Le document en format XML
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Koppe</name><affiliation><mods:affiliation>Ecobaby Foundation and Emma Children's Hospital Academic Medical Centre, University of Amsterdam, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Pædiatrica</title><idno type="ISSN">0803-5253</idno><idno type="eISSN">1651-2227</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2006-10">2006-10</date><biblScope unit="volume">95</biblScope><biblScope unit="supplement">s453</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="54">54</biblScope></imprint><idno type="ISSN">0803-5253</idno></series><idno type="istex">97C94856F3A4ED3A9B4B0C8A4934003F9A0BB880</idno><idno type="DOI">10.1080/08035320600886232</idno><idno type="ArticleID">APA50</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0803-5253</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Children</term><term>cadmium</term><term>environment</term><term>exposure</term><term>health effects</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cadmium exposure and accumulation in the body start at young age. Exposure routes in children are mainly via food, environmental tobacco smoke and house dust. Excretion from the body is limited. Cadmium accumulation in the kidney is responsible for effects such as nephrotoxicity and osteoporosis which are observed at adult age. Cadmium exposure through inhalation is also associated with lung cancer in adulthood. Although transfer to the neonate through the placenta and through breast milk is limited, teratogenic and developmental effects were observed in experimental animals. The database on human studies involving children is limited, yet effects on motoric and perceptual behaviour in children have been associated with elevated in utero cadmium exposure. In school age children urinary cadmium levels were associated with immune suppressive effects. More studies are needed to confirm these results. Experimental data in vitro and in animals refer to effects of cadmium on the hypothalamus‐pituitary axis at different levels. This may lead to disorders of the endocrine and/or immune system. Cadmium exposure at early age should be limited as much as possible to prevent direct effects on children and to prevent accumulation of cadmium which may have serious health effects only becoming manifest at older age.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>GREET SCHOETERS</name><affiliations><json:string>Vlaamse Instelling voor Technologisch Onderzoek, Mol, Belgium</json:string></affiliations></json:item><json:item><name>ELLY DEN HOND</name><affiliations><json:string>Vlaamse Instelling voor Technologisch Onderzoek, Mol, Belgium</json:string></affiliations></json:item><json:item><name>MONIEK ZUURBIER</name><affiliations><json:string>Public Health Services Gelderland Midden, Arnhem, The Netherlands</json:string></affiliations></json:item><json:item><name>RIMA NAGINIENE</name><affiliations><json:string>Institute for Biomedical Research, Kaunas University of Medicine, Lithuania</json:string></affiliations></json:item><json:item><name>PETER VAN DEN HAZEL</name><affiliations><json:string>Public Health Services Gelderland Midden, Arnhem, The Netherlands</json:string></affiliations></json:item><json:item><name>NIKOLAOS STILIANAKIS</name><affiliations><json:string>European Commission, Joint Research Centre, Ispra, Italy</json:string></affiliations></json:item><json:item><name>ROBERTO RONCHETTI</name><affiliations><json:string>Public Health Services Gelderland Midden, Arnhem, The Netherlands</json:string></affiliations></json:item><json:item><name>JANNA G. 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Cadmium accumulation in the kidney is responsible for effects such as nephrotoxicity and osteoporosis which are observed at adult age. Cadmium exposure through inhalation is also associated with lung cancer in adulthood. Although transfer to the neonate through the placenta and through breast milk is limited, teratogenic and developmental effects were observed in experimental animals. The database on human studies involving children is limited, yet effects on motoric and perceptual behaviour in children have been associated with elevated in utero cadmium exposure. In school age children urinary cadmium levels were associated with immune suppressive effects. More studies are needed to confirm these results. Experimental data in vitro and in animals refer to effects of cadmium on the hypothalamus‐pituitary axis at different levels. This may lead to disorders of the endocrine and/or immune system. 