Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus
Identifieur interne : 000621 ( Main/Corpus ); précédent : 000620; suivant : 000622Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus
Auteurs : F. AndersSource :
- Klinische Wochenschrift [ 0023-2173 ] ; 1981-09-01.
Abstract
Summary: The genetic information for neoplastic transformation is inherited as a normal part of the genome in all individuals of Xiphophorus. Neoplasia, however, was found only in hybrids between members of different populations and local races. It can be classified in (a) a large group that is triggered by mutagens, (b) a large group triggered by promoters, (c) a small group that develops “spontaneously”, and (d) a small group that is inherited according to Mendelian Laws. The process leading to susceptibility for neoplasia is represented by the disintegration of coadapted gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene-systems. Environmental mutagens and promoters (i.e. carcinogens) may complete disintegration and thus may trigger neoplasia. The phenomenon of introducing susceptibility to neoplasia by means of hybridization has been observed in a large variety of plants and animals (Table 2). While we have no data on the relation between hybridization and cancer in human beings comparable to those in plants and animals, we put the question whether the many facts on tumor incidence in humans, that do not agree with the concept of the primacy of environmental factors in carcinogenesis may be explained by interpopulational and interracial hybridization in preceding generations. Based on our studies on Xiphophorus we suppose that environmental factors represent only the peak of an iceberg in the multistep process of the causation of neoplasia. The most important steps leading to neoplasia, i.e. those that bring about susceptibility, are supposed to be hidden in our ancestry.
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DOI: 10.1007/BF02310969
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="de">Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus</title><author><name sortKey="Anders, F" sort="Anders, F" uniqKey="Anders F" first="F." last="Anders">F. 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Anders</name><affiliation><mods:affiliation>Genetisches Institut der Justus-Liebig-Universität Gießen, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Klinische Wochenschrift</title><title level="j" type="abbrev">Klin Wochenschr</title><idno type="ISSN">0023-2173</idno><idno type="eISSN">1432-1440</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1981-09-01">1981-09-01</date><biblScope unit="volume">59</biblScope><biblScope unit="issue">17</biblScope><biblScope unit="page" from="943">943</biblScope><biblScope unit="page" to="956">956</biblScope></imprint><idno type="ISSN">0023-2173</idno></series><idno type="istex">DC1DF82C7C359B35FFCBBE548E888C0376EBEDA5</idno><idno type="DOI">10.1007/BF02310969</idno><idno type="ArticleID">Art4</idno><idno type="ArticleID">BF02310969</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0023-2173</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="de">de</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The genetic information for neoplastic transformation is inherited as a normal part of the genome in all individuals of Xiphophorus. Neoplasia, however, was found only in hybrids between members of different populations and local races. It can be classified in (a) a large group that is triggered by mutagens, (b) a large group triggered by promoters, (c) a small group that develops “spontaneously”, and (d) a small group that is inherited according to Mendelian Laws. The process leading to susceptibility for neoplasia is represented by the disintegration of coadapted gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene-systems. Environmental mutagens and promoters (i.e. carcinogens) may complete disintegration and thus may trigger neoplasia. The phenomenon of introducing susceptibility to neoplasia by means of hybridization has been observed in a large variety of plants and animals (Table 2). While we have no data on the relation between hybridization and cancer in human beings comparable to those in plants and animals, we put the question whether the many facts on tumor incidence in humans, that do not agree with the concept of the primacy of environmental factors in carcinogenesis may be explained by interpopulational and interracial hybridization in preceding generations. Based on our studies on Xiphophorus we suppose that environmental factors represent only the peak of an iceberg in the multistep process of the causation of neoplasia. The most important steps leading to neoplasia, i.e. those that bring about susceptibility, are supposed to be hidden in our ancestry.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>F. 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Versammlung der Gesellschaft Deutscher Naturforscher und Ärzte, Hamburg, 21.–25. September 1980.</note><note>Die Arbeiten wurden durch die Deutsche Forschungsgemeinschaft (SFB 103, Zellenergetik und Zelldifferenzierung, Marburg), die Stiftung Volkswagenwerk und die Justus-Liebig-Universität Gießen unterstützt. Sie basieren auf Arbeiten von Curt Kosswig und Myron Gordon, enthalten Ideen von Walter Heston, und wären ohne die Hilfe meiner früheren und jetzigen Mitarbeiter, die die Daten 25 Jahre hindurch zusammengetragen haben, nicht möglich gewesen. — Bei der Anfertigung des Manuskriptes halften Frau Dipl. Biol. A. Schartl, Frau Silomon-Pflug und Herr Dr. E. Scholl</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="de">Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus</title><title level="a" type="alt" xml:lang="en">Hereditary and environmental factors in the causation of neoplasia based on studies in Xiphophorus</title><author><persName><forename type="first">F.</forename><surname>Anders</surname></persName><affiliation>Genetisches Institut der Justus-Liebig-Universität Gießen, Germany</affiliation></author></analytic><monogr><title level="j">Klinische Wochenschrift</title><title level="j" type="abbrev">Klin Wochenschr</title><idno type="JournalID">109</idno><idno type="pISSN">0023-2173</idno><idno type="eISSN">1432-1440</idno><idno type="IssueArticleCount">12</idno><idno type="VolumeIssueCount">24</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1981-09-01"></date><biblScope unit="volume">59</biblScope><biblScope unit="issue">17</biblScope><biblScope unit="page" from="943">943</biblScope><biblScope unit="page" to="956">956</biblScope></imprint></monogr><idno type="istex">DC1DF82C7C359B35FFCBBE548E888C0376EBEDA5</idno><idno type="DOI">10.1007/BF02310969</idno><idno type="ArticleID">Art4</idno><idno type="ArticleID">BF02310969</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1981-03-13</date></creation><langUsage><language ident="de">de</language></langUsage><abstract xml:lang="en"><p>Summary: The genetic information for neoplastic transformation is inherited as a normal part of the genome in all individuals of Xiphophorus. Neoplasia, however, was found only in hybrids between members of different populations and local races. It can be classified in (a) a large group that is triggered by mutagens, (b) a large group triggered by promoters, (c) a small group that develops “spontaneously”, and (d) a small group that is inherited according to Mendelian Laws. The process leading to susceptibility for neoplasia is represented by the disintegration of coadapted gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene-systems. Environmental mutagens and promoters (i.e. carcinogens) may complete disintegration and thus may trigger neoplasia. The phenomenon of introducing susceptibility to neoplasia by means of hybridization has been observed in a large variety of plants and animals (Table 2). While we have no data on the relation between hybridization and cancer in human beings comparable to those in plants and animals, we put the question whether the many facts on tumor incidence in humans, that do not agree with the concept of the primacy of environmental factors in carcinogenesis may be explained by interpopulational and interracial hybridization in preceding generations. Based on our studies on Xiphophorus we suppose that environmental factors represent only the peak of an iceberg in the multistep process of the causation of neoplasia. The most important steps leading to neoplasia, i.e. those that bring about susceptibility, are supposed to be hidden in our ancestry.