Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs.
Identifieur interne : 000170 ( PubMed/Curation ); précédent : 000169; suivant : 000171Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs.
Auteurs : Yumi Kondo [Japon] ; Gen Kinoshita [Japon] ; Marlene Drag [États-Unis] ; Theodore S. Chester [États-Unis] ; Diane Larsen [États-Unis]Source :
- Veterinary parasitology ; 2014.
English descriptors
- KwdEn :
- Acaricides (therapeutic use), Animals, Dog Diseases (drug therapy), Dog Diseases (prevention & control), Dogs, Female, Isoxazoles (administration & dosage), Ixodidae, Male, Naphthalenes (administration & dosage), Random Allocation, Tick Infestations (drug therapy), Tick Infestations (prevention & control), Tick Infestations (veterinary), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Isoxazoles, Naphthalenes.
- chemical , therapeutic use : Acaricides.
- drug therapy : Dog Diseases, Tick Infestations.
- prevention & control : Dog Diseases, Tick Infestations.
- veterinary : Tick Infestations.
- Animals, Dogs, Female, Ixodidae, Male, Random Allocation, Treatment Outcome.
Abstract
A controlled study to assess the acaricidal efficacy of afoxolaner in dogs after a single oral administration was conducted against Haemaphysalis longicornis ticks. The study was characterized by a negative controlled randomized block design and included sixteen beagle dogs of both sexes. Starting two days before treatment, each dog was infested weekly with 50 ticks over 4 weeks. The number of live ticks was determined 48 h after treatment and then 48 h after each infestation. The mean dose of afoxolaner received by dogs was 3.0mg/kg (range: 2.5-3.1mg/kg). Afoxolaner rapidly eliminated pre-existing tick infestations (100% ticks killed within 48 h of treatment) and controlled weekly re-infestations (91.9% prophylactic efficacy at Day 30).
DOI: 10.1016/j.vetpar.2014.02.019
PubMed: 24629429
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Electronic address: yumi.kondo@merial.com.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Merial Japan Limited, Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo 163-1488</wicri:regionArea></affiliation></author><author><name sortKey="Kinoshita, Gen" sort="Kinoshita, Gen" uniqKey="Kinoshita G" first="Gen" last="Kinoshita">Gen Kinoshita</name><affiliation wicri:level="1"><nlm:affiliation>Merial Japan Limited, Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo 163-1488, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Merial Japan Limited, Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo 163-1488</wicri:regionArea></affiliation></author><author><name sortKey="Drag, Marlene" sort="Drag, Marlene" uniqKey="Drag M" first="Marlene" last="Drag">Marlene Drag</name><affiliation wicri:level="1"><nlm:affiliation>Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096-4640, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096-4640</wicri:regionArea></affiliation></author><author><name sortKey="Chester, Theodore S" sort="Chester, Theodore S" uniqKey="Chester T" first="Theodore S" last="Chester">Theodore S. 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The study was characterized by a negative controlled randomized block design and included sixteen beagle dogs of both sexes. Starting two days before treatment, each dog was infested weekly with 50 ticks over 4 weeks. The number of live ticks was determined 48 h after treatment and then 48 h after each infestation. The mean dose of afoxolaner received by dogs was 3.0mg/kg (range: 2.5-3.1mg/kg). Afoxolaner rapidly eliminated pre-existing tick infestations (100% ticks killed within 48 h of treatment) and controlled weekly re-infestations (91.9% prophylactic efficacy at Day 30).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24629429</PMID><DateCreated><Year>2014</Year><Month>04</Month><Day>07</Day></DateCreated><DateCompleted><Year>2014</Year><Month>06</Month><Day>23</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2550</ISSN><JournalIssue CitedMedium="Internet"><Volume>201</Volume><Issue>3-4</Issue><PubDate><Year>2014</Year><Month>Apr</Month><Day>2</Day></PubDate></JournalIssue><Title>Veterinary parasitology</Title><ISOAbbreviation>Vet. Parasitol.</ISOAbbreviation></Journal><ArticleTitle>Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs.</ArticleTitle><Pagination><MedlinePgn>229-31</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vetpar.2014.02.019</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0304-4017(14)00092-2</ELocationID><Abstract><AbstractText>A controlled study to assess the acaricidal efficacy of afoxolaner in dogs after a single oral administration was conducted against Haemaphysalis longicornis ticks. The study was characterized by a negative controlled randomized block design and included sixteen beagle dogs of both sexes. Starting two days before treatment, each dog was infested weekly with 50 ticks over 4 weeks. The number of live ticks was determined 48 h after treatment and then 48 h after each infestation. The mean dose of afoxolaner received by dogs was 3.0mg/kg (range: 2.5-3.1mg/kg). Afoxolaner rapidly eliminated pre-existing tick infestations (100% ticks killed within 48 h of treatment) and controlled weekly re-infestations (91.9% prophylactic efficacy at Day 30).</AbstractText><CopyrightInformation>Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kondo</LastName><ForeName>Yumi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Merial Japan Limited, Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo 163-1488, Japan. Electronic address: yumi.kondo@merial.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kinoshita</LastName><ForeName>Gen</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Merial Japan Limited, Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo 163-1488, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drag</LastName><ForeName>Marlene</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096-4640, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chester</LastName><ForeName>Theodore S</ForeName><Initials>TS</Initials><AffiliationInfo><Affiliation>Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096-4640, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larsen</LastName><ForeName>Diane</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096-4640, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>03</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vet Parasitol</MedlineTA><NlmUniqueID>7602745</NlmUniqueID><ISSNLinking>0304-4017</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D056810">Acaricides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007555">Isoxazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009281">Naphthalenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>02L07H6D0U</RegistryNumber><NameOfSubstance UI="C000589002">afoxolaner</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D056810">Acaricides</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004283">Dog Diseases</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000517">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004285">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007555">Isoxazoles</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000008">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D026863">Ixodidae</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009281">Naphthalenes</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000008">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011897">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013984">Tick Infestations</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000517">prevention & control</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000662">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Afoxolaner</Keyword><Keyword MajorTopicYN="N">Dog</Keyword><Keyword MajorTopicYN="N">Efficacy</Keyword><Keyword MajorTopicYN="N">Haemaphysalis longicornis</Keyword><Keyword MajorTopicYN="N">Tick</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>3</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>6</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24629429</ArticleId><ArticleId IdType="pii">S0304-4017(14)00092-2</ArticleId><ArticleId IdType="doi">10.1016/j.vetpar.2014.02.019</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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