Interleukin-23 in early disease development in rheumatoid arthritis.
Identifieur interne : 000074 ( PubMed/Curation ); précédent : 000073; suivant : 000075Interleukin-23 in early disease development in rheumatoid arthritis.
Auteurs : T. Andersen ; M. Hvid ; C. Johansen ; K. Stengaard-Pedersen ; M L Hetland ; K. H Rslev-Petersen ; P. Junker ; M. Stergaard ; B. DeleuranSource :
- Scandinavian journal of rheumatology ; 2015.
Abstract
To investigate the levels of interleukin (IL)-23 in patients with early rheumatoid arthritis (eRA) and the effect of anti-tumour necrosis factor (anti-TNF)-α treatment on IL-23 levels.
DOI: 10.3109/03009742.2015.1033007
PubMed: 26087654
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interleukin-23 in early disease development in rheumatoid arthritis.</title><author><name sortKey="Andersen, T" sort="Andersen, T" uniqKey="Andersen T" first="T" last="Andersen">T. Andersen</name></author><author><name sortKey="Hvid, M" sort="Hvid, M" uniqKey="Hvid M" first="M" last="Hvid">M. Hvid</name></author><author><name sortKey="Johansen, C" sort="Johansen, C" uniqKey="Johansen C" first="C" last="Johansen">C. Johansen</name></author><author><name sortKey="Stengaard Pedersen, K" sort="Stengaard Pedersen, K" uniqKey="Stengaard Pedersen K" first="K" last="Stengaard-Pedersen">K. Stengaard-Pedersen</name></author><author><name sortKey="Hetland, M L" sort="Hetland, M L" uniqKey="Hetland M" first="M L" last="Hetland">M L Hetland</name></author><author><name sortKey="H Rslev Petersen, K" sort="H Rslev Petersen, K" uniqKey="H Rslev Petersen K" first="K" last="H Rslev-Petersen">K. H Rslev-Petersen</name></author><author><name sortKey="Junker, P" sort="Junker, P" uniqKey="Junker P" first="P" last="Junker">P. Junker</name></author><author><name sortKey=" Stergaard, M" sort=" Stergaard, M" uniqKey=" Stergaard M" first="M" last=" Stergaard">M. Stergaard</name></author><author><name sortKey="Deleuran, B" sort="Deleuran, B" uniqKey="Deleuran B" first="B" last="Deleuran">B. Deleuran</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="doi">10.3109/03009742.2015.1033007</idno><idno type="RBID">pubmed:26087654</idno><idno type="pmid">26087654</idno><idno type="wicri:Area/PubMed/Corpus">000074</idno><idno type="wicri:Area/PubMed/Curation">000074</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interleukin-23 in early disease development in rheumatoid arthritis.</title><author><name sortKey="Andersen, T" sort="Andersen, T" uniqKey="Andersen T" first="T" last="Andersen">T. Andersen</name></author><author><name sortKey="Hvid, M" sort="Hvid, M" uniqKey="Hvid M" first="M" last="Hvid">M. Hvid</name></author><author><name sortKey="Johansen, C" sort="Johansen, C" uniqKey="Johansen C" first="C" last="Johansen">C. Johansen</name></author><author><name sortKey="Stengaard Pedersen, K" sort="Stengaard Pedersen, K" uniqKey="Stengaard Pedersen K" first="K" last="Stengaard-Pedersen">K. Stengaard-Pedersen</name></author><author><name sortKey="Hetland, M L" sort="Hetland, M L" uniqKey="Hetland M" first="M L" last="Hetland">M L Hetland</name></author><author><name sortKey="H Rslev Petersen, K" sort="H Rslev Petersen, K" uniqKey="H Rslev Petersen K" first="K" last="H Rslev-Petersen">K. H Rslev-Petersen</name></author><author><name sortKey="Junker, P" sort="Junker, P" uniqKey="Junker P" first="P" last="Junker">P. Junker</name></author><author><name sortKey=" Stergaard, M" sort=" Stergaard, M" uniqKey=" Stergaard M" first="M" last=" Stergaard">M. Stergaard</name></author><author><name sortKey="Deleuran, B" sort="Deleuran, B" uniqKey="Deleuran B" first="B" last="Deleuran">B. Deleuran</name></author></analytic><series><title level="j">Scandinavian journal of rheumatology</title><idno type="e-ISSN">1502-7732</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the levels of interleukin (IL)-23 in patients with early rheumatoid arthritis (eRA) and the effect of anti-tumour necrosis factor (anti-TNF)-α treatment on IL-23 levels.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">26087654</PMID><DateCreated><Year>2016</Year><Month>02</Month><Day>18</Day></DateCreated><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1502-7732</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>6</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>Scandinavian journal of rheumatology</Title><ISOAbbreviation>Scand. J. Rheumatol.</ISOAbbreviation></Journal><ArticleTitle>Interleukin-23 in early disease development in rheumatoid arthritis.</ArticleTitle><Pagination><MedlinePgn>438-42</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To investigate the levels of interleukin (IL)-23 in patients with early rheumatoid arthritis (eRA) and the effect of anti-tumour necrosis factor (anti-TNF)-α treatment on IL-23 levels.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">Treatment-naïve eRA patients from the OPERA cohort were included (n = 151). Patients were randomized to methotrexate (MTX) plus adalimumab (ADA; n = 75) or MTX plus placebo-ADA (PLA; n = 76). Plasma samples were obtained at baseline and at months 3, 6, and 12 together with values for C-reactive protein (CRP), the 28-joint Disease Activity Score based on CRP (DAS28CRP), scores on the Clinical Disease Activity Index (CDAI) and the Simplified Disease Activity Index (SDAI), visual analogue scale (VAS) for pain/fatigue/physician global and total Sharp/van der Heijde score (TSS). IL-23 was measured at each time point.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">IL-23 levels decreased significantly in the ADA group from 20.6 pg/mL (IQR 13.1-32.7 pg/mL) at baseline to 18 pg/mL (IQR 7.2-25.0 pg/mL) at 12 months (p < 0.01). No significant decrease in IL-23 level was observed in the PLA group. No associations between baseline IL-23 levels and measures of disease activity (DAS28CRP, CRP, CDAI, or SDAI) at 12 or 24 months were present in the treatment groups. Baseline IL-23 correlated inversely with changes in TSS and symptom duration before diagnosis.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our data show increased baseline levels and a significant decrease in IL-23 levels in eRA patients treated with anti-TNF-α. The inverse correlation with duration of symptoms before diagnosis supports the importance of IL-23 in the preclinical disease development of RA.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Andersen</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Hvid</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Johansen</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Stengaard-Pedersen</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Hetland</LastName><ForeName>M L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Hørslev-Petersen</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Junker</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Østergaard</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Deleuran</LastName><ForeName>B</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Scand J Rheumatol</MedlineTA><NlmUniqueID>0321213</NlmUniqueID><ISSNLinking>0300-9742</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.3109/03009742.2015.1033007</ArticleId><ArticleId IdType="pubmed">26087654</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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