</p></abstract><abstract xml:lang="de"><p>Zusammenfassung: Alle Individuen von Xiphophorus haben in ihrem Genom die genetische Information zur Tumorbildung. Neoplasmen wurden allerdings nur bei Bastarden von Angehörigen verschiedener Populationen oder Lokalrassen gefunden. Vier Neoplasie-Typen verschiedener Ätiologie wurden nachgewiesen: (a) Eine große Gruppe mutagen-abhängiger, (b) eine ebenfalls große Gruppe promotor-abhängiger, (c) eine kleine Gruppe „spontan“ entstehender und (d) eine ebenfalls kleine Gruppe dominant erblicher Neoplasmen. Der Prozeß, der zur Krebs-Suszeptibilität führt, beruht auf einem bastardierungsbedingten genetischen Abbau koadaptierter Gensysteme, die normalerweise vor Krebs schützen. Mutagene und Promotoren (Karzinogene im herkömmlichen Sinne) vervollständigen den Abbau dieser Gensysteme in Somazellen und lösen auf diese Weise die Krebsbildung aus. Die Entstehung von Krebs-Suszeptibilität durch Bastardierung ist bei allen Gruppen der höheren Pflanzen und Tiere beobachtet worden (Tabelle 2). Es wird deshalb die Frage gestellt, ob und wie stark Bastardierung zwischen Angehörigen verschiedener menschlicher Populationen und Lokalrassen zur großen Krebshäufigkeit mancher hochentwickelter Nationen ursächlich beigetragen hat. Auf Grund unserer Studien an Xiphophorus vermuten wir, daß die Karzinogene aus der Umwelt im Ursachengefüge des neoplastischen Wachstums nur die Spitze eines Eisberges darstellen, während die wichtigste Komponente, die Suszeptibilität zur Krebsbildung, bei unseren Vorfahren im Verborgenen liegt.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Molecular Medicine</term></item><item><term>Internal Medicine</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1981-03-13">Created</change><change when="1981-09-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-2">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/DC1DF82C7C359B35FFCBBE548E888C0376EBEDA5/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>109</JournalID><JournalPrintISSN>0023-2173</JournalPrintISSN><JournalElectronicISSN>1432-1440</JournalElectronicISSN><JournalTitle>Klinische Wochenschrift</JournalTitle><JournalAbbreviatedTitle>Klin Wochenschr</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Molecular Medicine</JournalSubject><JournalSubject Type="Secondary">Internal Medicine</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo TocLevels="0" VolumeType="Regular"><VolumeIDStart>59</VolumeIDStart><VolumeIDEnd>59</VolumeIDEnd><VolumeIssueCount>24</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>17</IssueIDStart><IssueIDEnd>17</IssueIDEnd><IssueArticleCount>12</IssueArticleCount><IssueHistory><CoverDate><DateString>1. September 1981</DateString><Year>1981</Year><Month>9</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1981</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art4"><ArticleInfo ArticleType="OriginalPaper" ContainsESM="No" Language="De" NumberingStyle="Unnumbered" TocLevels="0"><ArticleID>BF02310969</ArticleID><ArticleDOI>10.1007/BF02310969</ArticleDOI><ArticleSequenceNumber>4</ArticleSequenceNumber><ArticleTitle Language="De">Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus</ArticleTitle><ArticleTitle Language="En">Hereditary and environmental factors in the causation of neoplasia based on studies in Xiphophorus</ArticleTitle><ArticleFirstPage>943</ArticleFirstPage><ArticleLastPage>956</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2006</Year><Month>1</Month><Day>14</Day></RegistrationDate><Received><Year>1981</Year><Month>3</Month><Day>13</Day></Received><Accepted><Year>1981</Year><Month>3</Month><Day>14</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1981</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>109</JournalID><VolumeIDStart>59</VolumeIDStart><VolumeIDEnd>59</VolumeIDEnd><IssueIDStart>17</IssueIDStart><IssueIDEnd>17</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>F.</GivenName><FamilyName>Anders</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgName>Genetisches Institut der Justus-Liebig-Universität Gießen</OrgName><OrgAddress><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>The genetic information for neoplastic transformation is inherited as a normal part of the genome in all individuals of Xiphophorus. Neoplasia, however, was found only in hybrids between members of different populations and local races. It can be classified in (a) a large group that is triggered by mutagens, (b) a large group triggered by promoters, (c) a small group that develops “spontaneously”, and (d) a small group that is inherited according to Mendelian Laws. The process leading to susceptibility for neoplasia is represented by the disintegration of coadapted gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene-systems. Environmental mutagens and promoters (i.e. carcinogens) may complete disintegration and thus may trigger neoplasia.</Para><Para>The phenomenon of introducing susceptibility to neoplasia by means of hybridization has been observed in a large variety of plants and animals (Table 2). While we have no data on the relation between hybridization and cancer in human beings comparable to those in plants and animals, we put the question whether the many facts on tumor incidence in humans, that do not agree with the concept of the primacy of environmental factors in carcinogenesis may be explained by interpopulational and interracial hybridization in preceding generations. Based on our studies on Xiphophorus we suppose that environmental factors represent only the peak of an iceberg in the multistep process of the causation of neoplasia. The most important steps leading to neoplasia, i.e. those that bring about susceptibility, are supposed to be hidden in our ancestry.</Para></Abstract><Abstract ID="Abs2" Language="De"><Heading>Zusammenfassung</Heading><Para>Alle Individuen von Xiphophorus haben in ihrem Genom die genetische Information zur Tumorbildung. Neoplasmen wurden allerdings nur bei Bastarden von Angehörigen verschiedener Populationen oder Lokalrassen gefunden. Vier Neoplasie-Typen verschiedener Ätiologie wurden nachgewiesen: (a) Eine große Gruppe mutagen-abhängiger, (b) eine ebenfalls große Gruppe promotor-abhängiger, (c) eine kleine Gruppe „spontan“ entstehender und (d) eine ebenfalls kleine Gruppe dominant erblicher Neoplasmen. Der Prozeß, der zur Krebs-Suszeptibilität führt, beruht auf einem bastardierungsbedingten genetischen Abbau koadaptierter Gensysteme, die normalerweise vor Krebs schützen. Mutagene und Promotoren (Karzinogene im herkömmlichen Sinne) vervollständigen den Abbau dieser Gensysteme in Somazellen und lösen auf diese Weise die Krebsbildung aus.</Para><Para>Die Entstehung von Krebs-Suszeptibilität durch Bastardierung ist bei allen Gruppen der höheren Pflanzen und Tiere beobachtet worden (Tabelle 2). Es wird deshalb die Frage gestellt, ob und wie stark Bastardierung zwischen Angehörigen verschiedener menschlicher Populationen und Lokalrassen zur großen Krebshäufigkeit mancher hochentwickelter Nationen ursächlich beigetragen hat. Auf Grund unserer Studien an Xiphophorus vermuten wir, daß die Karzinogene aus der Umwelt im Ursachengefüge des neoplastischen Wachstums nur die Spitze eines Eisberges darstellen, während die wichtigste Komponente, die Suszeptibilität zur Krebsbildung, bei unseren Vorfahren im Verborgenen liegt.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Carcinogens</Keyword><Keyword>Promoters</Keyword><Keyword>Tumor genes</Keyword><Keyword>Tumor incidence</Keyword><Keyword>Tumor susceptibility</Keyword></KeywordGroup><KeywordGroup Language="De"><Heading>Schlüsselwörter</Heading><Keyword>Karzinogene</Keyword><Keyword>Promotoren</Keyword><Keyword>Tumorgene</Keyword><Keyword>Krebs-Suszeptibilität</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>Vortrag auf der 111. Versammlung der Gesellschaft Deutscher Naturforscher und Ärzte, Hamburg, 21.–25. September 1980.</SimplePara></ArticleNote><ArticleNote Type="Misc"><SimplePara>Die Arbeiten wurden durch die Deutsche Forschungsgemeinschaft (SFB 103, Zellenergetik und Zelldifferenzierung, Marburg), die Stiftung Volkswagenwerk und die Justus-Liebig-Universität Gießen unterstützt. Sie basieren auf Arbeiten von Curt Kosswig und Myron Gordon, enthalten Ideen von Walter Heston, und wären ohne die Hilfe meiner früheren und jetzigen Mitarbeiter, die die Daten 25 Jahre hindurch zusammengetragen haben, nicht möglich gewesen. — Bei der Anfertigung des Manuskriptes halften Frau Dipl. Biol. A. Schartl, Frau Silomon-Pflug und Herr Dr. E. Scholl</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="de"><title>Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="de"><title>Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus</title></titleInfo><titleInfo lang="en"><title>Hereditary and environmental factors in the causation of neoplasia based on studies in Xiphophorus</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Hereditary and environmental factors in the causation of neoplasia based on studies in Xiphophorus</title></titleInfo><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Anders</namePart><affiliation>Genetisches Institut der Justus-Liebig-Universität Gießen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1981-03-13</dateCreated><dateIssued encoding="w3cdtf">1981-09-01</dateIssued><copyrightDate encoding="w3cdtf">1981</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">de</languageTerm><languageTerm type="code" authority="iso639-2b">deu</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: The genetic information for neoplastic transformation is inherited as a normal part of the genome in all individuals of