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E‐mail:</p></note><affiliation>Vlaamse Instelling voor Technologisch Onderzoek, Mol, Belgium</affiliation></author><author><persName><forename type="first">ELLY DEN</forename><surname>HOND</surname></persName><affiliation>Vlaamse Instelling voor Technologisch Onderzoek, Mol, Belgium</affiliation></author><author><persName><forename type="first">MONIEK</forename><surname>ZUURBIER</surname></persName><affiliation>Public Health Services Gelderland Midden, Arnhem, The Netherlands</affiliation></author><author><persName><forename type="first">RIMA</forename><surname>NAGINIENE</surname></persName><affiliation>Institute for Biomedical Research, Kaunas University of Medicine, Lithuania</affiliation></author><author><persName><forename type="first">PETER</forename><surname>VAN DEN HAZEL</surname></persName><affiliation>Public Health Services Gelderland Midden, Arnhem, The Netherlands</affiliation></author><author><persName><forename type="first">NIKOLAOS</forename><surname>STILIANAKIS</surname></persName><affiliation>European Commission, Joint Research Centre, Ispra, Italy</affiliation></author><author><persName><forename type="first">ROBERTO</forename><surname>RONCHETTI</surname></persName><affiliation>Public Health Services Gelderland Midden, Arnhem, The Netherlands</affiliation></author><author><persName><forename type="first">JANNA G.</forename><surname>KOPPE</surname></persName><affiliation>Ecobaby Foundation and Emma Children's Hospital Academic Medical Centre, University of Amsterdam, The Netherlands</affiliation></author></analytic><monogr><title level="j">Acta Pædiatrica</title><idno type="pISSN">0803-5253</idno><idno type="eISSN">1651-2227</idno><idno type="DOI">10.1111/(ISSN)1651-2227</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2006-10"></date><biblScope unit="volume">95</biblScope><biblScope unit="supplement">s453</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="54">54</biblScope></imprint></monogr><idno type="istex">97C94856F3A4ED3A9B4B0C8A4934003F9A0BB880</idno><idno type="DOI">10.1080/08035320600886232</idno><idno type="ArticleID">APA50</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Cadmium exposure and accumulation in the body start at young age. Exposure routes in children are mainly via food, environmental tobacco smoke and house dust. Excretion from the body is limited. Cadmium accumulation in the kidney is responsible for effects such as nephrotoxicity and osteoporosis which are observed at adult age. Cadmium exposure through inhalation is also associated with lung cancer in adulthood. Although transfer to the neonate through the placenta and through breast milk is limited, teratogenic and developmental effects were observed in experimental animals. The database on human studies involving children is limited, yet effects on motoric and perceptual behaviour in children have been associated with elevated in utero cadmium exposure. In school age children urinary cadmium levels were associated with immune suppressive effects. More studies are needed to confirm these results. Experimental data in vitro and in animals refer to effects of cadmium on the hypothalamus‐pituitary axis at different levels. This may lead to disorders of the endocrine and/or immune system. Cadmium exposure at early age should be limited as much as possible to prevent direct effects on children and to prevent accumulation of cadmium which may have serious health effects only becoming manifest at older age.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Children</term></item><item><term>environment</term></item><item><term>cadmium</term></item><item><term>health effects</term></item><item><term>exposure</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/97C94856F3A4ED3A9B4B0C8A4934003F9A0BB880/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1651-2227</doi><issn type="print">0803-5253</issn><issn type="electronic">1651-2227</issn><idGroup><id type="product" value="APA"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ACTA PAEDIATRICA">Acta Pædiatrica</title></titleGroup></publicationMeta><publicationMeta level="part" position="10000"><doi origin="wiley">10.1111/apa.2006.95.issue-s453</doi><numberingGroup><numbering type="journalVolume" number="95">95</numbering><numbering type="supplement">s453</numbering></numberingGroup><coverDate startDate="2006-10">October 2006</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0005000" status="forIssue"><doi origin="wiley">10.1080/08035320600886232</doi><idGroup><id type="unit" value="APA50"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Journal Article</title></titleGroup><eventGroup><event type="firstOnline" date="2008-10-09"></event><event type="publishedOnlineFinalForm" date="2008-10-09"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="50">50</numbering><numbering type="pageLast" number="54">54</numbering></numberingGroup><correspondenceTo>G. Schoeters, Environmental Toxicology Unit, Vlaamse Instelling voor Technologisch Onderzoek, Mol, Belgium. Tel: +32 14 335200. Fax: +32 14 33582657. 