A treat-to-target strategy with methotrexate and intra-articular triamcinolone with or without adalimumab effectively reduces MRI synovitis, osteitis and tenosynovitis and halts structural damage progression in early rheumatoid arthritis: results from the OPERA randomised controlled trial.
Identifieur interne : 000181 ( PubMed/Curation ); précédent : 000180; suivant : 000182A treat-to-target strategy with methotrexate and intra-articular triamcinolone with or without adalimumab effectively reduces MRI synovitis, osteitis and tenosynovitis and halts structural damage progression in early rheumatoid arthritis: results from the OPERA randomised controlled trial.
Auteurs : Mette Bj Rndal Axelsen [Danemark] ; Iris Eshed [Israël] ; Kim H Rslev-Petersen [Danemark] ; Kristian Stengaard-Pedersen [Danemark] ; Merete Lund Hetland [Danemark] ; Jakob M Ller [Danemark] ; Peter Junker [Danemark] ; Jan P Denphant [Danemark] ; Annette Schlemmer [Danemark] ; Torkell Ellingsen [Danemark] ; Palle Ahlquist [Danemark] ; Hanne Lindegaard [Danemark] ; Asta Linauskas [Danemark] ; Mette Yde Dam [Danemark] ; Ib Hansen [Danemark] ; Hans Christian Horn [Danemark] ; Christian Gytz Ammitzb Ll [Danemark] ; Anette J Rgensen [Danemark] ; Sophine B. Krintel [Danemark] ; Johnny Raun [Danemark] ; Niels S. Krogh [Danemark] ; Julia Sidenius Johansen [Danemark] ; Mikkel Stergaard [Danemark]Source :
- Annals of the rheumatic diseases ; 2015.
English descriptors
- KwdEn :
- Adalimumab, Adult, Aged, Aged, 80 and over, Anti-Inflammatory Agents (therapeutic use), Antibodies, Monoclonal, Humanized (therapeutic use), Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (complications), Arthritis, Rheumatoid (drug therapy), Arthritis, Rheumatoid (pathology), Clinical Protocols, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Injections, Intra-Articular, Magnetic Resonance Imaging, Male, Metacarpophalangeal Joint (pathology), Methotrexate (therapeutic use), Middle Aged, Osteitis (drug therapy), Osteitis (etiology), Osteitis (pathology), Patient Care Planning, Severity of Illness Index, Synovitis (drug therapy), Synovitis (etiology), Synovitis (pathology), Tenosynovitis (drug therapy), Tenosynovitis (etiology), Tenosynovitis (pathology), Treatment Outcome, Triamcinolone (therapeutic use), Wrist Joint (pathology), Young Adult.
- MESH :
- chemical , therapeutic use : Anti-Inflammatory Agents, Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Methotrexate, Triamcinolone.
- chemical : Adalimumab.
- complications : Arthritis, Rheumatoid.
- drug therapy : Arthritis, Rheumatoid, Osteitis, Synovitis, Tenosynovitis.
- etiology : Osteitis, Synovitis, Tenosynovitis.
- pathology : Arthritis, Rheumatoid, Metacarpophalangeal Joint, Osteitis, Synovitis, Tenosynovitis, Wrist Joint.
- Adult, Aged, Aged, 80 and over, Clinical Protocols, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Injections, Intra-Articular, Magnetic Resonance Imaging, Male, Middle Aged, Patient Care Planning, Severity of Illness Index, Treatment Outcome, Young Adult.
Abstract
To investigate whether a treat-to-target strategy with methotrexate and intra-articular glucocorticosteroid injections suppresses MRI inflammation and halts structural damage progression in patients with early rheumatoid arthritis (ERA), and whether adalimumab provides an additional effect.