Xiphophorus. Neoplasia, however, was found only in hybrids between members of different populations and local races. It can be classified in (a) a large group that is triggered by mutagens, (b) a large group triggered by promoters, (c) a small group that develops “spontaneously”, and (d) a small group that is inherited according to Mendelian Laws. The process leading to susceptibility for neoplasia is represented by the disintegration of coadapted gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene-systems. Environmental mutagens and promoters (i.e. carcinogens) may complete disintegration and thus may trigger neoplasia. The phenomenon of introducing susceptibility to neoplasia by means of hybridization has been observed in a large variety of plants and animals (Table 2). While we have no data on the relation between hybridization and cancer in human beings comparable to those in plants and animals, we put the question whether the many facts on tumor incidence in humans, that do not agree with the concept of the primacy of environmental factors in carcinogenesis may be explained by interpopulational and interracial hybridization in preceding generations. Based on our studies on Xiphophorus we suppose that environmental factors represent only the peak of an iceberg in the multistep process of the causation of neoplasia. The most important steps leading to neoplasia, i.e. those that bring about susceptibility, are supposed to be hidden in our ancestry.</abstract><abstract lang="de">Zusammenfassung: Alle Individuen von Xiphophorus haben in ihrem Genom die genetische Information zur Tumorbildung. Neoplasmen wurden allerdings nur bei Bastarden von Angehörigen verschiedener Populationen oder Lokalrassen gefunden. Vier Neoplasie-Typen verschiedener Ätiologie wurden nachgewiesen: (a) Eine große Gruppe mutagen-abhängiger, (b) eine ebenfalls große Gruppe promotor-abhängiger, (c) eine kleine Gruppe „spontan“ entstehender und (d) eine ebenfalls kleine Gruppe dominant erblicher Neoplasmen. Der Prozeß, der zur Krebs-Suszeptibilität führt, beruht auf einem bastardierungsbedingten genetischen Abbau koadaptierter Gensysteme, die normalerweise vor Krebs schützen. Mutagene und Promotoren (Karzinogene im herkömmlichen Sinne) vervollständigen den Abbau dieser Gensysteme in Somazellen und lösen auf diese Weise die Krebsbildung aus. Die Entstehung von Krebs-Suszeptibilität durch Bastardierung ist bei allen Gruppen der höheren Pflanzen und Tiere beobachtet worden (Tabelle 2). Es wird deshalb die Frage gestellt, ob und wie stark Bastardierung zwischen Angehörigen verschiedener menschlicher Populationen und Lokalrassen zur großen Krebshäufigkeit mancher hochentwickelter Nationen ursächlich beigetragen hat. Auf Grund unserer Studien an Xiphophorus vermuten wir, daß die Karzinogene aus der Umwelt im Ursachengefüge des neoplastischen Wachstums nur die Spitze eines Eisberges darstellen, während die wichtigste Komponente, die Suszeptibilität zur Krebsbildung, bei unseren Vorfahren im Verborgenen liegt.</abstract><note>Vortrag auf der 111. Versammlung der Gesellschaft Deutscher Naturforscher und Ärzte, Hamburg, 21.–25. September 1980.</note><note>Die Arbeiten wurden durch die Deutsche Forschungsgemeinschaft (SFB 103, Zellenergetik und Zelldifferenzierung, Marburg), die Stiftung Volkswagenwerk und die Justus-Liebig-Universität Gießen unterstützt. Sie basieren auf Arbeiten von Curt Kosswig und Myron Gordon, enthalten Ideen von Walter Heston, und wären ohne die Hilfe meiner früheren und jetzigen Mitarbeiter, die die Daten 25 Jahre hindurch zusammengetragen haben, nicht möglich gewesen. — Bei der Anfertigung des Manuskriptes halften Frau Dipl. Biol. A. Schartl, Frau Silomon-Pflug und Herr Dr. E. Scholl</note><relatedItem type="host"><titleInfo><title>Klinische Wochenschrift</title></titleInfo><titleInfo type="abbreviated"><title>Klin Wochenschr</title></titleInfo><genre type="Journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1981-09-01</dateIssued><copyrightDate encoding="w3cdtf">1981</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Molecular Medicine</topic><topic>Internal Medicine</topic></subject><identifier type="ISSN">0023-2173</identifier><identifier type="eISSN">1432-1440</identifier><identifier type="JournalID">109</identifier><identifier type="IssueArticleCount">12</identifier><identifier type="VolumeIssueCount">24</identifier><part><date>1981</date><detail type="volume"><number>59</number><caption>vol.</caption></detail><detail type="issue"><number>17</number><caption>no.</caption></detail><extent unit="pages"><start>943</start><end>956</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1981</recordOrigin></recordInfo></relatedItem><identifier type="istex">DC1DF82C7C359B35FFCBBE548E888C0376EBEDA5</identifier><identifier type="DOI">10.1007/BF02310969</identifier><identifier type="ArticleID">Art4</identifier><identifier type="ArticleID">BF02310969</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1981</recordOrigin></recordInfo></mods></metadata><enrichments><istex:refBibTEI uri="https://api.istex.fr/document/DC1DF82C7C359B35FFCBBE548E888C0376EBEDA5/enrichments/refBib"><teiHeader></teiHeader><text><front></front><body></body><back><listBibl><biblStruct xml:id="b0"><monogr><title level="m" type="main">Studies on neoplasia in Xiphophorus. Histomorphology of N-methyl-N-nitrosourea (MNU) induced neoplasms and cytology and cytochemistry of genetically conditioned amelanotic melanoma</title><author><persName><forename type="first">S</forename><surname>Abdo</surname></persName></author><imprint><date type="published" when="1979"></date><pubPlace>Dissertation, GieBen</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b1"><analytic><title level="a" type="main">A cytogenetic study of heritable tumor in nicotiana species hybrids</title><author><persName><forename type="first">Mr</forename><surname>Ahuja</surname></persName></author></analytic><monogr><title level="j">Genetics</title><imprint><biblScope unit="volume">47</biblScope><biblScope unit="page" from="865" to="880"></biblScope><date type="published" when="1962"></date></imprint></monogr></biblStruct><biblStruct xml:id="b2"><monogr><title level="m" type="main">Cancer as a problem of gene regulation Recent advances in cancer research: Cell biology, and tumor virology</title><author><persName><forename type="first">Mr</forename><surname>Ahuja</surname></persName></author><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author><editor>Gallo RC</editor><imprint><date type="published" when="1977"></date><publisher>CRC Press</publisher><biblScope unit="page" from="103" to="117"></biblScope><pubPlace>Cleveland</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b3"><analytic><title level="a" type="main">Sex chromosome aberrations involving loss and translocation of tumor-inducing loci in Xiphophorus Linkage between a regulatory locus for melanoma cell differentiation and an esterase locus in Xiphophorus</title><author><persName><forename type="first">Mr</forename><surname>Ahuja</surname></persName></author><author><persName><forename type="first">K</forename><surname>Lepper</surname></persName></author><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author></analytic><monogr><title level="j">Experientia J Heredity</title><imprint><biblScope unit="volume">35</biblScope><biblScope unit="issue">71</biblScope><biblScope unit="page" from="28" to="30"></biblScope><date type="published" when="1979"></date></imprint></monogr></biblStruct><biblStruct xml:id="b4"><analytic><title level="a" type="main">Identifying environmental chemicals causing mutation and cancer</title><author><persName><forename type="first">Bn</forename><surname>Ames</surname></persName></author></analytic><monogr><title level="j">Science</title><imprint><biblScope unit="volume">204</biblScope><biblScope unit="page" from="587" to="593"></biblScope><date type="published" when="1979"></date></imprint></monogr></biblStruct><biblStruct xml:id="b5"><analytic><title level="a" type="main">Etiology of cancer as studied in the platyfish-swordtail system</title><author><persName><forename type="first">A</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author></analytic><monogr><title level="j">Biochim Biophys Acta</title><imprint><biblScope unit="volume">516</biblScope><biblScope unit="page">61</biblScope><date type="published" when="1978"></date></imprint></monogr></biblStruct><biblStruct xml:id="b6"><monogr><title level="m" type="main">Regulation of gene expression in the Gordon-Kosswig melanoma system. I. The distribution of the controlling genes in the genome of the xiphophorine fish, Platypoecilus maculatus and Ptatypoecilus variatus Genetics and mutagenesis of fish</title><author><persName><forename type="first">A</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">K</forename><surname>Klinke</surname></persName></author><editor>Schr6der JH</editor><imprint><date type="published" when="1973"></date><publisher>Springer</publisher><biblScope unit="page" from="33" to="52"></biblScope><pubPlace>Berlin Heidelberg New York</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b7"><monogr><title