Lipopeptide als natürliche Adjuvantien für Impfstoffe aus Gram-negativen Bakterien
Identifieur interne : 000728 ( Main/Corpus ); précédent : 000727; suivant : 000729Lipopeptide als natürliche Adjuvantien für Impfstoffe aus Gram-negativen Bakterien
Auteurs : S. Schlecht ; -H. Wiesmüller ; G. Jung ; G. BesslerSource :
- Naturwissenschaften [ 0028-1042 ] ; 1993-01-01.
Abstract
Abstract: Bacterial cell wall components such as lipopolysaccharide, a variety of membrane proteins, murein, and lipoprotein can act as immunoadjuvants for bacterial vaccines, thus enhancing protection from bacterial infections. Synthetically prepared N-terminal parts of the lipoprotein from Enterobacteria carrying three fatty acid residues or lipopeptide analogs containing one to four aminoacids bound to S-glycerylcysteine act as potent immunoadjuvants in vivo in combination with or covalently linked to antiges. Here we demonstrate that the supplementation ofSalmonella vaccines with these synthetic lipopeptides significantly enhances their vaccine efficiency in mice. Variations in the native lipopeptide structure regarding chain length and amino acid sequence of the peptide moiety, as well as modifications of the lipoamino acid, lead to reduction or even complete loss of the adjuvant activity. The immunoadjuvant properties of the lipopeptides as described here are mediated by an enhancement of the humoral immune response.
Url:
DOI: 10.1007/BF01139751
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Synthetically prepared N-terminal parts of the lipoprotein from Enterobacteria carrying three fatty acid residues or lipopeptide analogs containing one to four aminoacids bound to S-glycerylcysteine act as potent immunoadjuvants in vivo in combination with or covalently linked to antiges. Here we demonstrate that the supplementation ofSalmonella vaccines with these synthetic lipopeptides significantly enhances their vaccine efficiency in mice. Variations in the native lipopeptide structure regarding chain length and amino acid sequence of the peptide moiety, as well as modifications of the lipoamino acid, lead to reduction or even complete loss of the adjuvant activity. The immunoadjuvant properties of the lipopeptides as described here are mediated by an enhancement of the humoral immune response.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>S. Schlecht</name><affiliations><json:string>Max-Planck-Institut für Immunbiologie, W-7800, Freiburg</json:string></affiliations></json:item><json:item><name>K. -H. Wiesmüller</name><affiliations><json:string>Institut für Organische Chemie der Universität, W7400, Tübingen</json:string></affiliations></json:item><json:item><name>G. Jung</name><affiliations><json:string>Institut für Organische Chemie der Universität, W7400, Tübingen</json:string></affiliations></json:item><json:item><name>W. G. Bessler</name><affiliations><json:string>Institut für Immunbiologie der Universität, W-7800, Freiburg, Germany</json:string></affiliations></json:item></author><language><json:string>deu</json:string></language><abstract>Abstract: Bacterial cell wall components such as lipopolysaccharide, a variety of membrane proteins, murein, and lipoprotein can act as immunoadjuvants for bacterial vaccines, thus enhancing protection from bacterial infections. 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Universität</OrgName><OrgAddress><Postcode>W-7800</Postcode><City>Freiburg</City><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Bacterial cell wall components such as lipopolysaccharide, a variety of membrane proteins, murein, and lipoprotein can act as immunoadjuvants for bacterial vaccines, thus enhancing protection from bacterial infections. Synthetically prepared N-terminal parts of the lipoprotein from Enterobacteria carrying three fatty acid residues or lipopeptide analogs containing one to four aminoacids bound to S-glycerylcysteine act as potent immunoadjuvants in vivo in combination with or covalently linked to antiges. Here we demonstrate that the supplementation of<Emphasis Type="Italic">Salmonella</Emphasis> vaccines with these synthetic lipopeptides significantly enhances their vaccine efficiency in mice. Variations in the native lipopeptide structure regarding chain length and amino acid sequence of the peptide moiety, as well as modifications of the lipoamino acid, lead to reduction or even complete loss of the adjuvant activity. The immunoadjuvant properties of the lipopeptides as described here are mediated by an enhancement of the humoral immune response.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="de"><title>Lipopeptide als natürliche Adjuvantien für Impfstoffe aus Gram-negativen Bakterien</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="de"><title>Lipopeptide als natürliche Adjuvantien für Impfstoffe aus Gram-negativen Bakterien</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Schlecht</namePart><affiliation>Max-Planck-Institut für Immunbiologie, W-7800, Freiburg</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="given">-H.</namePart><namePart type="family">Wiesmüller</namePart><affiliation>Institut für Organische Chemie der Universität, W7400, Tübingen</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Jung</namePart><affiliation>Institut für Organische Chemie der Universität, W7400, Tübingen</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="given">G.</namePart><namePart type="family">Bessler</namePart><affiliation>Institut für Immunbiologie der Universität, W-7800, Freiburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateIssued encoding="w3cdtf">1993-01-01</dateIssued><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">de</languageTerm><languageTerm type="code" authority="iso639-2b">deu</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Bacterial cell wall components such as lipopolysaccharide, a variety of membrane proteins, murein, and lipoprotein can act as immunoadjuvants for bacterial vaccines, thus enhancing protection from bacterial infections. 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