DOI: 10.1136/annrheumdis-2013-204537
PubMed: 24412895
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A treat-to-target strategy with methotrexate and intra-articular triamcinolone with or without adalimumab effectively reduces MRI synovitis, osteitis and tenosynovitis and halts structural damage progression in early rheumatoid arthritis: results from the OPERA randomised controlled trial.</title><author><name sortKey="Axelsen, Mette Bj Rndal" sort="Axelsen, Mette Bj Rndal" uniqKey="Axelsen M" first="Mette Bj Rndal" last="Axelsen">Mette Bj Rndal Axelsen</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Eshed, Iris" sort="Eshed, Iris" uniqKey="Eshed I" first="Iris" last="Eshed">Iris Eshed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Radiology, Sheba Medical Center, Tel Aviv University, Tel Hashomer</wicri:regionArea></affiliation></author><author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name><affiliation wicri:level="1"><nlm:affiliation>King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark</wicri:regionArea></affiliation></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Aarhus University Hospital, Aarhus</wicri:regionArea></affiliation></author><author><name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup</wicri:regionArea></affiliation></author><author><name sortKey="M Ller, Jakob" sort="M Ller, Jakob" uniqKey="M Ller J" first="Jakob" last="M Ller">Jakob M Ller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Radiology, Copenhagen University Hospital at Herlev, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense</wicri:regionArea></affiliation></author><author><name sortKey="P Denphant, Jan" sort="P Denphant, Jan" uniqKey="P Denphant J" first="Jan" last="P Denphant">Jan P Denphant</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Copenhagen University Hospital at Gentofte, Gentofte, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Copenhagen University Hospital at Gentofte, Gentofte, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Schlemmer, Annette" sort="Schlemmer, Annette" uniqKey="Schlemmer A" first="Annette" last="Schlemmer">Annette Schlemmer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital in Aalborg, Aalborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Aarhus University Hospital in Aalborg, Aalborg</wicri:regionArea></affiliation></author><author><name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name><affiliation wicri:level="1"><nlm:affiliation>Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg</wicri:regionArea></affiliation></author><author><name sortKey="Ahlquist, Palle" sort="Ahlquist, Palle" uniqKey="Ahlquist P" first="Palle" last="Ahlquist">Palle Ahlquist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Vejle Regional Hospital, Vejle, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Medicine, Vejle Regional Hospital, Vejle</wicri:regionArea></affiliation></author><author><name sortKey="Lindegaard, Hanne" sort="Lindegaard, Hanne" uniqKey="Lindegaard H" first="Hanne" last="Lindegaard">Hanne Lindegaard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense</wicri:regionArea></affiliation></author><author><name sortKey="Linauskas, Asta" sort="Linauskas, Asta" uniqKey="Linauskas A" first="Asta" last="Linauskas">Asta Linauskas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Vendsyssel Hospital, Hjørring, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Vendsyssel Hospital, Hjørring</wicri:regionArea></affiliation></author><author><name sortKey="Dam, Mette Yde" sort="Dam, Mette Yde" uniqKey="Dam M" first="Mette Yde" last="Dam">Mette Yde Dam</name><affiliation wicri:level="1"><nlm:affiliation>Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg</wicri:regionArea></affiliation></author><author><name sortKey="Hansen, Ib" sort="Hansen, Ib" uniqKey="Hansen I" first="Ib" last="Hansen">Ib Hansen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Viborg Regional Hospital, Viborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Viborg Regional Hospital, Viborg</wicri:regionArea></affiliation></author><author><name sortKey="Horn, Hans Christian" sort="Horn, Hans Christian" uniqKey="Horn H" first="Hans Christian" last="Horn">Hans Christian Horn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Vejle Regional Hospital, Vejle, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Medicine, Vejle Regional Hospital, Vejle</wicri:regionArea></affiliation></author><author><name sortKey="Ammitzb Ll, Christian Gytz" sort="Ammitzb Ll, Christian Gytz" uniqKey="Ammitzb Ll C" first="Christian Gytz" last="Ammitzb Ll">Christian Gytz Ammitzb Ll</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Aarhus University Hospital, Aarhus</wicri:regionArea></affiliation></author><author><name sortKey="J Rgensen, Anette" sort="J Rgensen, Anette" uniqKey="J Rgensen A" first="Anette" last="J Rgensen">Anette J Rgensen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Aarhus University Hospital, Aarhus</wicri:regionArea></affiliation></author><author><name sortKey="Krintel, Sophine B" sort="Krintel, Sophine B" uniqKey="Krintel S" first="Sophine B" last="Krintel">Sophine B. Krintel</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup</wicri:regionArea></affiliation></author><author><name sortKey="Raun, Johnny" sort="Raun, Johnny" uniqKey="Raun J" first="Johnny" last="Raun">Johnny Raun</name><affiliation wicri:level="1"><nlm:affiliation>King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark</wicri:regionArea></affiliation></author><author><name sortKey="Krogh, Niels S" sort="Krogh, Niels S" uniqKey="Krogh N" first="Niels S" last="Krogh">Niels S. Krogh</name><affiliation wicri:level="1"><nlm:affiliation>Zitelabs Aps, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Zitelabs Aps, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Johansen, Julia Sidenius" sort="Johansen, Julia Sidenius" uniqKey="Johansen J" first="Julia Sidenius" last="Johansen">Julia