level="m" type="main">Regulation of gene expression in the Gordon-Kosswig melanoma system. II. The arrangement of chromatophore determining Ioci and regulating elements in the sex chromosomes of xiphophorine fish, Platypoecilus maculatus and Ptatypoecilus variatus Genetics and mutagenesis of fish</title><author><persName><forename type="first">A</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">K</forename><surname>Klinke</surname></persName></author><editor>Schr6der JH</editor><imprint><date type="published" when="1973"></date><publisher>Springer</publisher><biblScope unit="page" from="53" to="63"></biblScope><pubPlace>Berlin Heidelberg New York</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b8"><monogr><title level="m" type="main">Heritable and induced melanoma in Xiphophorus</title><author><persName><forename type="first">A</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">G</forename><surname>Kollinger</surname></persName></author><author><persName><forename type="first">K ( Ira</forename><surname>Chatterjee</surname></persName></author><author><persName><surname>Druek</surname></persName></author><editor>Seiji M</editor><imprint><pubPlace>Basel</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b9"><analytic><title level="a" type="main">Tumour formation in platyfish-swordtail hybrids as a problem of gene regulation</title><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author></analytic><monogr><title level="j">Experientia</title><imprint><biblScope unit="volume">23</biblScope><biblScope unit="page" from="1" to="10"></biblScope><date type="published" when="1967"></date></imprint></monogr></biblStruct><biblStruct xml:id="b10"><analytic><title level="a" type="main">Genetische Faktoren bei der Entstehung von Neoplasmen</title><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author></analytic><monogr><title level="j">Zentral Vet Med</title><imprint><biblScope unit="volume">15</biblScope><biblScope unit="page" from="29" to="6"></biblScope><date type="published" when="1968"></date></imprint></monogr></biblStruct><biblStruct xml:id="b11"><monogr><title level="m" type="main">Differentiation of normal melanophores and of neoplastically transformed melanophores in the skin of Xiphophorus The skin of vertebrates</title><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">H</forename><surname>Diehl</surname></persName></author><author><persName><forename type="first">E</forename><surname>Scholl</surname></persName></author><editor>Spearman RIC, Riley PA</editor><imprint><date type="published" when="1980"></date><publisher>Academic Press</publisher><biblScope unit="page" from="211" to="224"></biblScope><pubPlace>London</pubPlace></imprint></monogr><note>Linnean. society symposium series number 9</note></biblStruct><biblStruct xml:id="b12"><analytic><title level="a" type="main">Contributions to an understanding of the cellular origin of melanomas in the Gordon-Kosswig xiphophorine fish tumor system</title><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">H</forename><surname>Diehl</surname></persName></author><author><persName><forename type="first">M</forename><surname>Schwab</surname></persName></author><author><persName><forename type="first">Anders</forename><forename type="middle">A</forename></persName></author></analytic><monogr><title level="j">Pigment Cell</title><editor>Klaus SN</editor><imprint><publisher>Karger</publisher><publisher>Karger</publisher><biblScope unit="volume">4</biblScope><biblScope unit="page" from="142" to="149"></biblScope><date type="published" when="1979"></date></imprint></monogr></biblStruct><biblStruct xml:id="b13"><analytic><title level="a" type="main">Genregulation und Diftbrenzierung im Melanom-System der Zahnkfirpflinge</title><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">K</forename><surname>Klinke</surname></persName></author><author><persName><forename type="first">U</forename><surname>Vielkind</surname></persName></author></analytic><monogr><title level="j">Biol in unserer Zeit</title><imprint><biblScope unit="volume">2</biblScope><biblScope unit="page" from="35" to="5"></biblScope><date type="published" when="1972"></date></imprint></monogr></biblStruct><biblStruct xml:id="b14"><monogr><title level="m" type="main">Evaluation of environmental and hereditary factors in carcinogenesis based on studies in Xiphophorns. Proceeding of the eleventh international symposium of the Princess Takamatsu cancer research fund</title><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">M</forename><surname>Schartl</surname></persName></author><author><persName><forename type="first">E ( Im</forename><surname>Scholl</surname></persName></author><author><persName><surname>Druck</surname></persName></author><imprint><publisher>University Park Press</publisher><pubPlace>Baltimore London Tokyo</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b15"><analytic><title level="a" type="main">Xiphophorus als Modell in der Krebsforschung</title><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">E</forename><surname>Scholl</surname></persName></author><author><persName><forename type="first">M</forename><surname>Schartl</surname></persName></author></analytic><monogr><title level="m">Organound Immuntherapie: Neue Perspektiven in der Medizin</title><editor>Porcher H, Theurer K</editor><meeting><address><addrLine>Stuttgart</addrLine></address></meeting><imprint><publisher>Enke</publisher><date type="published" when="1979"></date><biblScope unit="page" from="38" to="100"></biblScope></imprint></monogr></biblStruct><biblStruct xml:id="b16"><monogr><title level="m" type="main">Strategy for breeding test animals of high susceptibility to carcinogens Short-term tests for chemical carcinogens</title><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">M</forename><surname>Schwab</surname></persName></author><author><persName><forename type="first">E</forename><surname>Scholl</surname></persName></author><editor>Stich H, San R</editor><imprint><date type="published" when="1981"></date><publisher>Springer</publisher><pubPlace>New York</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b17"><analytic><title></title></analytic><monogr><title level="j">Beiderbeck R</title><imprint><publisher>Pflanzentumoren. Ulmer</publisher><publisher>Pflanzentumoren. Ulmer</publisher><date type="published" when="1977"></date></imprint></monogr></biblStruct><biblStruct xml:id="b18"><analytic><title level="a" type="main">Site-specific X-chromosome rearrangements from hybrid dysgenesis in Drosophila melanogaster</title><author><persName><forename type="first">R</forename><surname>Berg</surname></persName></author><author><persName><forename type="first">Wr</forename><surname>Engels</surname></persName></author><author><persName><forename type="first">Ra</forename><surname>Kreber</surname></persName></author></analytic><monogr><title level="j">Science</title><imprint><biblScope unit="volume">210</biblScope><biblScope unit="page" from="427" to="429"></biblScope><date type="published" when="1980"></date></imprint></monogr></biblStruct><biblStruct xml:id="b19"><analytic><title level="a" type="main">Ptant tumors</title><author><persName><forename type="first">Ac</forename><surname>Braun</surname></persName></author></analytic><monogr><title level="j">Biochim Biophys Acta</title><imprint><biblScope unit="volume">516</biblScope><biblScope unit="page" from="167" to="191"></biblScope><date type="published" when="1978"></date></imprint></monogr></biblStruct><biblStruct xml:id="b20"><monogr><title level="m" type="main">Morphology and physiology of plant tumors</title><author><persName><forename type="first">Ac</forename><surname>Braun</surname></persName></author><author><persName><forename type="first">T</forename><surname>Stonier</surname></persName></author><editor>Heilbrunn LV, Weber F</editor><imprint><date type="published" when="1958"></date><publisher>Springer</publisher><pubPlace>Wien Bd</pubPlace></imprint></monogr><note>Heft. 5a</note></biblStruct><biblStruct xml:id="b21"><analytic><title level="a" type="main">Smoking and lung cancer: the problem of inferring cause</title><author><persName><forename type="first">Prj</forename><surname>Burch</surname></persName></author></analytic><monogr><title level="j">JR Statist Soc A</title><imprint><biblScope unit="volume">141</biblScope><biblScope unit="page" from="43" to="477"></biblScope><date type="published" when="1978"></date></imprint></monogr></biblStruct><biblStruct xml:id="b22"><analytic><title level="a" type="main">Experimental evidence of dietary factors and hormonedependent cancer</title><author><persName><forename type="first">K</forename><surname>Carroll</surname></persName></author></analytic><monogr><title level="j">Cancer Res</title><imprint><biblScope unit="volume">35</biblScope><biblScope unit="page" from="3374" to="3383"></biblScope><date type="published" when="1975"></date></imprint></monogr></biblStruct><biblStruct xml:id="b23"><analytic><title level="a" type="main">Cancer incidence in defined populations</title><author><persName><forename