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Exposure routes in children are mainly via food, environmental tobacco smoke and house dust. Excretion from the body is limited. Cadmium accumulation in the kidney is responsible for effects such as nephrotoxicity and osteoporosis which are observed at adult age. Cadmium exposure through inhalation is also associated with lung cancer in adulthood. Although transfer to the neonate through the placenta and through breast milk is limited, teratogenic and developmental effects were observed in experimental animals. The database on human studies involving children is limited, yet effects on motoric and perceptual behaviour in children have been associated with elevated <i>in utero</i> cadmium exposure. In school age children urinary cadmium levels were associated with immune suppressive effects. More studies are needed to confirm these results. Experimental data <i>in vitro</i> and in animals refer to effects of cadmium on the hypothalamus‐pituitary axis at different levels. This may lead to disorders of the endocrine and/or immune system. Cadmium exposure at early age should be limited as much as possible to prevent direct effects on children and to prevent accumulation of cadmium which may have serious health effects only becoming manifest at older age.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cadmium and children: Exposure and health effects</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cadmium and children: Exposure and health effects</title></titleInfo><name type="personal"><namePart type="given">GREET</namePart><namePart type="family">SCHOETERS</namePart><affiliation>Vlaamse Instelling voor Technologisch Onderzoek, Mol, Belgium</affiliation><description>Correspondence: G. Schoeters, Environmental Toxicology Unit, Vlaamse Instelling voor Technologisch Onderzoek, Mol, Belgium. Tel: +32 14 335200. Fax: +32 14 33582657. E‐mail: </description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ELLY DEN</namePart><namePart type="family">HOND</namePart><affiliation>Vlaamse Instelling voor Technologisch Onderzoek, Mol, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MONIEK</namePart><namePart type="family">ZUURBIER</namePart><affiliation>Public Health Services Gelderland Midden, Arnhem, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RIMA</namePart><namePart type="family">NAGINIENE</namePart><affiliation>Institute for Biomedical Research, Kaunas University of Medicine, Lithuania</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PETER</namePart><namePart type="family">VAN DEN HAZEL</namePart><affiliation>Public Health Services Gelderland Midden, Arnhem, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NIKOLAOS</namePart><namePart type="family">STILIANAKIS</namePart><affiliation>European Commission, Joint Research Centre, Ispra, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ROBERTO</namePart><namePart type="family">RONCHETTI</namePart><affiliation>Public Health Services Gelderland Midden, Arnhem, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JANNA G.</namePart><namePart type="family">KOPPE</namePart><affiliation>Ecobaby Foundation and Emma Children's Hospital Academic Medical Centre, University of Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2006-10</dateIssued><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">47</extent></physicalDescription><abstract lang="en">Cadmium exposure and accumulation in the body start at young age. Exposure routes in children are mainly via food, environmental tobacco smoke and house dust. Excretion from the body is limited. Cadmium accumulation in the kidney is responsible for effects such as nephrotoxicity and osteoporosis which are observed at adult age. Cadmium exposure through inhalation is also associated with lung cancer in adulthood. Although transfer to the neonate through the placenta and through breast milk is limited, teratogenic and developmental effects were observed in experimental animals. The database on human studies involving children is limited, yet effects on motoric and perceptual behaviour in children have been associated with elevated in utero cadmium exposure. In school age children urinary cadmium levels were associated with immune suppressive effects. More studies are needed to confirm these results. Experimental data in vitro and in animals refer to effects of cadmium on the hypothalamus‐pituitary axis at different levels. This may lead to disorders of the endocrine and/or immune system. Cadmium exposure at early age should be limited as much as possible to prevent direct effects on children and to prevent accumulation of cadmium which may have serious health effects only becoming manifest at older age.</abstract><subject lang="en"><genre>Keywords</genre><topic>Children</topic><topic>environment</topic><topic>cadmium</topic><topic>health effects</topic><topic>exposure</topic></subject><relatedItem type="host"><titleInfo><title>Acta Pædiatrica</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0803-5253</identifier><identifier type="eISSN">1651-2227</identifier><identifier type="DOI">10.1111/(ISSN)1651-2227</identifier><identifier type="PublisherID">APA</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><detail type="supplement"><caption>Suppl. no.</caption><number>s453</number></detail><extent unit="pages"><start>50</start><end>54</end><total>5</total></extent></part></relatedItem><identifier type="istex">97C94856F3A4ED3A9B4B0C8A4934003F9A0BB880</identifier><identifier type="DOI">10.1080/08035320600886232</identifier><identifier type="ArticleID">APA50</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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