Sidenius Johansen</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark Department of Medicine and Oncology, Copenhagen University Hospital at Herlev, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark Department of Medicine and Oncology, Copenhagen University Hospital at Herlev, Herlev</wicri:regionArea></affiliation></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:24412895</idno><idno type="pmid">24412895</idno><idno type="doi">10.1136/annrheumdis-2013-204537</idno><idno type="wicri:Area/PubMed/Corpus">000181</idno><idno type="wicri:Area/PubMed/Curation">000181</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A treat-to-target strategy with methotrexate and intra-articular triamcinolone with or without adalimumab effectively reduces MRI synovitis, osteitis and tenosynovitis and halts structural damage progression in early rheumatoid arthritis: results from the OPERA randomised controlled trial.</title><author><name sortKey="Axelsen, Mette Bj Rndal" sort="Axelsen, Mette Bj Rndal" uniqKey="Axelsen M" first="Mette Bj Rndal" last="Axelsen">Mette Bj Rndal Axelsen</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Eshed, Iris" sort="Eshed, Iris" uniqKey="Eshed I" first="Iris" last="Eshed">Iris Eshed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Radiology, Sheba Medical Center, Tel Aviv University, Tel Hashomer</wicri:regionArea></affiliation></author><author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name><affiliation wicri:level="1"><nlm:affiliation>King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark</wicri:regionArea></affiliation></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Aarhus University Hospital, Aarhus</wicri:regionArea></affiliation></author><author><name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup</wicri:regionArea></affiliation></author><author><name sortKey="M Ller, Jakob" sort="M Ller, Jakob" uniqKey="M Ller J" first="Jakob" last="M Ller">Jakob M Ller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Radiology, Copenhagen University Hospital at Herlev, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense</wicri:regionArea></affiliation></author><author><name sortKey="P Denphant, Jan" sort="P Denphant, Jan" uniqKey="P Denphant J" first="Jan" last="P Denphant">Jan P Denphant</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Copenhagen University Hospital at Gentofte, Gentofte, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Copenhagen University Hospital at Gentofte, Gentofte, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Schlemmer, Annette" sort="Schlemmer, Annette" uniqKey="Schlemmer A" first="Annette" last="Schlemmer">Annette Schlemmer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital in Aalborg, Aalborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Aarhus University Hospital in Aalborg, Aalborg</wicri:regionArea></affiliation></author><author><name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name><affiliation wicri:level="1"><nlm:affiliation>Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg</wicri:regionArea></affiliation></author><author><name sortKey="Ahlquist, Palle" sort="Ahlquist, Palle" uniqKey="Ahlquist P" first="Palle" last="Ahlquist">Palle Ahlquist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Vejle Regional Hospital, Vejle, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Medicine, Vejle Regional Hospital, Vejle</wicri:regionArea></affiliation></author><author><name sortKey="Lindegaard, Hanne" sort="Lindegaard, Hanne" uniqKey="Lindegaard H" first="Hanne" last="Lindegaard">Hanne Lindegaard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense</wicri:regionArea></affiliation></author><author><name sortKey="Linauskas, Asta" sort="Linauskas, Asta" uniqKey="Linauskas A" first="Asta" last="Linauskas">Asta Linauskas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Vendsyssel Hospital, Hjørring, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Vendsyssel Hospital, Hjørring</wicri:regionArea></affiliation></author><author><name sortKey="Dam, Mette Yde" sort="Dam, Mette Yde" uniqKey="Dam M" first="Mette Yde" last="Dam">Mette Yde Dam</name><affiliation wicri:level="1"><nlm:affiliation>Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg</wicri:regionArea></affiliation></author><author><name sortKey="Hansen, Ib" sort="Hansen, Ib" uniqKey="Hansen I" first="Ib" last="Hansen">Ib Hansen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Viborg Regional Hospital, Viborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Viborg Regional Hospital, Viborg</wicri:regionArea></affiliation></author><author><name sortKey="Horn, Hans Christian" sort="Horn, Hans Christian" uniqKey="Horn H" first="Hans Christian" last="Horn">Hans Christian Horn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Vejle Regional Hospital, Vejle, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Medicine, Vejle Regional Hospital, Vejle</wicri:regionArea></affiliation></author><author><name sortKey="Ammitzb Ll, Christian Gytz" sort="Ammitzb Ll, Christian Gytz" uniqKey="Ammitzb Ll C" first="Christian Gytz" last="Ammitzb Ll">Christian Gytz Ammitzb Ll</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Aarhus University Hospital, Aarhus</wicri:regionArea></affiliation></author><author><name sortKey="J Rgensen, Anette" sort="J Rgensen, Anette" uniqKey="J Rgensen A" first="Anette" last="J Rgensen">Anette J Rgensen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Rheumatology, Aarhus University Hospital, Aarhus</wicri:regionArea></affiliation></author><author><name sortKey="Krintel, Sophine B" sort="Krintel, Sophine B" uniqKey="Krintel S" first="Sophine B" last="Krintel">Sophine B. Krintel</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup</wicri:regionArea></affiliation></author><author><name sortKey="Raun, Johnny" sort="Raun, Johnny" uniqKey="Raun J" first="Johnny" last="Raun">Johnny Raun</name><affiliation