type="first">J</forename><surname>Cairns</surname></persName></author><author><persName><forename type="first">Jl</forename><surname>Lyon</surname></persName></author><author><persName><forename type="first">M</forename><surname>Skolnick</surname></persName></author></analytic><monogr><title level="j">Banbury Report</title><imprint><biblScope unit="volume">4</biblScope><date type="published" when="1980"></date></imprint></monogr></biblStruct><biblStruct xml:id="b24"><analytic><title level="a" type="main">Cytogenetics of Neoplasia of Xiphophorus</title><author><persName><forename type="first">K</forename><surname>Chatterjee</surname></persName></author><author><persName><forename type="first">G</forename><surname>Kollinger</surname></persName></author><author><persName><forename type="first">Cr</forename><surname>Schmidt</surname></persName></author><author><persName><forename type="first">Anders</forename><forename type="middle">A</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">F</forename></persName></author></analytic><monogr><title level="j">Cancer Genet Cytogenet</title><imprint><biblScope unit="volume">3</biblScope><biblScope unit="page" from="195" to="210"></biblScope><date type="published" when="1981"></date></imprint></monogr></biblStruct><biblStruct xml:id="b25"><analytic><title level="a" type="main">Genetical and cytological studies on the intergenetic hybrid of Cairina moschata and Anas platyrhynchos</title><author><persName><forename type="first">Fae</forename><surname>Crew</surname></persName></author><author><persName><forename type="first">P</forename><surname>Koller</surname></persName></author></analytic><monogr><title level="j">Proc R Soc Edinb</title><imprint><biblScope unit="volume">56</biblScope><biblScope unit="page">210</biblScope><date type="published" when="1936"></date></imprint></monogr></biblStruct><biblStruct xml:id="b26"><analytic><title level="a" type="main">Neoplasms in purebred boxer dogs following long-term administration of N-Methyl-N-Nitrosourea</title><author><persName><forename type="first">Rh</forename><surname>Denlinger</surname></persName></author><author><persName><forename type="first">A</forename><surname>Koestner</surname></persName></author><author><persName><forename type="first">Ja</forename><surname>Swenber</surname></persName></author></analytic><monogr><title level="j">Cancer Res</title><imprint><biblScope unit="volume">38</biblScope><biblScope unit="page" from="1711" to="1717"></biblScope><date type="published" when="1978"></date></imprint></monogr></biblStruct><biblStruct xml:id="b27"><analytic><title level="a" type="main">Strategy for detection of cancer hazards to man</title><author><persName><forename type="first">Doll</forename><surname>Sir</surname></persName></author><author><persName><forename type="first">R</forename></persName></author></analytic><monogr><title level="j">Nature</title><imprint><biblScope unit="volume">265</biblScope><biblScope unit="page" from="589" to="596"></biblScope><date type="published" when="1977"></date></imprint></monogr></biblStruct><biblStruct xml:id="b28"><analytic><title></title><author><persName><forename type="first">R</forename><surname>Flindt</surname></persName></author><author><persName><forename type="first">H</forename><surname>Hemmer</surname></persName></author><author><persName><forename type="first">R</forename><surname>Schipp</surname></persName></author></analytic><monogr><title level="m">St6rungen in der Ausbildung des Axialskeletts</title><imprint><date type="published" when="1968"></date><biblScope unit="page" from="51" to="71"></biblScope></imprint></monogr></biblStruct><biblStruct xml:id="b29"><analytic><title level="a" type="main">Nahrungsmittel und Krebsverdacht am Beispiel von Zucker</title><author><persName><forename type="first">H</forename><surname>Foerster</surname></persName></author></analytic><monogr><title level="j">Umschau</title><imprint><biblScope unit="volume">80</biblScope><biblScope unit="page" from="22" to="23"></biblScope><date type="published" when="1980"></date></imprint></monogr></biblStruct><biblStruct xml:id="b30"><analytic><title level="a" type="main">Statistical studies on protein polymorphism in natural populations I. Distribution of single locus heterozygosity</title><author><persName><forename type="first">Pa</forename><surname>Fuerst</surname></persName></author><author><persName><forename type="first">R</forename><surname>Chakraborty</surname></persName></author><author><persName><forename type="first">M</forename><surname>Nei</surname></persName></author></analytic><monogr><title level="j">Genetics</title><imprint><biblScope unit="volume">86</biblScope><biblScope unit="page" from="455" to="483"></biblScope><date type="published" when="1977"></date></imprint></monogr></biblStruct><biblStruct xml:id="b31"><analytic><title level="a" type="main">Malignant neoplasms of genetic origin in Drosophila melanogaster</title><author><persName><forename type="first">E</forename><surname>Gateff</surname></persName></author></analytic><monogr><title level="j">Science</title><imprint><biblScope unit="volume">200</biblScope><biblScope unit="page" from="1448" to="1459"></biblScope><date type="published" when="1978"></date></imprint></monogr></biblStruct><biblStruct xml:id="b32"><analytic><title></title><author><persName><forename type="first">K</forename><surname>Gebhard</surname></persName></author><author><persName><forename type="first">F</forename><surname>Niebauer</surname></persName></author></analytic><monogr><title level="m">Abstract, Second European Workshop on Mammalian Melanin Pigmentation</title><meeting><address><addrLine>London</addrLine></address></meeting><imprint><date type="published" when="1979"></date></imprint></monogr></biblStruct><biblStruct xml:id="b33"><analytic><title level="a" type="main">The genetics of a viviparous topminnow Platypoecilus the inheritance of two kinds of melanophores</title><author><persName><forename type="first">M</forename><surname>Gordon</surname></persName></author></analytic><monogr><title level="j">Genetics</title><imprint><biblScope unit="volume">12</biblScope><biblScope unit="page" from="253" to="283"></biblScope><date type="published" when="1927"></date></imprint></monogr></biblStruct><biblStruct xml:id="b34"><analytic><title level="a" type="main">Spontaneous tumors in Sprague- Dawley and Long-Evans rats and their FI hybrids: carcinogenic effect of total body x-irradiation</title><author><persName><forename type="first">L</forename><surname>Gross</surname></persName></author><author><persName><forename type="first">Y</forename><surname>Dreyfuss</surname></persName></author></analytic><monogr><title level="j">Proc Natl Acad Sci</title><imprint><biblScope unit="volume">76</biblScope><biblScope unit="page" from="5910" to="5913"></biblScope><date type="published" when="1979"></date></imprint></monogr></biblStruct><biblStruct xml:id="b35"><monogr><title level="m" type="main">Versuche zur genetischen Transformation yon Pigmen~ellen bei lebendgeNirenden Zahnkarpfen (Poeciliidae)</title><author><persName><forename type="first">H</forename><surname>Haas-Andela</surname></persName></author><imprint><date type="published" when="1978"></date><biblScope unit="page">3</biblScope><pubPlace>Dissertation</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b36"><monogr><title></title><author><persName><forename type="first">J</forename><surname>Haas</surname></persName></author><imprint><date type="published" when="1981"></date><biblScope unit="page">3</biblScope></imprint></monogr><note>Nachweis. somatischer Mutationen im Melanomsystem der lebendgeb~irenden Zahnkarpfen (Poeciliidae). Dissertation</note></biblStruct><biblStruct xml:id="b37"><analytic><title level="a" type="main">l~ber Melanombildung bei Bastarden von Xiphophorus helleri und Platypoecilus maculatus var</title><author><persName><forename type="first">G</forename><surname>Hfiussler</surname></persName></author></analytic><monogr><title level="j">Rubra Klin Wochenschr</title><imprint><biblScope unit="volume">7</biblScope><biblScope unit="page" from="1561" to="1562"></biblScope><date type="published" when="1928"></date></imprint></monogr></biblStruct><biblStruct xml:id="b38"><analytic><title level="a" type="main">Trout hepatoma research conference papers</title><author><persName><forename type="first">Je</forename><surname>Halver</surname></persName></author><author><persName><forename type="first">Ia</forename><surname>Mitchel</surname></persName></author></analytic><monogr><title level="j">Res Rep US Fish Wildl Serv</title><imprint><biblScope unit="volume">70</biblScope><biblScope unit="page" from="1" to="99"></biblScope><date type="published" when="1967"></date></imprint></monogr></biblStruct><biblStruct xml:id="b39"><analytic><title level="a" type="main">Genetics of cancer</title><author><persName><forename type="first">We</forename><surname>Heston</surname></persName></author></analytic><monogr><title level="j">J Hereditty</title><imprint><biblScope unit="volume">65</biblScope><biblScope unit="page" from="262" to="272"></biblScope><date type="published" when="1974"></date></imprint></monogr></biblStruct><biblStruct xml:id="b40"><analytic><title level="a" type="main">C3H-A vy a high hepatoma and high mammary tumor strain of mice</title><author><persName><forename type="first">We</forename><surname>Heston</surname></persName></author><author><persName><forename type="first">G</forename><surname>Vlahakis</surname></persName></author></analytic><monogr><title level="j">J Natl Cancer Inst</title><imprint><biblScope unit="volume">40</biblScope><biblScope unit="page" from="1161" to="1"></biblScope><date type="published" when="1968"></date></imprint></monogr></biblStruct><biblStruct xml:id="b41"><analytic><title level="a" type="main">Present trends in cancer epidemiology</title><author><persName><forename type="first">J</forename><surname>Higginson</surname></persName></author></analytic><monogr><title level="m">Proceedings of the 8th Canadian cancer conference</title><meeting>the 8th Canadian cancer conference<address><addrLine>Ontario</addrLine></address></meeting><imprint><publisher>Pergamon Press of Canada, Honey Harbor</publisher><date type="published" when="1969"></date><biblScope unit="page" from="40" to="75"></biblScope></imprint></monogr></biblStruct><biblStruct xml:id="b42"><analytic><title level="a" type="main">Influence of selective breeding on the incidence of melanomas in sinclair miniature swine</title><author><persName><forename type="first">Rr</forename><surname>Hook</surname></persName></author><author><persName><forename type="first">Md</forename><surname>Aultman</surname></persName></author><author><persName><forename type="first">Eh</forename><surname>Adelstein</surname></persName></author><author><persName><forename type="first">Rw</forename><surname>Oxenhandler</surname></persName></author><author><persName><forename type="first">Le</forename><surname>Milliken</surname></persName></author><author><persName><forename type="first">Cc</forename><surname>Middleton</surname></persName></author></analytic><monogr><title level="j">Int J Cancer</title><imprint><biblScope unit="volume">24</biblScope><biblScope unit="page" from="668" to="672"></biblScope><date type="published" when="1979"></date></imprint></monogr></biblStruct><biblStruct xml:id="b43"><analytic><title level="a" type="main">Morphologic and biochemical characterization of erythrophoromas in goldfish (Carassius auratus)</title><author><persName><forename type="first">T</forename><surname>Ishikawa</surname></persName></author><author><persName><forename type="first">Prince</forename><surname>Masahito</surname></persName></author><author><persName><forename type="first">J</forename><surname>Matsumoto</surname></persName></author><author><persName><forename type="first">S</forename><surname>Takayama</surname></persName></author></analytic><monogr><title level="j">J Natl Cancer Inst</title><imprint><biblScope unit="volume">61</biblScope><biblScope unit="page" from="1461" to="1470"></biblScope><date type="published" when="1978"></date></imprint></monogr></biblStruct><biblStruct xml:id="b44"><analytic><title level="a" type="main">Olfactory Neuroepthelioma in a domestic carp (Cyprinus carpio)</title><author><persName><forename type="first">T</forename><surname>Ishikawa</surname></persName></author><author><persName><forename type="first">Prince</forename><surname>Masahito</surname></persName></author><author><persName><forename type="first">S</forename><surname>Takayama</surname></persName></author></analytic><monogr><title level="j">Cancer Res</title><imprint><biblScope unit="volume">38</biblScope><biblScope unit="page" from="3954" to="3959"></biblScope><date type="published" when="1978"></date></imprint></monogr></biblStruct><biblStruct xml:id="b45"><analytic><title level="a" type="main">Ovarian neoplasia in ornamental hybrid carp (Nishikigoi) in Japan</title><author><persName><forename type="first">T</forename><surname>Ishikawa</surname></persName></author><author><persName><forename type="first">S</forename><surname>Takayama</surname></persName></author></analytic><monogr><title level="j">Ann NY Acad Sci</title><imprint><biblScope unit="volume">198</biblScope><biblScope unit="page" from="330" to="341"></biblScope><date type="published" when="1977"></date></imprint></monogr></biblStruct><biblStruct xml:id="b46"><monogr><title level="m" type="main">The Platyfish Xiphophorus maculatus Handbook of genetics</title><author><persName><forename type="first">K</forename><surname>Kallman</surname></persName></author><editor>King RC</editor><imprint><publisher>Plenum Press</publisher><biblScope unit="page">132</biblScope><pubPlace>New York</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b47"><analytic><title level="a" type="main">l~lberlegungen zur Krebsstatistik und -epidemiologie</title><author><persName><forename type="first">P</forename><surname>Koeppe</surname></persName></author></analytic><monogr><title level="j">Biol Med</title><imprint><biblScope unit="volume">9</biblScope><biblScope unit="page" from="99" to="110"></biblScope><date type="published" when="1980"></date></imprint></monogr></biblStruct><biblStruct xml:id="b48"><analytic><title level="a" type="main">Zelldifferenzierung und Malignit~it spontaner und carcinogen-induzierter Neoplasmen (Melanom und Neuroblastom) bei Xiphophorus</title><author><persName><forename type="first">G</forename><surname>Kollinger</surname></persName></author></analytic><monogr><title level="j">Eine licht-und etektronenmirkroskopische Untersuchung. Dissertation, GieBen Kosswig C Z Indukt Abstamm Vererbungsl</title><imprint><biblScope unit="volume">44</biblScope><biblScope unit="page">253</biblScope><date type="published" when="1927"></date></imprint></monogr></biblStruct><biblStruct xml:id="b49"><analytic><title level="a" type="main">Structure of normal testis and testicular tumors in cyprinids from Lake Ontario</title><author><persName><forename type="first">Jf</forename><surname>Leatherland</surname></persName></author><author><persName><forename type="first">Ra</forename><surname>Sonstegard</surname></persName></author></analytic><monogr><title level="j">Cancer Res</title><imprint><biblScope unit="volume">38</biblScope><biblScope unit="page" from="3164" to="3173"></biblScope><date type="published" when="1978"></date></imprint></monogr></biblStruct><biblStruct xml:id="b50"><analytic><title level="a" type="main">Suszeptibilit~it fiJr neoplastisches Wachstum 53 The genetics of cancer in mice</title><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author></analytic><monogr><title level="j">Little CC Biol Rev</title><imprint><biblScope unit="volume">22</biblScope><biblScope unit="page">315</biblScope><date type="published" when="1947"></date></imprint></monogr></biblStruct><biblStruct xml:id="b51"><analytic><title level="a" type="main">Racial differences in the frequency of Q and C chromosomal heteromorphism</title><author><persName><forename type="first">Ha</forename><surname>Lubs</surname></persName></author><author><persName><forename type="first">W</forename><forename type="middle">J</forename><surname>Kimberling</surname></persName></author><author><persName><forename type="first">F</forename><surname>Hecht</surname></persName></author><author><persName><forename type="first">Sr</forename><surname>Patil</surname></persName></author><author><persName><forename type="first">J</forename><surname>Brown</surname></persName></author><author><persName><forename type="first">P</forename><surname>Gerald</surname></persName></author><author><persName><forename type="first">Rl</forename><surname>Summitt</surname></persName></author></analytic><monogr><title level="j">Nature</title><imprint><biblScope unit="volume">268</biblScope><biblScope unit="issue">I977</biblScope><biblScope unit="page" from="631" to="632"></biblScope></imprint></monogr></biblStruct><biblStruct xml:id="b52"><analytic><title level="a" type="main">Cancer and Environment: Higginson speaks out (Interview with J Higginson)</title><author><persName><forename type="first">Th</forename><surname>Maugh</surname></persName></author></analytic><monogr><title level="j">Science</title><imprint><biblScope unit="volume">205</biblScope><biblScope unit="page" from="1363" to="1366"></biblScope><date type="published" when="1979"></date></imprint></monogr></biblStruct><biblStruct xml:id="b53"><analytic><title level="a" type="main">The extent and character of biochemical genetic variation in the domestic cat</title><author><persName><forename type="first">O</forename><surname>Brien</surname></persName></author><author><persName><forename type="first">Sj</forename></persName></author></analytic><monogr><title level="j">J Heredity</title><imprint><biblScope unit="volume">71</biblScope><biblScope unit="page" from="2" to="8"></biblScope><date type="published" when="1980"></date></imprint></monogr></biblStruct><biblStruct xml:id="b54"><monogr><title level="m" type="main">Krebs: Schicksal oder Verschulden? Thieme</title><author><persName><forename type="first">H</forename><surname>Oeser</surname></persName></author><author><persName><forename