wicri:level="1"><nlm:affiliation>King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark</wicri:regionArea></affiliation></author><author><name sortKey="Krogh, Niels S" sort="Krogh, Niels S" uniqKey="Krogh N" first="Niels S" last="Krogh">Niels S. Krogh</name><affiliation wicri:level="1"><nlm:affiliation>Zitelabs Aps, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Zitelabs Aps, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Johansen, Julia Sidenius" sort="Johansen, Julia Sidenius" uniqKey="Johansen J" first="Julia Sidenius" last="Johansen">Julia Sidenius Johansen</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark Department of Medicine and Oncology, Copenhagen University Hospital at Herlev, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark Department of Medicine and Oncology, Copenhagen University Hospital at Herlev, Herlev</wicri:regionArea></affiliation></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of the rheumatic diseases</title><idno type="e-ISSN">1468-2060</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adalimumab</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Anti-Inflammatory Agents (therapeutic use)</term><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Rheumatoid (complications)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Arthritis, Rheumatoid (pathology)</term><term>Clinical Protocols</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Injections, Intra-Articular</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Metacarpophalangeal Joint (pathology)</term><term>Methotrexate (therapeutic use)</term><term>Middle Aged</term><term>Osteitis (drug therapy)</term><term>Osteitis (etiology)</term><term>Osteitis (pathology)</term><term>Patient Care Planning</term><term>Severity of Illness Index</term><term>Synovitis (drug therapy)</term><term>Synovitis (etiology)</term><term>Synovitis (pathology)</term><term>Tenosynovitis (drug therapy)</term><term>Tenosynovitis (etiology)</term><term>Tenosynovitis (pathology)</term><term>Treatment Outcome</term><term>Triamcinolone (therapeutic use)</term><term>Wrist Joint (pathology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Antibodies, Monoclonal, Humanized</term><term>Antirheumatic Agents</term><term>Methotrexate</term><term>Triamcinolone</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adalimumab</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Osteitis</term><term>Synovitis</term><term>Tenosynovitis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Osteitis</term><term>Synovitis</term><term>Tenosynovitis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Metacarpophalangeal Joint</term><term>Osteitis</term><term>Synovitis</term><term>Tenosynovitis</term><term>Wrist Joint</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Clinical Protocols</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Injections, Intra-Articular</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Patient Care Planning</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate whether a treat-to-target strategy with methotrexate and intra-articular glucocorticosteroid injections suppresses MRI inflammation and halts structural damage progression in patients with early rheumatoid arthritis (ERA), and whether adalimumab provides an additional effect.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24412895</PMID><DateCreated><Year>2015</Year><Month>04</Month><Day>03</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>02</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-2060</ISSN><JournalIssue CitedMedium="Internet"><Volume>74</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>Annals of the rheumatic diseases</Title><ISOAbbreviation>Ann. Rheum. Dis.</ISOAbbreviation></Journal><ArticleTitle>A treat-to-target strategy with methotrexate and intra-articular triamcinolone with or without adalimumab effectively reduces MRI synovitis, osteitis and tenosynovitis and halts structural damage progression in early rheumatoid arthritis: results from the OPERA randomised controlled trial.</ArticleTitle><Pagination><MedlinePgn>867-75</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/annrheumdis-2013-204537</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To investigate whether a treat-to-target strategy with methotrexate and intra-articular glucocorticosteroid injections suppresses MRI inflammation and halts structural damage progression in patients with early rheumatoid arthritis (ERA), and whether adalimumab provides an additional effect.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In a double-blind, placebo-controlled trial, 85 disease-modifying antirheumatic drug-naïve patients with ERA were randomised to receive methotrexate, intra-articular glucocorticosteroid injections and placebo/adalimumab (43/42). Contrast-enhanced MRI of the right hand was performed at months 0, 6 and 12. Synovitis, osteitis, tenosynovitis, MRI bone erosion and joint space narrowing (JSN) were scored with validated methods. Dynamic contrast-enhanced MRI (DCE-MRI) was carried out in 14 patients.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Synovitis, osteitis and tenosynovitis scores decreased highly significantly (p<0.0001) during the 12-months' follow-up, with mean change scores of -3.7 (median -3.0), -2.2 (-1) and -5.3 (-4.0), respectively. No overall change in MRI bone erosion and JSN scores was seen, with change scores of 0.1 (0) and 0.2 (0). The tenosynovitis score at month 6 was significantly lower in the adalimumab group, 1.3 (0), than in the placebo group, 3.9 (2), Mann-Whitney: p<0.035. Furthermore, the osteitis score decreased significantly during the 12-months' follow-up in the adalimumab group, but not in the placebo group, Wilcoxon: p=0.001-0.002 and p=0.062-0.146. DCE-MRI parameters correlated closely with conventional MRI inflammatory parameters. Clinical measures decreased highly significantly during follow-up.