type="first">P</forename><surname>Koeppe</surname></persName></author><imprint><date type="published" when="1979"></date><pubPlace>Stuttgart</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b55"><analytic><title level="a" type="main">Zwischenzellengeschwulst des Hodens bei Vogelmischlingen</title></analytic><monogr><title level="j">Poll H Beitr Pathol Anat</title><imprint><biblScope unit="volume">67</biblScope><biblScope unit="page">40</biblScope><date type="published" when="1920"></date></imprint></monogr></biblStruct><biblStruct xml:id="b56"><analytic><title level="a" type="main">Synopsis der Gattung Xiphophorus Heckel</title></analytic><monogr><title level="j">Radda AC Aquearia</title><imprint><biblScope unit="volume">27</biblScope><biblScope unit="page" from="39" to="44"></biblScope><date type="published" when="1980"></date></imprint></monogr></biblStruct><biblStruct xml:id="b57"><analytic><title level="a" type="main">Fishes from the uplands and inter-mountain basins of Guatemala: Revisionary studies and comparative geography</title><author><persName><forename type="first">D</forename><surname>Rosen</surname></persName></author></analytic><monogr><title level="j">Bull Am Natl Hist</title><imprint><biblScope unit="volume">162</biblScope><biblScope unit="page" from="267" to="376"></biblScope><date type="published" when="1979"></date></imprint></monogr></biblStruct><biblStruct xml:id="b58"><analytic><title level="a" type="main">Hepatic tumors in the Guppy (Lebistes reticulatus) induced by aflatoxin Bt, dimethylnitrosamine, and 2-acetylami- nofluorene</title><author><persName><forename type="first">S</forename><surname>Sato</surname></persName></author><author><persName><forename type="first">T</forename><surname>Matsushima</surname></persName></author><author><persName><forename type="first">N</forename><surname>Tanaka</surname></persName></author><author><persName><forename type="first">T</forename><surname>Sugimura</surname></persName></author><author><persName><forename type="first">F</forename><surname>Takashima</surname></persName></author></analytic><monogr><title level="j">J NatI Cancer Inst</title><imprint><biblScope unit="volume">50</biblScope><biblScope unit="page" from="767" to="776"></biblScope><date type="published" when="1973"></date></imprint></monogr></biblStruct><biblStruct xml:id="b59"><analytic><title level="a" type="main">Promotion of neoplasia by testosterone-promoted cell differentiation in Xiphophorus and Girardinus</title><author><persName><forename type="first">A</forename><surname>Schartl</surname></persName></author><author><persName><forename type="first">M</forename><surname>Schartl</surname></persName></author><author><persName><forename type="first">F ( Ira</forename><surname>Anders</surname></persName></author><author><persName><surname>Druck</surname></persName></author></analytic><monogr><title level="m">Proceedings of the symposium of carcinogenesis and biological effects of tumor promotors</title><editor>Hecker E</editor><meeting>the symposium of carcinogenesis and biological effects of tumor promotors</meeting><imprint></imprint></monogr></biblStruct><biblStruct xml:id="b60"><monogr><title level="m" type="main">Phenotypic conversion of malignant melanoma to benign melanoma and vice versa in Xiphophorus</title><author><persName><forename type="first">M</forename><surname>Schartl</surname></persName></author><author><persName><forename type="first">A</forename><surname>Schartl</surname></persName></author><author><persName><forename type="first">F ( Im</forename><surname>Anders</surname></persName></author><author><persName><surname>Druck</surname></persName></author><editor>Seiji M</editor><imprint><pubPlace>Basel</pubPlace></imprint></monogr><note>Pigment. cell. Karger</note></biblStruct><biblStruct xml:id="b61"><monogr><title level="m" type="main">Untersuchungen fiber MNU-induzierte Neoplasmen bei Xiphophorus</title><author><persName><surname>64</surname></persName></author><author><persName><forename type="first">Cr</forename><surname>Schmidt</surname></persName></author><imprint><date type="published" when="1981"></date></imprint></monogr><note>Abhfingigkeit. der Induzierbarkeit yon Genotyp und Entwicklungsstadium. Dissertation, Gie[3en</note></biblStruct><biblStruct xml:id="b62"><monogr><title level="m" type="main">Biochemical evolution in the genus Xiphophorus (Poeciliidae Teleostei) Genetics and mutagenesis of fish</title><author><persName><forename type="first">A</forename><surname>Scholl</surname></persName></author><editor>Schr6der JH</editor><imprint><date type="published" when="1973"></date><publisher>Springer</publisher><biblScope unit="page" from="277" to="299"></biblScope><pubPlace>Berlin Heidelberg New York</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b63"><analytic><title level="a" type="main">Electrophoretic variation of enzymproteins in platyfish and swordtails (Poeciliidae; Teleostei)</title><author><persName><forename type="first">A</forename><surname>Scholl</surname></persName></author><author><persName><forename type="first">F</forename><surname>Anders</surname></persName></author></analytic><monogr><title level="j">Arch Gen</title><imprint><biblScope unit="volume">46</biblScope><biblScope unit="page" from="121" to="129"></biblScope><date type="published" when="1973"></date></imprint></monogr></biblStruct><biblStruct xml:id="b64"><monogr><title level="m" type="main">Biochemische Markierung von Chromosomen und differentielle Genexpression in Tumor-und Embryonalgewebe bei Zahnkarpfen (Poeciliidae)</title><author><persName><forename type="first">E</forename><surname>Scholi</surname></persName></author><imprint><date type="published" when="1977"></date><pubPlace>Staatsexamensarbeit, Giegen</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b65"><monogr><title level="m" type="main">Untersuchungen am Melanomsystem yon Xiphophorus -Koppelung eines Esterase-Gens (Est-1)</title><author><persName><forename type="first">E</forename><surname>Scholl</surname></persName></author><imprint><date type="published" when="1980"></date><biblScope unit="page">3</biblScope></imprint></monogr><note>mit. einem Differenzierungsgen (Diff). Dissertation</note></biblStruct><biblStruct xml:id="b66"><analytic><title level="a" type="main">Genetic structure of human populations</title><author><persName><forename type="first">Wj</forename><surname>Schull</surname></persName></author></analytic><monogr><title level="j">J Toxicol Environ Health</title><imprint><biblScope unit="volume">5</biblScope><biblScope unit="page" from="17" to="25"></biblScope><date type="published" when="1979"></date></imprint></monogr></biblStruct><biblStruct xml:id="b67"><analytic><title level="a" type="main">Genome organisation in the tumor model of Xiphophorus (Poeciliidae; Teleostei)</title><author><persName><forename type="first">M</forename><surname>Schwab</surname></persName></author><author><persName><surname>I980</surname></persName></author></analytic><monogr><title level="j">Verb Dtsch Zool Ges</title><imprint><biblScope unit="volume">73</biblScope><biblScope unit="page">285</biblScope></imprint></monogr></biblStruct><biblStruct xml:id="b68"><monogr><title level="m" type="main">How can altered differentiation induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA)be related to tumor promotion? in: Hecker E (ed) Carcinogenesis and biological effects of tumor promoters</title><author><persName><forename type="first">M</forename><surname>Schwab</surname></persName></author><imprint><date type="published" when="1981"></date><publisher>Raven Press</publisher><pubPlace>New York</pubPlace></imprint></monogr><note>im. Druck</note></biblStruct><biblStruct xml:id="b69"><monogr><title level="m" type="main">Carcinogenesis in Xiphophorus and the role of the genotype in tumor susceptibility Neoplasms -comparative pathology of growth in animals, plants, and man</title><author><persName><forename type="first">M</forename><surname>Schwab</surname></persName></author><author><persName><forename type="first">Anders</forename><forename type="middle">A</forename></persName></author><editor>Kaiser HE</editor><imprint><date type="published" when="1981"></date><publisher>Williams and Wilkins</publisher><pubPlace>Baltimore</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b70"><analytic><title level="a" type="main">Genetic basis of the susceptibility for the induction of neoplasms by N-methyl-N-nitrosourea (MNU) and X-rays in the platyfish-swordtail tumor system</title><author><persName><forename type="first">M</forename><surname>Schwab</surname></persName></author><author><persName><forename type="first">J</forename><surname>Haas</surname></persName></author><author><persName><forename type="first">S</forename><surname>Abdo</surname></persName></author><author><persName><forename type="first">Mr</forename><surname>Ahuja</surname></persName></author><author><persName><forename type="first">G</forename><surname>Kollinger</surname></persName></author><author><persName><forename type="first">Anders</forename><forename type="middle">A</forename><surname>Anders</surname></persName></author><author><persName><forename type="first">F</forename></persName></author></analytic><monogr><title level="j">Experientia</title><imprint><biblScope unit="volume">34</biblScope><biblScope unit="page" from="780" to="782"></biblScope><date type="published" when="1978"></date></imprint></monogr></biblStruct><biblStruct xml:id="b71"><monogr><title level="m" type="main">Untersuchungen zur Dinitrochlorbenzol (DNCB)-induzierten Regression kreuzungsbedingter Melanome der lebendgeb~renden Zahnkarpfen (Poeciliidae)</title><author><persName><forename type="first">A</forename><surname>Scholz</surname></persName></author><imprint><date type="published" when="1977"></date><pubPlace>Staatsexamensarbeit , Giegen</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b72"><analytic><title level="a" type="main">Die Entwicklung des Genitalapparates bei triploiden Intersexen von Solenobia triquetrella F.R. (Lepid. Psychidae) Deutung des Intersexualit~itph~inomens</title><author><persName><forename type="first">J</forename><surname>Seiler</surname></persName></author><author><persName><forename type="first">O</forename><surname>Puchta</surname></persName></author><author><persName><forename type="first">E</forename><surname>Brunold</surname></persName></author><author><persName><forename type="first">Rainer</forename><forename type="middle">M</forename></persName></author></analytic><monogr><title level="j">Wilhelm Roux's Arch Entwickl Mech</title><imprint><biblScope unit="volume">150</biblScope><biblScope unit="page" from="199" to="372"></biblScope><date type="published" when="1958"></date></imprint></monogr></biblStruct><biblStruct xml:id="b73"><monogr><title level="m" type="main">Licht-und elektronenmikroskopische Untersuchungen an Mitose-und Meiosechromosomen von Xiphophorus</title><author><persName><forename type="first">E</forename><surname>Siegmund</surname></persName></author><imprint><date type="published" when="1981"></date><pubPlace>Diplomarbeit, Giegen</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b74"><analytic><title level="a" type="main">Can mutation theories of carcinogenesis set priorities for carcinogen testing programs? Can</title><author><persName><forename type="first">Hf</forename><surname>Stich</surname></persName></author><author><persName><forename type="first">Ab</forename><surname>Acton</surname></persName></author></analytic><monogr><title level="j">J Genet Cytol</title><imprint><biblScope unit="volume">21</biblScope><biblScope unit="issue">I979</biblScope><biblScope unit="page" from="155" to="177"></biblScope></imprint></monogr></biblStruct><biblStruct xml:id="b75"><analytic><title level="a" type="main">Fibrosarcoma in pond-cultured hybrids of Salvelinus</title><author><persName><forename type="first">F</forename><surname>Takasbima</surname></persName></author><author><persName><forename type="first">T</forename><surname>Hibiya</surname></persName></author></analytic><monogr><title level="j">J Ichthyol</title><imprint><biblScope unit="volume">19</biblScope><biblScope unit="page" from="97" to="101"></biblScope><date type="published" when="1972"></date></imprint></monogr></biblStruct><biblStruct xml:id="b76"><analytic><title level="a" type="main">Comparability of histological alteration during carcinogenesis in animals and man in special reference to hepatocarcinogenesis in fish</title><author><persName><forename type="first">S</forename><surname>Takayama</surname></persName></author><author><persName><forename type="first">T</forename><surname>Ishikawa</surname></persName></author></analytic><monogr><title level="j">IARC Sci Publ</title><imprint><biblScope unit="volume">16</biblScope><biblScope unit="page" from="2" to="71"></biblScope><date type="published" when="1977"></date></imprint></monogr></biblStruct><biblStruct xml:id="b77"><analytic><title level="a" type="main">Increased mutation in crosses between geographically separated strains of Drosophila malenogaster</title><author><persName><forename type="first">Jn</forename><surname>Thompson</surname></persName></author><author><persName><forename type="first">Rr</forename><surname>Woodruff</surname></persName></author></analytic><monogr><title level="j">Proc Natl Acad Sci</title><imprint><biblScope unit="volume">77</biblScope><biblScope unit="page" from="1059" to="1062"></biblScope><date type="published" when="1980"></date></imprint></monogr></biblStruct><biblStruct xml:id="b78"><analytic><title level="a" type="main">Genetic control of cell differentiation in platyfish-swordtail melanoma</title><author><persName><forename type="first">U</forename><surname>Vielkind</surname></persName></author></analytic><monogr><title level="j">J Exp Zool</title><imprint><biblScope unit="volume">196</biblScope><biblScope unit="page" from="97" to="204"></biblScope><date type="published" when="1976"></date></imprint></monogr></biblStruct><biblStruct xml:id="b79"><analytic><title level="a" type="main">Inhibitiory effect of dibutryt cyclic AMP on fish melanoma growth, in vitro, as measured by H3-Thymidine incorporation into DNA</title><author><persName><forename type="first">U</forename><surname>Vielkind</surname></persName></author><author><persName><forename type="first">J</forename><surname>Vielkind</surname></persName></author></analytic><monogr><title level="j">IRCS</title><imprint><biblScope unit="page" from="73" to="3"></biblScope><date type="published" when="1973"></date></imprint></monogr></biblStruct><biblStruct xml:id="b80"><analytic><title level="a" type="main">Multiple myeloma and related immunoglobulin-producing neoplasms</title><author><persName><forename type="first">Nl</forename><surname>Warner</surname></persName></author><author><persName><forename type="first">M</forename><surname>Potter</surname></persName></author><author><persName><forename type="first">D</forename><surname>Metcalf</surname></persName></author></analytic><monogr><title level="j">CC Techn Rep Ser</title><imprint><biblScope unit="volume">13</biblScope><date type="published" when="1974"></date></imprint></monogr></biblStruct><biblStruct xml:id="b81"><monogr><title level="m" type="main">Geschwfilste</title><author><persName><forename type="first">E</forename><surname>Weiss</surname></persName></author><editor>Frei A (ed) Allgemeine Pathologie . Parey</editor><imprint><date type="published" when="1972"></date><biblScope unit="page" from="295" to="347"></biblScope><pubPlace>Berlin</pubPlace></imprint></monogr></biblStruct><biblStruct xml:id="b82"><analytic><title level="a" type="main">Adrenal tumors and other pathological changes in reciprocal crosses in mice I</title><author><persName><forename type="first">Ow</forename><surname>Wolley</surname></persName></author><author><persName><forename type="first">Mm</forename><surname>Dickie</surname></persName></author><author><persName><forename type="first">Cc</forename><surname>Little</surname></persName></author></analytic><monogr><title level="j">Cancer Res</title><imprint><biblScope unit="volume">12</biblScope><biblScope unit="page">142</biblScope><date type="published" when="1952"></date></imprint></monogr></biblStruct><biblStruct xml:id="b83"><analytic><title level="a" type="main">Intraspecific hybridization and the release of mutator activity</title><author><persName><forename type="first">Rc</forename><surname>Woodruff</surname></persName></author><author><persName><forename type="first">Jn</forename><surname>Thompson</surname></persName></author><author><persName><forename type="first">Rf</forename><surname>Lyman</surname></persName></author></analytic><monogr><title level="j">Nature</title><imprint><biblScope unit="volume">278</biblScope><biblScope unit="page" from="277" to="279"></biblScope><date type="published" when="1979"></date></imprint></monogr></biblStruct><biblStruct xml:id="b84"><analytic><title level="a" type="main">Types of frequencies of Qvariant chromosomes in a Japanese population</title><author><persName><forename type="first">K</forename><surname>Yamada</surname></persName></author><author><persName><forename type="first">T</forename><surname>Hasegawa</surname></persName></author></analytic><monogr><title level="j">Hum Genet</title><imprint><biblScope unit="volume">44</biblScope><biblScope unit="page" from="89" to="98"></biblScope><date type="published" when="1978"></date></imprint></monogr></biblStruct><biblStruct xml:id="b85"><analytic><title></title></analytic><monogr><title level="m">Eingegangen am 13. MS.rz 1981 Angenommen am 14</title><imprint><date type="published" when="1981"></date></imprint></monogr></biblStruct><biblStruct xml:id="b86"><monogr><title level="m" type="main">Anders Genetisches Institut Heinrich-Buff-Ring 58~2 D-6300 GieBen Bundesrepublik Deutschland</title><author><persName><surname>Prof</surname></persName></author><author><persName><forename type="middle">F</forename><surname>Dr</surname></persName></author><imprint></imprint></monogr></biblStruct></listBibl></back></text></istex:refBibTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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