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A treat-to-target strategy with methotrexate and intra-articular glucocorticosteroid in patients with ERA effectively decreased synovitis, osteitis and tenosynovitis and halted structural damage progression as judged by MRI. The findings suggest that addition of adalimumab is associated with further suppression of osteitis and tenosynovitis.</AbstractText><CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Axelsen</LastName><ForeName>Mette Bjørndal</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eshed</LastName><ForeName>Iris</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Radiology, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hørslev-Petersen</LastName><ForeName>Kim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stengaard-Pedersen</LastName><ForeName>Kristian</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hetland</LastName><ForeName>Merete Lund</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Møller</LastName><ForeName>Jakob</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Radiology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Junker</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pødenphant</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Copenhagen University Hospital at Gentofte, Gentofte, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schlemmer</LastName><ForeName>Annette</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Aarhus University Hospital in Aalborg, Aalborg, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ellingsen</LastName><ForeName>Torkell</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahlquist</LastName><ForeName>Palle</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medicine, Vejle Regional Hospital, Vejle, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lindegaard</LastName><ForeName>Hanne</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Linauskas</LastName><ForeName>Asta</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Vendsyssel Hospital, Hjørring, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dam</LastName><ForeName>Mette Yde</ForeName><Initials>MY</Initials><AffiliationInfo><Affiliation>Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>Ib</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Viborg Regional Hospital, Viborg, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horn</LastName><ForeName>Hans Christian</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Department of Medicine, Vejle Regional Hospital, Vejle, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ammitzbøll</LastName><ForeName>Christian Gytz</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jørgensen</LastName><ForeName>Anette</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krintel</LastName><ForeName>Sophine B</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raun</LastName><ForeName>Johnny</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krogh</LastName><ForeName>Niels S</ForeName><Initials>NS</Initials><AffiliationInfo><Affiliation>Zitelabs Aps, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johansen</LastName><ForeName>Julia Sidenius</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark Department of Medicine and Oncology, Copenhagen University Hospital at Herlev, Herlev, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Østergaard</LastName><ForeName>Mikkel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>OPERA study group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Rheum Dis</MedlineTA><NlmUniqueID>0372355</NlmUniqueID><ISSNLinking>0003-4967</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D061067">Antibodies, Monoclonal, Humanized</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>1ZK20VI6TY</RegistryNumber><NameOfSubstance UI="D014221">Triamcinolone</NameOfSubstance></Chemical><Chemical><RegistryNumber>FYS6T7F842</RegistryNumber><NameOfSubstance UI="D000068879">Adalimumab</NameOfSubstance></Chemical><Chemical><RegistryNumber>YL5FZ2Y5U1</RegistryNumber><NameOfSubstance UI="D008727">Methotrexate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000068879">Adalimumab</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000893">Anti-Inflammatory Agents</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D061067">Antibodies, Monoclonal, Humanized</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018501">Antirheumatic Agents</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001172">Arthritis, Rheumatoid</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002985">Clinical Protocols</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004311">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004359">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007270">Injections, Intra-Articular</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008662">Metacarpophalangeal Joint</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008727">Methotrexate</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010000">Osteitis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010347">Patient Care Planning</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013585">Synovitis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013717">Tenosynovitis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014221">Triamcinolone</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014955">Wrist Joint</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D055815">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Magnetic Resonance Imaging</Keyword><Keyword MajorTopicYN="N">Rheumatoid Arthritis</Keyword><Keyword MajorTopicYN="N">Treatment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>8</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>12</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>1</Month><Day>10</Day></PubMedPubDate><PubMedPubDate 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